Azetidine-1-carboxylic acid (BioDeep_00000174849)
human metabolite blood metabolite
代谢物信息卡片
Azetidine-1-carboxylic acid
化学式: C4H7NO2 (101.0476762)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: C1CN(C1)C(=O)O
InChI: InChI=1S/C4H7NO2/c6-4(7)5-2-1-3-5/h1-3H2,(H,6,7)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Scott Aleksander Sinclair, Ute Krämer. The zinc homeostasis network of land plants.
Biochimica et biophysica acta.
2012 Sep; 1823(9):1553-67. doi:
10.1016/j.bbamcr.2012.05.016. [PMID: 22626733] - Maria N Hindt, Mary Lou Guerinot. Getting a sense for signals: regulation of the plant iron deficiency response.
Biochimica et biophysica acta.
2012 Sep; 1823(9):1521-30. doi:
10.1016/j.bbamcr.2012.03.010. [PMID: 22483849] - Rongli Shi, Günther Weber, Jessica Köster, Mohammad Reza-Hajirezaei, Chunqin Zou, Fusuo Zhang, Nicolaus von Wirén. Senescence-induced iron mobilization in source leaves of barley (Hordeum vulgare) plants.
The New phytologist.
2012 Jul; 195(2):372-383. doi:
10.1111/j.1469-8137.2012.04165.x. [PMID: 22591276] - Ishari Waduwara-Jayabahu, Yasmin Oppermann, Markus Wirtz, Zachary T Hull, Sarah Schoor, Alexander N Plotnikov, Rüdiger Hell, Margret Sauter, Barbara A Moffatt. Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis.
Plant physiology.
2012 Apr; 158(4):1728-44. doi:
10.1104/pp.111.191072. [PMID: 22345506] - Hajime Nagasu, Minoru Satoh, Sohachi Fujimoto, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Mar; 35(3):348-55. doi:
10.1038/hr.2011.184. [PMID: 22072106] - Ulrich Deinlein, Michael Weber, Holger Schmidt, Stefan Rensch, Aleksandra Trampczynska, Thomas H Hansen, Søren Husted, Jan K Schjoerring, Ina N Talke, Ute Krämer, Stephan Clemens. Elevated nicotianamine levels in Arabidopsis halleri roots play a key role in zinc hyperaccumulation.
The Plant cell.
2012 Feb; 24(2):708-23. doi:
10.1105/tpc.111.095000. [PMID: 22374395] - Michael J Haydon, Miki Kawachi, Markus Wirtz, Stefan Hillmer, Rüdiger Hell, Ute Krämer. Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis.
The Plant cell.
2012 Feb; 24(2):724-37. doi:
10.1105/tpc.111.095042. [PMID: 22374397] - Reiko Nishiyama, Mariyo Kato, Shinji Nagata, Shuichi Yanagisawa, Tadakatsu Yoneyama. Identification of Zn-nicotianamine and Fe-2'-Deoxymugineic acid in the phloem sap from rice plants (Oryza sativa L.).
Plant & cell physiology.
2012 Feb; 53(2):381-90. doi:
10.1093/pcp/pcr188. [PMID: 22218421] - T Ohyama, K Sato, K Kishimoto, Y Yamazaki, N Horiguchi, T Ichikawa, S Kakizaki, H Takagi, T Izumi, M Mori. Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
British journal of pharmacology.
2012 Feb; 165(4b):1173-87. doi:
10.1111/j.1476-5381.2011.01599.x. [PMID: 21790536] - Nancy R Hofmann. Nicotianamine in zinc and iron homeostasis.
The Plant cell.
2012 Feb; 24(2):373. doi:
10.1105/tpc.112.240212. [PMID: 22374391] - Sichul Lee, Daniel P Persson, Thomas H Hansen, Søren Husted, Jan K Schjoerring, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Yusuke Kakei, Hiroshi Masuda, Naoko K Nishizawa, Gynheung An. Bio-available zinc in rice seeds is increased by activation tagging of nicotianamine synthase.
Plant biotechnology journal.
2011 Oct; 9(8):865-73. doi:
10.1111/j.1467-7652.2011.00606.x. [PMID: 21426477] - Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).
Cardiovascular diabetology.
2011 Sep; 10(?):79. doi:
10.1186/1475-2840-10-79. [PMID: 21906391] - Masanori Abe, Noriaki Maruyama, Kazuyoshi Okada, Shiro Matsumoto, Koichi Matsumoto, Masayoshi Soma. Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Aug; 34(8):935-41. doi:
10.1038/hr.2011.67. [PMID: 21654755] - Katsuyuki Ando, Masakazu Haneda, Sadayoshi Ito, Naoki Kashihara, Koichi Node, Masaomi Nangaku, Tatsuo Shimosawa, Junji Kishimoto, Toshiro Fujita. Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria.
Cardiovascular drugs and therapy.
2011 Aug; 25(4):341-7. doi:
10.1007/s10557-011-6309-5. [PMID: 21637969] - Koichi Hayashi. L-/T-type Ca channel blockers for kidney protection: ready for sophisticated use of Ca channel blockers.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Aug; 34(8):910-2. doi:
10.1038/hr.2011.74. [PMID: 21753772] - Tsukasa Nakamura, Eiichi Sato, Nobuharu Fujiwara, Yasuhiro Kawagoe, Hikaru Koide, Yoshihiko Ueda, Masayoshi Takeuchi, Sho-ichi Yamagishi. Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease.
Clinical cardiology.
2011 Jun; 34(6):372-7. doi:
10.1002/clc.20885. [PMID: 21432860] - Yoshio Matsui, Kazuo Eguchi, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario. Urinary albumin excretion during angiotensin II receptor blockade: comparison of combination treatment with a diuretic or a calcium-channel blocker.
American journal of hypertension.
2011 Apr; 24(4):466-73. doi:
10.1038/ajh.2010.240. [PMID: 21164498] - Yoshio Matsui, Kazuo Eguchi, Michael F O'Rourke, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario. Association between aldosterone induced by antihypertensive medication and arterial stiffness reduction: the J-CORE study.
Atherosclerosis.
2011 Mar; 215(1):184-8. doi:
10.1016/j.atherosclerosis.2010.12.022. [PMID: 21241987] - Tomoko Nozoye, Seiji Nagasaka, Takanori Kobayashi, Michiko Takahashi, Yuki Sato, Yoko Sato, Nobuyuki Uozumi, Hiromi Nakanishi, Naoko K Nishizawa. Phytosiderophore efflux transporters are crucial for iron acquisition in graminaceous plants.
The Journal of biological chemistry.
2011 Feb; 286(7):5446-54. doi:
10.1074/jbc.m110.180026. [PMID: 21156806] - Hajime Nagasu, Minoru Satoh, Daisuke Yorimitsu, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Comparison of combination therapy of olmesartan plus azelnidipine or hydrochlorothiazide on renal and vascular damage in SHR/NDmcr-cp rats.
Kidney & blood pressure research.
2011; 34(2):87-96. doi:
10.1159/000323535. [PMID: 21273789] - Takahiko Kojima, Katsumi Miyauchi, Takayuki Yokoyama, Ken Yokoyama, Takeshi Kurata, Satoru Suwa, Masaki Kawamura, Hiroshi Tamura, Shinya Okazaki, Kenji Inoue, Yasumasa Fujiwara, Masataka Sumiyoshi, Kosei Tanimoto, Yuji Nakazato, Shinichiro Yamagami, Takafumi Hiro, Nobuyuki Komiyama, Hiroyuki Daida. Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo University (ALPS-J).
Circulation journal : official journal of the Japanese Circulation Society.
2011; 75(5):1071-9. doi:
10.1253/circj.cj-11-0141. [PMID: 21471671] - Holger Schmidt, Christoph Böttcher, Aleksandra Trampczynska, Stephan Clemens. Use of recombinantly produced 15N3-labelled nicotianamine for fast and sensitive stable isotope dilution ultra-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry.
Analytical and bioanalytical chemistry.
2011 Jan; 399(3):1355-61. doi:
10.1007/s00216-010-4436-7. [PMID: 21110009] - Vasundhara Kain, Sandeep Kumar, Amrutesh S Puranik, Sandhya L Sitasawad. Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage.
Cardiovascular diabetology.
2010 Dec; 9(?):82. doi:
10.1186/1475-2840-9-82. [PMID: 21118576] - Takeshi Yamamoto, Jun Matsuda, Hiroyuki Kadoya, Tomoko Namba, Masanobu Takeji, Atsushi Yamauchi. Azelnidipine-induced chyloperitoneum in a patient with microscopic polyangiitis.
Clinical and experimental nephrology.
2010 Oct; 14(5):496-500. doi:
10.1007/s10157-010-0302-3. [PMID: 20556459] - Jiahn-Chou Guan, Ching-Hui Yeh, Ya-Ping Lin, Yi-Ting Ke, Ming-Tse Chen, Jia-Wen You, Yi-Hsin Liu, Chung-An Lu, Shaw-Jye Wu, Chu-Yung Lin. A 9 bp cis-element in the promoters of class I small heat shock protein genes on chromosome 3 in rice mediates L-azetidine-2-carboxylic acid and heat shock responses.
Journal of experimental botany.
2010 Oct; 61(15):4249-61. doi:
10.1093/jxb/erq230. [PMID: 20643810] - Heng-Hsuan Chu, Jeff Chiecko, Tracy Punshon, Antonio Lanzirotti, Brett Lahner, David E Salt, Elsbeth L Walker. Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures.
Plant physiology.
2010 Sep; 154(1):197-210. doi:
10.1104/pp.110.159103. [PMID: 20625001] - Peter V Minorsky. Plant Physiology. On the inside.
Plant physiology.
2010 Sep; 154(1):1-2. doi:
10.1104/pp.110.900331. [PMID: 20836252] - Fei-Yi Tsai, Xing-Hai Zhang, Alexander Ulanov, Jack M Widholm. The application of the yeast N-acetyltransferase MPR1 gene and the proline analogue L-azetidine-2-carboxylic acid as a selectable marker system for plant transformation.
Journal of experimental botany.
2010 Jun; 61(10):2561-73. doi:
10.1093/jxb/erq086. [PMID: 20430752] - Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Shigeshi Kamikawa, Shinichi Usui, Youko Kaji, Kosuke Sakane, Hiroko Ogawa, Yoshifumi Ninomiya, Shozo Kusachi. Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients.
The American journal of the medical sciences.
2010 May; 339(5):433-9. doi:
10.1097/maj.0b013e3181d658c4. [PMID: 20234301] - Luqing Zheng, Zhiqiang Cheng, Chunxiang Ai, Xinhang Jiang, Xiaoshu Bei, Ye Zheng, Raymond P Glahn, Ross M Welch, Dennis D Miller, Xin Gen Lei, Huixia Shou. Nicotianamine, a novel enhancer of rice iron bioavailability to humans.
PloS one.
2010 Apr; 5(4):e10190. doi:
10.1371/journal.pone.0010190. [PMID: 20419136] - Basuki Widodo, Martin R Broadley, Terry Rose, Michael Frei, Juan Pariasca-Tanaka, Tadashi Yoshihashi, Michael Thomson, John P Hammond, Alessio Aprile, Timothy J Close, Abdelbagi M Ismail, Matthias Wissuwa. Response to zinc deficiency of two rice lines with contrasting tolerance is determined by root growth maintenance and organic acid exudation rates, and not by zinc-transporter activity.
The New phytologist.
2010 Apr; 186(2):400-14. doi:
10.1111/j.1469-8137.2009.03177.x. [PMID: 20100202] - Kosuke Namba, Yoshiko Murata. Toward mechanistic elucidation of iron acquisition in barley: efficient synthesis of mugineic acids and their transport activities.
Chemical record (New York, N.Y.).
2010 Apr; 10(2):140-50. doi:
10.1002/tcr.200900028. [PMID: 20354995] - Tomomichi Ishizaka, Akira Takahara, Hiroshi Iwasaki, Yoshitaka Mitsumori, Hiroaki Kise, Yuji Nakamura, Atsushi Sugiyama. Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog.
Basic & clinical pharmacology & toxicology.
2010 Feb; 106(2):135-43. doi:
10.1111/j.1742-7843.2009.00478.x. [PMID: 19906049] - Atsumi Hayashi, Koichi Kimoto. Studies on the mechanism of antihypertensive action by nicotianamine.
Journal of nutritional science and vitaminology.
2010; 56(4):242-6. doi:
10.3177/jnsv.56.242. [PMID: 20924146] - Tatsuya Kondo, Rieko Goto, Kazuhiro Sonoda, Takeomi Yasuda, Kaoru Ono, Yuki Takaki, Riichiro Yatsuda, Nobuhiro Miyamura, Eiichi Araki. Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients.
Internal medicine (Tokyo, Japan).
2010; 49(7):637-43. doi:
10.2169/internalmedicine.49.2749. [PMID: 20371952] - Yukiko Inoue, Tatsuyuki Kakuma, Yoshisuke Nonaka, Shunichiro Sumi, Keisuke Okamura, Sunao Kodama, Chie Ando, Hideya Niimura, Kei Miyoshi, Yoshihiro Tsuchiya, Yoshio Yamanouchi, Hidenori Urata. Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010 Jan; 32(1):21-8. doi:
10.3109/10641960902960516. [PMID: 20144069] - Hiroshi Komoda, Teruo Inoue, Koichi Node. Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010 Jan; 32(2):121-8. doi:
10.3109/10641960903254414. [PMID: 20374186] - Masaki Watanabe, Teruyuki Hirano, Sadahisa Okamoto, Shinya Shiraishi, Seiji Tomiguchi, Makoto Uchino. Azelnidipine, a long-acting calcium channel blocker, could control hypertension without decreasing cerebral blood flow in post-ischemic stroke patients. A 123I-IMP SPECT follow-up study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Jan; 33(1):43-8. doi:
10.1038/hr.2009.179. [PMID: 19876061] - Aleksandra Trampczynska, Hendrik Küpper, Wolfram Meyer-Klaucke, Holger Schmidt, Stephan Clemens. Nicotianamine forms complexes with Zn(II) in vivo.
Metallomics : integrated biometal science.
2010 Jan; 2(1):57-66. doi:
10.1039/b913299f. [PMID: 21072375] - Sohachi Fujimoto, Minoru Satoh, Hajime Nagasu, Hideyuki Horike, Tamaki Sasaki, Naoki Kashihara. Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Dec; 24(12):3651-8. doi:
10.1093/ndt/gfp407. [PMID: 19666664] - Toshihiko Ishimitsu, Atsushi Numabe, Toshihide Masuda, Tomoyuki Akabane, Atsushi Okamura, Junichi Minami, Hiroaki Matsuoka. Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2009 Nov; 32(11):962-8. doi:
10.1038/hr.2009.133. [PMID: 19696778] - Yusuke Kakei, Isomaro Yamaguchi, Takanori Kobayashi, Michiko Takahashi, Hiromi Nakanishi, Takashi Yamakawa, Naoko K Nishizawa. A highly sensitive, quick and simple quantification method for nicotianamine and 2'-deoxymugineic acid from minimum samples using LC/ESI-TOF-MS achieves functional analysis of these components in plants.
Plant & cell physiology.
2009 Nov; 50(11):1988-93. doi:
10.1093/pcp/pcp141. [PMID: 19880395] - Hongmei Lu, Masayuki Kanazawa, Atsuko Ishida, Andreia Tufescu, Yuko Sasaki, Osamu Ito, Hajime Kurosawa, Toshinobu Sato, Tetsuya Ootaka, Masahiro Kohzuki. Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation.
American journal of hypertension.
2009 Oct; 22(10):1101-6. doi:
10.1038/ajh.2009.148. [PMID: 19730414] - Yu-Yan Fan, Masakazu Kohno, Daisuke Nakano, Hirofumi Hitomi, Yukiko Nagai, Yoshihide Fujisawa, Xiao-Mei Lu, Hua Fu, Jun Du, Koji Ohmori, Naohisa Hosomi, Shoji Kimura, Hideyasu Kiyomoto, Akira Nishiyama. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats.
Journal of hypertension.
2009 Sep; 27(9):1855-62. doi:
10.1097/hjh.0b013e32832dda6f. [PMID: 19633569] - Takahiro Aoyama, Takanori Kobayashi, Michiko Takahashi, Seiji Nagasaka, Kanako Usuda, Yusuke Kakei, Yasuhiro Ishimaru, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints.
Plant molecular biology.
2009 Aug; 70(6):681-92. doi:
10.1007/s11103-009-9500-3. [PMID: 19468840] - T Abe, I Fuse, M Narita, M Takahashi, Y Aizawa. Combination use of immune complexes and a Ca2(+) channel blocker azelnidipine enhances interleukin-12 p40 secretion without T helper type 17 cytokine secretion in human monocyte-derived dendritic cells.
Clinical and experimental immunology.
2009 Jun; 156(3):405-12. doi:
10.1111/j.1365-2249.2009.03911.x. [PMID: 19438591] - Marco Klatte, Mara Schuler, Markus Wirtz, Claudia Fink-Straube, Rüdiger Hell, Petra Bauer. The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses.
Plant physiology.
2009 May; 150(1):257-71. doi:
10.1104/pp.109.136374. [PMID: 19304929] - Seiji Nagasaka, Michiko Takahashi, Reiko Nakanishi-Itai, Khurram Bashir, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Time course analysis of gene expression over 24 hours in Fe-deficient barley roots.
Plant molecular biology.
2009 Mar; 69(5):621-31. doi:
10.1007/s11103-008-9443-0. [PMID: 19089316] - Haruhiko Inoue, Takanori Kobayashi, Tomoko Nozoye, Michiko Takahashi, Yusuke Kakei, Kazumasa Suzuki, Mikio Nakazono, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Rice OsYSL15 is an iron-regulated iron(III)-deoxymugineic acid transporter expressed in the roots and is essential for iron uptake in early growth of the seedlings.
The Journal of biological chemistry.
2009 Feb; 284(6):3470-9. doi:
10.1074/jbc.m806042200. [PMID: 19049971] - Yutaka Haitani, Maiko Nakata, Toshiya Sasaki, Akiko Uchida, Hiroshi Takagi. Engineering of the yeast ubiquitin ligase Rsp5: isolation of a new variant that induces constitutive inactivation of the general amino acid permease Gap1.
FEMS yeast research.
2009 Feb; 9(1):73-86. doi:
10.1111/j.1567-1364.2008.00460.x. [PMID: 19054125] - Akiko Sugio, René Dreos, Frederic Aparicio, Andrew J Maule. The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis.
The Plant cell.
2009 Feb; 21(2):642-54. doi:
10.1105/tpc.108.062596. [PMID: 19244141] - Tatsuro Suzuki, Masami Watanabe, Makiko Iki, Yasuo Aoyagi, Sun-Ju Kim, Yuji Mukasa, Satoshi Yokota, Shigenobu Takigawa, Naoto Hashimoto, Takahiro Noda, Hiroaki Yamauchi, Chie Matsuura-Endo. Time-course study and effects of drying method on concentrations of gamma-aminobutyric acid, flavonoids, anthocyanin, and 2''-hydroxynicotianamine in leaves of buckwheats.
Journal of agricultural and food chemistry.
2009 Jan; 57(1):259-64. doi:
10.1021/jf802731d. [PMID: 19090759] - Edward Rubenstein, Theresa McLaughlin, Richard C Winant, Agustin Sanchez, Michael Eckart, Karolina M Krasinska, Allis Chien. Azetidine-2-carboxylic acid in the food chain.
Phytochemistry.
2009 Jan; 70(1):100-4. doi:
10.1016/j.phytochem.2008.11.007. [PMID: 19101705] - Catherine Curie, Gaëlle Cassin, Daniel Couch, Fanchon Divol, Kyoko Higuchi, Marie Le Jean, Julie Misson, Adam Schikora, Pierre Czernic, Stéphane Mari. Metal movement within the plant: contribution of nicotianamine and yellow stripe 1-like transporters.
Annals of botany.
2009 Jan; 103(1):1-11. doi:
10.1093/aob/mcn207. [PMID: 18977764] - Gaëlle Cassin, Stéphane Mari, Catherine Curie, Jean-François Briat, Pierre Czernic. Increased sensitivity to iron deficiency in Arabidopsis thaliana overaccumulating nicotianamine.
Journal of experimental botany.
2009; 60(4):1249-59. doi:
10.1093/jxb/erp007. [PMID: 19188276] - Chiaki Tanifuji, Yusuke Suzuki, Wong Mu Geot, Satoshi Horikoshi, Hisahide Takahashi, Yasuhiko Tomino. Beneficial effects of combination therapy with olmesartan and azelnidipine in murine polycystic kidneys.
Kidney & blood pressure research.
2009; 32(4):239-49. doi:
10.1159/000238821. [PMID: 19752573] - Eiji Nakamura, Hidetoshi Akashi, Shinichi Hiromatsu, Atsuhisa Tanaka, Seiji Onitsuka, Shigeaki Aoyagi. Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair.
The Kurume medical journal.
2009; 56(1-2):25-32. doi:
10.2739/kurumemedj.56.25. [PMID: 20103998] - Yusuke Tanigawara, Kazutaka Yoshihara, Kizuku Kuramoto, Kikuo Arakawa. Comparative pharmacodynamics of olmesartan and azelnidipine in patients with hypertension: a population pharmacokinetic/pharmacodynamic analysis.
Drug metabolism and pharmacokinetics.
2009; 24(4):376-88. doi:
10.2133/dmpk.24.376. [PMID: 19745564] - Kanako Usuda, Yasuaki Wada, Yasuhiro Ishimaru, Takanori Kobayashi, Michiko Takahashi, Hiromi Nakanishi, Yasuo Nagato, Satoshi Mori, Naoko K Nishizawa. Genetically engineered rice containing larger amounts of nicotianamine to enhance the antihypertensive effect.
Plant biotechnology journal.
2009 Jan; 7(1):87-95. doi:
10.1111/j.1467-7652.2008.00374.x. [PMID: 18823453] - M'Barek Bouazaoui, Stéphane Mari, Pierre Czernic, Catherine Curie, Jean Martinez, Florine Cavelier. Synthesis and biological activity of nicotianamine and analogues.
Advances in experimental medicine and biology.
2009; 611(?):555-7. doi:
10.1007/978-0-387-73657-0_244. [PMID: 19400311] - Tomomi Kurashige, Katsushige Abe, Akira Furusu, Masanobu Miyazaki, Yoko Obata, Zihyin Xia, Masayuki Nakazawa, Yuka Nakazawa, Satoshi Funakoshi, Takashi Harada, Takehiko Koji, Shigeru Kohno. Renoprotective effect of azelnidipine in rats.
Biological & pharmaceutical bulletin.
2008 Dec; 31(12):2237-44. doi:
10.1248/bpb.31.2237. [PMID: 19043206] - Satomi Konno, Yoshitaka Hirooka, Shuichiro Araki, Yasuaki Koga, Takuya Kishi, Kenji Sunagawa. Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2008 Dec; 52(6):555-60. doi:
10.1097/fjc.0b013e318192690e. [PMID: 19057394] - Eleftherios Sachlos, Debra T Auguste. Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation.
Biomaterials.
2008 Dec; 29(34):4471-80. doi:
10.1016/j.biomaterials.2008.08.012. [PMID: 18793799] - T Nakamura, T Inoue, N Fujiwara, Y Kawagoe, T Sugaya, Y Ueda, H Koide, K Node. Additional renoprotective effects of azelnidipine combined with angiotensin receptor blockers in patients with diabetic nephropathy.
Clinical nephrology.
2008 Nov; 70(5):385-92. doi:
10.5414/cnp70385. [PMID: 19000538] - Günther Weber, Nicolaus von Wirén, Heiko Hayen. Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2008 Oct; 21(5):503-13. doi:
10.1007/s10534-008-9137-8. [PMID: 18322653] - Jian-Jun Zou, Hong-Jian Ji, Xiao-Hua Zhou, Yu-Bin Zhu, Hong-Wei Fan, Da-Wei Xiao, Qin Hu. Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers.
Die Pharmazie.
2008 Aug; 63(8):568-70. doi:
NULL. [PMID: 18771003] - Aki Hirayama, Atsushi Ueda, Takaaki Oteki, Sohji Nagase, Kazumasa Aoyagi, Akio Koyama. In vivo imaging of renal redox status during azelnidipine treatment.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Aug; 31(8):1643-50. doi:
10.1291/hypres.31.1643. [PMID: 18971540] - Shigehiro Katayama, Ryuzo Kawamori, Yasuhiko Iwamoto, Ikuo Saito, Kizuku Kuramoto. In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diabetes (ATTEST) study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Aug; 31(8):1499-508. doi:
10.1291/hypres.31.1499. [PMID: 18971523] - Susumu Ogawa, Takefumi Mori, Kazuhiro Nako, Sadayoshi Ito. Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jun; 31(6):1147-55. doi:
10.1291/hypres.31.1147. [PMID: 18716362] - Rubén Rellán-Alvarez, Javier Abadía, Ana Alvarez-Fernández. Formation of metal-nicotianamine complexes as affected by pH, ligand exchange with citrate and metal exchange. A study by electrospray ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008 May; 22(10):1553-62. doi:
10.1002/rcm.3523. [PMID: 18421700] - Jiko Yamada, Hirofumi Tomiyama, Chisa Matsumoto, Masanobu Yoshida, Kazuki Shiina, Akira Yamashina. Effects of azelnidipine on the autonomic functions and its influence on arterial stiffness and endothelial functions.
Journal of cardiology.
2008 Apr; 51(2):114-20. doi:
10.1016/j.jjcc.2008.01.005. [PMID: 18522784] - Motofumi Suzuki, Takashi Tsukamoto, Haruhiko Inoue, Satoshi Watanabe, Shinpei Matsuhashi, Michiko Takahashi, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Deoxymugineic acid increases Zn translocation in Zn-deficient rice plants.
Plant molecular biology.
2008 Apr; 66(6):609-17. doi:
10.1007/s11103-008-9292-x. [PMID: 18224446] - Nan Wang, Ling Ye, Fangfei Yan, Ren Xu. Spectroscopic studies on the interaction of azelnidipine with bovine serum albumin.
International journal of pharmaceutics.
2008 Mar; 351(1-2):55-60. doi:
10.1016/j.ijpharm.2007.09.016. [PMID: 18029121] - Kaku Nakano, Kensuke Egashira, Kisho Ohtani, Zhao Gang, Eiko Iwata, Miho Miyagawa, Kenji Sunagawa. Azelnidipine has anti-atherosclerotic effects independent of its blood pressure-lowering actions in monkeys and mice.
Atherosclerosis.
2008 Jan; 196(1):172-179. doi:
10.1016/j.atherosclerosis.2007.03.036. [PMID: 17481639] - Longjun Cheng, Fang Wang, Huixia Shou, Fangliang Huang, Luqing Zheng, Fei He, Jinhui Li, Fang-Jie Zhao, Daisei Ueno, Jian Feng Ma, Ping Wu. Mutation in nicotianamine aminotransferase stimulated the Fe(II) acquisition system and led to iron accumulation in rice.
Plant physiology.
2007 Dec; 145(4):1647-57. doi:
10.1104/pp.107.107912. [PMID: 17951455] - Chie Ohmura, Hirotaka Watada, Tomoaki Shimizu, Ken Sakai, Hiroshi Uchino, Yoshio Fujitani, Akio Kanazawa, Takahisa Hirose, Ryuzo Kawamori. Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure.
Endocrine journal.
2007 Dec; 54(5):805-11. doi:
10.1507/endocrj.k07-063. [PMID: 17895576] - Yue Xuan, Enrico B Scheuermann, Anderson R Meda, Peter Jacob, Nicolaus von Wirén, Günther Weber. CE of phytosiderophores and related metal species in plants.
Electrophoresis.
2007 Oct; 28(19):3507-19. doi:
10.1002/elps.200700117. [PMID: 17768721] - Atsumi Hayashi, Koichi Kimoto. Nicotianamine preferentially inhibits Angiotensin I-converting enzyme.
Journal of nutritional science and vitaminology.
2007 Aug; 53(4):331-6. doi:
10.3177/jnsv.53.331. [PMID: 17934238] - Yuko Ogo, Reiko Nakanishi Itai, Hiromi Nakanishi, Takanori Kobayashi, Michiko Takahashi, Satoshi Mori, Naoko K Nishizawa. The rice bHLH protein OsIRO2 is an essential regulator of the genes involved in Fe uptake under Fe-deficient conditions.
The Plant journal : for cell and molecular biology.
2007 Aug; 51(3):366-77. doi:
10.1111/j.1365-313x.2007.03149.x. [PMID: 17559517] - Kiyoshi Kawabata, Naozumi Samata, Yoko Urasaki, Ichiro Fukazawa, Naoki Uchida, Eiji Uchida, Hajime Yasuhara. Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):389-97. doi:
10.1016/j.jchromb.2007.01.050. [PMID: 17350354] - Tsukasa Nakamura, Takeshi Sugaya, Yasuhiro Kawagoe, Tsukasa Suzuki, Yoshihiko Ueda, Hikaru Koide, Teruo Inoue, Koichi Node. Azelnidipine reduces urinary protein excretion and urinary liver-type fatty acid binding protein in patients with hypertensive chronic kidney disease.
The American journal of the medical sciences.
2007 Jun; 333(6):321-6. doi:
10.1097/maj.0b013e318065c254. [PMID: 17570983] - Jean-François Briat, Catherine Curie, Frédéric Gaymard. Iron utilization and metabolism in plants.
Current opinion in plant biology.
2007 Jun; 10(3):276-82. doi:
10.1016/j.pbi.2007.04.003. [PMID: 17434791] - Tomoko Nozoye, Haruhiko Inoue, Michiko Takahashi, Yasuhiro Ishimaru, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. The expression of iron homeostasis-related genes during rice germination.
Plant molecular biology.
2007 May; 64(1-2):35-47. doi:
10.1007/s11103-007-9132-4. [PMID: 17333504] - Reiko N Itai, Naoko K Nishizawa. [Responses to iron-deficiency stress by graminaceous plants].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
2007 May; 52(6 Suppl):606-11. doi:
". [PMID: 17566362] - Yasuaki Wada, Isomaro Yamaguchi, Michiko Takahashi, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Highly sensitive quantitative analysis of nicotianamine using LC/ESI-TOF-MS with an internal standard.
Bioscience, biotechnology, and biochemistry.
2007 Feb; 71(2):435-41. doi:
10.1271/bbb.60496. [PMID: 17284859] - Li Ding, Li Li, Pengcheng Ma. Determination of azelnidipine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(2):575-9. doi:
10.1016/j.jpba.2006.07.011. [PMID: 16920318] - Delphine Gendre, Pierre Czernic, Geneviève Conéjéro, Katia Pianelli, Jean-François Briat, Michel Lebrun, Stéphane Mari. TcYSL3, a member of the YSL gene family from the hyper-accumulator Thlaspi caerulescens, encodes a nicotianamine-Ni/Fe transporter.
The Plant journal : for cell and molecular biology.
2007 Jan; 49(1):1-15. doi:
10.1111/j.1365-313x.2006.02937.x. [PMID: 17144893] - Yoshikuni Kimura, Yoshitaka Hirooka, Yoji Sagara, Kenji Sunagawa. Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2007 Jan; 29(1):13-21. doi:
10.1080/10641960601096745. [PMID: 17190727] - Damien L Callahan, Spas D Kolev, Richard A J O'Hair, David E Salt, Alan J M Baker. Relationships of nicotianamine and other amino acids with nickel, zinc and iron in Thlaspi hyperaccumulators.
The New phytologist.
2007; 176(4):836-848. doi:
10.1111/j.1469-8137.2007.02216.x. [PMID: 17897323] - Teru Nada, Masahiro Nomura, Kunihiko Koshiba, Tomohito Kawano, Jyunichi Mikawa, Susumu Ito. Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity.
Arzneimittel-Forschung.
2007; 57(11):698-704. doi:
10.1055/s-0031-1296670. [PMID: 18193691] - Kosuke Namba, Yoshiko Murata, Manabu Horikawa, Takashi Iwashita, Shoichi Kusumoto. A practical synthesis of the phytosiderophore 2'-deoxymugineic acid: a key to the mechanistic study of iron acquisition by graminaceous plants.
Angewandte Chemie (International ed. in English).
2007; 46(37):7060-3. doi:
10.1002/anie.200702403. [PMID: 17691091] - Masarsu Iwai, Huan-Sheng Li, Rui Chen, Tetsuya Shiuchi, Lan Wu, Li-Juan Min, Jian-Mei Li, Masahiro Tsuda, Jun Suzuki, Yumiko Tomono, Hirokazu Tomochika, Masaki Mogi, Masatsugu Horiuchi. Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan.
The Journal of pharmacology and experimental therapeutics.
2006 Dec; 319(3):1081-7. doi:
10.1124/jpet.106.108894. [PMID: 16990512] - Kiyoshi Kawabata, Yoko Urasaki. Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):45-52. doi:
10.1016/j.jchromb.2006.06.031. [PMID: 16854634] - T Matsui, S Yamagishi, K Nakamura, H Inoue. Azelnidipine, a new long-acting calcium-channel blocker, inhibits tumour necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells.
The Journal of international medical research.
2006 Nov; 34(6):671-5. doi:
10.1177/147323000603400613. [PMID: 17295000] - Khurram Bashir, Haruhiko Inoue, Seiji Nagasaka, Michiko Takahashi, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Cloning and characterization of deoxymugineic acid synthase genes from graminaceous plants.
The Journal of biological chemistry.
2006 Oct; 281(43):32395-402. doi:
10.1074/jbc.m604133200. [PMID: 16926158] - Estelle Bakkaus, Richard N Collins, Jean-Louis Morel, Barbara Gouget. Anion exchange liquid chromatography--inductively coupled plasma-mass spectrometry detection of the Co2+, Cu2+, Fe3+ and Ni2+ complexes of mugineic and deoxymugineic acid.
Journal of chromatography. A.
2006 Oct; 1129(2):208-15. doi:
10.1016/j.chroma.2006.07.004. [PMID: 16876808] - Tetsuya Nakamura, Yuichiro Saito, Tomoko Saito, Masahiko Kurabayashi. Azelnidipine down-regulates renal angiotensin-converting enzyme and mineralocorticoid receptor mRNA in diabetic hypertensive rats.
Journal of pharmacological sciences.
2006 Oct; 102(2):239-42. doi:
10.1254/jphs.sc0060064. [PMID: 17031066] - Motofumi Suzuki, Michiko Takahashi, Takashi Tsukamoto, Satoshi Watanabe, Shinpei Matsuhashi, Junshi Yazaki, Naoki Kishimoto, Shoshi Kikuchi, Hiromi Nakanishi, Satoshi Mori, Naoko K Nishizawa. Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley.
The Plant journal : for cell and molecular biology.
2006 Oct; 48(1):85-97. doi:
10.1111/j.1365-313x.2006.02853.x. [PMID: 16972867] - Kaku Nakano, Kensuke Egashira, Hideo Tada, Yoshiro Kohjimoto, Yasuhiko Hirouchi, Shun-ichi Kitajima, Yasuhisa Endo, Xiao-Hang Li, Kenji Sunagawa. A third-generation, long-acting, dihydropyridine calcium antagonist, azelnidipine, attenuates stent-associated neointimal formation in non-human primates.
Journal of hypertension.
2006 Sep; 24(9):1881-9. doi:
10.1097/01.hjh.0000242414.96277.95. [PMID: 16915039]