Methyl(acetoxymethyl)nitrosamine (BioDeep_00000174853)

   

human metabolite blood metabolite


代谢物信息卡片


[methyl(nitroso)amino]methyl acetate

化学式: C4H8N2O3 (132.0535)
中文名称: 亚硝基(乙酰氧基甲基)甲胺(Dmn-oac)
谱图信息: 最多检出来源 Homo sapiens(blood) 3.89%

分子结构信息

SMILES: CC(=O)OCN(C)N=O
InChI: InChI=1S/C4H8N2O3/c1-4(7)9-3-6(2)5-8/h3H2,1-2H3

描述信息

D009676 - Noxae > D002273 - Carcinogens

同义名列表

3 个代谢物同义名

[methyl(nitroso)amino]methyl acetate; NITROSO(ACETOXYMETHYL)-METHYLAMINE; Methyl(acetoxymethyl)nitrosamine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • . Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. International journal of toxicology. 2007; 26 Suppl 1(?):3-106. doi: 10.1080/10915810601163939. [PMID: 17365137]
  • C M Weghorst, K H Dragnev, G S Buzard, K L Thorne, G F Vandeborne, K A Vincent, J M Rice. Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors. Cancer research. 1994 Jan; 54(1):215-9. doi: NULL. [PMID: 8261441]
  • M A Azuine, S V Bhide. Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis. International journal of cancer. 1992 May; 51(3):412-5. doi: 10.1002/ijc.2910510313. [PMID: 1592532]
  • K G Higinbotham, J M Rice, A O Perantoni. Activating point mutation in Ki-ras codon 63 in a chemically induced rat renal tumor. Molecular carcinogenesis. 1992; 5(2):136-9. doi: 10.1002/mc.2940050209. [PMID: 1554412]
  • U Santhanam, V S Lalitha, S V Bhide. Diethylnitrosamine and acetoxymethyl methylnitrosamine-induced carcinogenesis in mice and vitamin A deficiency. In vivo (Athens, Greece). 1989 May; 3(3):231-5. doi: NULL. [PMID: 2519857]
  • B A Diwan, M Ohshima, J M Rice. Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either renal or intestinal tumors. Carcinogenesis. 1989 Jan; 10(1):183-8. doi: 10.1093/carcin/10.1.183. [PMID: 2910521]
  • B L Pool, S Brendler, R G Klein, S Monarca, R Pasquini, P Schmezer, W J Zeller. Effects of SO2 or NOx on toxic and genotoxic properties of chemical carcinogens. II. Short term in vivo studies. Carcinogenesis. 1988 Jul; 9(7):1247-52. doi: 10.1093/carcin/9.7.1247. [PMID: 2898305]
  • W K Kaufmann, D G Ririe, D G Kaufman. Phenobarbital-dependent proliferation of putative initiated rat hepatocytes. Carcinogenesis. 1988 May; 9(5):779-82. doi: 10.1093/carcin/9.5.779. [PMID: 3130204]
  • N Frank, M Wiessler. Inhibition of the metabolism of N-nitrosoacetoxymethylmethylamine in the rat by disulfiram. Carcinogenesis. 1986 May; 7(5):755-8. doi: 10.1093/carcin/7.5.755. [PMID: 3084117]
  • A Ia Likhachev, V N Anisimov, A I Ovsiannikov. [Characteristics of the carcinogenic action of methyl(acetoxymethyl)nitrosamine and DNA repair in rats of different ages]. Eksperimental'naia onkologiia. 1986; 8(2):18-21. doi: NULL. [PMID: 3698877]
  • R C Agrawal, A V Sarode, V S Lalitha, S V Bhide. Chilli extract treatment and induction of eye lesions in hamsters. Toxicology letters. 1985 Oct; 28(1):1-7. doi: 10.1016/0378-4274(85)90002-5. [PMID: 4060190]
  • R Caesar, N Frank, M Wiessler. Stability of various alpha-esters of 1-(N-methyl-N-nitrosamino)-methanol in vitro and in vivo. Carcinogenesis. 1984 Oct; 5(10):1231-4. doi: 10.1093/carcin/5.10.1231. [PMID: 6548422]
  • P Eid, M P Goeldner, C G Hirth, P Jost. Photosuicide inactivation of acetylcholinesterase by nitrosamine derivatives. Biochemistry. 1981 Apr; 20(8):2251-6. doi: 10.1021/bi00511a028. [PMID: 7236595]
  • J J Berman, J M Rice, R Reddick. Endocardial schwannomas in rats. Their characterization by light and electron microscopy. Archives of pathology & laboratory medicine. 1980 Apr; 104(4):187-91. doi: NULL. [PMID: 6892679]