5-Methyl-1H-pyrazole-3-carboxylic acid (BioDeep_00000174735)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


5-Methyl-1H-pyrazole-3-carboxylic acid

化学式: C5H6N2O2 (126.04292559999999)
中文名称: 3-甲基-1H-吡唑-5-甲酸, 5-甲基-1H-吡唑-3-羧酸
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=CC(=NN1)C(=O)O
InChI: InChI=1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)

描述信息

同义名列表

5 个代谢物同义名

5-Methyl-1H-pyrazole-3-carboxylic acid; 5-Methyl-1H-pyrazole-3-carboxylate; 3-Methylpyrazole-5-carboxylic acid; 5-Methylpyrazole-3-carboxylic acid; 5-Methyl-1H-pyrazole-3-carboxylic acid



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Devendra Kumar, Ashok K Khanna, Ram Pratap, Jitendra K Sexana, Rabi S Bhatta. Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone. Indian journal of pharmacology. 2012 Jan; 44(1):57-62. doi: 10.4103/0253-7613.91868. [PMID: 22345871]
  • Hideaki Iizuka, Kana Ishii, Yasushi Hirasa, Kazumi Kubo, Takeshi Fukushima. Fluorescence determination of D- and L-tryptophan concentrations in rat plasma following administration of tryptophan enantiomers using HPLC with pre-column derivatization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(29):3208-13. doi: 10.1016/j.jchromb.2011.02.014. [PMID: 21388898]
  • Naomi Haruta, Hideaki Iizuka, Kana Ishii, Shunsuke Yoshihara, Hideaki Ichiba, Takeshi Fukushima. Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2011; 87(10):641-8. doi: 10.2183/pjab.87.641. [PMID: 22156410]
  • Kana Ishii, Tadahiro Ogaya, Ziyu Song, Hideaki Iizuka, Takeshi Fukushima. Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers. Chirality. 2010 Nov; 22(10):901-6. doi: 10.1002/chir.20850. [PMID: 20872665]
  • Takeshi Fukushima, Yukiko Sone, Shogo Mitsuhashi, Masayuki Tomiya, Toshimasa Toyo'oka. Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers. Chirality. 2009 Apr; 21(4):468-72. doi: 10.1002/chir.20620. [PMID: 18655158]
  • T J French, M J Holness, P A MacLennan, M C Sugden. Effects of nutritional status and acute variation in substrate supply on cardiac and skeletal-muscle fructose 2,6-bisphosphate concentrations. The Biochemical journal. 1988 Mar; 250(3):773-9. doi: 10.1042/bj2500773. [PMID: 3291855]
  • M J Holness, M C Sugden. Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. Possible mechanisms and a regulatory role for thyroid hormone. The Biochemical journal. 1987 Jan; 241(2):421-5. doi: 10.1042/bj2410421. [PMID: 3297032]
  • M J Holness, T N Palmer, M C Sugden. Effects of administration of tri-iodothyronine on the response of cardiac and renal pyruvate dehydrogenase complex to starvation for 48 h. The Biochemical journal. 1985 Nov; 232(1):255-9. doi: 10.1042/bj2320255. [PMID: 4084232]
  • L Axelrod, L Levine. Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. Diabetes. 1982 Nov; 31(11):994-1001. doi: 10.2337/diacare.31.11.994. [PMID: 6816644]
  • H J Steinfelder, H G Joost. In vitro effects of theophylline on insulin receptors in adipocytes: correlation with the lipolytic action of the agent. Biochemical and biophysical research communications. 1982 Jan; 104(1):45-51. doi: 10.1016/0006-291x(82)91938-6. [PMID: 7073681]
  • A McAllister, J P Haddy, M V Sennitt, D E Thorne. The effect of 5-methylpyrazole-3-carboxylate and nicotinic acid on abnormalities of carbohydrate metabolism in alloxan-diabetic rat muscle. Biochemical pharmacology. 1982 Jan; 31(1):63-8. doi: 10.1016/0006-2952(82)90237-4. [PMID: 7059353]
  • K Credner, M Tauscher, L Jozić, G Brenner. [Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)]. Arzneimittel-Forschung. 1981; 31(12):2096-100. doi: NULL. [PMID: 7199305]
  • D L SMITH, A A FORIST, W E DULIN. 5-METHYLPYRAZOLE-3-CARBOXYLIC ACID. THE POTENT HYPOGLYCEMIC METABOLITE OF 3,5-DIMETHYLPYRAZOLE IN THE RAT. Journal of medicinal chemistry. 1965 May; 8(?):350-3. doi: 10.1021/jm00327a015. [PMID: 14323145]