5-Iodo-2-pyrimidinone-2'-deoxyribose (BioDeep_00000174725)
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H11IN2O4 (337.97635560000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C=C(C=NC2=O)I)CO)O
InChI: InChI=1S/C9H11IN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2
描述信息
D000970 - Antineoplastic Agents
同义名列表
6 个代谢物同义名
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2-dihydropyrimidin-2-one; 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one; 1-(2-Deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone; 5-Iodo-2-pyrimidinone 2 deoxyribonucleoside; 5-Iodo-2-pyrimidinone-2-deoxyribose; Ropidoxuridine
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Timothy Kinsella, Howard Safran, Susan Wiersma, Thomas DiPetrillo, Andrew Schumacher, Kayla Rosati, John Vatkevich, Lawrence W Anderson, Kimberly D Hill, Charles Kunos, Jerry M Collins. Phase I and Pharmacology Study of Ropidoxuridine (IPdR) as Prodrug for Iododeoxyuridine-Mediated Tumor Radiosensitization in Advanced GI Cancer Undergoing Radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 10; 25(20):6035-6043. doi:
10.1158/1078-0432.ccr-19-0862. [PMID: 31337643] - Shivaani Kummar, Larry Anderson, Kimberly Hill, Eva Majerova, Deborah Allen, Yvonne Horneffer, S Percy Ivy, Larry Rubinstein, Pamela Harris, James H Doroshow, Jerry M Collins. First-in-human phase 0 trial of oral 5-iodo-2-pyrimidinone-2'-deoxyribose in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2013 Apr; 19(7):1852-7. doi:
10.1158/1078-0432.ccr-12-3118. [PMID: 23403637] - Timothy J Kinsella, Michael T Kinsella, Seongwon Hong, Jerry P Johnson, Brian Burback, Patricia J Tosca. Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Cancer chemotherapy and pharmacology.
2008 Feb; 61(2):323-34. doi:
10.1007/s00280-007-0518-4. [PMID: 17562042] - Muhammad Wasif Saif, Greg Berk, Yung-Chi Cheng, Timothy James Kinsella. IPdR: a novel oral radiosensitizer.
Expert opinion on investigational drugs.
2007 Sep; 16(9):1415-24. doi:
10.1517/13543784.16.9.1415. [PMID: 17714027] - Yuji Seo, Tao Yan, Jane E Schupp, Tomas Radivoyevitch, Timothy J Kinsella. Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Oct; 11(20):7499-507. doi:
10.1158/1078-0432.ccr-05-1138. [PMID: 16243824] - T J Kinsella, J E Schupp, T W Davis, S E Berry, H S Hwang, K Warren, F Balis, J Barnett, H Sands. Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2000 Sep; 6(9):3670-9. doi:
NULL. [PMID: 10999760] - T J Kinsella, K A Kunugi, K A Vielhuber, D M Potter, M E Fitzsimmons, J M Collins. Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Jan; 4(1):99-109. doi:
NULL. [PMID: 9516958] - T J Kinsella, K A Kunugi, K A Vielhuber, W McCulloch, S H Liu, Y C Cheng. An in vivo comparison of oral 5-iodo-2'-deoxyuridine and 5-iodo-2-pyrimidinone-2'-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116.
Cancer research.
1994 May; 54(10):2695-700. doi:
NULL. [PMID: 8168099] - C N Chang, S L Doong, Y C Cheng. Conversion of 5-iodo-2-pyrimidinone-2'-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design.
Biochemical pharmacology.
1992 May; 43(10):2269-73. doi:
10.1016/0006-2952(92)90186-m. [PMID: 1599512]