8-Cyclopentyl-1,3-dimethylxanthine (BioDeep_00000175245)

   

human metabolite blood metabolite


代谢物信息卡片


8-cyclopentyl-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C12H16N4O2 (248.1273196)
中文名称: A1受体拮抗剂,CPT
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: CN1C2=C(C(=O)N(C1=O)C)NC(=N2)C3CCCC3
InChI: InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively[1].

同义名列表

5 个代谢物同义名

8-cyclopentyl-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 8-cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione; 8-Cyclopentyl-1,3-dimethylxanthine; 8-Cyclopentyltheophylline; 8-CPDMX



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kana N Miyata, Chao-Sheng Lo, Shuiling Zhao, Xin-Ping Zhao, Isabelle Chenier, Michifumi Yamashita, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan. Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes. Diabetologia. 2021 11; 64(11):2589-2601. doi: 10.1007/s00125-021-05538-9. [PMID: 34370045]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mariola Herbet, Aleksandra Szopa, Sylwia Wosko, Anna Serefko, Magdalena Izdebska, Monika Gawronska-Grzywacz, Iwona Piatkowska-Chmiel, Martyna Janas, Renata Gieroba, Agnieszka Korga, Ewa Poleszak, Jaroslaw Dudka. The Positive Synergism of CPT and MK-801 in Behavioral Tests and in Reduction of Environmental Stress and Redox Signaling Changes in Mice Cerebral Cortex. CNS & neurological disorders drug targets. 2017; 16(7):837-845. doi: 10.2174/1871527315666161010152414. [PMID: 27748185]
  • Yong Zhang, Ming-liang Chen, Yong Zhou, Long Yi, Yan-xiang Gao, Li Ran, Shi-hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi. Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway. Molecular nutrition & food research. 2015 Aug; 59(8):1443-57. doi: 10.1002/mnfr.201500016. [PMID: 25943029]
  • Nobuo Momoi, Joseph P Tinney, Li J Liu, Huda Elshershari, Paul J Hoffmann, John C Ralphe, Bradley B Keller, Kimimasa Tobita. Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth. American journal of physiology. Heart and circulatory physiology. 2008 May; 294(5):H2248-56. doi: 10.1152/ajpheart.91469.2007. [PMID: 18359892]
  • E Y Lai, A Patzak, A Steege, R Mrowka, R Brown, N Spielmann, P B Persson, B B Fredholm, A E G Persson. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney international. 2006 Aug; 70(4):690-8. doi: 10.1038/sj.ki.5001650. [PMID: 16807541]
  • Eun-Joo Shin, Ki-Wan Oh, Kee-Won Kim, Yong Soo Kwon, Jin Hyeong Jhoo, Wang-Kee Jhoo, Joo-Young Cha, Yong Kwang Lim, In Soon Kim, Hyoung-Chun Kim. Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia root extract. Life sciences. 2004 Oct; 75(23):2751-64. doi: 10.1016/j.lfs.2004.04.045. [PMID: 15464827]
  • Yong Soo Kwon, Toshitaka Nabeshima, Eun-Joo Shin, Wanjoo Chun, Jin Hyeong Jhoo, Wang-Kee Jhoo, Myung Bok Wie, Choon-Gon Jang, Heesun Chung, Young Eun Sung, Hyoung-Chun Kim. PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. Biological & pharmaceutical bulletin. 2004 Jun; 27(6):906-9. doi: 10.1248/bpb.27.906. [PMID: 15187444]
  • Lap-Ming Tang, I-Min Liu, Juei-Tang Cheng. Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat. Planta medica. 2003 Apr; 69(4):332-6. doi: 10.1055/s-2003-38878. [PMID: 12709900]
  • Kinga K Borowicz, Jarogniew Łuszczki, Stanisław J Czuczwar. 2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2002 Apr; 12(2):173-9. doi: 10.1016/s0924-977x(02)00009-3. [PMID: 11872335]
  • W M Webe, A Segal, A Vankeerberghen, J J Cassiman, W Van Driessche. Different activation mechanisms of cystic fibrosis transmembrane conductance regulator expressed in Xenopus laevis oocytes. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2001 Oct; 130(3):521-31. doi: 10.1016/s1095-6433(01)00427-5. [PMID: 11913463]
  • K K Borowicz, Z Kleinrok, S J Czuczwar. N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2000 Jul; 10(4):237-43. doi: 10.1016/s0924-977x(00)00081-x. [PMID: 10871705]
  • J G Gerber, D Detmar-Hanna, N R Zahniser. Lack of an effect of age on beta-adrenoceptor-mediated lipolysis in isolated human adipocytes. The journals of gerontology. Series A, Biological sciences and medical sciences. 1999 Feb; 54(2):B71-7. doi: 10.1093/gerona/54.2.b71. [PMID: 10051853]
  • R Coulson, P S Proch, R A Olsson, C E Chalfant, D R Cooper. Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation. The American journal of physiology. 1996 Feb; 270(2 Pt 2):F263-74. doi: 10.1152/ajprenal.1996.270.2.f263. [PMID: 8779886]
  • H Weihprecht, J N Lorenz, J P Briggs, J Schnermann. Synergistic effects of angiotensin and adenosine in the renal microvasculature. The American journal of physiology. 1994 Feb; 266(2 Pt 2):F227-39. doi: 10.1152/ajprenal.1994.266.2.f227. [PMID: 8141324]
  • F Suzuki, J Shimada, H Mizumoto, A Karasawa, K Kubo, H Nonaka, A Ishii, T Kawakita. Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. Journal of medicinal chemistry. 1992 Aug; 35(16):3066-75. doi: 10.1021/jm00094a022. [PMID: 1501234]
  • H M Snyder, T D Noland, M D Breyer. cAMP-dependent protein kinase mediates hydrosmotic effect of vasopressin in collecting duct. The American journal of physiology. 1992 Jul; 263(1 Pt 1):C147-53. doi: 10.1152/ajpcell.1992.263.1.c147. [PMID: 1322038]
  • M R Panjehshahin, T S Munsey, M G Collis, C J Bowmer, M S Yates. Further characterization of the protective effect of 8-cyclopentyl-1,3-dipropylxanthine on glycerol-induced acute renal failure in the rat. The Journal of pharmacy and pharmacology. 1992 Feb; 44(2):109-13. doi: 10.1111/j.2042-7158.1992.tb03572.x. [PMID: 1352809]
  • O Nikodijević, R Sarges, J W Daly, K A Jacobson. Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism. The Journal of pharmacology and experimental therapeutics. 1991 Oct; 259(1):286-94. doi: NULL. [PMID: 1920121]
  • R Kellett, C J Bowmer, M G Collis, M S Yates. Amelioration of glycerol-induced acute renal failure in the rat with 8-cyclopentyl-1,3-dipropylxanthine. British journal of pharmacology. 1989 Nov; 98(3):1066-74. doi: 10.1111/j.1476-5381.1989.tb14639.x. [PMID: 2590769]