(R)-5-(2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one (BioDeep_00000174631)
human metabolite blood metabolite
代谢物信息卡片
化学式: C24H28N2O3 (392.20998180000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 95.83%
分子结构信息
SMILES: CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC
InChI: InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Soichiro Matsushima, Ivan Matthews, Ralph Woessner, Gregory Pinault, Hisanori Hara, Justin Wilkins, Kaneo Sekiguchi. Systemic pharmacokinetics of indacaterol, an inhaled once-daily long-acting beta2-agonist, in different ethnic populations.
International journal of clinical pharmacology and therapeutics.
2012 Aug; 50(8):545-56. doi:
10.5414/cp201719. [PMID: 22735463] - Corinne Emotte, Olivier Heudi, Fanny Deglave, Adrien Bonvie, Laurence Masson, Franck Picard, Animesh Chaturvedi, Tapan Majumdar, Ashish Agarwal, Ralph Woessner, Olivier Kretz. Validation of an on-line solid-phase extraction method coupled to liquid chromatography-tandem mass spectrometry detection for the determination of Indacaterol in human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 895-896(?):1-9. doi:
10.1016/j.jchromb.2012.02.025. [PMID: 22483398] - Kenneth R Chapman, Stephen I Rennard, Angeli Dogra, Roger Owen, Cheryl Lassen, Benjamin Kramer. Long-term safety and efficacy of indacaterol, a long-acting β₂-agonist, in subjects with COPD: a randomized, placebo-controlled study.
Chest.
2011 Jul; 140(1):68-75. doi:
10.1378/chest.10-1830. [PMID: 21349928] - S Pascoe, C Reynolds, W Pleskow, S Perry, A Hmissi, G Kaiser, L Brookman. Safety, tolerability and pharmacokinetics of single escalating doses of indacaterol, a once-daily beta2-agonist bronchodilator, in subjects with COPD.
International journal of clinical pharmacology and therapeutics.
2011 Feb; 49(2):153-61. doi:
10.5414/cpp49153. [PMID: 21255532] - James F Donohue, Dave Singh, Oliver Kornmann, David Lawrence, Cheryl Lassen, Benjamin Kramer. Safety of indacaterol in the treatment of patients with COPD.
International journal of chronic obstructive pulmonary disease.
2011; 6(?):477-92. doi:
10.2147/copd.s23816. [PMID: 22003293] - Motoi Hosoe, Ralph Woessner, Soichiro Matsushima, David Lawrence, Benjamin Kramer. Efficacy, safety and pharmacokinetics of indacaterol in Caucasian and Japanese patients with chronic obstructive pulmonary disease: a comparison of data from two randomized, placebo-controlled studies.
Clinical drug investigation.
2011; 31(4):247-55. doi:
10.2165/11586520-000000000-00000. [PMID: 21184620] - James F Donohue, Charles Fogarty, Jan Lötvall, Donald A Mahler, Heinrich Worth, Arzu Yorgancioglu, Amir Iqbal, James Swales, Roger Owen, Mark Higgins, Benjamin Kramer. Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium.
American journal of respiratory and critical care medicine.
2010 Jul; 182(2):155-62. doi:
10.1164/rccm.200910-1500oc. [PMID: 20463178] - Gregory Feldman, Thomas Siler, Niyati Prasad, Damon Jack, Simon Piggott, Roger Owen, Mark Higgins, Benjamin Kramer. Efficacy and safety of indacaterol 150 microg once-daily in COPD: a double-blind, randomised, 12-week study.
BMC pulmonary medicine.
2010 Mar; 10(?):11. doi:
10.1186/1471-2466-10-11. [PMID: 20211002] - Dario Lombardi, Bernard Cuenoud, Stefanie D Krämer. Lipid membrane interactions of indacaterol and salmeterol: do they influence their pharmacological properties?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2009 Dec; 38(5):533-47. doi:
10.1016/j.ejps.2009.10.001. [PMID: 19819331] - Craig LaForce, Phillip Korenblat, Pamela Osborne, Fang Dong, Mark Higgins. 24-hour bronchodilator efficacy of single doses of indacaterol in patients with persistent asthma: comparison with placebo and formoterol.
Current medical research and opinion.
2009 Oct; 25(10):2353-9. doi:
10.1185/03007990903143143. [PMID: 19650753] - Olivier Bauwens, Vincent Ninane, Boudewijn Van de Maele, Roz Firth, Fang Dong, Roger Owen, Mark Higgins. 24-hour bronchodilator efficacy of single doses of indacaterol in subjects with COPD: comparison with placebo and formoterol.
Current medical research and opinion.
2009 Feb; 25(2):463-70. doi:
10.1185/03007990802675096. [PMID: 19192991] - Jutta Beier, Pascal Chanez, Jean-Benoit Martinot, A J M Schreurs, Ruzena Tkácová, Weibin Bao, Damon Jack, Mark Higgins. Safety, tolerability and efficacy of indacaterol, a novel once-daily beta(2)-agonist, in patients with COPD: a 28-day randomised, placebo controlled clinical trial.
Pulmonary pharmacology & therapeutics.
2007; 20(6):740-9. doi:
10.1016/j.pupt.2006.09.001. [PMID: 17088091]