5-Acetoxyindole (BioDeep_00000174657)
human metabolite blood metabolite
代谢物信息卡片
5-hydroxyindole acetic acid
化学式: C10H9NO2 (175.0633254)
中文名称: 5-乙酰氧基吲哚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1=CC2=C(C=C1)NC=C2
InChI: InChI=1S/C10H9NO2/c1-7(12)13-9-2-3-10-8(6-9)4-5-11-10/h2-6,11H,1H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
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Phytotherapy research : PTR.
2012 May; 26(5):758-63. doi:
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Basic & clinical pharmacology & toxicology.
2012 May; 110(5):421-6. doi:
10.1111/j.1742-7843.2011.00829.x. [PMID: 22141426] - Hiroshi Murase, Eiji Suzuki, Yoshitaka Tajima, Kanako Hayashi, Tomohiko Nakamura, Nobuyasu Noritake, Jun Takeda. Associations of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic acid concentrations with blood flow in lower-leg arteries in Japanese type 2 diabetic patients with normal ankle-brachial index.
Journal of diabetes and its complications.
2012 Mar; 26(2):113-7. doi:
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Neuroscience.
2012 Jan; 201(?):20-33. doi:
10.1016/j.neuroscience.2011.11.025. [PMID: 22133893] - Danny J Eapen, Stephen Clements, Peter Block, Laurence Sperling. Metastatic carcinoid disease inducing coronary vasospasm.
Texas Heart Institute journal.
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Analytica chimica acta.
2011 Aug; 699(1):81-6. doi:
10.1016/j.aca.2011.05.012. [PMID: 21704761] - Gehan Ahmed Mostafa, Laila Yousef Al-Ayadhi. A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children.
Journal of neuroinflammation.
2011 Jun; 8(?):71. doi:
10.1186/1742-2094-8-71. [PMID: 21696608] - Hiroshi Kobayashi, Shin-ichi Kikuchi, Shin-ichi Konno, Kinshi Kato, Miho Sekiguchi. Interaction of 5-hydroxytryptamine and tumor necrosis factor-α to pain-related behavior by nucleus pulposus applied on the nerve root in rats.
Spine.
2011 Feb; 36(3):210-8. doi:
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Neuroimmunomodulation.
2011; 18(1):52-6. doi:
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International journal of molecular sciences.
2011; 12(10):6619-34. doi:
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PloS one.
2011; 6(9):e25158. doi:
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BMC urology.
2010 Dec; 10(?):22. doi:
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Endocrine-related cancer.
2010 Dec; 17(4):897-908. doi:
10.1677/erc-10-0020. [PMID: 20696814] - Adrian G Miller, Heather Brown, Tim Degg, Keith Allen, Brian G Keevil. Measurement of plasma 5-hydroxyindole acetic acid by liquid chromatography tandem mass spectrometry--comparison with HPLC methodology.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Mar; 878(7-8):695-9. doi:
10.1016/j.jchromb.2010.01.010. [PMID: 20117968] - Tsukasa Sasaki, Takeshi Fukushima, Kazuhide Yamashita, Toshimasa Toyo'oka. Stereoselective effect of kynurenine enantiomers on the excretion of serotonin and its metabolite in rat urine.
Chirality.
2010 Feb; 22(2):258-61. doi:
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PloS one.
2010 Jan; 5(1):e8790. doi:
10.1371/journal.pone.0008790. [PMID: 20098750] - David Calderón Guzmán, Norma Labra Ruiz, Ernestina Hernández García, Hugo Juárez Olguín. Levels of 5-hydroxyindol acetic acid and lipid peroxidation in brain after administration of marijuana and nalbuphine in male and female rat.
Proceedings of the Western Pharmacology Society.
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Dec; 29(49):15575-85. doi:
10.1523/jneurosci.3138-09.2009. [PMID: 20007481] - Jean-Marie Launay, Muriel Del Pino, Gilles Chironi, Jacques Callebert, Katell Peoc'h, Jean-Louis Mégnien, Jacques Mallet, Alain Simon, Francine Rendu. Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation.
PloS one.
2009 Nov; 4(11):e7959. doi:
10.1371/journal.pone.0007959. [PMID: 19956754] - Ivan Berlin, Claire Heilbronner, Sabine Georgieu, Cathy Meier, Jean-Marie Launay, Odile Spreux-Varoquaux. Reduced monoamine oxidase A activity in pregnant smokers and in their newborns.
Biological psychiatry.
2009 Oct; 66(8):728-33. doi:
10.1016/j.biopsych.2009.05.029. [PMID: 19615672] - David Calderón Guzmán, Norma Osnaya Brizuela, Raquel García Alvarez, Ernestina Hernández García, Gerardo Barragán Mejía, Hugo Juárez Olguín. Cerebrolysin and morphine decrease glutathione and 5-hydroxyindole acetic acid levels in fasted rat brain.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2009 Aug; 63(7):517-21. doi:
10.1016/j.biopha.2008.09.013. [PMID: 18993027] - Stephanie W Watts, Jessica R C Priestley, Janice M Thompson. Serotonylation of vascular proteins important to contraction.
PloS one.
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Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2009 May; 26(155):452-4. doi:
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Clinical and experimental pharmacology & physiology.
2009 May; 36(5-6):599-601. doi:
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Andrologia.
2009 Feb; 41(1):29-34. doi:
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Journal of medicinal food.
2008 Dec; 11(4):675-9. doi:
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Psychoneuroendocrinology.
2008 Oct; 33(9):1297-301. doi:
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The Journal of pharmacology and experimental therapeutics.
2008 Jun; 325(3):714-22. doi:
10.1124/jpet.107.135699. [PMID: 18322152] - Kinshi Kato, Shin-ichi Kikuchi, Shin-ichi Konno, Miho Sekiguchi. Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats.
Spine.
2008 May; 33(12):1330-6. doi:
10.1097/brs.0b013e318173298b. [PMID: 18496345] - Roy M Preshaw, Daniel Leavitt, Gordon Hoag. The dietary supplement 5-hydroxytryptophan and urinary 5-hydroxyindole acetic acid.
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2008 Apr; 178(8):993. doi:
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Annals of clinical biochemistry.
2008 Mar; 45(Pt 2):149-52. doi:
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Pakistan journal of pharmaceutical sciences.
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Neuroreport.
2007 Dec; 18(18):1981-5. doi:
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Journal of gastroenterology and hepatology.
2007 Dec; 22(12):2330-7. doi:
10.1111/j.1440-1746.2006.04772.x. [PMID: 18265445] - Murray Esler, Elisabeth Lambert, Marlies Alvarenga, Florentia Socratous, Jeff Richards, David Barton, Ciaran Pier, Celia Brenchley, Tye Dawood, Jacqueline Hastings, Ling Guo, Deepak Haikerwal, David Kaye, Garry Jennings, Victor Kalff, Michael Kelly, Glen Wiesner, Gavin Lambert. Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor.
Stress (Amsterdam, Netherlands).
2007 Aug; 10(3):295-304. doi:
10.1080/10253890701300904. [PMID: 17613943] - Jeong Won Jahng, Jae Goo Kim, Hyoung Jin Kim, Bom-Taeck Kim, Dong-Won Kang, Jong-Ho Lee. Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter.
Brain research.
2007 May; 1150(?):100-7. doi:
10.1016/j.brainres.2007.02.080. [PMID: 17383614] - Jong-Ho Lee, Hyung Jin Kim, Jae Goo Kim, Vitaly Ryu, Bom-Taeck Kim, Dong-Won Kang, Jeong Won Jahng. Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation.
Neuroscience research.
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Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2007 May; 22(131):366-8. doi:
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British journal of cancer.
2007 Apr; 96(8):1178-82. doi:
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Molecular and cellular biochemistry.
2007 Apr; 298(1-2):69-81. doi:
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Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
2007 Mar; 41(2):91-5. doi:
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Hepato-gastroenterology.
2007 Mar; 54(74):382-5. doi:
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The European journal of neuroscience.
2006 Aug; 24(4):1053-62. doi:
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The International journal of neuroscience.
2006 Jul; 116(7):775-826. doi:
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Environmental health perspectives.
2006 Jun; 114(6):870-4. doi:
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American journal of physiology. Cell physiology.
2005 Nov; 289(5):C1075-84. doi:
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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
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Brain research bulletin.
2005 Oct; 67(3):235-41. doi:
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Abdominal imaging.
2005 May; 30(3):281-5. doi:
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Alcoholism, clinical and experimental research.
2005 May; 29(5):781-7. doi:
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Journal of neuroscience research.
2005 Mar; 79(6):756-71. doi:
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Biological & pharmaceutical bulletin.
2005 Mar; 28(3):490-4. doi:
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Scottish medical journal.
2005 Feb; 50(1):27-9. doi:
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Gut.
2004 Dec; 53(12):1794-800. doi:
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International journal of radiation biology.
2004 Jun; 80(6):399-411. doi:
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Journal of cardiovascular pharmacology.
2004 Jun; 43(6):770-81. doi:
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Hepato-gastroenterology.
2004 May; 51(57):830-2. doi:
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2004 May; 138(1):33-44. doi:
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Cancer investigation.
2004; 22(3):353-9. doi:
10.1081/cnv-200029058. [PMID: 15493355] - Jukka Hintikka, Tommi Tolmunen, Antti Tanskanen, Heimo Viinamäki. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder.
BMC psychiatry.
2003 Dec; 3(?):17. doi:
10.1186/1471-244x-3-17. [PMID: 14641930] - Elena B C Llambías, Carmen Aldonatti, Leonor C San Martín de Viale. Tryptophan metabolism via serotonin in rats with hexachlorobenzene experimental porphyria.
Biochemical pharmacology.
2003 Jul; 66(1):35-42. doi:
10.1016/s0006-2952(03)00241-7. [PMID: 12818363] - L A Houghton, W Atkinson, R P Whitaker, P J Whorwell, M J Rimmer. Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome.
Gut.
2003 May; 52(5):663-70. doi:
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