5-Hydroxy-6-methoxy-1h-indole-2-carboxylic acid (BioDeep_00000174713)

   

human metabolite blood metabolite


代谢物信息卡片


5-Hydroxy-6-methoxy-1h-indole-2-carboxylic acid

化学式: C10H9NO4 (207.05315539999998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 83.33%

分子结构信息

SMILES: COC1=C(C=C2C=C(NC2=C1)C(=O)O)O
InChI: InChI=1S/C10H9NO4/c1-15-9-4-6-5(3-8(9)12)2-7(11-6)10(13)14/h2-4,11-12H,1H3,(H,13,14)

描述信息

同义名列表

6 个代谢物同义名

5-Hydroxy-6-methoxy-1h-indole-2-carboxylic acid; 5-Hydroxy-6-methoxy-2-indolylcarboxylic acid; 5-Hydroxy-6-methoxy-2-indolecarboxylic acid; 5-Hydroxy-6-methoxy-1H-indole-2-carboxylate; 5H6MI2c; HMICA



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Meyerhöffer, Z Lindberg, A Häger, B Kågedal, I Rosdahl. Urinary excretion of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in children. Acta dermato-venereologica. 1998 Jan; 78(1):31-5. doi: 10.1080/00015559850135797. [PMID: 9498023]
  • T Horikoshi, S Ito, K Wakamatsu, H Onodera, H Eguchi. Evaluation of melanin-related metabolites as markers of melanoma progression. Cancer. 1994 Feb; 73(3):629-36. doi: 10.1002/1097-0142(19940201)73:3<629::aid-cncr2820730321>3.0.co;2-w. [PMID: 8299084]
  • J M Duthel, J J Vallon. Indolic urinary melanogens: separation and identification by gas chromatography with selected-ion monitoring mass spectrometry of 5-hydroxy-6-methoxyindole-2-carboxylic and 5-methoxy-6-hydroxyindole-2- carboxylic acids. Journal of chromatography. 1991 Sep; 570(1):166-72. doi: 10.1016/0378-4347(91)80211-t. [PMID: 1797822]
  • K Wakamatsu, S Ito, T Horikoshi. Normal values of urinary excretion and serum concentration of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid, biochemical markers of melanoma progression. Melanoma research. 1991 Jun; 1(2):141-7. doi: 10.1097/00008390-199106000-00009. [PMID: 1823626]
  • N Saito, T Morishima. Eumelanin and pheomelanin contents in hair and 5-S-cysteinyldopa and 5-hydroxy-6-methoxyindole-2-carboxylic acid levels in urine in Japanese oculocutaneous albinism. Archives of dermatological research. 1991; 283(1):7-9. doi: 10.1007/bf01207242. [PMID: 2059060]
  • K Wakamatsu, S Ito. Identification of ester glucuronide and sulfate conjugates of 5-hydroxy-6-methoxyindole-2-carboxylic acid and 6-hydroxy-5-methoxyindole-2-carboxylic acid in melanoma urine. Journal of dermatological science. 1990 Jul; 1(4):253-9. doi: 10.1016/0923-1811(90)90117-v. [PMID: 2095194]
  • N Saito, T Morishima. [Eumelanin and pheomelanin contents in hairs of healthy Japanese and patients with oculocutaneous albinism, and 5-S-cysteinyldopa and 5-hydroxy-6-methoxyindole-2-carboxylic acid levels in urine of oculocutaneous albinism]. Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology. 1990 Jul; 100(8):853-61. doi: NULL. [PMID: 2122048]
  • K Wakamatsu, S Ito, K Fujita. Production, circulation, and excretion of melanin-related metabolites in B16 melanoma-bearing mice. Acta dermato-venereologica. 1990; 70(5):367-72. doi: 102340/0001555570367372. [PMID: 1980967]
  • S Ito, K Wakamatsu. Melanin chemistry and melanin precursors in melanoma. The Journal of investigative dermatology. 1989 May; 92(5 Suppl):261S-265S. doi: 10.1111/1523-1747.ep13076587. [PMID: 2654299]
  • K Wakamatsu, S Ito, K Fujita. Melanin-related metabolites in urine of B16 melanoma-bearing mice. Acta dermato-venereologica. 1988; 68(5):385-9. doi: NULL. [PMID: 2461020]
  • W Westerhof, S Pavel, A Kammeyer, F D Beusenberg, R Cormane. Melanin-related metabolites as markers of the skin pigmentary system. The Journal of investigative dermatology. 1987 Jul; 89(1):78-81. doi: 10.1111/1523-1747.ep12580422. [PMID: 3598203]
  • S Pavel, F A Muskiet, G T Nagel, J Duchon. [Identification of some indolic acids in urine using mass fragmentography (author's transl)]. Sbornik lekarsky. 1981 May; 83(5):121-7. doi: NULL. [PMID: 7256174]