8-Chlorodiltiazem (BioDeep_00000175241)

   

human metabolite blood metabolite


代谢物信息卡片


3-Acetoxy-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one maleate

化学式: C22H25ClN2O4S (448.12234800000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
InChI: InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3

描述信息

D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators

同义名列表

5 个代谢物同义名

3-Acetoxy-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one maleate; 8-chloro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; Clentiazem maleate; 8-Chlorodiltiazem; Clentiazem



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • K Hanada, R Fujisawa, R Kataoka, S Nakamura, H Ogata. Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat. Xenobiotica; the fate of foreign compounds in biological systems. 2001 Oct; 31(10):725-31. doi: 10.1080/00498250110052706. [PMID: 11695851]
  • S Giasson, D Garceau, W Homsy, L Dumont. Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs. Cardiovascular drugs and therapy. 1995 Oct; 9(5):685-92. doi: 10.1007/bf00878551. [PMID: 8573551]
  • J C Russell, S E Graham, B Stewart, P J Dolphin. Sexual dimorphism in the metabolic response to the calcium channel antagonists, diltiazem and clentiazem, by hyperlipidemic JCR:LA-cp rats. Biochimica et biophysica acta. 1995 Sep; 1258(2):199-205. doi: 10.1016/0005-2760(95)00124-u. [PMID: 7548184]
  • M Tanguay, G Lepage, G Blaise, D Garceau, L Dumont. Clentiazem, diltiazem, and cold cardioplegia in isolated ischemic rabbit hearts: relation between additive cardioprotection, physicochemical properties, and preservation of myocardial lipid components. Journal of cardiovascular pharmacology. 1994 Dec; 24(6):950-9. doi: 10.1097/00005344-199424060-00013. [PMID: 7898079]
  • L Gaber, C Walton, S Brown, G Bakris. Effects of different antihypertensive treatments on morphologic progression of diabetic nephropathy in uninephrectomized dogs. Kidney international. 1994 Jul; 46(1):161-9. doi: 10.1038/ki.1994.255. [PMID: 7933834]
  • Y Saso, H Iwasaki, A Yasoshima, K Takashima, T Morita. Comparison of atherogenicity of soybean oil and peanut oil, and effect of clentiazem on diet-induced atherosclerosis in rabbits. The Journal of veterinary medical science. 1994 Feb; 56(1):83-9. doi: 10.1292/jvms.56.83. [PMID: 8204766]
  • K Kikkawa, S Murata, H Kurosawa, W Toriumi, H Iwasaki, T Nagao. Effect of clentiazem (TA-3090) with posttreatment on neurologic and histologic disorders of stroke-prone spontaneously hypertensive rats with history of stroke. Journal of cardiovascular pharmacology. 1994 Jan; 23(1):166-74. doi: 10.1097/00005344-199401000-00023. [PMID: 7511730]
  • H Inoue, S Nakamura, H Otsuka, M Gaino, T Harada, K Matsuki, M Takeda. Synthesis of the metabolites of clentiazem. Chemical & pharmaceutical bulletin. 1994 Jan; 42(1):167-72. doi: 10.1248/cpb.42.167. [PMID: 8124760]
  • S Nakamura, Y Sugawara, T Fukushima, Y Ito, M Ohashi, O Takaiti. Disposition and metabolic fate of clentiazem in rats and dogs. Biological & pharmaceutical bulletin. 1993 Jul; 16(7):647-55. doi: 10.1248/bpb.16.647. [PMID: 8401396]
  • S Nakamura, Y Sugawara, T Fukushima, Y Ito, M Ohashi, O Takaiti. Metabolism of clentiazem in rats. Biological & pharmaceutical bulletin. 1993 Jul; 16(7):635-46. doi: 10.1248/bpb.16.635. [PMID: 8401395]
  • S A Brown, C L Walton, P Crawford, G L Bakris. Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria. Kidney international. 1993 Jun; 43(6):1210-8. doi: 10.1038/ki.1993.171. [PMID: 8391095]
  • V O Bhargava, A K Shah, S J Weir, E E Nordbrock, D H Giesing. Single and multiple oral dose pharmacokinetics of clentiazem in normal volunteers. Journal of clinical pharmacology. 1993 May; 33(5):439-43. doi: 10.1002/j.1552-4604.1993.tb04684.x. [PMID: 8331200]
  • A K Shah, V O Bhargava, S J Weir, D H Giesing. Pharmacokinetics of clentiazem after intravenous and oral administration in healthy subjects. Journal of clinical pharmacology. 1993 Apr; 33(4):354-9. doi: 10.1002/j.1552-4604.1993.tb04669.x. [PMID: 8473551]
  • Y Saso, A Ohtani, A Odawara, H Iwasaki, K Takashima, T Morita. Inhibitory effect of clentiazem (TA-3090), a new calcium antagonist, on balloon catheter-induced intimal thickening of rabbit aorta. Cardiovascular drugs and therapy. 1993 Apr; 7(2):257-64. doi: 10.1007/bf00878516. [PMID: 8357780]
  • J J Nunnari, M Fisher, S D White. Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker. Experimental and molecular pathology. 1992 Dec; 57(3):193-204. doi: 10.1016/0014-4800(92)90010-9. [PMID: 1286670]
  • S Lu, R J Roman, D L Mattson, A W Cowley. Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats. The American journal of physiology. 1992 Nov; 263(5 Pt 2):R1064-70. doi: 10.1152/ajpregu.1992.263.5.r1064. [PMID: 1443224]
  • A K Laflamme, G Caillé, R Cardinal, D Croteau, C Lamoureux, C Lambert. Effect of congestive heart failure on clentiazem pharmacokinetics in a dog model. Biopharmaceutics & drug disposition. 1992 Oct; 13(7):513-20. doi: 10.1002/bdd.2510130705. [PMID: 1489942]
  • R Gaspo, L Lamarche, N Yamaguchi, J de Champlain, D Garceau. Effects of clentiazem (TA-3090) and nifedipine on basal circulating catecholamine levels and on stimulation-evoked adrenal catecholamine secretion in anesthetized dogs. Canadian journal of physiology and pharmacology. 1992 Jul; 70(7):983-9. doi: 10.1139/y92-135. [PMID: 1451037]
  • K Kikkawa, S Murata, H Iwasaki, W Toriumi, K Banno, T Nagao. Prophylactic effects of a new 1,5-benzothiazepine calcium antagonist on stroke in salt-loaded stroke-prone spontaneously hypertensive rats. Arzneimittel-Forschung. 1992 Jun; 42(6):781-6. doi: NULL. [PMID: 1418031]
  • F J Fenoy, I Milicic, M Mistry, T E Mecca, R J Roman. Effect of clentiazem on arterial pressure and renal function in normotensive and hypertensive rats. The Journal of pharmacology and experimental therapeutics. 1992 May; 261(2):470-5. doi: NULL. [PMID: 1578362]
  • S Suzuki, M Mori, S Kusano. Analysis of the daily variation in blood pressure and pharmacokinetics after single or repeated administration of clentiazem to patients with essential hypertension. Arzneimittel-Forschung. 1992 Apr; 42(4):533-9. doi: NULL. [PMID: 1642678]
  • E D Frohlich, M McLoughlin, R Ketelhut. Hemodynamic and metabolic effects of intravenous clentiazem in hypertensive patients. The American journal of cardiology. 1992 Jan; 69(3):229-32. doi: 10.1016/0002-9149(92)91310-z. [PMID: 1731463]
  • E Levy, L Smith, L Dumont, D Garceau, C Garofalo, L Thibault, E Seidman. The effect of a new calcium channel blocker (TA-3090) on lipoprotein profile and intestinal lipid handling in rodents. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1992 Jan; 199(1):128-35. doi: 10.3181/00379727-199-43340. [PMID: 1728031]
  • V Valérie, D Louis, L Marc, G Denis, C Claude, C Gilles. Relationship between the cardiovascular effects and both plasma and myocardial levels of clentiazem, a new benzothiazepine calcium antagonist, in anesthetized dogs. Cardiovascular drugs and therapy. 1991 Dec; 5(6):997-1003. doi: 10.1007/bf00143527. [PMID: 1801898]
  • E Levy, J Tardif, P Russo, F Lavigne, L Thibault, J St-Louis, C Garofalo, M Bendayan, D Bouthillier, D Garceau. Effect of clentiazem on lipid profile, lipoprotein composition and aortic fatty streaks in cholesterol-fed rabbits. Atherosclerosis. 1991 Oct; 90(2-3):141-8. doi: 10.1016/0021-9150(91)90108-f. [PMID: 1759985]
  • L Dumont, M Derouin, C Chartrand, P Archambeault, D Garceau, G Caillé. Peripheral vasodilator and cardiac properties of the 1,5-benzothiazepine calcium antagonist analog, TA-3090, in dogs. Canadian journal of physiology and pharmacology. 1991 Apr; 69(4):512-7. doi: 10.1139/y91-077. [PMID: 2059913]
  • J P Tolins, L Raij. Comparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury. Hypertension (Dallas, Tex. : 1979). 1990 Oct; 16(4):452-61. doi: 10.1161/01.hyp.16.4.452. [PMID: 2210813]
  • J Sasaki, M Ideishi, K Saku, K Arakawa, K Tominaga, Y Saeki, N Otake, K Kawasaki, K Shirai, I Sumida. Effects of a new calcium channel blocker, TA 3090, on serum lipoprotein levels in mild to moderate essential hypertension. Clinical therapeutics. 1990 Jul; 12(4):327-34. doi: NULL. [PMID: 2224947]
  • S Nakamura, M Ohashi, T Suzuki, Y Sugawara, S Usuki, O Takaiti. Metabolic fate of the new Ca++-channel blocking agent (+)-(2S,3S)-3-acetoxy-8-chloro-(2-(dimethylamino)ethyl)-2,3-dihydro- 2-(4-methoxyphenyl)-2,5-benzothiazepin-4-(5H)-one maleate. Distribution, excretion and protein binding in rats and dogs. Arzneimittel-Forschung. 1989 Sep; 39(9):1100-8. doi: NULL. [PMID: 2590259]
  • H Narita, S Murata, H Yabana, K Kikkawa, Y Sugawara, Y Akimoto, T Nagao. Long-lasting hypotensive and antihypertensive effects of a new 1,5-benzothiazepine calcium antagonist in hypertensive rats and renal hypertensive dogs. Arzneimittel-Forschung. 1988 Apr; 38(4):515-20. doi: . [PMID: 3041970]
  • H Takahashi, M Handa, K Watanabe, Y Ando, R Nagayama, A Hattori, A Shibata, A B Federici, Z M Ruggeri, T S Zimmerman. Further characterization of platelet-type von Willebrand's disease in Japan. Blood. 1984 Dec; 64(6):1254-62. doi: NULL. [PMID: 6333901]