1-beta-D-Arabinofuranosyl-5-fluorocytosine (BioDeep_00000174704)
human metabolite blood metabolite
代谢物信息卡片
4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2-dihydropyrimidin-2-one
化学式: C9H12FN3O5 (261.0760954)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 25%
分子结构信息
SMILES: C1=C(C(=NC(=O)N1C2C(C(C(O2)CO)O)O)N)F
InChI: InChI=1S/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zeinab A El-Gendy, Shimaa Abdelazeem, Gehad A Abdel Jaleel, Merhan E Ali, Asmaa Mohamed, Ahmad Salah, Mona A Raslan. Anti-inflammatory and anti-rheumatic effects of Phoenix dactylifera L. (date palm) seed by controlling cytokines and inhibiting JAK1/STAT3 pathway on CFA-induced arthritis rat and its phytochemical profiling.
Journal of ethnopharmacology.
2024 Jul; 329(?):118138. doi:
10.1016/j.jep.2024.118138. [PMID: 38565410] - Farah Zafar, Ghazala Shaheen, Hafiz Muhammad Asif, Mohd Farhan, Ghazala Muteeb, Mohammad Aatif. Onosma bracteatum Wall Aqueous-Ethanolic Extract Suppresses Complete Freund's Adjuvant-Induced Arthritis in Rats via Regulation of TNF-α, IL-6, and C-Reactive Protein.
Molecules (Basel, Switzerland).
2024 Apr; 29(8):. doi:
10.3390/molecules29081830. [PMID: 38675650] - Adyasha Anindita Panda, Jayanti Prava Behera, Y Roja Ramani, Abinash Panda, Padmaja Priyadarshini Kar, Snigdha Rani Panigrahy. Antiarthritic potential of ethanolic extract of Ixora coccinea leaves on complete Freund's adjuvant-induced arthritis in animal model.
Indian journal of pharmacology.
2024 Mar; 56(2):112-119. doi:
10.4103/ijp.ijp_210_23. [PMID: 38687315] - Jia-Li Yang, Jun-Jing Shi, Nai-Qi Ma, Min-Jiao Jiang, Rou Peng, Li-Yao Chen, Mei-Ling Yu, Sheng-Feng Lu. Effect of electroacupuncture on inflammatory response and immune cells in mice with chronic inflammatory pain.
Zhen ci yan jiu = Acupuncture research.
2024 Jan; 49(1):30-36. doi:
10.13702/j.1000-0607.20221174. [PMID: 38239136] - Siyi Liu, Shuting Yang, Xuan Zhu, Xiang Li, Xi Zhang, Xiaoqiong Zhou, Hong Cheng, Fu-Quan Huo, Qingxiang Mao, Lingli Liang. Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn.
Biology direct.
2023 12; 18(1):85. doi:
10.1186/s13062-023-00444-z. [PMID: 38071369] - Nimra Nazar, Malik Hassan Mehmood, Rida Siddique, Muhammad Naeem Faisal. Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2.
Inflammopharmacology.
2023 Dec; ?(?):. doi:
10.1007/s10787-023-01391-x. [PMID: 38057565] - Mingfei Liu, Shirong Li, Ningning Cao, Qingguo Wang, Yuhao Liu, Qianqian Xu, Lin Zhang, Chenghong Sun, Xuefeng Xiao, Jingchun Yao. Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete Freud's adjuvant-rheumatoid arthritis C57BL/6 mice.
International immunopharmacology.
2023 Dec; 125(Pt A):111090. doi:
10.1016/j.intimp.2023.111090. [PMID: 37866312] - Sumera Qasim, Yusra Habib Khan, Ambreen Malik Uttra, Nasser Hadal Alotaibi, Abdullah Salah Alanazi, Abdulaziz I Alzarea, Ahmed D Alatawi, Tauqeer Hussain Mallhi. Appraisal of anti-inflammatory and immunomodulatory potential of ramipril against Freund's adjuvant-provoked arthritic rat model.
Inflammopharmacology.
2023 Dec; 31(6):3115-3125. doi:
10.1007/s10787-023-01306-w. [PMID: 37543980] - Uzma Saleem, Zunera Chauhdary, Zunaira Bakhtawar, Jawaher Alqahtani, Maryam Farrukh, Ifat Alsharif, Tourki A S Baokbah, Muhammad Ajmal Shah, Renald Blundell, Pharkphoom Panichayupakaranant. Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund's adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers.
Inflammopharmacology.
2023 Nov; ?(?):. doi:
10.1007/s10787-023-01370-2. [PMID: 37955785] - Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Mobasher Ahmad, Muhammad Ihsan Ullah, Shahzad Kamran. Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts.
Inflammopharmacology.
2023 Oct; ?(?):. doi:
10.1007/s10787-023-01357-z. [PMID: 37864683] - Muhammad Usman Ali Khan, Tasleem Akhtar, Nadia Naseem, Usman Aftab, Safdar Hussain, Muhammad Shahzad. Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant-induced arthritis in rats: Involvement of inflammatory mediators.
Fundamental & clinical pharmacology.
2023 Oct; 37(5):971-982. doi:
10.1111/fcp.12902. [PMID: 37085956] - Silan An, Xiaoting Yan, Huaguo Chen, Xin Zhou. Investigation of the Mechanism of Action of Periploca forrestii Schltr. Extract on Adjuvant Collagen Rats Based on UPLC-Q-Orbitrap-HRMS Non-Targeted Lipidomics.
Molecules (Basel, Switzerland).
2023 Sep; 28(19):. doi:
10.3390/molecules28196751. [PMID: 37836594] - Shoaib Nawaz, Hafiz Muhammad Irfan, Alamgeer, Laiba Arshad, Shah Jahan. Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea.
Inflammopharmacology.
2023 Sep; ?(?):. doi:
10.1007/s10787-023-01333-7. [PMID: 37689616] - Dipak Biswas, Bharat Gopalrao Somkuwar, Jagat Chandra Borah, Pritish Kumar Varadwaj, Saurabh Gupta, Zeeshan Ahmad Khan, Gopinath Mondal, Asamanja Chattoraj, Lokesh Deb. Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis.
Scientific reports.
2023 08; 13(1):13612. doi:
10.1038/s41598-023-37729-2. [PMID: 37604838] - Chang-Le Liu, Meng-Qi Yang, Zhi-Shu Tang, Yan-Ru Liu, Zhong-Xing Song, Xin Zhang, Xing-Jing Yang, Yan-Ting Zhao. Research on the improvement effect of Saposhnikovia divaricata (Trucz.) Schischk on rheumatoid arthritis based on the "component-target-pathway" association.
Analytical biochemistry.
2023 Aug; 674(?):115184. doi:
10.1016/j.ab.2023.115184. [PMID: 37285946] - Mahmoud A M Arafat, Mohammed N A Khalil, Osama G Mohamed, Omnia A M Abd El-Ghafar, Ashootosh Tripathi, Engy A Mahrous, Essam M Abd El-Kader, Seham El-Hawary. Vetiver aerial parts and roots ameliorate rheumatoid arthritis in complete Freund's adjuvant rat model, a phytochemical profiling and mechanistic study.
Journal of ethnopharmacology.
2023 Jun; 317(?):116764. doi:
10.1016/j.jep.2023.116764. [PMID: 37315650] - Li Gao, Jin-Xia Zhao, Xue-Mei Qin, Jing Zhao. The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Journal of ethnopharmacology.
2023 Jun; ?(?):116762. doi:
10.1016/j.jep.2023.116762. [PMID: 37301308] - S Vigneshwaran, K Maharani, P Sivasakthi, P Senthamil Selvan, S D Saraswathy, E Sanmuga Priya. Bioactive fraction of Tragia involucrata Linn leaves attenuates inflammation in Freund's complete adjuvant-induced arthritis in Wistar albino rats via inhibiting NF-κB.
Inflammopharmacology.
2023 Apr; 31(2):967-981. doi:
10.1007/s10787-023-01154-8. [PMID: 36949217] - Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah. Cassia absus-mediated upregulation of IL-4, IL-10 and downregulation of IL-1β, IL-6, TNF- α, NF-κB, IFN-γ in CFA-induced arthritis model.
Inflammopharmacology.
2023 Apr; ?(?):. doi:
10.1007/s10787-023-01185-1. [PMID: 37005957] - Ashwini Lydia Manoharan, Gayathri Jagadeesan, Gayathri Nataraj, Kasipandi Muniyandi, Gurusubramanian Guruswami, Karuppusamy Arunachalam, Parimelazhagan Thangaraj. Efficacy of Trevesia palmata (Roxb. ex Lindl.) Vis. Extract on MG 63 cell lines and arthritis-induced animal models.
Journal of ethnopharmacology.
2023 Jan; 300(?):115742. doi:
10.1016/j.jep.2022.115742. [PMID: 36152784] - Qing Qiao, Dandan Yao, Yongjie Wang, Shuxia Zhang, Gang Chen. Transcrocetin Meglumine Salt Inhibits Spinal Glial Cell-Mediated Proinflammatory Cytokines and Attenuates Complete Freund's Adjuvant-Induced Inflammatory Pain.
Neuroimmunomodulation.
2023; 30(1):315-324. doi:
10.1159/000534607. [PMID: 37899033] - Dong-Lai Xi, Shen-Qiao Yang, Yi Wang, Jun Chen, Xiao-Qing Lu, Hai-Yan Zhou, Wen-Bin Ma, Fei Wu, Xin Yang. [Effect of moxibustion on JAK2/STAT3 signal pathway in synovial tissues of rabbits with adjuvant arthritis under the overexpression of NLRP3 inflammatory bodies].
Zhen ci yan jiu = Acupuncture research.
2022 Dec; 47(12):1095-100. doi:
10.13702/j.1000-0607.20211160. [PMID: 36571225] - Ayesha Amin, Muhammad Furqan Akhtar, Ammara Saleem, Ali Sharif, Shahid Shah, Muhammad Imran Khan, Fareeha Anwar, Ghulam Abbas, Hafiz Muhammad Zubair, Muhammad Farhan Sohail. Pterostilbene improves CFA-induced arthritis and peripheral neuropathy through modulation of oxidative stress, inflammatory cytokines and neurotransmitters in Wistar rats.
Inflammopharmacology.
2022 Dec; 30(6):2285-2300. doi:
10.1007/s10787-022-01069-w. [PMID: 36138303] - X U Chang, L I Na, W U Xiaoling, Dai Xingye, Yang Zhiwen, Sun Qianhui, Shi Tianyu, Chai Yemao, Pang Dandan, Cheng Kai. Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome based on purinergic 2X7 receptor/NOD-like receptor pyrin domain-containing 3 signal pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 12; 42(6):965-971. doi:
10.19852/j.cnki.jtcm.20220928.003. [PMID: 36378055] - Mengling Xia, Fei Xu, Hangqi Ni, Qing Wang, Ruhui Zhang, Yafang Lou, Jianying Zhou. Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA/CFA/LPS induced murine model.
Respiratory research.
2022 Oct; 23(1):289. doi:
10.1186/s12931-022-02209-0. [PMID: 36271366] - Hany H Arab, Sarah A Abd El-Aal, Ahmed M Ashour, Azza A K El-Sheikh, Hana J Al Khabbaz, El-Shaimaa A Arafa, Ayman M Mahmoud, Ahmed M Kabel. Targeting inflammation and redox perturbations by lisinopril mitigates Freund's adjuvant-induced arthritis in rats: role of JAK-2/STAT-3/RANKL axis, MMPs, and VEGF.
Inflammopharmacology.
2022 Oct; 30(5):1909-1926. doi:
10.1007/s10787-022-00998-w. [PMID: 35764864] - Nida Iftikhar, Ammara Saleem, Muhammad Furqan Akhtar, Ghulam Abbas, Shahid Shah, Shabana Bibi, Ghulam Md Ashraf, Badrah S Alghamdi, Turki S Abujamel. In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196323. [PMID: 36234860] - Gisèle Atsang À Kiki, Raluca Maria Pop, Octavia Sabin, Ioana Corina Bocsan, Veronica Sanda Chedea, Sonia Ancuța Socaci, Alina Elena Pârvu, Egre Finsia, Takvou Francis, Zramah Mathieu, Anca Dana Buzoianu. Polyphenols from Dichrostachys cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model.
Molecules (Basel, Switzerland).
2022 Aug; 27(17):. doi:
10.3390/molecules27175445. [PMID: 36080212] - Yashika Mirchandani, Vandana B Patravale, S Brijesh. Hyaluronic acid-coated solid lipid nanoparticles enhance antirheumatic activity and reduce toxicity of methotrexate.
Nanomedicine (London, England).
2022 07; 17(16):1099-1114. doi:
10.2217/nnm-2022-0009. [PMID: 36178114] - Oluwakemi O Ariyo, Abayomi M Ajayi, Benneth Ben-Azu, Adegbuyi O Aderibigbe. Morus mesozygia leaf extract ameliorates behavioral deficits, oxidative stress and inflammation in Complete Freund's adjuvant-induced arthritis in rats.
Journal of ethnopharmacology.
2022 Jun; 292(?):115202. doi:
10.1016/j.jep.2022.115202. [PMID: 35331880] - Aymun Madni Zubair, Muhammad Nasir Hayat Malik, Waqas Younis, Muhammad Atif Hayat Malik, Shah Jahan, Ishtiaq Ahmed, Alamgeer Yuchi, Muhammad Naveed Mushtaq, Romeeza Tahir, Muhammad Bilal Sarwar, Muhammad Roman, Ayaz Ali Khan, Muhammad Nouman Tahir, Muhammad Tariq Khan, Hafiz Amir Ali Kharl, Gagun Kamran, Abdullah Abdo Albegali, Ali Imran. Novel acetamide derivatives of 2-aminobenzimidazole prevent inflammatory arthritis in rats via suppression of pro-inflammatory mediators.
Inflammopharmacology.
2022 Jun; 30(3):1005-1019. doi:
10.1007/s10787-022-00969-1. [PMID: 35429318] - JiSuk Lee, YoungChul Bae, Nam Jae Kim, Sabina Lim, Young-Mi Kim, Jinwoong Kim, Young-Won Chin. Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats.
Journal of ethnopharmacology.
2022 May; 289(?):114518. doi:
10.1016/j.jep.2021.114518. [PMID: 34637968] - Ze Rui, Ling Zhang, Xuefei Li, Jinxue Han, Yufeng Yuan, Hui Ding, Yang Liu, Xiaolin Ding. Pterostilbene exert an anti-arthritic effect by attenuating inflammation, oxidative stress, and alteration of gut microbiota.
Journal of food biochemistry.
2022 05; 46(5):e14011. doi:
10.1111/jfbc.14011. [PMID: 35060152] - Yonggen Chen, Erjin Xu, Ming Sang, Zhiheng Wang, Yuxin Zhang, Juan Ye, Qian Zhou, Chenglei Zhao, Chunping Hu, Wuguang Lu, Peng Cao. Makatoxin-3, a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models.
Journal of ethnopharmacology.
2022 Apr; 288(?):114998. doi:
10.1016/j.jep.2022.114998. [PMID: 35063590] - Jing-Wei Peng, Yin-Yin Gu, Jia Wei, Ye Sun, Chun-Long Zhu, Ling Zhang, Yu Song, Long Chen, Xia Chen, Qian Wang, Hai-Long Zhang. LncRNA MEG3-TRPV1 signaling regulates chronic inflammatory pain in rats.
Molecular pain.
2022 04; 18(?):17448069221144246. doi:
10.1177/17448069221144246. [PMID: 36424837] - Manoela Sacramento, Angélica S Reis, Carolina C Martins, Cristiane Luchese, Ethel A Wilhelm, Diego Alves. Synthesis and Evaluation of Antioxidant, Anti-Edematogenic and Antinociceptive Properties of Selenium-Sulfa Compounds.
ChemMedChem.
2022 02; 17(4):e202100507. doi:
10.1002/cmdc.202100507. [PMID: 34854233] - Yiqin Lin, Yingle Chen, Jingyang Zeng, Shunyuan Li. Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway.
Neuroimmunomodulation.
2022; 29(4):486-492. doi:
10.1159/000525690. [PMID: 35995035] - Yufang Dai, Jiaoe Sheng, Sanshan He, Qingchao Wu, Yunlong Wang, Linchong Su. Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes.
Bioengineered.
2022 01; 13(1):268-279. doi:
10.1080/21655979.2021.1999554. [PMID: 34719315] - Muhammad Furqan Akhtar, Syed Ahmad Raza, Ammara Saleem, Irfan Hamid, Mirza Muhammad Faran Ashraf Baig, Ali Sharif, Kashif Sohail, Zeeshan Javaid, Uzma Saleem, Azhar Rasul. Appraisal of Anti-Arthritic and Anti-Inflammatory Potential of Folkloric Medicinal Plant Peganum harmala.
Endocrine, metabolic & immune disorders drug targets.
2022; 22(1):49-63. doi:
10.2174/1871530321666210208211310. [PMID: 33563161] - Chunhong Liu, Yetian Li, Chaoling Wen, Zheng Yan, Opeyemi Joshua Olatunji, Zongsheng Yin. Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund's Adjuvant-Induced Arthritic Rats.
Drug design, development and therapy.
2022; 16(?):3015-3022. doi:
10.2147/dddt.s374827. [PMID: 36105319] - Yonglan Ruan, Jinying Ling, Fan Ye, Nuo Cheng, Fei Wu, Zongxiang Tang, Xiaolan Cheng, Hongquan Liu. Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway.
International immunopharmacology.
2021 Dec; 101(Pt B):108364. doi:
10.1016/j.intimp.2021.108364. [PMID: 34844873] - Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia, Shengyong Luo. Qingluoyin granules protect against adjuvant-induced arthritis in rats via downregulating the CXCL12/CXCR4-NF-κB signalling pathway.
Pharmaceutical biology.
2021 Dec; 59(1):1441-1451. doi:
10.1080/13880209.2021.1991386. [PMID: 34693865] - Manal A Hamed, Asmaa F Aboul Naser, Mona E Aboutabl, Abeer F Osman, Entesar E S Hassan, Wessam M Aziz, Wagdy K B Khalil, Ayman A Farghaly, Ali M El-Hagrassi. Bioactive compounds and therapeutic role of Brassica oleracea L. seeds in rheumatoid arthritis rats via regulating inflammatory signalling pathways and antagonizing interleukin-1 receptor action.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2021 Dec; 26(8):788-807. doi:
10.1080/1354750x.2021.1999504. [PMID: 34704882] - Dan Wu, Xi Li, Jun Liu, Can Hu, Jiefang Li. Wutou decoction attenuates rheumatoid arthritis by modulating the Ahr/LOC101928120/SHC1 pathway.
Pharmaceutical biology.
2021 Dec; 59(1):811-822. doi:
10.1080/13880209.2021.1941131. [PMID: 34184948] - Stephen Adeniyi Adefegha, Renata da Silva Pereira Saccol, Matheus Henrique Jantsch, Karine Lanes da Silveira, Daniela Bitencourt Rosa Leal. Hesperidin mitigates inflammation and modulates ectoenzymes activity and some cellular processes in complete Freund's adjuvant-induced arthritic rats.
The Journal of pharmacy and pharmacology.
2021 Oct; 73(11):1547-1561. doi:
10.1093/jpp/rgab100. [PMID: 34427673] - JiSuk Lee, Sabina Lim. Anti-inflammatory, and anti-arthritic effects by the twigs of Cinnamomum cassia on complete Freund's adjuvant-induced arthritis in rats.
Journal of ethnopharmacology.
2021 Oct; 278(?):114209. doi:
10.1016/j.jep.2021.114209. [PMID: 34015366] - Yongliang Tang, Daotao Xie, Wenqing Gong, Hongtao Wu, Yi Qiang. Pentahydroxy flavonoid isolated from Madhuca indica ameliorated adjuvant-induced arthritis via modulation of inflammatory pathways.
Scientific reports.
2021 09; 11(1):17971. doi:
10.1038/s41598-021-97474-2. [PMID: 34504248] - Guofeng Wu, Wenbo Nie, Qiu Wang, Youguo Hao, Shaohua Gong, Yuxin Zheng, Hao Lv. Umbelliferone Ameliorates Complete Freund Adjuvant-Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation.
Inflammation.
2021 Aug; 44(4):1315-1329. doi:
10.1007/s10753-021-01418-x. [PMID: 33484396] - Haidy Abbas, Nehal M El-Deeb, Mariam Zewail. PLA-coated Imwitor® 900 K-based herbal colloidal carriers as novel candidates for the intra-articular treatment of arthritis.
Pharmaceutical development and technology.
2021 Jul; 26(6):682-692. doi:
10.1080/10837450.2021.1920617. [PMID: 33952085] - Tingting Liu, Min Zhao, Yumeng Zhang, Zhaozhao Qiu, Yixin Zhang, Chunjie Zhao, Miao Wang. Pharmacokinetic-pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis.
Biomedical chromatography : BMC.
2021 Jul; 35(7):e5101. doi:
10.1002/bmc.5101. [PMID: 33625739] - Rania M Kamal, Manal M Sabry, Zeinab Y Aly, Mohamed S Hifnawy. Phytochemical and In-Vivo Anti-Arthritic Significance of Aloe thraskii Baker in Combined Therapy with Methotrexate in Adjuvant-Induced Arthritis in Rats.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123660. [PMID: 34203991] - Reine-Solange Sauer, Ivo Krummenacher, Ezgi Eylül Bankoglu, Shaobing Yang, Beatrice Oehler, Friedrich Schöppler, Milad Mohammadi, Paul Güntzel, Adel Ben-Kraiem, Ulrike Holzgrabe, Helga Stopper, Jens A Broscheit, Holger Braunschweig, Norbert Roewer, Alexander Brack, Heike L Rittner. Stabilization of Delphinidin in Complex with Sulfobutylether-β-Cyclodextrin Allows for Antinociception in Inflammatory Pain.
Antioxidants & redox signaling.
2021 06; 34(16):1260-1279. doi:
10.1089/ars.2019.7957. [PMID: 32977733] - Riham A El-Shiekh, Sahar El-Mekkawy, Samar M Mouneir, Azza Hassan, Essam Abdel-Sattar. Therapeutic potential of russelioside B as anti-arthritic agent in Freund's adjuvant-induced arthritis in rats.
Journal of ethnopharmacology.
2021 Apr; 270(?):113779. doi:
10.1016/j.jep.2021.113779. [PMID: 33418032] - Lia Tsiklauri, Karol Švík, Martin Chrastina, Silvester Poništ, František Dráfi, Lukáš Slovák, Mery Alania, Ether Kemertelidze, Katarina Bauerova. Bioflavonoid Robinin from Astragalus falcatus Lam. Mildly Improves the Effect of Metothrexate in Rats with Adjuvant Arthritis.
Nutrients.
2021 Apr; 13(4):. doi:
10.3390/nu13041268. [PMID: 33924354] - Muhammad Furqan Akhtar, Khushdil Khan, Ammara Saleem, Mirza Muhammad Faran Ashraf Baig, Azhar Rasul, Mohamed M Abdel-Daim. Chemical characterization and anti-arthritic appraisal of Monotheca buxifolia methanolic extract in Complete Freund's Adjuvant-induced arthritis in Wistar rats.
Inflammopharmacology.
2021 Apr; 29(2):393-408. doi:
10.1007/s10787-020-00783-7. [PMID: 33386491] - Yo Han Hong, Chaoran Song, Kon Kuk Shin, Eunju Choi, So-Hyeon Hwang, Young-Jin Jang, Amani Taamalli, Jinwhoa Yum, Jong-Hoon Kim, Eunji Kim, Jae Youl Cho. Tunisian Olea europaea L. leaf extract suppresses Freund's complete adjuvant-induced rheumatoid arthritis and lipopolysaccharide-induced inflammatory responses.
Journal of ethnopharmacology.
2021 Mar; 268(?):113602. doi:
10.1016/j.jep.2020.113602. [PMID: 33246116] - Li Yang, Ronghua Liu, Aiguo Fan, Guoyue Zhong, Junwei He. Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats.
Journal of ethnopharmacology.
2021 Mar; 267(?):113631. doi:
10.1016/j.jep.2020.113631. [PMID: 33246122] - Hai-Jiao Chen, Hao-Ran Yang, Ying Zhi, Qing-Qiang Yao, Bo Liu. Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Bioorganic & medicinal chemistry letters.
2021 02; 34(?):127754. doi:
10.1016/j.bmcl.2020.127754. [PMID: 33347967] - Amir Reza Abdollahi, Farzin Firouzian, Rasool Haddadi, Alireza Nourian. Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation.
Inflammopharmacology.
2021 Feb; 29(1):107-121. doi:
10.1007/s10787-020-00776-6. [PMID: 33179175] - Peng Quan, Baixin Jiao, Rui Shang, Chao Liu, Liang Fang. Alternative therapy of rheumatoid arthritis with a novel transdermal patch containing Siegesbeckiae Herba extract.
Journal of ethnopharmacology.
2021 Jan; 265(?):113294. doi:
10.1016/j.jep.2020.113294. [PMID: 32841693] - Tapan Behl, Rashita Makkar, Sandeep Arora. Exploring the Effect of Terminalia catappa Fruit Extract in Rheumatoid Arthritis: An Evaluation of Behavioural, Hematologiocal and Histopathological Parameters.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(6):1073-1082. doi:
10.2174/1871530320666200825191804. [PMID: 32842950] - Ammara Saleem, Mohammad Saleem, Muhammad Furqan Akhtar, Muhammad Shahzad, Shah Jahan. Polystichum braunii extracts inhibit Complete Freund's adjuvant-induced arthritis via upregulation of I-κB, IL-4, and IL-10, downregulation of COX-2, PGE2, IL-1β, IL-6, NF-κB, and TNF-α, and subsiding oxidative stress.
Inflammopharmacology.
2020 Dec; 28(6):1633-1648. doi:
10.1007/s10787-020-00688-5. [PMID: 32162074] - Sateesh Alavala, Nasiruddin Nalban, Rajendra Sangaraju, Madhusudana Kuncha, Mahesh Kumar Jerald, Eswar Kumar Kilari, Ramakrishna Sistla. Anti-inflammatory effect of stevioside abates Freund's complete adjuvant (FCA)-induced adjuvant arthritis in rats.
Inflammopharmacology.
2020 Dec; 28(6):1579-1597. doi:
10.1007/s10787-020-00736-0. [PMID: 32617791] - Feng Zhang, Zhiyu Liu, Xijing He, Zhanqi Li, Bin Shi, Fengmei Cai. β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway.
Drug delivery.
2020 Dec; 27(1):1329-1341. doi:
10.1080/10717544.2020.1818883. [PMID: 32945205] - Xing Dai, Dongping Yang, Jinping Bao, Qiying Zhang, Jiemin Ding, Min Liu, Meihuizi Ding, Mengli Liu, Juan Liang, Xiaoyi Jia. Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells.
Pharmaceutical biology.
2020 Dec; 58(1):157-164. doi:
10.1080/13880209.2020.1720745. [PMID: 32037930] - Shuping Sun, Shengli Li, Yunyan Du, Chenguang Wu, Mengyuan Zhang, Jiarong Li, Xiaoping Zhang. Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats.
Pharmaceutical biology.
2020 Dec; 58(1):528-537. doi:
10.1080/13880209.2020.1767159. [PMID: 32503379] - Swati Gupta, K P Mishra, Bhuvnesh Kumar, S B Singh, Lilly Ganju. Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines.
Journal of ethnopharmacology.
2020 Oct; 261(?):113022. doi:
10.1016/j.jep.2020.113022. [PMID: 32569719] - Selvakumar Murugesan, Devibala Ravichandran, Dinesh Kumar Lakshmanan, Guna Ravichandran, Velusamy Arumugam, Karthik Raju, Karuppasamy Geetha, Sivasudha Thilagar. Evaluation of anti rheumatic activity of Piper betle L. (Betelvine) extract using in silico, in vitro and in vivo approaches.
Bioorganic chemistry.
2020 10; 103(?):104227. doi:
10.1016/j.bioorg.2020.104227. [PMID: 32891004] - Xiaole Chen, Kaimei Nie, Xin Zhang, Shuangyu Tan, Qingmei Zheng, Yaduan Wang, Xiaofeng Chen, Zhiyu Tang, Rui Liu, Mengru Yan, Zhiwei Liu, Jianbo Lin, Jianhua Xu, Nanwen Zhang, He Wang, Juhua Yang. The recombinant anti-TNF-α fusion protein ameliorates rheumatoid arthritis by the protective role of autophagy.
Bioscience reports.
2020 09; 40(9):. doi:
10.1042/bsr20194515. [PMID: 32880389] - Mei-Ling Yu, Rui-de Wei, Tao Zhang, Jun-Meng Wang, Yu Cheng, Fen-Fen Qin, Shu-Ping Fu, Zhi-Gang Lu, Sheng-Feng Lu. Electroacupuncture Relieves Pain and Attenuates Inflammation Progression Through Inducing IL-10 Production in CFA-Induced Mice.
Inflammation.
2020 Aug; 43(4):1233-1245. doi:
10.1007/s10753-020-01203-2. [PMID: 32198725] - Rehab G El-Sharkawy, Rania H Taha, Heba B Ghanem. Immobilization of novel inorganic nano-complexes onto MWCNT nanomaterials as a novel adsorbent and anti-inflammatory therapy in an induced model of rheumatoid arthritis.
Nanotechnology.
2020 Jul; 31(30):305706. doi:
10.1088/1361-6528/ab851a. [PMID: 32235044] - Jian Zuo, Cong-Lan Ji, Opeyemi Joshua Olatunji, Zhe Yang, Hui-Fang Xu, Jun Han, Jiyang Dong. Bioactive fractions from Securidaca inappendiculata alleviated collagen-induced arthritis in rats by regulating metabolism-related signaling.
The Kaohsiung journal of medical sciences.
2020 Jul; 36(7):523-534. doi:
10.1002/kjm2.12205. [PMID: 32187848] - Mohamed T Khayyal, Rania M El-Hazek, Walaa A El-Sabbagh, Jan Frank, Dariush Behnam, Mona Abdel-Tawab. Micellar solubilization enhances the anti-inflammatory effect of xanthohumol.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Jun; 71(?):153233. doi:
10.1016/j.phymed.2020.153233. [PMID: 32454348] - Allisson Benatti Justino, Mônica Soares Costa, André Lopes Saraiva, Pedro Henrique Silva, Thiago Neves Vieira, Priscilla Dias, Camila Rodrigues Borges Linhares, Paula Dechichi, Veridiana de Melo Rodrigues Avila, Foued Salmen Espindola, Cassia Regina Silva. Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain.
Inflammopharmacology.
2020 Jun; 28(3):759-771. doi:
10.1007/s10787-019-00673-7. [PMID: 31845053] - Huiqing Lv, Zihan Li, Zhijun Xie, Xuanming Hu, Haichang Li, Jing Sun, Xuezhi Chen, Chengping Wen. Innovated formulation of TCM pangolin scales to develop a nova therapy of rheumatoid arthritis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jun; 126(?):109872. doi:
10.1016/j.biopha.2020.109872. [PMID: 32151943] - Isaac T Henneh, Boshi Huang, Faik N Musayev, Rana Al Hashimi, Martin K Safo, Francis A Armah, Elvis O Ameyaw, Christian K Adokoh, Martins Ekor, Yan Zhang. Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).
Bioorganic chemistry.
2020 05; 98(?):103744. doi:
10.1016/j.bioorg.2020.103744. [PMID: 32179280] - Zartash Zahra, Muhammad Rashid Khan, Sayed Afzal Shah, Sonia Maryam, Muhammad Majid, Tahira Younis, Moniba Sajid. Vincetoxicum arnottianum ameliorate inflammation by suppressing oxidative stress and pro-inflammatory mediators in rat.
Journal of ethnopharmacology.
2020 Apr; 252(?):112565. doi:
10.1016/j.jep.2020.112565. [PMID: 31935495] - Ming-Ming Li, Yu Zhang, Jun Wu, Kai-Ping Wang. Polysaccharide from Angelica Sinensis Suppresses Inflammation and Reverses Anemia in Complete Freund's Adjuvant-induced Rats.
Current medical science.
2020 Apr; 40(2):265-274. doi:
10.1007/s11596-020-2183-3. [PMID: 32337688] - Renata da Silva Pereira Saccol, Karine Lanes da Silveira, Alessandra Guedes Manzoni, Fátima Husein Abdalla, Juliana Sorraila de Oliveira, Guilherme Lopes Dornelles, Fernanda Barbisan, Daniela Ferreira Passos, Emerson André Casali, Cinthia Melazzo de Andrade, Ivana Beatrice Mânica da Cruz, Daniela Bitencourt Rosa Leal. Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis.
Journal of cellular biochemistry.
2020 04; 121(4):2792-2801. doi:
10.1002/jcb.29502. [PMID: 31691375] - Lijuan Zhu, Zhenshan Zhang, Nannan Xia, Weifeng Zhang, Yanlin Wei, Jiashu Huang, Zhijuan Ren, Feilong Meng, Lei Yang. Anti-arthritic activity of ferulic acid in complete Freund's adjuvant (CFA)-induced arthritis in rats: JAK2 inhibition.
Inflammopharmacology.
2020 Apr; 28(2):463-473. doi:
10.1007/s10787-019-00642-0. [PMID: 31562605] - Yuntai Huang, Lubo Guo, Renukaradhya Chitti, Nagaraja Sreeharsha, Anurag Mishra, Shiva K Gubbiyappa, Yogendra Singh. Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway.
BioFactors (Oxford, England).
2020 Mar; 46(2):283-291. doi:
10.1002/biof.1585. [PMID: 31721330] - Ângela Midori Kuraoka-Oliveira, Joyce Alencar Santos Radai, Maicon Matos Leitão, Claudia Andrea Lima Cardoso, Saulo Euclides Silva-Filho, Cândida Aparecida Leite Kassuya. Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica.
Journal of ethnopharmacology.
2020 Mar; 249(?):112418. doi:
10.1016/j.jep.2019.112418. [PMID: 31770567] - S Latha, D Chamundeeswari, S Seethalakshmi, R Senthamarai. Attenuation of adjuvant-induced arthrits by Stereospermum colais and Stereospermum suaveolens via modulation of inflammatory mediators.
Journal of ethnopharmacology.
2020 Mar; 249(?):112394. doi:
10.1016/j.jep.2019.112394. [PMID: 31734448] - Shasha Luo, He Li, Jingjing Liu, Xiaoqian Xie, Zhijie Wan, Yale Wang, Zeyue Zhao, Xiaohan Wu, Xinxin Li, Min Yang, Xiaotian Li. Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.
Chemico-biological interactions.
2020 Mar; 319(?):108984. doi:
10.1016/j.cbi.2020.108984. [PMID: 32061742] - Gaëlle Vial, Cécile Coudy-Gandilhon, Alexandre Pinel, Fabien Wauquier, Carole Chevenet, Daniel Béchet, Yohan Wittrant, Véronique Coxam, Martin Soubrier, Anne Tournadre, Frédéric Capel. Lipid accumulation and mitochondrial abnormalities are associated with fiber atrophy in the skeletal muscle of rats with collagen-induced arthritis.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 02; 1865(2):158574. doi:
10.1016/j.bbalip.2019.158574. [PMID: 31747539] - Hongjie Yuan, Shibin Du, Liping Chen, Xiaoqing Xu, Yufeng Wang, Fuhai Ji. Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats.
Journal of neuroinflammation.
2020 Jan; 17(1):34. doi:
10.1186/s12974-020-1711-1. [PMID: 31980031] - Lu Gan, Jun Ji, Ling Wang, Qi-Yan Li, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan. Identification of the metabolites in normal and AA rat plasma, urine and feces after oral administration of Daphne genkwa flavonoids by LC-Q-TOF-MS spectrometry.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 177(?):112856. doi:
10.1016/j.jpba.2019.112856. [PMID: 31521020] - Shao-Yu Guan, Kun Zhang, Xin-Shang Wang, Le Yang, Bin Feng, Dan-Dan Tian, Mei-Rong Gao, Shui-Bing Liu, An Liu, Ming-Gao Zhao. Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model.
Molecular pain.
2020 Jan; 16(?):1744806919900717. doi:
10.1177/1744806919900717. [PMID: 31964240] - Yehong Fang, Jie Zhu, Wanru Duan, Yikuan Xie, Chao Ma. Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain.
Neuroscience bulletin.
2020 Jan; 36(1):1-10. doi:
10.1007/s12264-019-00406-4. [PMID: 31230211] - Hem Raj, Avneet Gupta, Neeraj Upmanyu. Anti-inflammatory Effect of Woodfordia fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2020; 19(2):103-112. doi:
10.2174/1871523018666190222120127. [PMID: 30799799] - Shanqin Peng, Congqi Hu, Xi Liu, Lei Lei, Guodong He, Chenming Xiong, Wenqian Wu. Rhoifolin regulates oxidative stress and proinflammatory cytokine levels in Freund's adjuvant-induced rheumatoid arthritis via inhibition of NF-κB.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2020; 53(6):e9489. doi:
10.1590/1414-431x20209489. [PMID: 32401927] - Xin Cui, Ruijing Wang, Peimin Bian, Qingke Wu, Vidya Devanatha Desikan Seshadri, Lun Liu. Evaluation of antiarthritic activity of nimbolide against Freund's adjuvant induced arthritis in rats.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):3391-3398. doi:
10.1080/21691401.2019.1649269. [PMID: 31394949] - Chunfang Zhang, Wenfeng Zhang, Rongyu Shi, Bangyi Tang, Shicheng Xie. Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund's adjuvant-induced rheumatoid arthritis model.
Pharmaceutical biology.
2019 Dec; 57(1):792-798. doi:
10.1080/13880209.2019.1687526. [PMID: 31747811] - Juliana Vitoriano-Souza, Fernando Augusto Siqueira Mathias, Nádia das Dores Moreira, Rodrigo Dian de Oliveira Aguiar-Soares, Paula Melo de Abreu Vieira, Andréa Teixeira-Carvalho, Cláudia Martins Carneiro, Rodolfo Cordeiro Giunchetti, Rory Cristiane Fortes de Brito, Ricardo Toshio Fujiwara, Bruno Mendes Roatt, Maria Norma Melo, Alexandre Barbosa Reis. Effect on cellular recruitment and the innate immune response by combining saponin, monophosphoryl lipid-A and Incomplete Freund's Adjuvant with Leishmania (Viannia) braziliensis antigens for a vaccine formulation.
Vaccine.
2019 11; 37(49):7269-7279. doi:
10.1016/j.vaccine.2019.09.067. [PMID: 31575491] - Mahalingam S Sundaram, Manoj Kumar Neog, Mahaboobkhan Rasool, G Suresh Kumar, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Girish. Guggulipid ameliorates adjuvant-induced arthritis and liver oxidative damage by suppressing inflammatory and oxidative stress mediators.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Nov; 64(?):152924. doi:
10.1016/j.phymed.2019.152924. [PMID: 31465983] - Hamza Ibrahim Isa, Gezina Catharina Helena Ferreira, Jan Ernst Crafford, Christoffel Jacobus Botha. Raising antibodies against epoxyscillirosidine, the toxic principle contained in Moraea pallida Bak. (Iridaceae), in rabbits.
Journal of immunological methods.
2019 11; 474(?):112670. doi:
10.1016/j.jim.2019.112670. [PMID: 31525365] - Chia-Ming Yen, Tong-Chien Wu, Ching-Liang Hsieh, Yu-Wei Huang, Yi-Wen Lin. Distal Electroacupuncture at the LI4 Acupoint Reduces CFA-Induced Inflammatory Pain via the Brain TRPV1 Signaling Pathway.
International journal of molecular sciences.
2019 Sep; 20(18):. doi:
10.3390/ijms20184471. [PMID: 31510092] - Fu-Chao Liu, Huang-Ping Yu, Po-Jen Chen, Hsuan-Wu Yang, Shih-Hsin Chang, Cherng-Chyi Tzeng, Wei-Jen Cheng, You-Ren Chen, Yeh-Long Chen, Tsong-Long Hwang. A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice.
Redox biology.
2019 09; 26(?):101273. doi:
10.1016/j.redox.2019.101273. [PMID: 31325723] - Huan Chen, Yueqiang Wen, Ting Pan, Shijun Xu. Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2019 08; 39(4):566-574. doi:
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