1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea (BioDeep_00000175212)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2-Methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hydrochloride

化学式: C17H13N5O2 (319.1069198)
中文名称: 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
InChI: InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)

描述信息

同义名列表

5 个代谢物同义名

1-(2-Methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hydrochloride; 3-(2-methyl-1,3-benzoxazol-6-yl)-1-(1,5-naphthyridin-4-yl)urea; 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea; 1-(2-Methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea; SB 334867



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Saeedeh Bahramzadeh Zoeram, Mahmoud Elahdadi Salmani, Taghi Lashkarbolouki, Iran Goudarzi. Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits. Neurobiology of learning and memory. 2019 01; 157(?):12-23. doi: 10.1016/j.nlm.2018.11.009. [PMID: 30458283]
  • Abdolkarim Hosseini, Homayoun Khazali. Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats. Neuromolecular medicine. 2018 12; 20(4):525-536. doi: 10.1007/s12017-018-8506-x. [PMID: 30218420]
  • Li-Na Zhang, Cen Yang, Peng-Rong Ouyang, Zhi-Chao Zhang, Ming-Zi Ran, Li Tong, Hai-Long Dong, Yong Liu. Orexin-A facilitates emergence of the rat from isoflurane anesthesia via mediation of the basal forebrain. Neuropeptides. 2016 Aug; 58(?):7-14. doi: 10.1016/j.npep.2016.02.003. [PMID: 26919917]
  • Giovanna Morello, Roberta Imperatore, Letizia Palomba, Carmine Finelli, Giuseppe Labruna, Fabrizio Pasanisi, Lucia Sacchetti, Lorena Buono, Fabiana Piscitelli, Pierangelo Orlando, Vincenzo Di Marzo, Luigia Cristino. Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling. Proceedings of the National Academy of Sciences of the United States of America. 2016 Apr; 113(17):4759-64. doi: 10.1073/pnas.1521304113. [PMID: 27071101]
  • Shu-Jing Ju, Yuyan Zhao, Xiaocen Chang, Lei Guo. Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes. International journal of molecular medicine. 2014 Jul; 34(1):153-9. doi: 10.3892/ijmm.2014.1769. [PMID: 24807827]
  • Marilyn J Duncan, Kathleen M Franklin, Xiaoli Peng, Christopher Yun, Sandra J Legan. Circadian rhythm disruption by a novel running wheel: roles of exercise and arousal in blockade of the luteinizing hormone surge. Physiology & behavior. 2014 May; 131(?):7-16. doi: 10.1016/j.physbeh.2014.04.006. [PMID: 24727338]
  • Philip L Johnson, Brian C Samuels, Stephanie D Fitz, Stafford L Lightman, Christopher A Lowry, Anantha Shekhar. Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012 Jul; 37(8):1911-22. doi: 10.1038/npp.2012.38. [PMID: 22453138]
  • Rong Jiang, Xinyi Song, Purva Bali, Anthony Smith, Claudia Ruiz Bayona, Li Lin, Michael D Cameron, Patricia H McDonald, Paul J Kenny, Theodore M Kamenecka. Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists. Bioorganic & medicinal chemistry letters. 2012 Jun; 22(12):3890-4. doi: 10.1016/j.bmcl.2012.04.122. [PMID: 22617492]
  • Luyi Zhou, Shannon M Ghee, Clifford Chan, Li Lin, Michael D Cameron, Paul J Kenny, Ronald E See. Orexin-1 receptor mediation of cocaine seeking in male and female rats. The Journal of pharmacology and experimental therapeutics. 2012 Mar; 340(3):801-9. doi: 10.1124/jpet.111.187567. [PMID: 22186370]
  • M H Jäntti, J Putula, P Somerharju, M A Frohman, J P Kukkonen. OX1 orexin/hypocretin receptor activation of phospholipase D. British journal of pharmacology. 2012 Feb; 165(4b):1109-23. doi: 10.1111/j.1476-5381.2011.01565.x. [PMID: 21718304]
  • V Nimet İzgüt-Uysal, Burcu Gemici, Ruken Tan. Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats. Cellular immunology. 2011; 271(1):85-8. doi: 10.1016/j.cellimm.2011.06.005. [PMID: 21741630]
  • Mehmet Bülbül, Ruken Tan, Burcu Gemici, Sebahat Ozdem, Ismail Ustünel, Nuray Acar, V Nimet Izgüt-Uysal. Endogenous orexin-A modulates gastric motility by peripheral mechanisms in rats. Peptides. 2010 Jun; 31(6):1099-108. doi: 10.1016/j.peptides.2010.03.007. [PMID: 20307611]
  • Pari Malherbe, Edilio Borroni, Emmanuel Pinard, Joseph G Wettstein, Frédéric Knoflach. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Molecular pharmacology. 2009 Sep; 76(3):618-31. doi: 10.1124/mol.109.055152. [PMID: 19542319]
  • Kazuyoshi Hirota, Tetsuya Kushikata, Hitoshi Yoshida, Mihoko Kudo, Tsuyoshi Kudo. Role of the orexinergic system in acute haemorrhage in the rat. Neuroscience letters. 2008 Feb; 432(2):162-6. doi: 10.1016/j.neulet.2007.12.015. [PMID: 18187260]
  • Patricia Silveyra, Victoria Lux-Lantos, Carlos Libertun. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. American journal of physiology. Endocrinology and metabolism. 2007 Oct; 293(4):E977-85. doi: 10.1152/ajpendo.00179.2007. [PMID: 17638707]
  • Sachin Paranjape, Kamlesh Vavaiya, Ajay Kale, Karen Briski. Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration. Neuropeptides. 2007 Apr; 41(2):111-6. doi: 10.1016/j.npep.2006.11.001. [PMID: 17276508]
  • Y Ishii, J E Blundell, J C G Halford, N Upton, R Porter, A Johns, P Jeffrey, S Summerfield, R J Rodgers. Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867. Behavioural brain research. 2005 Feb; 157(2):331-41. doi: 10.1016/j.bbr.2004.07.012. [PMID: 15639184]
  • Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, Tsuyoshi Kudo, Darren Smart, Akitomo Matsuki. Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats. Brain research. 2003 Aug; 981(1-2):143-50. doi: 10.1016/s0006-8993(03)03002-6. [PMID: 12885435]
  • C J Small, M-L Goubillon, J F Murray, A Siddiqui, S E Grimshaw, H Young, V Sivanesan, T Kalamatianos, A R Kennedy, C W Coen, S R Bloom, C A Wilson. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology. 2003 Jul; 144(7):3225-36. doi: 10.1210/en.2002-0041. [PMID: 12810579]
  • Andrea C Haynes, Helen Chapman, Colleen Taylor, Gary B T Moore, Michael A Cawthorne, Mohammad Tadayyon, John C Clapham, Jonathan R S Arch. Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regulatory peptides. 2002 Mar; 104(1-3):153-9. doi: 10.1016/s0167-0115(01)00358-5. [PMID: 11830290]
  • D N Jones, J Gartlon, F Parker, S G Taylor, C Routledge, P Hemmati, R P Munton, T E Ashmeade, J P Hatcher, A Johns, R A Porter, J J Hagan, A J Hunter, N Upton. Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity. Psychopharmacology. 2001 Jan; 153(2):210-8. doi: 10.1007/s002130000551. [PMID: 11205421]