8-(3-Chlorostyryl)caffeine (BioDeep_00000175225)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H15ClN4O2 (330.088348)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CN1C(C=CC2=CC(Cl)=CC=C2)=NC2=C1C(=O)N(C)C(=O)N2C
InChI: InChI=1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-14-13(19)15(22)21(3)16(23)20(14)2/h4-9H,1-3H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Osama F Harraz, Hanan M El-Gowelli, Mahmoud M Mohy El-Din, Abdel-Rheem M Ghazal, Mahmoud M El-Mas. Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Aug; 50(8):2622-8. doi:
10.1016/j.fct.2012.05.015. [PMID: 22613216] - Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern. A new drug design targeting the adenosinergic system for Huntington's disease.
PloS one.
2011; 6(6):e20934. doi:
10.1371/journal.pone.0020934. [PMID: 21713039] - Hélio Vitoriano Nobre, Geanne Matos de Andrade Cunha, Lissiana Magna de Vasconcelos, Hemerson Iury Ferreira Magalhães, Raimundo Nogueira Oliveira Neto, Flávio Damasceno Maia, Manoel Odorico de Moraes, L Kalyne A Moreira Leal, Glauce Socorro de Barros Viana. Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells.
Neurochemistry international.
2010 Jan; 56(1):51-8. doi:
10.1016/j.neuint.2009.09.001. [PMID: 19782116] - Lissiana M V Aguiar, Danielle S Macêdo, Silvania M M Vasconcelos, Aline A Oliveira, F Cléa F de Sousa, Glauce S B Viana. CSC, an adenosine A(2A) receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats.
Brain research.
2008 Jan; 1191(?):192-9. doi:
10.1016/j.brainres.2007.11.051. [PMID: 18164694] - Ruimin Gu, Jing Wang, Yunhong Zhang, Wennan Li, Ying Xu, Hongli Shan, Wen-Hui Wang, Baofeng Yang. Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.
American journal of physiology. Renal physiology.
2007 Jul; 293(1):F299-305. doi:
10.1152/ajprenal.00008.2007. [PMID: 17475899] - Gwenn E McLaughlin, Maria D Alva, Marcelo Egea. Adenosine receptor antagonism in acute tacrolimus toxicity.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Jul; 21(7):1961-5. doi:
10.1093/ndt/gfl082. [PMID: 16522656] - Z Vissiennon, K Sichardt, U Koetter, A Brattström, K Nieber. Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neurons.
Planta medica.
2006 Jun; 72(7):579-83. doi:
10.1055/s-2006-931561. [PMID: 16673319] - Yong Soo Kwon, Toshitaka Nabeshima, Eun-Joo Shin, Wanjoo Chun, Jin Hyeong Jhoo, Wang-Kee Jhoo, Myung Bok Wie, Choon-Gon Jang, Heesun Chung, Young Eun Sung, Hyoung-Chun Kim. PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice.
Biological & pharmaceutical bulletin.
2004 Jun; 27(6):906-9. doi:
10.1248/bpb.27.906. [PMID: 15187444] - Lawrence J Macala, John P Hayslett. Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells.
American journal of physiology. Renal physiology.
2002 Dec; 283(6):F1216-25. doi:
10.1152/ajprenal.00085.2002. [PMID: 12388417] - István Boros, Zsolt Lengyel, László Balkay, Géza Horváth, A József Szentmiklósi, István Fekete, Teréz Márián. [In vivo investigation of the A2A adenosine receptor distribution using the [11C]-CSC radioligand].
Orvosi hetilap.
2002 May; 143(21 Suppl 3):1317-9. doi:
NULL. [PMID: 12077927] - H T Lee, C W Emala. Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Sep; 38(3):610-8. doi:
10.1053/ajkd.2001.26888. [PMID: 11532695] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
Biochimica et biophysica acta.
1976 Apr; 428(2):525-31. doi:
10.1016/0304-4165(76)90061-1. [PMID: 6049]
