Thymoquinone (BioDeep_00000017484)

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity

代谢物信息卡片

ethyl 2-hydroxy-5-[[2-(trifluoromethyl)phenyl]carbamoyl]benzoate;Thymoquinon

化学式: C10H12O2 (164.0837252)
中文名称: 百里醌
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C(=O)C=C(C1=O)C)C(C)C
InChI: InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3

描述信息

Thymoquinone is a member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. It has a role as an anti-inflammatory agent, an antioxidant, an adjuvant, an antineoplastic agent, a cardioprotective agent, an antidepressant and a plant metabolite.
Thymoquinone is a natural compound with widespread protective effects, including anti-oxidative, anti-inflammatory, immunomodulatory, anti-cancer, and anti-microbial.
Thymoquinone is a natural product found in Ayapana triplinervis, Tetraclinis articulata, and other organisms with data available.
A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Major constituent of seed oil of black cumin, Nigella sativa (24\\\%). Thymoquinone is found in herbs and spices and winter savory.
Thymoquinone is found in herbs and spices. Thymoquinone is a major constituent of seed oil of black cumin, Nigella sativa (24\\\%
COVID info from DrugBank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation [1][2][3][4][5].

同义名列表

53 个代谢物同义名

ethyl 2-hydroxy-5-[[2-(trifluoromethyl)phenyl]carbamoyl]benzoate;Thymoquinon; 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione, 9CI; 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione (F8); 2,5-CYCLOHEXADIENE-1,4-DIONE, 2-METHYL-5-(1-METHYLETHYL)-; InChI=1/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H; 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione; 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione; Thymoquinone; 2-isopropyl-5-methylbenzo-1,4-quinone; 2,5-Cyclohexadiene-1,4-dione, 5-isopropyl-2-methyl-; 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione; 5-Isopropyl-2-methyl-2,5-Cyclohexadiene-1,4-dione; 2-Isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione; 2-Isopropyl-5-methylbenzo-1,4-quinone #; 2,4-dione, 2-methyl-5-(1-methylethyl)-; 2-Methyl-5-isopropyl-1,4-benzoquinone; 5-Isopropyl-2-methyl-1,4-benzoquinone; 2-Isopropyl-5-methyl-1,4-benzoquinone; 2-Isopropyl-5-methylbenzo-1,4-quinone; 2-Isopropyl-5-methyl-p-benzoquinone; 2-methyl-5-isopropyl-p-benzoquinone; 5-Isopropyl-2-methyl-p-benzoquinone; p-Mentha-3,6-diene-2,5-dione (8CI); Thymoquinone, analytical standard; 2-Methyl-5-iso-propylbenzoquinone; 2-isopropyl-5-methylbenzoquinone; 2,4-dione, 5-isopropyl-2-methyl-; p-Mentha-3,6-diene-2,5-dione; THYMOQUINONE [WHO-DD]; WLN: L6V DVJ B1 EY1&1; Thymoquinone, >=98\\%; dihydrothymoquinone; p-Mentha-3,5-dione; p-Cymene-2,5-dione; Polythymoquinone; Spectrum5_000550; Spectrum4_001895; Spectrum3_001345; Spectrum2_000700; UNII-O60IE26NUF; thymolquinone; DivK1c_006553; KBio3_002349; KBio2_006853; KBio2_004285; KBio2_001717; Thymoquinone; KBio1_001497; Thymoquinon; O60IE26NUF; AI3-17758; Thymoil; 4hco; TQ

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:113532
PubChem: 10281
HMDB: HMDB0034732
DrugBank: DB16447
ChEMBL: CHEMBL1672002
Wikipedia: Thymoquinone
MeSH: thymoquinone
ChemIDplus: 0000490915
KNApSAcK: C00010876
foodb: FDB013274
chemspider: 9861
CAS: 490-91-5
medchemexpress: HY-D0803
PMhub: MS000012874
MetaboLights: MTBLC113532

分类词条

P-benzoquinones

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

1090619 - Ayapana triplinervis: 10.1055/S-2006-959619
204180 - Coleus amboinicus: 10.1016/J.BMC.2014.01.009
9606 - Homo sapiens: -
313967 - Laggera decurrens: 10.1016/S0031-9422(00)80757-8
39344 - Monarda fistulosa: 10.1080/10575639808044955
516065 - Mosla chinensis: 10.1002/CJOC.201180379
555479 - Nigella sativa:
497761 - Origanum dictamnus: 10.1021/JF904596M
3440 - Ranunculaceae: 10.1016/J.BBAGEN.2007.01.002
13717 - Tetraclinis articulata: 10.3891/ACTA.CHEM.SCAND.16-1291
228974 - Thymus quinquecostatus: 10.1002/JSSC.201000192

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Eunjee Kim, Minsun Kim, Min-Kyu Oh. Whole-cell bioconversion for producing thymoquinone by engineered Saccharomyces cerevisiae. Enzyme and microbial technology. 2024 Aug; 178(?):110455. doi: 10.1016/j.enzmictec.2024.110455. [PMID: 38723387]
Grzegorz Dąbrowski, Sylwester Czaplicki, Iwona Konopka. Variation in the Composition and Quality of Nigella sativa L. Seed Oils-The Underestimated Impact on Possible Health-Promoting Properties. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061360. [PMID: 38542995]
Mohsen Karami Fath, Kamyar Nasiri, Shabnam Ghasemzadeh, Seyedeh Tabasom Nejati, Nima Ghafari, Sahand Saeidpour Masouleh, Esmaeel Dadgar, Kimia Sadat Kazemi, Mahla Esfahaniani. Thymoquinone potentiates anti-cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress. Chemical biology & drug design. 2024 03; 103(3):e14492. doi: 10.1111/cbdd.14492. [PMID: 38485457]
S Doğru, S Taysi, A Yücel. Effects of thymoquinone in the lungs of rats against radiation-induced oxidative stress. European review for medical and pharmacological sciences. 2024 Jan; 28(1):191-198. doi: 10.26355/eurrev_202401_34904. [PMID: 38235870]
Huijing Zhang, Yuanqing Liu, Yanjun Dong, Gebin Li, Shuaiyu Wang. Thymoquinone: An Effective Natural Compound for Kidney Protection. The American journal of Chinese medicine. 2024; 52(3):775-797. doi: 10.1142/s0192415x24500319. [PMID: 38715182]
Shakiba Azami, Fatemeh Forouzanfar. Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke. Current molecular medicine. 2024; 24(3):327-334. doi: 10.2174/1566524023666230410101724. [PMID: 37038292]
Ravi Y, Irene Vethamoni Periyanadar, Shailendra Nath Saxena, Raveendran Muthurajan, Velmurugan Sundararajan, Santhanakrishnan Vichangal Pridiuldi, Sumer Singh Meena, Ashoka Narayana Naik, C B Harisha, Honnappa Asangi, Sharda Choudhary, Ravindra Singh, Yallappa Dengeru, Kavan Kumar V, Narottam Kumar Meena, Ram Swaroop Meena, Arvind Kumar Verma. Identification, validation and quantification of thymoquinone in conjunction with assessment of bioactive possessions and GC-MS profiling of pharmaceutically valuable crop Nigella (Nigella sativa L.) varieties. PeerJ. 2024; 12(?):e17177. doi: 10.7717/peerj.17177. [PMID: 38563005]
Jing-Jing Liu, Zhan-Yi Wang, Bin-Bin Jiang, Shu-Qin Gao, Ying-Wu Lin. Protective effect of thymoquinone on glycation of human myoglobin induced by d-ribose. International journal of biological macromolecules. 2023 Dec; 253(Pt 4):127016. doi: 10.1016/j.ijbiomac.2023.127016. [PMID: 37741485]
Diana Di Liberto, Nicolò Iacuzzi, Giovanni Pratelli, Antonella Porrello, Antonella Maggio, Salvatore La Bella, Anna De Blasio, Antonietta Notaro, Antonella D'Anneo, Sonia Emanuele, Federica Affranchi, Michela Giuliano, Marianna Lauricella, Daniela Carlisi. Cytotoxic Effect Induced by Sicilian Oregano Essential Oil in Human Breast Cancer Cells. Cells. 2023 11; 12(23):. doi: 10.3390/cells12232733. [PMID: 38067161]
A Tekbaş, S Bremer-Streck, D K Wissenbach, F T Peters, M von Lilienfeld-Toal, Z Soonawalla, F Rauchfuß, U Settmacher, U Dahmen. Gas Chromatography-Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies. International journal of molecular sciences. 2023 Nov; 24(22):. doi: 10.3390/ijms242216431. [PMID: 38003621]
Farima Kaviani, Bibi Marjan Razavi, Mahdieh Sadat Mohsenzadeh, Maryam Rameshrad, Hossein Hosseinzadeh. Thymoquinone attenuates olanzapine-induced metabolic disorders in rats. Molecular biology reports. 2023 Sep; ?(?):. doi: 10.1007/s11033-023-08726-5. [PMID: 37707771]
Yan Shan Loo, N Idayu Zahid, Thiagarajan Madheswaran, Shinya Ikeno, Armania Nurdin, Intan Diana Mat Azmi. Coencapsulation of Gemcitabine and Thymoquinone in Citrem-Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells. Molecular pharmaceutics. 2023 09; 20(9):4611-4628. doi: 10.1021/acs.molpharmaceut.3c00333. [PMID: 37587099]
Hadi Shabani, Mohammad Hossein Karami, Jalili Kolour, Zeinab Sayyahi, Mohammad Amir Parvin, Shahrad Soghala, Sadegh Shojaei Baghini, Mahsa Mardasi, Ali Chopani, Pooria Moulavi, Tahereh Farkhondeh, Majid Darroudi, Mahboubeh Kabiri, Saeed Samarghandian. Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 165(?):114972. doi: 10.1016/j.biopha.2023.114972. [PMID: 37481931]
Nuzhat Parveen, Mohammad Abdulkader Akbarsha, A B Latif Wani, Mohd Owais Ansari, Md Fahim Ahmad, G G H A Shadab. Protective effect of quercetin and thymoquinone against genotoxicity and oxidative stress induced by ZnO nanoparticles in the Wistar rat model. Mutation research. Genetic toxicology and environmental mutagenesis. 2023 Aug; 890(?):503661. doi: 10.1016/j.mrgentox.2023.503661. [PMID: 37567646]
Marwa M Qadri, Mohammad Firoz Alam, Zenat A Khired, Reem O Alaqi, Amani A Khardali, Moudi M Alasmari, Ahmad S S Alrashah, Hisham M A Muzafar, Abdullah M Qahl. Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310621. [PMID: 37445797]
Ehsan Sadeghi, Mohsen Imenshahidi, Hossein Hosseinzadeh. Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review. Molecular biology reports. 2023 Jun; 50(6):5439-5454. doi: 10.1007/s11033-023-08363-y. [PMID: 37155017]
S M Alanazi, R A Alsaqer, F I Alsaeed, R M Almakhaytah, N T Buwashl, M E Mohamed, N S Younis. Studying the actions of sage and thymoquinone combination on metabolic syndrome induced by high-fat diet in rats. European review for medical and pharmacological sciences. 2023 03; 27(6):2404-2418. doi: 10.26355/eurrev_202303_31775. [PMID: 37013759]
Hend Ashour, Laila A Rashed, Radwa T M Hassanein, Basma E Aboulhoda, Hasnaa A Ebrahim, Mohamed H Elsayed, Miran A Elkordy, Omaima M Abdelwahed. Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases. Archives of physiology and biochemistry. 2023 Feb; 129(1):268-281. doi: 10.1080/13813455.2022.2134423. [PMID: 36264662]
Ravi Raj Pal, Vasundhara Rajpal, Neelu Singh, Sukhveer Singh, Nidhi Mishra, Priya Singh, Priyanka Maurya, Alka, Shubhini A Saraf. Downregulation of pro-inflammatory markers IL-6 and TNF-α in rheumatoid arthritis using nano-lipidic carriers of a quinone-based phenolic: an in vitro and in vivo study. Drug delivery and translational research. 2023 02; 13(2):627-641. doi: 10.1007/s13346-022-01221-7. [PMID: 35963927]
Priya Gupta, Yub Raj Neupane, Suhel Parvez, Kanchan Kohli, Yasmin Sultana. Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer. Current molecular medicine. 2023; 23(9):876-888. doi: 10.2174/1566524023666220819122948. [PMID: 35986537]
Boinu Babu, Pooja Rao, Ethel Suman, Jeppu Udayalaxmi. A Study of Antibacterial Effect of Nigella sativa Seed Extracts on Bacterial Isolates from Cases of Wound Infection. Infectious disorders drug targets. 2023; 23(5):e030423215400. doi: 10.2174/1871526523666230403095441. [PMID: 37016531]
Vildan Betul Yenigun, Hasan Acar, Ebru Kanimdan, Alper Yenigun, Abdurrahim Kocyigit, Tulin Cora. KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis. Anti-cancer agents in medicinal chemistry. 2023; 23(15):1747-1753. doi: 10.2174/1871520623666230517123807. [PMID: 37194932]
Sedat Bilgiç, Meltem Özgöçmen, Mehmet Kaya Ozer. Thymoquinone ameliorates amikacin induced oxidative damage in rat brain tissue. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Jan; 98(1):38-45. doi: 10.1080/10520295.2022.2087905. [PMID: 35811486]
Gajendran Nithya, Rajasekaran Santhanasabapathy, Manickam Kalappan Vanitha, Pandi Anandakumar, Dhanapalan Sakthisekaran. Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene-induced experimental lung cancer. Journal of biochemical and molecular toxicology. 2023 Jan; 37(1):e23230. doi: 10.1002/jbt.23230. [PMID: 36193556]
Di Zhang, Yinghui Zhang, Zhilan Wang, Lei Lei. Thymoquinone attenuates hepatic lipid accumulation by inducing autophagy via AMPK/mTOR/ULK1-dependent pathway in nonalcoholic fatty liver disease. Phytotherapy research : PTR. 2022 Dec; ?(?):. doi: 10.1002/ptr.7662. [PMID: 36479746]
Monireh Shahbodi, Seyed Ahmad Emami, Behjat Javadi, Zahra Tayarani-Najaran. Effects of Thymoquinone on Adipocyte Differentiation in Human Adipose-Derived Stem Cells. Cell biochemistry and biophysics. 2022 Dec; 80(4):771-779. doi: 10.1007/s12013-022-01095-z. [PMID: 36074244]
Maria Chiara Bruno, Agnese Gagliardi, Antonia Mancuso, Antonella Barone, Martine Tarsitano, Donato Cosco, Maria Chiara Cristiano, Massimo Fresta, Donatella Paolino. Oleic acid-based vesicular nanocarriers for topical delivery of the natural drug thymoquinone: Improvement of anti-inflammatory activity. Journal of controlled release : official journal of the Controlled Release Society. 2022 12; 352(?):74-86. doi: 10.1016/j.jconrel.2022.10.011. [PMID: 36228953]
Reem J Abdualmjid, Consolato M Sergi. Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone. International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232314669. [PMID: 36498999]
Dinesh Kumar, Amisha Desa, Sana Chougle, Shruti G Bhatkalkar, Shilpee Sachar, C Selvaa Kumar, Ahmad Ali. Evaluation of the antiglycating potential of thymoquinone and its interaction with BSA. Journal of biomolecular structure & dynamics. 2022 11; 40(18):8455-8463. doi: 10.1080/07391102.2021.1912642. [PMID: 33908315]
Emin Kaymak, Emel Öztürk, Ali Tuğrul Akİn, Derya Karabulut, Birkan Yakan. Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2022 Nov; 97(8):622-634. doi: 10.1080/10520295.2022.2111465. [PMID: 35989671]
Muhammed Enes İnanç, Şükrü Güngör, Fatih Avdatek, Deniz Yeni, Mehmet Fuat Gülhan, Kemal Tuna Olğaç, Barış Denk, Umut Taşdemir. Thymoquinone improves motility, plasma membrane integrity and DNA integrity of frozen-thawed ram semen. Andrologia. 2022 Nov; 54(10):e14547. doi: 10.1111/and.14547. [PMID: 36177794]
Heba M Fahmy, Mostafa M Ahmed, Ayman S Mohamed, Engy Shams-Eldin, Taiseer M Abd El-Daim, Amena S El-Feky, Amira B Mustafa, Mai W Abd Alrahman, Faten F Mohammed, Mohamed M Fathy. Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats. BMC pharmacology & toxicology. 2022 09; 23(1):71. doi: 10.1186/s40360-022-00616-z. [PMID: 36163187]
Zhen Wang, Zhe Wang, Xiaoyu Wang, Xin Lv, Hang Yin, Lili Jiang, Yangliu Xia, Wei Li, Wenli Li, Yong Liu. Potential food-drug interaction risk of thymoquinone with warfarin. Chemico-biological interactions. 2022 Sep; 365(?):110070. doi: 10.1016/j.cbi.2022.110070. [PMID: 35921950]
Sagar Trivedi, Kamlesh Wadher, Milind Umekar. Development of topical thymoquinone loaded polymer-lipid hybrid vesicular gel: in-vitro and ex-vivo evaluation. Journal of liposome research. 2022 Sep; 32(3):224-236. doi: 10.1080/08982104.2021.1929311. [PMID: 34003069]
Monica Butnariu, Cristina Quispe, Jesús Herrera-Bravo, Paweł Helon, Wirginia Kukula-Koch, Víctor López, Francisco Les, Cristian Valdés Vergara, Pedro Alarcón-Zapata, Barbara Alarcón-Zapata, Miquel Martorell, Marius Pentea, Aneta Anca Dragunescu, Ionel Samfira, Zura Yessimsiitova, Sevgi Durna Daştan, Carla Marina Salgado Castillo, Thomas H Roberts, Javad Sharifi-Rad, Wojciech Koch, William C Cho. The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113364. doi: 10.1016/j.biopha.2022.113364. [PMID: 35810693]
Nashwa Amin, Shijia Chen, Shan Ye, Fei Wu, Azhar B Hussien, Chengjian Lou, Zhiying Hu, Yanyan Wang, Junsong Wu, Marong Fang. Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154298. doi: 10.1016/j.phymed.2022.154298. [PMID: 35797865]
Elisabeth Khaikin, Sigrun Chrubasik-Hausmann, Sebahat Kaya, Benno F Zimmermann. Screening of Thymoquinone Content in Commercial Nigella sativa Products to Identify a Promising and Safe Study Medication. Nutrients. 2022 Aug; 14(17):. doi: 10.3390/nu14173501. [PMID: 36079759]
Deniz Kantar, Alev Duygu Acun, Betül Danışman. Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment. Behavioural brain research. 2022 08; 431(?):113972. doi: 10.1016/j.bbr.2022.113972. [PMID: 35718231]
Chaitali Prajapati, Yogeeta O Agrawal, Vinit V Agnihotri, Umesh B Mahajan, Kalpesh R Patil, Dipak D Patil, Chandragouda R Patil. Development and biological evaluation of protective effect of kidney targeted N-acetylated chitosan nanoparticles containing thymoquinone for the treatment of DNA damage in cyclophosphamide-induced haemorrhagic cystitis. International journal of biological macromolecules. 2022 Aug; 214(?):391-401. doi: 10.1016/j.ijbiomac.2022.06.070. [PMID: 35714868]
Sumit Rathod, Yogeeta Agrawal, Abdulla Sherikar, Kartik T Nakhate, Chandragouda R Patil, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goyal. Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation. Nutrients. 2022 Jun; 14(13):. doi: 10.3390/nu14132742. [PMID: 35807920]
Bin Xue, Debarati DasGupta, Manzar Alam, Mohd Shahnawaz Khan, Shuo Wang, Anas Shamsi, Asimul Islam, Md Imtaiyaz Hassan. Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy. Journal of cellular biochemistry. 2022 Jun; ?(?):. doi: 10.1002/jcb.30299. [PMID: 35722728]
Semiha Dede, Vedat Turkoglu, Zehra Bas. The inhibitory effects of lycopene and thymoquinone on angiotensin converting enzyme from human plasma (An in vitro study). Pakistan journal of pharmaceutical sciences. 2022 May; 35(3):801-805. doi: NULL. [PMID: 35791479]
Lei Zhang, Hujin Zhang, Jing Ma, Yun Wang, Zuowei Pei, Hui Ding. Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice. International journal of molecular medicine. 2022 May; 49(5):. doi: 10.3892/ijmm.2022.5119. [PMID: 35293590]
Farzad Ghasemi, Fatemeh Ghaffari, Navid Omidifar, Masoumeh Taheri Azandaryani, Amir Nili-Ahmadabadi. Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study. Biological trace element research. 2022 Apr; ?(?):. doi: 10.1007/s12011-022-03249-9. [PMID: 35484332]
Abdullah Al Mamun, Kentaro Matsuzaki, Rafiad Islam, Shahdat Hossain, Md Emon Hossain, Masanori Katakura, Hiroyuki Arai, Osamu Shido, Michio Hashimoto. Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway. Neurochemical research. 2022 Apr; 47(4):933-951. doi: 10.1007/s11064-021-03495-8. [PMID: 34855048]
Sedat Kacar, Varol Sahinturk, Ozlem Tomsuk, Hatice M Kutlu. The effects of thymoquinone and quercetin on the toxicity of acrylamide in rat glioma cells. Journal of biochemical and molecular toxicology. 2022 Apr; 36(4):e22992. doi: 10.1002/jbt.22992. [PMID: 35187760]
Marwa Medhet, Wesam M El-Bakly, Amira M Badr, Azza Awad, Ebtehal El-Demerdash. Thymoquinone attenuates isoproterenol-induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase-9 expression. Clinical and experimental pharmacology & physiology. 2022 03; 49(3):391-405. doi: 10.1111/1440-1681.13614. [PMID: 34767666]
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Mustafa Fatih Dasci, Elif Yaprak Sarac, Asiye Gok Yurttas, Tolgahan Atci, Muhammed Uslu, Abdurrahman Acar, Mehmet Akif Gulec, Ender Alagoz. The effects of thymoquinone on steroid-induced femoral head osteonecrosis: An experimental study in rats. Joint diseases and related surgery. 2022; 33(3):553-566. doi: 10.52312/jdrs.2022.752. [PMID: 36345183]
Abolfazl Saravani Jahantiq, Seyyed Amin Ayatollahi Mousavi, Neda Mohamadi, Fariba Sharififar. Inhibitory Effect of Standardized Extract and Fractions of Nigella sativa L. on Nystatin Susceptible and Clinically Nystatin Resistant Candida albicans. Current drug discovery technologies. 2022; 19(5):e120522204695. doi: 10.2174/1570163819666220512164337. [PMID: 35549875]
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Rishabh Verma, Ali Sartaj, Farheen Fatima Qizilbash, Mohammed M Ghoneim, Sultan Alshehri, Syed Sarim Imam, Chandra Kala, Md Shamsher Alam, Sadaf Jamal Gilani, Mohamad Taleuzzaman. An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder. Current drug metabolism. 2022; 23(6):447-459. doi: 10.2174/1389200223666220608142506. [PMID: 35676849]
Wanjing Li, Hujin Zhang, Lei Zhang, Taipeng Zhang, Hui Ding. Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R-/-) Mice. BioMed research international. 2022; 2022(?):7709926. doi: 10.1155/2022/7709926. [PMID: 35845925]
Juveriya Farooq, Rokeya Sultana, Tahreen Taj, Syed Mohammed Basheeruddin Asdaq, Abdulkhaliq J Alsalman, Mohammed Al Mohaini, Maitham A Al Hawaj, Mehnaz Kamal, Saad Alghamdi, Mohd Imran, Haleema Shahin, Ruheena Tabassum. Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010226. [PMID: 35011457]
Yuri Yoshioka, Shinichi Matsumura, Masanori Morimoto. Deodorant Activity of Black Cumin Seed Essential Oil against Garlic Organosulfur Compound. Biomolecules. 2021 12; 11(12):. doi: 10.3390/biom11121874. [PMID: 34944518]
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Noreen Samad, Natasha Manzoor, Zahra Muneer, Sheraz A Bhatti, Imran Imran. Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice. Metabolic brain disease. 2021 12; 36(8):2535-2552. doi: 10.1007/s11011-021-00789-2. [PMID: 34309746]
Mohammad Reza Khazdair, Shoukouh Ghafari, Mahmood Sadeghi. Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19. Pharmaceutical biology. 2021 Dec; 59(1):696-703. doi: 10.1080/13880209.2021.1931353. [PMID: 34110959]
Kaneez Fatima Shad, Wissam Soubra, Dennis John Cordato. The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases. Clinical and experimental pharmacology & physiology. 2021 11; 48(11):1445-1453. doi: 10.1111/1440-1681.13553. [PMID: 34297870]
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Sanaa A El-Benhawy, Mohamed I Morsi, Rasha A El-Tahan, Noura A Matar, Hawa Mg Ehmaida. Radioprotective Effect of Thymoquinone in X-irradiated Rats. Asian Pacific journal of cancer prevention : APJCP. 2021 Sep; 22(9):3005-3015. doi: 10.31557/apjcp.2021.22.9.3005. [PMID: 34582673]
Md Abdul Hannan, Md Sarwar Zahan, Partha Protim Sarker, Akhi Moni, Hunjoo Ha, Md Jamal Uddin. Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22169078. [PMID: 34445781]
Fatih Mehmet Gur, Ibrahim Aktas. The ameliorative effects of thymoquinone and beta-aminoisobutyric acid on streptozotocin-induced diabetic cardiomyopathy. Tissue & cell. 2021 Aug; 71(?):101582. doi: 10.1016/j.tice.2021.101582. [PMID: 34171519]
Mahmoud M Farag, Asmaa A Khalifa, Wessam F Elhadidy, Radwa M Rashad. Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis, autophagy, and fibrosis. Naunyn-Schmiedeberg's archives of pharmacology. 2021 08; 394(8):1787-1801. doi: 10.1007/s00210-021-02087-1. [PMID: 34216225]
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Marketa Houdkova, Aishwarya Chaure, Ivo Doskocil, Jaroslav Havlik, Ladislav Kokoska. New Broth Macrodilution Volatilization Method for Antibacterial Susceptibility Testing of Volatile Agents and Evaluation of Their Toxicity Using Modified MTT Assay In Vitro. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144179. [PMID: 34299454]
Mohammed Shariq Iqbal, Zahra Iqbal, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd-Allah, Asif Jafri, Shamim Akhtar Ansari, Mohammad Israil Ansari. Nigella sativa callus treated with sodium azide exhibit augmented antioxidant activity and DNA damage inhibition. Scientific reports. 2021 07; 11(1):13954. doi: 10.1038/s41598-021-93370-x. [PMID: 34230566]
Hilal Alkis, Elif Demir, Mehmet Resit Taysi, Suleyman Sagir, Seyithan Taysi. Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111540. doi: 10.1016/j.biopha.2021.111540. [PMID: 33831837]
Ravi Raj Pal, Deepak Kumar, Vinit Raj, Vasundhara Rajpal, Priyanka Maurya, Samipta Singh, Nidhi Mishra, Neelu Singh, Priya Singh, Nidhi Tiwari, Shubhini A Saraf. Synthesis of pH-sensitive crosslinked guar gum-g-poly(acrylic acid-co-acrylonitrile) for the delivery of thymoquinone against inflammation. International journal of biological macromolecules. 2021 Jul; 182(?):1218-1228. doi: 10.1016/j.ijbiomac.2021.05.072. [PMID: 33991556]
Junfang Liang, Liyang Lian, Xiaoli Wang, Liang Li. Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction. Molecular immunology. 2021 07; 135(?):21-27. doi: 10.1016/j.molimm.2021.03.015. [PMID: 33857815]
Somayeh Hajipour, Alireza Sarkaki, Mahin Dianat, Mohammad Rashno, Laaya Sadat Khorsandi, Yaghoob Farbood. The effects of thymoquinone on memory impairment and inflammation in rats with hepatic encephalopathy induced by thioacetamide. Metabolic brain disease. 2021 06; 36(5):991-1002. doi: 10.1007/s11011-021-00688-6. [PMID: 33620578]
Saeideh Saadat, Mohammad Reza Aslani, Vahideh Ghorani, Rana Keyhanmanesh, Mohammad Hossein Boskabady. The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review. Phytotherapy research : PTR. 2021 Jun; 35(6):2968-2996. doi: 10.1002/ptr.7003. [PMID: 33455047]
Heba El-Sayed Mostafa, Eman Ahmed Alaa El-Din, Dalia Abdallah El-Shafei, Nehal S Abouhashem, Aisha Abdallah Abouhashem. Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats. Environmental science and pollution research international. 2021 Jun; 28(24):31174-31184. doi: 10.1007/s11356-021-12997-5. [PMID: 33595798]
Fatih Mehmet Gur, Sema Timurkaan, Eylem Taskin, Celal Guven, Hatice Emel Gur, Meryem Senturk, Sevgi Dastan, Nursultan Nurdinov, Adnan Unalan, Senay Cankut, Ilhan Tatyuz. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats. Andrologia. 2021 Jun; 53(5):e14033. doi: 10.1111/and.14033. [PMID: 33660882]
Mohammad A Alzohairy, Amjad Ali Khan, Mohammed A Alsahli, Saleh A Almatroodi, Arshad Husain Rahmani. Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113218. [PMID: 34072086]
Md Abdul Hannan, Md Ataur Rahman, Abdullah Al Mamun Sohag, Md Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md Mohibbullah, Md Nazmul Haque, Israt Jahan, Md Tahmeed Hossain, Tania Afrin, Md Mahbubur Rahman, Md Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon, Bonglee Kim. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients. 2021 May; 13(6):. doi: 10.3390/nu13061784. [PMID: 34073784]
Muhammad Fakhar-E-Alam Kulyar, Rongrong Li, Khalid Mehmood, Muhammad Waqas, Kun Li, Jiakui Li. Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153277. doi: 10.1016/j.phymed.2020.153277. [PMID: 32773257]
Omeima Abdullah, Ziad Omran, Salman Hosawi, Ali Hamiche, Christian Bronner, Mahmoud Alhosin. Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex. Genes. 2021 04; 12(5):. doi: 10.3390/genes12050622. [PMID: 33922029]
Mohamed Faisal Lutfi, Abdel-Moneim Hafez Abdel-Moneim, Ashwag Saleh Alsharidah, Mugahid A Mobark, Ahmed A H Abdellatif, Imran Y Saleem, Osamah Al Rugaie, Khalid M Mohany, Mansour Alsharidah. Thymoquinone Lowers Blood Glucose and Reduces Oxidative Stress in a Rat Model of Diabetes. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082348. [PMID: 33920728]
Johura Ansary, Francesca Giampieri, Tamara Y Forbes-Hernandez, Lucia Regolo, Denise Quinzi, Santos Gracia Villar, Eduardo Garcia Villena, Kilian Tutusaus Pifarre, José M Alvarez-Suarez, Maurizio Battino, Danila Cianciosi. Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082108. [PMID: 33916916]
Hari Krishnareddy Rachamalla, Santanu Bhattacharya, Ajaz Ahmad, Kathyayani Sridharan, Vijay Sagar Madamsetty, Sujan Kumar Mondal, Enfeng Wang, Shamit K Dutta, Basit L Jan, Sudhakar Jinka, Madan Mohan Chandra Sekhar Jaggarapu, Venu Yakati, Debabrata Mukhopadhyay, Khalid M Alkharfy, Rajkumar Banerjee. Enriched pharmacokinetic behavior and antitumor efficacy of thymoquinone by liposomal delivery. Nanomedicine (London, England). 2021 04; 16(8):641-656. doi: 10.2217/nnm-2020-0470. [PMID: 33769068]
Masoumeh Fadishei, Mahboobeh Ghasemzadeh Rahbardar, Mohsen Imenshahidi, Ahmad Mohajeri, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of Nigella sativa oil and thymoquinone against bisphenol A-induced metabolic disorder in rats. Phytotherapy research : PTR. 2021 Apr; 35(4):2005-2024. doi: 10.1002/ptr.6944. [PMID: 33315269]
Mohammad Nazrul Islam, Khandkar Shaharina Hossain, Partha Protim Sarker, Jannatul Ferdous, Md Abdul Hannan, Md Masudur Rahman, Dinh-Toi Chu, Md Jamal Uddin. Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure. Phytotherapy research : PTR. 2021 Mar; 35(3):1329-1344. doi: 10.1002/ptr.6895. [PMID: 33047412]
Yumei Pu, Shiqi Hu, Yongfeng Chen, Qian Zhang, Chengwan Xia, Han Deng, Yuxin Wang, Qingang Hu. Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12-dimethylbenz[a]anthracene-induced hamster oral cancer via the down-regulation of PI3K/AKT/mTOR signaling pathways. Environmental toxicology. 2021 Mar; 36(3):339-351. doi: 10.1002/tox.23040. [PMID: 33068063]
Sadia Nazir, Rai Khalid Farooq, Hina Khan, Tahseen Alam, Aneela Javed. Thymoquinone harbors protection against Concanavalin A-induced behavior deficit in BALB/c mice model. Journal of food biochemistry. 2021 03; 45(3):e13348. doi: 10.1111/jfbc.13348. [PMID: 32618005]
Somayeh Hajipour, Yaghoob Farbood, Mahin Dianat, Mohammad Rashno, Laya Sadat Khorsandi, Alireza Sarkaki. Thymoquinone improves behavioral and biochemical deficits in hepatic encephalopathy induced by thioacetamide in rats. Neuroscience letters. 2021 02; 745(?):135617. doi: 10.1016/j.neulet.2020.135617. [PMID: 33421492]
Sawsan Elgohary, Aya A Elkhodiry, Nada S Amin, Ulrike Stein, Hend M El Tayebi. Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020302. [PMID: 33540625]
Khalid Shaaban Hashem, Ahmed Zakaria Abdelazem, Marwa Abdeltawab Mohammed, Amr M Nagi, Basma Emad Aboulhoda, Eman T Mohammed, Mohamed M Abdel-Daim. Thymoquinone alleviates mitochondrial viability and apoptosis in diclofenac-induced acute kidney injury (AKI) via regulating Mfn2 and miR-34a mRNA expressions. Environmental science and pollution research international. 2021 Feb; 28(8):10100-10113. doi: 10.1007/s11356-020-11313-x. [PMID: 33165700]
Daifullah Al Aboud, Roua S Baty, Khalaf F Alsharif, Khalid Ebrahim Hassan, Ahmed S Zhery, Ola A Habotta, Ehab K Elmahallawy, Hatim K Amin, Ahmed E Abdel Moneim, Rami B Kassab. Protective efficacy of thymoquinone or ebselen separately against arsenic-induced hepatotoxicity in rat. Environmental science and pollution research international. 2021 Feb; 28(5):6195-6206. doi: 10.1007/s11356-020-10955-1. [PMID: 32989703]
Walied Abdo, Mostafa A Elmadawy, Ehab Yahya Abdelhiee, Mona A Abdel-Kareem, Amira Farag, Mohamed Aboubakr, Emad Ghazy, Sabreen E Fadl. Protective effect of thymoquinone against lung intoxication induced by malathion inhalation. Scientific reports. 2021 01; 11(1):2498. doi: 10.1038/s41598-021-82083-w. [PMID: 33510276]
Mehmet Burak Ates, Mustafa Ortatatli. Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111774. doi: 10.1016/j.ecoenv.2020.111774. [PMID: 33396089]
Nida Nehal, Bushra Nabi, Saleha Rehman, Ankita Pathak, Ashif Iqubal, Saif Ahmad Khan, M Shahar Yar, Suhel Parvez, Sanjula Baboota, Javed Ali. Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment. International journal of biological macromolecules. 2021 Jan; 167(?):605-619. doi: 10.1016/j.ijbiomac.2020.11.207. [PMID: 33278450]
Mahtab Alam, Md Noushad Javed, Abul Kalam Najmi, Farhan Jalees Ahmad, Syed Sarim Imam, Mohd Akhtar. Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats. Current drug metabolism. 2021; 22(12):978-988. doi: 10.2174/1389200222666211108101531. [PMID: 34749619]
Masood Alam Khan, Hina Younus. Potential Implications of Black Seed and its Principal Constituent Thymoquinone in the Treatment of COVID-19 Patients. Current pharmaceutical biotechnology. 2021; 22(10):1315-1324. doi: 10.2174/1389201021999201110205048. [PMID: 33176642]
Mohammed Dalli, Nour Elhouda Daoudi, Salah-Eddine Azizi, Hind Benouda, Mohamed Bnouham, Nadia Gseyra. Chemical Composition Analysis Using HPLC-UV/GC-MS and Inhibitory Activity of Different Nigella sativa Fractions on Pancreatic α-Amylase and Intestinal Glucose Absorption. BioMed research international. 2021; 2021(?):9979419. doi: 10.1155/2021/9979419. [PMID: 34258287]
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