4alpha-Phorbol 12,13-didecanoate (BioDeep_00000174623)
human metabolite blood metabolite
代谢物信息卡片
化学式: C40H64O8 (672.4600944)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.44%
分子结构信息
SMILES: CCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C(C)(C)C12OC(=O)CCCCCCCCC
InChI: InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3
描述信息
同义名列表
13 个代谢物同义名
Decanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)]-; 14-(decanoyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0^{2,6}.0^{11,13}]pentadeca-3,8-dien-13-yl decanoate; 14-(Decanoyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0,.0,]pentadeca-3,8-dien-13-yl decanoic acid; Phorbol-12,13-didecanoate, (1ar-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))-isomer; 4alpha-Phorbol 12,13-didecanoic acid; 4alpha-Phorbol 12,13-didecanoate; 4a-Phorbol 12,13-didecanoic acid; 4Α-phorbol 12,13-didecanoic acid; beta-Phorbol-12,13-didecanoate; 4Α-phorbol 12,13-didecanoate; 4a-Phorbol 12,13-didecanoate; 4 alpha-PDD; 4 beta-PDD
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kevin Lowe, Diego Alvarez, Judy King, Troy Stevens. Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance.
The Journal of surgical research.
2007 Nov; 143(1):70-7. doi:
10.1016/j.jss.2007.03.047. [PMID: 17950075] - Lori Birder, F Aura Kullmann, Hyosang Lee, Stacey Barrick, William de Groat, Anthony Kanai, Michael Caterina. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat.
The Journal of pharmacology and experimental therapeutics.
2007 Oct; 323(1):227-35. doi:
10.1124/jpet.107.125435. [PMID: 17636010] - Joris Vriens, Grzegorz Owsianik, Annelies Janssens, Thomas Voets, Bernd Nilius. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.
The Journal of biological chemistry.
2007 Apr; 282(17):12796-803. doi:
10.1074/jbc.m610485200. [PMID: 17341586] - D Carter, B Fuhrman, M Aviram. Macrophage activation with phorbol myristate acetate is associated with cellular lipid peroxidation.
Israel journal of medical sciences.
1996 Jun; 32(6):479-85. doi:
. [PMID: 8682655] - M Mattie, G Brooker, S Spiegel. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
The Journal of biological chemistry.
1994 Feb; 269(5):3181-8. doi:
". [PMID: 8106352] - E M Rohlfs, D S Louie, S H Zeisel. Lipid synthesis and secretion by primary cultures of rat mammary epithelial cells.
Journal of cellular physiology.
1993 Dec; 157(3):469-80. doi:
10.1002/jcp.1041570306. [PMID: 8253858] - J Brom, W König. Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.
Immunology.
1989 Dec; 68(4):479-85. doi:
. [PMID: 2558070] - R S Dewdney, C J Soper, D Anderson. Characterization of lymphocyte stimulation by phorbol related compounds.
Human toxicology.
1988 Mar; 7(2):153-9. doi:
10.1177/096032718800700208. [PMID: 3163986] - M M Dale, A W Obianime. 4 beta-PDBu contracts parenchymal strip and synergizes with raised cytosolic calcium.
European journal of pharmacology.
1987 Sep; 141(1):23-32. doi:
10.1016/0014-2999(87)90407-9. [PMID: 3478200] - G B Zavoico, S P Halenda, R I Sha'afi, M B Feinstein. Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.
Proceedings of the National Academy of Sciences of the United States of America.
1985 Jun; 82(11):3859-62. doi:
10.1073/pnas.82.11.3859. [PMID: 2987951] - M Deleers, F Defrise-Quertain, J M Ruysschaert, W J Malaisse. Interaction of phorbol esters with lipid bilayers : thermotropic changes in fluorescence polarization, phase transition and calcium ionophoresis.
Research communications in chemical pathology and pharmacology.
1981 Dec; 34(3):423-39. doi:
". [PMID: 6798652]