5-Amino-1,3,4-thiadiazole-2-sulfonamide (BioDeep_00000174658)

   

human metabolite blood metabolite


代谢物信息卡片


5-imino-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide

化学式: C2H4N4O2S2 (179.9775684)
中文名称: 乙酰唑胺杂质D
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: C1(=NN=C(S1)S(=O)(=O)N)N
InChI: InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)

描述信息

同义名列表

6 个代谢物同义名

5-imino-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide; 5-imino-4H-1,3,4-thiadiazole-2-sulfonamide; 5-Amino-1,3,4-thiadiazole-2-sulphonamide; 5-Amino-1,3,4-thiadiazole-2-sulfonamide; 5-Amino-TDSNH2; Hats CPD



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Alexander W Schüttelkopf, Ludovic Gros, David E Blair, Julie A Frearson, Daan M F van Aalten, Ian H Gilbert. Acetazolamide-based fungal chitinase inhibitors. Bioorganic & medicinal chemistry. 2010 Dec; 18(23):8334-40. doi: 10.1016/j.bmc.2010.09.062. [PMID: 21044846]
  • Palraj Kalimuthu, S Abraham John. Simultaneous determination of epinephrine, uric acid and xanthine in the presence of ascorbic acid using an ultrathin polymer film of 5-amino-1,3,4-thiadiazole-2-thiol modified electrode. Analytica chimica acta. 2009 Aug; 647(1):97-103. doi: 10.1016/j.aca.2009.05.036. [PMID: 19576392]
  • Mika Hilvo, Anna Maria Salzano, Alessio Innocenti, Markku S Kulomaa, Andrea Scozzafava, Andrea Scaloni, Seppo Parkkila, Claudiu T Supuran. Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Journal of medicinal chemistry. 2009 Feb; 52(3):646-54. doi: 10.1021/jm801267c. [PMID: 19193158]
  • A Scozzafava, F Briganti, M A Ilies, C T Supuran. Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. Journal of medicinal chemistry. 2000 Jan; 43(2):292-300. doi: 10.1021/jm990479+. [PMID: 10649985]
  • A Scozzafava, F Briganti, G Mincione, L Menabuoni, F Mincione, C T Supuran. Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. Journal of medicinal chemistry. 1999 Sep; 42(18):3690-700. doi: 10.1021/jm9901879. [PMID: 10479300]
  • A Scozzafava, L Menabuoni, F Mincione, F Briganti, G Mincione, C T Supuran. Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?. Journal of medicinal chemistry. 1999 Jul; 42(14):2641-50. doi: 10.1021/jm9900523. [PMID: 10411484]