Daporinad (BioDeep_00000175029)
human metabolite blood metabolite
代谢物信息卡片
化学式: C24H29N3O2 (391.2259654)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)C=CC1=CN=CC=C1
InChI: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Laura Evans, Anwen S Williams, Anthony J Hayes, Simon A Jones, Mari Nowell. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis.
Arthritis and rheumatism.
2011 Jul; 63(7):1866-77. doi:
10.1002/art.30338. [PMID: 21400478] - Hyun You, Hyung-Seop Youn, Isak Im, Man-Ho Bae, Sang-Kook Lee, Hyojin Ko, Soo Hyun Eom, Yong-Chul Kim. Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents.
European journal of medicinal chemistry.
2011 Apr; 46(4):1153-64. doi:
10.1016/j.ejmech.2011.01.034. [PMID: 21330015] - Gabriele Zoppoli, Michele Cea, Debora Soncini, Floriana Fruscione, Justine Rudner, Eva Moran, Irene Caffa, Davide Bedognetti, Giulia Motta, Riccardo Ghio, Fabio Ferrando, Alberto Ballestrero, Silvio Parodi, Claus Belka, Franco Patrone, Santina Bruzzone, Alessio Nencioni. Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
Experimental hematology.
2010 Nov; 38(11):979-88. doi:
10.1016/j.exphem.2010.07.013. [PMID: 20696207] - Hye Kyoung Song, Mi Hwa Lee, Bo Kyung Kim, Yun Gyu Park, Gang Jee Ko, Young Sun Kang, Jee Young Han, Sang Youb Han, Kum Hyun Han, Hyoung Kyu Kim, Dae Ryong Cha. Visfatin: a new player in mesangial cell physiology and diabetic nephropathy.
American journal of physiology. Renal physiology.
2008 Nov; 295(5):F1485-94. doi:
10.1152/ajprenal.90231.2008. [PMID: 18768589] - Richard A Billington, Armando A Genazzani, Cristina Travelli, Fabrizio Condorelli. NAD depletion by FK866 induces autophagy.
Autophagy.
2008 Apr; 4(3):385-7. doi:
10.4161/auto.5635. [PMID: 18227641] - Richard A Billington, Cristina Travelli, Emanuela Ercolano, Ubaldina Galli, Cintia Blasi Roman, Ambra A Grolla, Pier Luigi Canonico, Fabrizio Condorelli, Armando A Genazzani. Characterization of NAD uptake in mammalian cells.
The Journal of biological chemistry.
2008 Mar; 283(10):6367-74. doi:
10.1074/jbc.m706204200. [PMID: 18180302] - Kyle Holen, Leonard B Saltz, Ellen Hollywood, Konrad Burk, Axel-Rainer Hanauske. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor.
Investigational new drugs.
2008 Feb; 26(1):45-51. doi:
10.1007/s10637-007-9083-2. [PMID: 17924057] - Joachim Drevs, Roland Löser, Benno Rattel, Norbert Esser. Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.
Anticancer research.
2003 Nov; 23(6C):4853-8. doi:
NULL. [PMID: 14981935]