2-Chloro-6-(1-piperazinyl)pyrazine (BioDeep_00000175017)

   

human metabolite blood metabolite


代谢物信息卡片


6-Chloro-2-(1-piperazinyl)pyrazine, monohydrochloride

化学式: C8H11ClN4 (198.0672196)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCN1)C2=CN=CC(=N2)Cl
InChI: InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists

同义名列表

6 个代谢物同义名

6-Chloro-2-(1-piperazinyl)pyrazine, monohydrochloride; 2-chloro-6-(piperazin-1-yl)pyrazine; 6-Chloro-2-(1-piperazinyl)pyrazine; 2-Chloro-6-(1-piperazinyl)pyrazine; MK212 CPD; CPP



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nayere Askari, Ali Mousavi, Mohammad Reza Vaez-Mahdavi. Maternal deprivation effect on morphine-induced CPP is related to changes in opioid receptors in selected rat brain regions (hippocampus, prefrontal cortex, and nucleus accumbens). Behavioural processes. 2022 Apr; 197(?):104607. doi: 10.1016/j.beproc.2022.104607. [PMID: 35218881]
  • Katsuya Morita, Masahiro Hamamoto, Shigeaki Arai, Shigeo Kitayama, Masahiro Irifune, Michio Kawahara, Kenji Kihira, Toshihiro Dohi. Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain research. 2005 Sep; 1057(1-2):153-60. doi: 10.1016/j.brainres.2005.07.049. [PMID: 16125150]
  • S K Hemrick-Luecke, R W Fuller. Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. European journal of pharmacology. 1996 Sep; 311(2-3):207-11. doi: 10.1016/0014-2999(96)00439-6. [PMID: 8891601]
  • H Y Meltzer, M Maes. Effect of pindolol pretreatment on MK-212-induced plasma cortisol and prolactin responses in normal men. Biological psychiatry. 1995 Sep; 38(5):310-8. doi: 10.1016/0006-3223(95)00301-v. [PMID: 7495925]
  • M J Ramalho, L C Reis, J Antunes-Rodrigues, K O Nonaka, E De Castro e Silva. Reduced prolactin release during immobilization stress in thyrotoxic rats: role of the central serotoninergic system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1995 Mar; 27(3):121-5. doi: 10.1055/s-2007-979922. [PMID: 7607600]
  • M A Lee, H Y Meltzer. Blunted oral body temperature response to MK-212 in cocaine addicts. Drug and alcohol dependence. 1994 Jun; 35(3):217-22. doi: 10.1016/0376-8716(94)90077-9. [PMID: 7956751]
  • A Albinsson, E Palazidou, J Stephenson, G Andersson. Involvement of the 5-HT2 receptor in the 5-HT receptor-mediated stimulation of prolactin release. European journal of pharmacology. 1994 Jan; 251(2-3):157-61. doi: 10.1016/0014-2999(94)90396-4. [PMID: 8149973]
  • Q Li, M S Brownfield, G Battaglia, T M Cabrera, A D Levy, P A Rittenhouse, L D van de Kar. Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). The Journal of pharmacology and experimental therapeutics. 1993 Aug; 266(2):836-44. doi: . [PMID: 8394920]
  • A D Levy, Q Li, M C Alvarez Sanz, P A Rittenhouse, M S Brownfield, L D Van de Kar. Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. European journal of pharmacology. 1992 Oct; 221(1):121-7. doi: 10.1016/0014-2999(92)90780-8. [PMID: 1333968]
  • M J Ramalho, L C Reis, J Antunes-Rodrigues, E De-Castro-e-Silva. Thyroidectomy blocks stress-induced prolactin rise in rats: role of the central serotonergic system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1992 Oct; 24(10):462-5. doi: 10.1055/s-2007-1003363. [PMID: 1464410]
  • L D Van de Kar, P A Rittenhouse, P O'Connor, T Palionis, M S Brownfield, S J Lent, M Carnes, C L Bethea. Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biological psychiatry. 1992 Aug; 32(3):258-69. doi: 10.1016/0006-3223(92)90107-b. [PMID: 1330009]
  • J A Carr, L C Saland, A Samora, S Benavidez, K Krobert. In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion. Neuroendocrinology. 1991 Dec; 54(6):616-22. doi: 10.1159/000125968. [PMID: 1664500]
  • M A Lee, H Y Meltzer. Neuroendocrine responses to serotonergic agents in alcoholics. Biological psychiatry. 1991 Nov; 30(10):1017-30. doi: 10.1016/0006-3223(91)90122-3. [PMID: 1756196]
  • B Bastani, J F Nash, H Y Meltzer. Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. Archives of general psychiatry. 1990 Sep; 47(9):833-9. doi: 10.1001/archpsyc.1990.01810210041006. [PMID: 2203327]
  • M J Ramalho, L C Reis, K Nonaka, J Antunes-Rodrigues, E de-Castro-e-Silva. Thyroidectomy reduces stress-induced prolactin secretion in rats. Participation of brain serotonergic systems. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1990; 23(8):747-50. doi: NULL. [PMID: 2101105]
  • B H King, C Brazell, C T Dourish, D N Middlemiss. MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype. Neuroscience letters. 1989 Oct; 105(1-2):174-6. doi: 10.1016/0304-3940(89)90032-3. [PMID: 2562060]
  • J F Nash, H Y Meltzer. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. The Journal of pharmacology and experimental therapeutics. 1989 Apr; 249(1):236-41. doi: NULL. [PMID: 2565390]
  • L D Van de Kar, S A Lorens, J H Urban, C L Bethea. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology. 1989 Mar; 28(3):299-305. doi: 10.1016/0028-3908(89)90107-x. [PMID: 2524677]
  • L C Reis, M J Ramalho, J Antunes-Rodrigues. Participation of the serotonergic system in the regulation of water and electrolyte balance. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1989; 22(6):761-3. doi: NULL. [PMID: 2620188]
  • M T Lowy, H Y Meltzer. Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist. Biological psychiatry. 1988 Apr; 23(8):818-28. doi: 10.1016/0006-3223(88)90070-4. [PMID: 3365458]
  • M S Brownfield, J Greathouse, S A Lorens, J Armstrong, J H Urban, L D Van de Kar. Neuropharmacological characterization of serotoninergic stimulation of vasopressin secretion in conscious rats. Neuroendocrinology. 1988 Apr; 47(4):277-83. doi: 10.1159/000124925. [PMID: 3374754]
  • J I Koenig, G A Gudelsky, H Y Meltzer. Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation. European journal of pharmacology. 1987 May; 137(1):1-8. doi: 10.1016/0014-2999(87)90175-0. [PMID: 2956114]
  • S A Lorens, L D Van de Kar. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. 1987 Apr; 45(4):305-10. doi: 10.1159/000124754. [PMID: 2952898]
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