(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]-N-methylsulfonylhept-5-enamide (BioDeep_00000174983)
human metabolite blood metabolite
代谢物信息卡片
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(e,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]-N-methylsulphonylhept-5-enamide
化学式: C23H31NO7S (465.18211360000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NC(=O)CCCC=CCC1C(C=CC(O)COC2=CC=CC=C2)C(O)CC1=O
InChI: InChI=1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)
描述信息
同义名列表
13 个代谢物同义名
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(e,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]-N-methylsulphonylhept-5-enamide; (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]-N-methylsulfonylhept-5-enamide; 5Z,13E-18R,11R,12R,15R- Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid methylsulfonylamide; 7-[3-Hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]-N-methanesulphonylhept-5-enimidic acid; 7-[3-Hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]-N-methanesulphonylhept-5-enimidate; 7-[3-Hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]-N-methanesulfonylhept-5-enimidate; 7-[3-hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]-N-methanesulfonylhept-5-enamide; 16-Phenoxy-omega-17,18,19,20-tetranor-pge2 methylsulfonylamide; 16-Phenoxytetranor-pge2 methylsulfonylamide; 34.089 Pfizer; Sulproston; SHB 286; Nalador
数据库引用编号
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Carlos P Vio, Mariana Quiroz-Munoz, Catherina A Cuevas, Carlos Cespedes, Nicholas R Ferreri. Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney.
American journal of physiology. Renal physiology.
2012 Aug; 303(3):F449-57. doi:
10.1152/ajprenal.00634.2011. [PMID: 22622465] - Zhi-Hua Zhang, Yang Yu, Shun-Guang Wei, Yoshiko Nakamura, Kazuhiro Nakamura, Robert B Felder. EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation.
American journal of physiology. Heart and circulatory physiology.
2011 Oct; 301(4):H1559-69. doi:
10.1152/ajpheart.00262.2011. [PMID: 21803943] - Eri Kawashita, Daisuke Tsuji, Masahiro Toyoshima, Yosuke Kanno, Hiroyuki Matsuno, Kohji Itoh. Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway.
PloS one.
2011 Jan; 6(1):e16269. doi:
10.1371/journal.pone.0016269. [PMID: 21298000] - Kirsten Schulte, Manush Kumar, Jean-Marie Zajac, Eberhard Schlicker. Noradrenaline release in rodent tissues is inhibited by interleukin-1β but is not affected by urotensin II, MCH, NPW and NPFF.
Pharmacological reports : PR.
2011; 63(1):102-11. doi:
10.1016/s1734-1140(11)70404-2. [PMID: 21441617] - Luciana B Gentile, Bruno Piva, Bruno L Diaz. Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE₂.
PloS one.
2011; 6(9):e25193. doi:
10.1371/journal.pone.0025193. [PMID: 21980393] - Thomas G Lauridsen, Henrik Vase, Jørn Starklint, Carolina C Graffe, Jesper N Bech, Søren Nielsen, Erling B Pedersen. Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels.
BMC nephrology.
2010 Oct; 11(?):28. doi:
10.1186/1471-2369-11-28. [PMID: 21029429] - Ruyue Ji, Chih-Ling Chou, Wei Xu, Xiao-Bo Chen, David F Woodward, John W Regan. EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.
Molecular pharmacology.
2010 Jun; 77(6):1025-36. doi:
10.1124/mol.110.063933. [PMID: 20335389] - Y S Weems, T M Nett, L A Rispoli, T L Davis, D L Johnson, T Uchima, A Raney, E Lennon, T Harbert, G Bowers, N Tsutahara, R D Randel, C W Weems. Effects of prostaglandin E and F receptor agonists in vivo on luteal function in ewes.
Prostaglandins & other lipid mediators.
2010 Jun; 92(1-4):67-72. doi:
10.1016/j.prostaglandins.2010.03.004. [PMID: 20381634] - Alexis A González, Carlos Céspedes, Sandra Villanueva, Luis Michea, Carlos P Vio. E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II.
Biochemical and biophysical research communications.
2009 Nov; 389(2):372-7. doi:
10.1016/j.bbrc.2009.08.157. [PMID: 19732740] - Stan Heptinstall, David Iyu Espinosa, Panagiotis Manolopoulos, Jackie R Glenn, Ann E White, Andrew Johnson, Natalia Dovlatova, Sue C Fox, Jane A May, David Hermann, Olafur Magnusson, Kari Stefansson, Dan Hartman, Mark Gurney. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease.
Platelets.
2008 Dec; 19(8):605-13. doi:
10.1080/09537100802351073. [PMID: 19012178] - Michelle Boone, Peter M T Deen. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Archiv : European journal of physiology.
2008 Sep; 456(6):1005-24. doi:
10.1007/s00424-008-0498-1. [PMID: 18431594] - Natalia Dovlatova, Yanushi D Wijeyeratne, Susan C Fox, Panagiotis Manolopoulos, Andrew J Johnson, Ann E White, M Liaque Latif, Vera Ralevic, Stanley Heptinstall. Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.
Thrombosis and haemostasis.
2008 Aug; 100(2):261-70. doi:
10.1160/th07-10-0601. [PMID: 18690346] - Ruimin Gu, Yan Jin, Yuanyuan Zhai, Lei Yang, Chengbiao Zhang, Wennan Li, Lijun Wang, Shumin Kong, Yunhong Zhang, Baofeng Yang, Wen-Hui Wang. PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.
Kidney international.
2008 Aug; 74(4):478-85. doi:
10.1038/ki.2008.198. [PMID: 18496512] - Jinshan Cao, Tatsuro Nakamura, Takio Kitazawa, Naoko Yamashiki, Tsubasa Yamamoto, Tetsuro Taneike. Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle.
Prostaglandins & other lipid mediators.
2008 Jun; 86(1-4):26-34. doi:
10.1016/j.prostaglandins.2008.02.002. [PMID: 18403225] - Victoria Seto, Christina Hirota, Simon Hirota, Luke J Janssen. E-Ring Isoprostanes Stimulate a Cl Conductance in Airway Epithelium via Prostaglandin E2-Selective Prostanoid Receptors.
American journal of respiratory cell and molecular biology.
2008 Jan; 38(1):88-94. doi:
10.1165/rcmb.2007-0117oc. [PMID: 17673688] - Yan Jin, Zhijian Wang, Yan Zhang, Baofeng Yang, Wen-Hui Wang. PGE2 inhibits apical K channels in the CCD through activation of the MAPK pathway.
American journal of physiology. Renal physiology.
2007 Oct; 293(4):F1299-307. doi:
10.1152/ajprenal.00293.2007. [PMID: 17686952] - Samuel A Black, Amitha H Palamakumbura, Maria Stan, Philip C Trackman. Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.
The Journal of biological chemistry.
2007 May; 282(21):15416-29. doi:
10.1074/jbc.m610432200. [PMID: 17428796] - Huang-Wei Shen, Yu-Lin Chen, Ching-Yuh Chern, Wai-Ming Kan. The effect of prostacyclin agonists on the differentiation of phorbol ester treated human erythroleukemia cells.
Prostaglandins & other lipid mediators.
2007 May; 83(3):231-6. doi:
10.1016/j.prostaglandins.2007.01.012. [PMID: 17481561] - William F van Rodijnen, Iolente J Korstjens, Natalee Legerstee, Piet M Ter Wee, Geert-Jan Tangelder. Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor.
American journal of physiology. Renal physiology.
2007 Mar; 292(3):F1094-101. doi:
10.1152/ajprenal.00351.2005. [PMID: 17148783] - Laura Grasa, M Pilar Arruebo, Miguel A Plaza, M Divina Murillo. PGE(2) receptors and their intracellular mechanisms in rabbit small intestine.
Prostaglandins & other lipid mediators.
2006 May; 79(3-4):206-17. doi:
10.1016/j.prostaglandins.2006.01.001. [PMID: 16647635] - Richard L Hébert, Monica Carmosino, Osamu Saito, Guangrui Yang, Cynthia A Jackson, Zhonghua Qi, Richard M Breyer, Chandramohan Natarajan, Aaron N Hata, Yahua Zhang, Youfei Guan, Matthew D Breyer. Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.
The Journal of biological chemistry.
2005 Oct; 280(41):35028-37. doi:
10.1074/jbc.m505852200. [PMID: 16096282] - Xavier Norel, Vincent de Montpreville, Charles Brink. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713.
Prostaglandins & other lipid mediators.
2004 Oct; 74(1-4):101-12. doi:
10.1016/j.prostaglandins.2004.07.003. [PMID: 15560119] - David M Aronoff, Claudio Canetti, Marc Peters-Golden. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP.
Journal of immunology (Baltimore, Md. : 1950).
2004 Jul; 173(1):559-65. doi:
10.4049/jimmunol.173.1.559. [PMID: 15210817] - Cang-hai Li, Jun Zhou, Hai-ru Huo, Xu-liang Kang, Ting-liang Jiang. [Effect of guizhi tang and its active components on the fever induced by EP3 agonist].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2003 Nov; 28(11):1056-60. doi:
". [PMID: 15615417] - Grazia Tamma, Burkhard Wiesner, Jens Furkert, Daniel Hahm, Alexander Oksche, Michael Schaefer, Giovanna Valenti, Walter Rosenthal, Enno Klussmann. The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Journal of cell science.
2003 Aug; 116(Pt 16):3285-94. doi:
10.1242/jcs.00640. [PMID: 12829746] - John D Imig, Matthew D Breyer, Richard M Breyer. Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice.
American journal of physiology. Renal physiology.
2002 Sep; 283(3):F415-22. doi:
10.1152/ajprenal.00351.2001. [PMID: 12167591] - Youfei Guan, Brett A Stillman, Yahua Zhang, André Schneider, Osamu Saito, Linda S Davis, Reyadh Redha, Richard M Breyer, Matthew D Breyer. Cloning and expression of the rabbit prostaglandin EP2 receptor.
BMC pharmacology.
2002 Jun; 2(?):14. doi:
10.1186/1471-2210-2-14. [PMID: 12097143] - Vera T Bachteeva, Ekaterina M Fock, Elena A Lavrova, Elena V Naboka, Rimma G Parnova. Regulation of urea permeability in frog urinary bladder by prostaglandin E(2).
Pflugers Archiv : European journal of physiology.
2002 May; 444(1-2):159-66. doi:
10.1007/s00424-001-0780-y. [PMID: 11976928] - Najam A Sharif, Terry L Davis. Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques.
The Journal of pharmacy and pharmacology.
2002 Apr; 54(4):539-47. doi:
10.1211/0022357021778655. [PMID: 11999132] - M Kimura, S Osumi, M Ogihara. Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha.
Endocrinology.
2001 Oct; 142(10):4428-40. doi:
10.1210/endo.142.10.8450. [PMID: 11564707] - T A Castleberry, B Lu, S L Smock, T A Owen. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype.
Prostaglandins & other lipid mediators.
2001 Jul; 65(4):167-87. doi:
10.1016/s0090-6980(01)00129-0. [PMID: 11444589] - T Suganami, I Tanaka, M Mukoyama, M Kotani, S Muro, K Mori, M Goto, R Ishibashi, M Kasahara, K Yahata, H Makino, A Sugawara, K Nakao. Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats.
Journal of hypertension.
2001 Jun; 19(6):1095-103. doi:
10.1097/00004872-200106000-00015. [PMID: 11403359] - S Tavakoli, M J Cowan, T Benfield, C Logun, J H Shelhamer. Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line.
American journal of physiology. Lung cellular and molecular physiology.
2001 Jan; 280(1):L127-33. doi:
10.1152/ajplung.2001.280.1.l127. [PMID: 11133502]