3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (BioDeep_00000175012)

   

human metabolite blood metabolite


代谢物信息卡片


3,5-diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate

  化学式: C14H21NO4 (267.1471)
中文名称: 3,5-二乙氧羰基-1,4-二氢-2,4,6-三甲吡啶
  谱图信息: 最多检出来源 Homo sapiens(blood) 93.51%

分子结构信息

SMILES: CCOC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCC
InChI: InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3


描述信息

同义名列表

10 个代谢物同义名

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester; 3,5-Pyridinedicarboxylate, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester; 3,5-diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate; 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine; 3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine; 3,5-Dicarbethoxy-1,4-dihydrocollidine; Diethoxycarbonyldihydrocollidine; Dicarbethoxydihydrocollidine; DDC



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Shu Dai, Rui Wu, Ke Fu, Yanzhi Li, Chenghao Yao, Yanfang Liu, Fang Zhang, Shenglin Zhang, Yiling Guo, Yuxin Yao, Yunxia Li. Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification. Journal of ethnopharmacology. 2024 Mar; 322(?):117584. doi: 10.1016/j.jep.2023.117584. [PMID: 38104874]
  • Dabing Ping, Jingshu Qi, Meng Li, Xin Sun, Yuan Peng, Chenghai Liu. Fuzheng Huayu recipe alleviates liver fibrosis via inhibiting NLRP3 inflammasome activation in macrophages. Journal of ethnopharmacology. 2024 Jan; 318(Pt B):117001. doi: 10.1016/j.jep.2023.117001. [PMID: 37544346]
  • Wen-Kai Li, Guo-Feng Wang, Tian-Ming Wang, Yuan-Yuan Li, Yi-Fei Li, Xin-Yi Lu, Ya-Hang Wang, Hua Zhang, Ping Liu, Jia-Sheng Wu, Yue-Ming Ma. Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152948. doi: 10.1016/j.phymed.2019.152948. [PMID: 31129431]
  • Akinori Takemura, Simin Gong, Shuichi Sekine, Kousei Ito. Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury. Toxicology. 2019 07; 423(?):32-41. doi: 10.1016/j.tox.2019.05.004. [PMID: 31102694]
  • Bartosz Proniewski, Agnieszka Kij, Barbara Sitek, Eric E Kelley, Stefan Chlopicki. Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based In Vivo Approach. Oxidative medicine and cellular longevity. 2019; 2019(?):7838406. doi: 10.1155/2019/7838406. [PMID: 31249650]
  • Keiko Taguchi, Saho Masui, Tohru Itoh, Atsushi Miyajima, Masayuki Yamamoto. Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. Toxicological sciences : an official journal of the Society of Toxicology. 2019 01; 167(1):227-238. doi: 10.1093/toxsci/kfy233. [PMID: 30215777]
  • Bruno Mesmin, Joëlle Bigay, Joël Polidori, Denisa Jamecna, Sandra Lacas-Gervais, Bruno Antonny. Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. The EMBO journal. 2017 11; 36(21):3156-3174. doi: 10.15252/embj.201796687. [PMID: 28978670]
  • Zhengyang Wang, Xiaoming Yang, Liang Chen, Xiuling Zhi, Hanyu Lu, Yanxia Ning, Joe Yeong, Sifeng Chen, Lianhua Yin, Xinhong Wang, Xiaobo Li. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. Archives of toxicology. 2017 Jan; 91(1):271-287. doi: 10.1007/s00204-016-1693-z. [PMID: 27052460]
  • Zhi Z Liu, Vinicius U Viegas, Andrea Perlewitz, En Y Lai, Pontus B Persson, Andreas Patzak, Mauricio M Sendeski. Iodinated contrast media differentially affect afferent and efferent arteriolar tone and reactivity in mice: a possible explanation for reduced glomerular filtration rate. Radiology. 2012 Dec; 265(3):762-71. doi: 10.1148/radiol.12120044. [PMID: 23023964]
  • Harrie A Verhoeven, Leo J L D van Griensven. Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis. Journal of bioenergetics and biomembranes. 2012 Feb; 44(1):91-9. doi: 10.1007/s10863-012-9414-7. [PMID: 22318358]
  • Tsukasa Nakamura, Yasuhiro Kawagoe, Yoshihiko Ueda, Shingo Yamada, Hikaru Koide. Hemoperfusion treatment in a septic shock patient with autosomal dominant polycystic kidney disease and increased HMGB1 protein levels. Blood purification. 2011; 32(2):139-42. doi: 10.1159/000325731. [PMID: 21654166]
  • Konstantinos Grintzalis, Ioannis Papapostolou, Stelios F Assimakopoulos, Adamantios Mavrakis, Konstantinos Faropoulos, Nikolaos Karageorgos, Christos Georgiou, Elisabeth Chroni, Dimitris Konstantinou. Time-related alterations of superoxide radical levels in diverse organs of bile duct-ligated rats. Free radical research. 2009 Sep; 43(9):803-8. doi: 10.1080/10715760903062903. [PMID: 19548155]
  • Michele M Castro, Elen Rizzi, Gerson J Rodrigues, Carla S Ceron, Lusiane M Bendhack, Raquel F Gerlach, Jose E Tanus-Santos. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free radical biology & medicine. 2009 May; 46(9):1298-307. doi: 10.1016/j.freeradbiomed.2009.02.011. [PMID: 19248829]
  • Gaelle del Castillo, Valentina M Factor, Margarita Fernández, Alberto Alvarez-Barrientos, Isabel Fabregat, Snorri S Thorgeirsson, Aránzazu Sánchez. Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro. The American journal of pathology. 2008 May; 172(5):1238-47. doi: 10.2353/ajpath.2008.070793. [PMID: 18385520]
  • Stelios F Assimakopoulos, Adamantios G Mavrakis, Konstantinos Grintzalis, Ioannis Papapostolou, George Zervoudakis, Dimitris Konstantinou, Elisabeth Chroni, Constantine E Vagianos, Christos Georgiou. Superoxide radical formation in diverse organs of rats with experimentally induced obstructive jaundice. Redox report : communications in free radical research. 2008; 13(4):179-84. doi: 10.1179/135100008x308902. [PMID: 18647488]
  • Naomi Zurgil, Yana Shafran, Elena Afrimzon, Dror Fixler, Asher Shainberg, Mordechai Deutsch. Concomitant real-time monitoring of intracellular reactive oxygen species and mitochondrial membrane potential in individual living promonocytic cells. Journal of immunological methods. 2006 Oct; 316(1-2):27-41. doi: 10.1016/j.jim.2006.07.013. [PMID: 17011571]
  • Fabrizio Facchinetti, Cristina Fasolato, Elda Del Giudice, Andrea Burgo, Sara Furegato, Mariella Fusco, Elisa Basso, Roberta Seraglia, Antonello D'Arrigo, Alberta Leon. Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage. Neurobiology of aging. 2006 Feb; 27(2):218-27. doi: 10.1016/j.neurobiolaging.2005.02.006. [PMID: 16399208]
  • G I Klebanov, O B Liubitskiĭ, S E Il'ina, E O Medusheva, V V Ryl'tsev, V N Filatov. [Antioxidant activity of inhibitors of free radical reactions in the dressing materials for wound healing]. Biomeditsinskaia khimiia. 2006 Jan; 52(1):69-82. doi: ". [PMID: 16739923]
  • Sandra M Lelli, Leonor C San Martín de Viale, Marta B Mazzetti. Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. Toxicology. 2005 Dec; 216(1):49-58. doi: 10.1016/j.tox.2005.07.016. [PMID: 16125296]
  • Bruce D Pauli, Sean W Kennedy. Hepatic porphyria induced by the herbicide tralkoxydim in small mammals is species-specific. Environmental toxicology and chemistry. 2005 Feb; 24(2):450-6. doi: 10.1897/03-536.1. [PMID: 15720007]
  • Fawzia Bardag-Gorce, Nora E Riley, Li Nan, Rosalyn O Montgomery, Jun Li, Barbara A French, Yan H Lue, Samuel W French. The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation. Experimental and molecular pathology. 2004 Feb; 76(1):9-16. doi: 10.1016/j.yexmp.2003.08.006. [PMID: 14738863]
  • G Goerz, K Bolsen, H Böhrer, C Fritsch, K Kalka, K L Rominger. Effects of clonidine in a primed rat model of acute hepatic porphyria. Arzneimittel-Forschung. 1997 Jun; 47(6):731-3. doi: NULL. [PMID: 9239451]
  • K Berg, H Anholt, O Bech, J Moan. The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells. British journal of cancer. 1996 Sep; 74(5):688-97. doi: 10.1038/bjc.1996.423. [PMID: 8795569]
  • O Fonia, R Weizman, R Coleman, E Kaganovskaya, M Gavish. PK 11195 aggravates 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced hepatic porphyria in rats. Hepatology (Baltimore, Md.). 1996 Sep; 24(3):697-701. doi: 10.1053/jhep.1996.v24.pm0008781345. [PMID: 8781345]
  • N Schoenfeld, R Mamet, Y Nordenberg, M Shafran, T Babushkin, Z Malik. Protoporphyrin biosynthesis in melanoma B16 cells stimulated by 5-aminolevulinic acid and chemical inducers: characterization of photodynamic inactivation. International journal of cancer. 1994 Jan; 56(1):106-12. doi: 10.1002/ijc.2910560119. [PMID: 8262664]
  • L Cantoni, M Rizzardini, M Skorupska, A Cagnotto, A Codegoni, N Pecora, L Frigo, C Ferrarese, T Mennini. Hepatic protoporphyria is associated with a decrease in ligand binding for the mitochondrial benzodiazepine receptors in the liver. Biochemical pharmacology. 1992 Sep; 44(6):1159-64. doi: 10.1016/0006-2952(92)90380-2. [PMID: 1329761]
  • N Schoenfeld, R Mamet, R Mevasser, A Atsmon. Experimental latent and acute porphyria in the non-fasted rat; preventive effect of propranolol. Scandinavian journal of clinical and laboratory investigation. 1991 Dec; 51(8):667-73. doi: 10.3109/00365519109104579. [PMID: 1806982]
  • F De Matteis, S J Dawson, A R Boobis, A Comoglio. Inducible bilirubin-degrading system of rat liver microsomes: role of cytochrome P450IA1. Molecular pharmacology. 1991 Nov; 40(5):686-91. doi: NULL. [PMID: 1944239]
  • V F Dubrovskaja, A V Gubareva, R P Stepanov. [The modifying effect of a hypoxic gas mixture on the development of radiation-induced sclerosis]. Radiobiologia, radiotherapia. 1990; 31(1):79-84. doi: NULL. [PMID: 2188283]
  • A Holley, L J King, A H Gibbs, F De Matteis. Strain and sex differences in the response of mice to drugs that induce protoporphyria: role of porphyrin biosynthesis and removal. Journal of biochemical toxicology. 1990; 5(3):175-82. doi: 10.1002/jbt.2570050307. [PMID: 2283668]
  • M V Bilenko, L N Shelenkova, G Ia Dubur, A Kh Velena. [Use of antioxidants to prevent damage during acute ischemia and reperfusion of the kidneys]. Biulleten' eksperimental'noi biologii i meditsiny. 1983 Sep; 96(9):8-11. doi: NULL. [PMID: 6616061]
  • M Mamadiev, M Khuzhamberdiev, V Z Gorkin. [Normalization of impairments in deamination of nitrogen compounds in experimental hypercholesterolemia]. Voprosy meditsinskoi khimii. 1983 Mar; 29(2):83-9. doi: NULL. [PMID: 6858040]
  • V N Kovalenko, G V Donchenko, I V Kuz'menko, N M Gurina, V P Makovetskiĭ. [Possibility of preventing muscular dystrophy in E avitaminosis with alpha-tocopheronolactone and diludin]. Voprosy pitaniia. 1982 Mar; ?(2):44-9. doi: . [PMID: 7090325]
  • H H Liem, K Miyai, U Muller-Eberhard. Effect of porphyrinogenic agents on protein synthesis and bilirubin formation by the isolated perfused rat liver. Biochimica et biophysica acta. 1977 Jan; 496(1):52-64. doi: 10.1016/0304-4165(77)90114-3. [PMID: 836897]
  • N Schoenfeld, O Epstein, A Atsmon. The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro. Biochimica et biophysica acta. 1976 Aug; 444(1):286-93. doi: 10.1016/0304-4165(76)90245-2. [PMID: 8132]
  • P W Fischer, R O Morgan, V Krupa, G S Marks. Drug-induced porphyrin biosynthesis -XV. Induction of porphyrin biosynthesis in chick embryo liver cells maintained in serum-free Waymouth medium. Biochemical pharmacology. 1976 Mar; 25(6):687-93. doi: 10.1016/0006-2952(76)90245-8. [PMID: 1275951]