5-Methylurapidil (BioDeep_00000174738)
human metabolite blood metabolite
代谢物信息卡片
6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3,5-trimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
化学式: C21H31N5O3 (401.2426776)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N(C(=O)N(C1=O)C)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
InChI: InChI=1S/C21H31N5O3/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4/h5-6,8-9,22H,7,10-15H2,1-4H3
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ashfaq Ahmad, Munavvar A Sattar, Maleeha Azam, Mohammed H Abdulla, Safia A Khan, Fayyaz Hashmi, Nor A Abdullah, Edward J Johns. Cystathione gamma lyase/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of α1A and α1B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy.
PloS one.
2016; 11(5):e0154995. doi:
10.1371/journal.pone.0154995. [PMID: 27191852] - R N Kazi, A S Munavvar, N A Abdullah, A H Khan, E J Johns. Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
Autonomic & autacoid pharmacology.
2009 Jan; 29(1-2):25-31. doi:
10.1111/j.1474-8673.2009.00428.x. [PMID: 19302553] - Mary L García-Cazarín, Jennifer L Smith, Daret K St Clair, Michael T Piascik. The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
Molecular pharmacology.
2008 Oct; 74(4):1000-7. doi:
10.1124/mol.108.047993. [PMID: 18628404] - A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension.
Acta pharmacologica Sinica.
2008 May; 29(5):564-72. doi:
10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364] - M A Sattar, N A Abdullah, Md A H Khan, E J Johns. Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats.
Autonomic & autacoid pharmacology.
2008 Jan; 28(1):1-10. doi:
10.1111/j.1474-8673.2007.00412.x. [PMID: 18257746] - M P Cruz-Domínguez, R Villalobos-Molina, A Miliar-García, D H Montes-Cortés, A C Reséndiz-Ramírez, J Asbun-Bojalil, J Cervantes-Cruz, M C Castillo-Hernández, C Castillo-Henkel. Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease.
Autonomic & autacoid pharmacology.
2008 Jan; 28(1):19-27. doi:
10.1111/j.1474-8673.2007.00413.x. [PMID: 18257748] - Abdul H Khan, Munavvar A Sattar, Nor A Abdullah, Edward J Johns. Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat.
European journal of pharmacology.
2007 Aug; 569(1-2):110-8. doi:
10.1016/j.ejphar.2007.04.063. [PMID: 17559832] - Atso Raasmaja, David A York. Pharmacological characterization of alpha1- and beta-adrenergic synergism of 5'DII activity in rat brown adipocytes.
Archives of physiology and biochemistry.
2006 Feb; 112(1):23-30. doi:
10.1080/13813450500500464. [PMID: 16754200] - Jonas Lindblom, Ramona Petrovska, Mathias Hallberg, Kristina Magnusson, Fred Nyberg, Staffan Uhlén. Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells.
European journal of pharmacology.
2005 Dec; 527(1-3):157-62. doi:
10.1016/j.ejphar.2005.09.062. [PMID: 16309668] - Vanessa Lima, André Mueller, Susana Y Kamikihara, Vanessa Raymundi, Dianne Alewood, Richard J Lewis, Zhongjian Chen, Kenneth P Minneman, André S Pupo. Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta.
European journal of pharmacology.
2005 Jan; 508(1-3):183-92. doi:
10.1016/j.ejphar.2004.12.011. [PMID: 15680270] - Dian Zhang, Bingxiang Yuan, Xiuling Deng, Guangde Yang, Langchong He, Youyi Zhang, Qide Han. Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane.
Science in China. Series C, Life sciences.
2004 Aug; 47(4):376-81. doi:
10.1360/03yc0109. [PMID: 15493479] - A Armenia, A S Munavvar, N A Abdullah, A Helmi, E J Johns. The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats.
British journal of pharmacology.
2004 Jun; 142(4):719-26. doi:
10.1038/sj.bjp.0705842. [PMID: 15172958] - M A Sattar, E J Johns. alpha1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats.
European journal of pharmacology.
1995 Dec; 294(2-3):727-36. doi:
10.1016/0014-2999(95)00637-0. [PMID: 8750739] - T A Esbenshade, A Hirasawa, G Tsujimoto, T Tanaka, J Yano, K P Minneman, T J Murphy. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.
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1995 May; 47(5):977-85. doi:
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1994 Sep; 24(3):420-8. doi:
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1994 Feb; 23(2):232-9. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
1993 Feb; 347(2):180-5. doi:
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European journal of pharmacology.
1992 Dec; 224(2-3):125-36. doi:
10.1016/0014-2999(92)90796-7. [PMID: 1361446] - D R Blue, R L Vimont, D E Clarke. Evidence for a noradrenergic innervation to alpha 1A-adrenoceptors in rat kidney.
British journal of pharmacology.
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Neuropharmacology.
1992 Jul; 31(7):643-7. doi:
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10.1097/00005344-199206000-00003. [PMID: 1376804] - K Klijn, S R Slivka, K Bell, P A Insel. Renal alpha 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical membranes possess a single population of receptors.
Molecular pharmacology.
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