5,6-Dimethylbenzanthracene (BioDeep_00000174770)
human metabolite blood metabolite
代谢物信息卡片
5,6-Dimethylbenzanthracene
化学式: C20H16 (256.1252)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90.48%
分子结构信息
SMILES: CC1=C(C)C2=CC3=CC=CC=C3C=C2C2=CC=CC=C12
InChI: InChI=1S/C20H16/c1-13-14(2)19-11-15-7-3-4-8-16(15)12-20(19)18-10-6-5-9-17(13)18/h3-12H,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- N Sithranga Boopathy, K Kathiresan, Y J Jeon. Effect of mangrove black tea extract from Ceriops decandra (Griff.) on hematology and biochemical changes in dimethyl benz[a]anthracene-induced hamster buccal pouch carcinogenesis.
Environmental toxicology and pharmacology.
2011 Sep; 32(2):193-200. doi:
10.1016/j.etap.2011.05.003. [PMID: 21843799] - Song Yao, Lara E Sucheston, Amy E Millen, Candace S Johnson, Donald L Trump, Mary K Nesline, Warren Davis, Chi-Chen Hong, Susan E McCann, Helena Hwang, Swati Kulkarni, Stephen B Edge, Tracey L O'Connor, Christine B Ambrosone. Pretreatment serum concentrations of 25-hydroxyvitamin D and breast cancer prognostic characteristics: a case-control and a case-series study.
PloS one.
2011 Feb; 6(2):e17251. doi:
10.1371/journal.pone.0017251. [PMID: 21386992] - Jan B Howes, Paul L de Souza, Leanne West, Li Jiu Huang, Laurence G Howes. Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
BMC clinical pharmacology.
2011 Feb; 11(?):1. doi:
10.1186/1472-6904-11-1. [PMID: 21291562] - Timea Varjas, Ghodratollah Nowrasteh, Ferenc Budán, Gábor Horváth, József Cseh, Zoltán Gyöngyi, Sándor Makai, István Ember. The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.
Phytotherapy research : PTR.
2011 Feb; 25(2):221-7. doi:
10.1002/ptr.3231. [PMID: 20641053] - Sharad S Singhal, Dilki Wickramarachchi, Sushma Yadav, Jyotsana Singhal, Kathryn Leake, Rit Vatsyayan, Pankaj Chaudhary, Poorna Lelsani, Sumihiro Suzuki, Shaohua Yang, Yogesh C Awasthi, Sanjay Awasthi. Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Molecular cancer therapeutics.
2011 Jan; 10(1):16-28. doi:
10.1158/1535-7163.mct-10-0699. [PMID: 21220488] - Lu Wang, Alvin C Camus, Wu Dong, Cammi Thornton, Kristine L Willett. Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Aquatic toxicology (Amsterdam, Netherlands).
2010 Sep; 99(4):439-47. doi:
10.1016/j.aquatox.2010.06.002. [PMID: 20621368] - Aaron T Jacobs, Lawrence J Marnett. Systems analysis of protein modification and cellular responses induced by electrophile stress.
Accounts of chemical research.
2010 May; 43(5):673-83. doi:
10.1021/ar900286y. [PMID: 20218676] - Nadine M Brown, Carrie A Belles, Stephanie L Lindley, Linda D Zimmer-Nechemias, Xueheng Zhao, David P Witte, Mi-Ok Kim, Kenneth D R Setchell. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.
Carcinogenesis.
2010 May; 31(5):886-93. doi:
10.1093/carcin/bgq025. [PMID: 20110282] - B K Ojeswi, M Khoobchandani, D K Hazra, M M Srivastava. Protective effect of Thuja occidentalis against DMBA-induced breast cancer with reference to oxidative stress.
Human & experimental toxicology.
2010 May; 29(5):369-75. doi:
10.1177/0960327110364150. [PMID: 20200195] - Juan Sun, Yanxin Hu, Shanping Cao, Guozhong Zhang, Lun-Quan Sun, Ming Wang. Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent.
Journal of biomedicine & biotechnology.
2010; 2010(?):. doi:
10.1155/2010/362524. [PMID: 20706607] - M Pandi, R Manikandan, J Muthumary. Anticancer activity of fungal taxol derived from Botryodiplodia theobromae Pat., an endophytic fungus, against 7, 12 dimethyl benz(a)anthracene (DMBA)-induced mammary gland carcinogenesis in Sprague Dawley rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2010 Jan; 64(1):48-53. doi:
10.1016/j.biopha.2009.03.001. [PMID: 19762199] - Kulbhushan Tikoo, Parveen Kumar, Jeena Gupta. Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats.
BMC cancer.
2009 Apr; 9(?):107. doi:
10.1186/1471-2407-9-107. [PMID: 19356226] - Javier A Menendez, Alejandro Vazquez-Martin, Rocio Garcia-Villalba, Alegria Carrasco-Pancorbo, Cristina Oliveras-Ferraros, Alberto Fernandez-Gutierrez, Antonio Segura-Carretero. tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO).
BMC cancer.
2008 Dec; 8(?):377. doi:
10.1186/1471-2407-8-377. [PMID: 19094209] - Ruth De Celis, Alfredo Feria-Velasco, Alejandro Bravo-Cuellar, Juan José Hicks-Gómez, Trinidad García-Iglesias, Verónica Preciado-Martínez, Laura Muñoz-Islas, Marco González-Unzaga. Expression of NK cells activation receptors after occupational exposure to toxics: a preliminary study.
Immunology letters.
2008 Jun; 118(2):125-31. doi:
10.1016/j.imlet.2008.03.010. [PMID: 18468695] - Hong-Bo Tang, Yu-Ping Ren, Ying Hu, Zhan-Yong Zhu, Yong-Feng Shuai, Yi-Ping Wu. [Different expression of liver-specific insulin-like growth factor I gene in breast cancer; expression with mice].
Zhonghua yi xue za zhi.
2008 Jun; 88(22):1553-6. doi:
NULL. [PMID: 18956639] - Linda E B Stuhr, Ingrid Moen, Torbjørn Nedrebø, Alexei V Salnikov, Helge Wiig, Kristofer Rubin, Rolf K Reed. Peritumoral TNFalpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours.
Scandinavian journal of clinical and laboratory investigation.
2008; 68(7):602-11. doi:
10.1080/00365510801971703. [PMID: 19378432] - P Mathivadhani, P Shanthi, P Sachdanandam. Effect of Semecarpus anacardium nut extract on ECM and proteases in mammary carcinoma rats.
Vascular pharmacology.
2007 Jun; 46(6):419-26. doi:
10.1016/j.vph.2006.12.004. [PMID: 17337360] - Pawel Sienkiewicz, Henry P Ciolino, Benjamin J Leslie, Paul J Hergenrother, Keith Singletary, Grace Chao Yeh. A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor.
Carcinogenesis.
2007 May; 28(5):1052-7. doi:
10.1093/carcin/bgl248. [PMID: 17183067] - Tsugitaka Natsume, Junichi Watanabe, Kenji Ogawa, Kazuhiko Yasumura, Motohiro Kobayashi. Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy.
Cancer science.
2007 Apr; 98(4):598-604. doi:
10.1111/j.1349-7006.2007.00418.x. [PMID: 17284247] - Edward R Sauter, Wenyi Qin, Lisa Schlatter, John E Hewett, John T Flynn. Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer.
BMC cancer.
2006 Oct; 6(?):248. doi:
10.1186/1471-2407-6-248. [PMID: 17049084] - Timothy Whitsett, Mark Carpenter, Coral A Lamartiniere. Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats.
Journal of carcinogenesis.
2006 May; 5(?):15. doi:
10.1186/1477-3163-5-15. [PMID: 16700914] - Gregory T Wurz, Cristina Marchisano-Karpman, Michael W DeGregorio. Ineffectiveness of American ginseng in the prevention of dimethylbenzanthracene-induced mammary tumors in mice.
Oncology research.
2006; 16(6):251-60. doi:
10.3727/000000006783981017. [PMID: 17476970] - Mukul Das, Kausar M Ansari, Alok Dhawan, Yogeshwer Shukla, Subhash K Khanna. Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice.
International journal of cancer.
2005 Dec; 117(5):709-17. doi:
10.1002/ijc.21234. [PMID: 15981203] - Helge Wiig, Christina C Gyenge, Olav Tenstad. The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components.
The Journal of physiology.
2005 Sep; 567(Pt 2):557-67. doi:
10.1113/jphysiol.2005.089615. [PMID: 15994186] - Selvanathan Saravana Perumal, Palanivelu Shanthi, Panchanadham Sachdanandam. Combined efficacy of tamoxifen and coenzyme Q10 on the status of lipid peroxidation and antioxidants in DMBA induced breast cancer.
Molecular and cellular biochemistry.
2005 May; 273(1-2):151-60. doi:
10.1007/s11010-005-0325-3. [PMID: 16013450] - George Kossoy, Herzl Ben-Hur, Asher Elhayany, David F Schneider, Itshak Zusman. Rat soluble tumor-associated antigens inhibit chemically-induced mammary tumorigenesis in syngeneic rats.
Oncology reports.
2005 Apr; 13(4):585-8. doi:
10.3892/or.13.4.585. [PMID: 15756427] - L Michelle Bennett, Jennifer L Montgomery, Seth M Steinberg, Kristen S Kulp. Flor-Essence herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats.
Breast cancer research and treatment.
2004 Nov; 88(1):87-93. doi:
10.1007/s10549-004-1203-5. [PMID: 15538049] - G F Combs. Status of selenium in prostate cancer prevention.
British journal of cancer.
2004 Jul; 91(2):195-9. doi:
10.1038/sj.bjc.6601974. [PMID: 15213714] - Prosenjit Saha, Suvra Mandal, Ashes Das, Prabhas C Das, Sukta Das. Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model.
Phytotherapy research : PTR.
2004 May; 18(5):373-8. doi:
10.1002/ptr.1436. [PMID: 15173996] - George Kossoy, Ilana Avinoach, Itshak Zusman, David P Scheider, Herzl Ben-Hur, Asher Elhayany. Human soluble p66 and p51 tumor-associated antigens promote the suppression of rat mammary tumors in comparison to commercial human albumin.
Oncology reports.
2004 Feb; 11(2):487-91. doi:
NULL. [PMID: 14719088] - Vahdettin Bayazit. Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma.
Saudi medical journal.
2004 Feb; 25(2):156-63. doi:
. [PMID: 14968209] - G Arathi, P Sachdanandam. Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats.
The Journal of pharmacy and pharmacology.
2003 Sep; 55(9):1283-90. doi:
10.1211/0022357021710. [PMID: 14604472] - R Thapliyal, K N Naresh, K V K Rao, G B Maru. Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats.
Toxicology letters.
2003 Mar; 139(1):45-54. doi:
10.1016/s0378-4274(02)00440-x. [PMID: 12595157] - Gayatri Bhasin, Hina Kausar, M Sarwar Alam, Mohammad Athar. Progressive iron overload enhances chemically mediated tumor promotion in murine skin.
Archives of biochemistry and biophysics.
2003 Jan; 409(2):262-73. doi:
10.1016/s0003-9861(02)00616-1. [PMID: 12504893] - Peter P A Smyth. The thyroid, iodine and breast cancer.
Breast cancer research : BCR.
2003; 5(5):235-8. doi:
10.1186/bcr638. [PMID: 12927031] - Leonard A Cohen. A review of animal model studies of tomato carotenoids, lycopene, and cancer chemoprevention.
Experimental biology and medicine (Maywood, N.J.).
2002 Nov; 227(10):864-8. doi:
10.1177/153537020222701005. [PMID: 12424327] - Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale, Maurizio Civelli. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen.
The Journal of pharmacology and experimental therapeutics.
2002 Oct; 303(1):196-203. doi:
10.1124/jpet.102.038034. [PMID: 12235251] - Lauri Kangas, Niina Saarinen, Marja Mutanen, Markku Ahotupa, Riikka Hirsinummi, Mikko Unkila, Merja Perälä, Pasi Soininen, Reino Laatikainen, Helena Korte, Risto Santti. Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2002 Aug; 11 Suppl 2(?):S48-57. doi:
. [PMID: 12570335] - Coral A Lamartiniere, Jun Wang, Michelle Smith-Johnson, Isam-Eldin Eltoum. Daidzein: bioavailability, potential for reproductive toxicity, and breast cancer chemoprevention in female rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Feb; 65(2):228-38. doi:
10.1093/toxsci/65.2.228. [PMID: 11812927] - K Yamanaka, M Mizol, K Kato, A Hasegawa, M Nakano, S Okada. Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter.
Biological & pharmaceutical bulletin.
2001 May; 24(5):510-4. doi:
10.1248/bpb.24.510. [PMID: 11379771] - H Miyauchi-Hashimoto, K Kuwamoto, Y Urade, K Tanaka, T Horio. Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Journal of immunology (Baltimore, Md. : 1950).
2001 May; 166(9):5782-91. doi:
10.4049/jimmunol.166.9.5782. [PMID: 11313422] - J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonald. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice.
Nutrition and cancer.
2001; 39(2):226-32. doi:
10.1207/s15327914nc392_11. [PMID: 11759285]
