Norquetiapine (BioDeep_00000174859)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H17N3S (295.11431220000003)
中文名称: 11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓, N-脱烷基喹硫(去甲喹硫平)
谱图信息:
最多检出来源 Homo sapiens(blood) 33.33%
Last reviewed on 2024-09-14.
Cite this Page
Norquetiapine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/norquetiapine (retrieved
2024-11-08) (BioDeep RN: BioDeep_00000174859). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1CN(CCN1)C1=NC2=CC=CC=C2SC2=CC=CC=C12
InChI: InChI=1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:188278
- PubChem: 11369918
- HMDB: HMDB0246982
- ChEMBL: CHEMBL3526391
- chemspider: 9544835
- CAS: 5747-48-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Claudia Vignali, Francesca Freni, Camilla Magnani, Matteo Moretti, Chiara Siodambro, Angelo Groppi, Antonio Marco Maria Osculati, Luca Morini. Distribution of quetiapine and metabolites in biological fluids and tissues.
Forensic science international.
2020 Feb; 307(?):110108. doi:
10.1016/j.forsciint.2019.110108. [PMID: 31877542] - Lakshmi N Yatham, Vesna Sossi, Yu-Shin Ding, Nasim Vafai, Shyam Sundar Arumugham, Taj Dhanoa, Raymond W Lam, David J Bond, Joseph H Puyat. A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR.
The international journal of neuropsychopharmacology.
2018 02; 21(2):108-113. doi:
10.1093/ijnp/pyx066. [PMID: 29016993] - Dong-Wook Kim, Kwon-Yeon Weon, Eon-Pyo Hong, Eun Kyoung Chung, Kyung-Tae Lee. Comparative Physicochemical and Pharmacokinetic Properties of Quetiapine and Its Active Metabolite Norquetiapine.
Chemical & pharmaceutical bulletin.
2016; 64(11):1546-1554. doi:
10.1248/cpb.c16-00223. [PMID: 27803466] - A J Cross, D Widzowski, C Maciag, A Zacco, T Hudzik, J Liu, S Nyberg, M W Wood. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.
British journal of pharmacology.
2016 Jan; 173(1):155-66. doi:
10.1111/bph.13346. [PMID: 26436896] - Emily J Jaehne, Frances Corrigan, Catherine Toben, M Catharine Jawahar, Bernhard T Baune. The effect of the antipsychotic drug quetiapine and its metabolite norquetiapine on acute inflammation, memory and anhedonia.
Pharmacology, biochemistry, and behavior.
2015 Aug; 135(?):136-44. doi:
10.1016/j.pbb.2015.05.021. [PMID: 26047769] - Svante Nyberg, Aurelija Jucaite, Akihiro Takano, Matts Kågedal, Zsolt Cselényi, Christer Halldin, Lars Farde. Norepinephrine transporter occupancy in the human brain after oral administration of quetiapine XR.
The international journal of neuropsychopharmacology.
2013 Nov; 16(10):2235-44. doi:
10.1017/s1461145713000680. [PMID: 23809226] - Xin Xiong, Li Yang, Jingli Duan. Development and validation of a sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of quetiapine and its active metabolite norquetiapine in human plasma.
Clinica chimica acta; international journal of clinical chemistry.
2013 Aug; 423(?):69-74. doi:
10.1016/j.cca.2013.04.016. [PMID: 23623924] - Elnaz Ostad Haji, Stefanie Wagner, Mirijam Fric, Gerd Laux, Patrick Pittermann, Joachim Röschke, Christoph Hiemke. Quetiapine and norquetiapine serum concentrations and clinical effects in depressed patients under augmentation therapy with quetiapine.
Therapeutic drug monitoring.
2013 Aug; 35(4):539-45. doi:
10.1097/ftd.0b013e31828d221f. [PMID: 23739636] - A Carlo Altamura, Donatella Moliterno, Silvia Paletta, Massimiliano Buoli, Bernardo Dell'osso, Massimo C Mauri, Silvio R Bareggi. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.
Clinical drug investigation.
2012 Mar; 32(3):213-9. doi:
10.2165/11597330-000000000-00000. [PMID: 22299714] - Magdalena Nord, Svante Nyberg, Jacob Brogren, Aurelija Jucaite, Christer Halldin, Lars Farde. Comparison of D₂ dopamine receptor occupancy after oral administration of quetiapine fumarate immediate-release and extended-release formulations in healthy subjects.
The international journal of neuropsychopharmacology.
2011 Nov; 14(10):1357-66. doi:
10.1017/s1461145711000514. [PMID: 21477416] - Helen R Winter, Willie R Earley, Jennifer E Hamer-Maansson, Patty C Davis, Mark A Smith. Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disorders.
Journal of child and adolescent psychopharmacology.
2008 Feb; 18(1):81-98. doi:
10.1089/cap.2007.0084. [PMID: 18294091]