5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-,(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)- (BioDeep_00000174595)

   

human metabolite blood metabolite Marine Natural Products Volatile Flavor Compounds


代谢物信息卡片


5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-,(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-

化学式: C11H17N3O8 (319.1015602)
中文名称: 河豚毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O
InChI: InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D049990 - Membrane Transport Modulators

同义名列表

9 个代谢物同义名

5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, octahydro-12-(hydroxymethyl)-2-imino-,(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-; 3-Amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol; 14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1⁷,¹¹.0¹,⁶]tetradecane-5,9,12,13,14-pentol; Tarichatoxin; TETRODOTOXIN; Tetradotoxin; Toxin, fugu; Fugu toxin; Tetrodotoxin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Annelies Noorlander, Mengying Zhang, Bennard van Ravenzwaay, Ivonne M C M Rietjens. Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents. Toxicological sciences : an official journal of the Society of Toxicology. 2022 04; 187(1):127-138. doi: 10.1093/toxsci/kfac022. [PMID: 35218365]
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  • Badria Alhatali, Sultan Al Lawatia, Faryal Khamis, Sandeep Kantur, Seif Al-Abri, Vikas Kapil, Jerry Thomas, Rudolph Johnson, Elizabeth I Hamelin, Rebecca M Coleman, Ziad Kazzi. A cluster of tetrodotoxin poisoning in Oman. Clinical toxicology (Philadelphia, Pa.). 2022 Feb; 60(2):262-266. doi: 10.1080/15563650.2021.1917595. [PMID: 33913398]
  • Shin-Ichiro Karaki, Ryo Tanaka. Role of PGE2 in colonic motility: PGE2 attenuates spontaneous contractions of circular smooth muscle via EP4 receptors in the rat colon. The journal of physiological sciences : JPS. 2021 Feb; 71(1):8. doi: 10.1186/s12576-021-00791-4. [PMID: 33622238]
  • Qi-Cheng Chen, Zhi Jiang, Jun-Hong Zhang, Li-Xing Cao, Zhi-Qiang Chen. Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice. World journal of gastroenterology. 2021 Feb; 27(7):576-591. doi: 10.3748/wjg.v27.i7.576. [PMID: 33642830]
  • Woon Yi Law, Mohd Razip Asaruddin, Showkat Ahamd Bhawani, Samsur Mohamad. Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as MPro inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). BMC research notes. 2020 Nov; 13(1):527. doi: 10.1186/s13104-020-05379-6. [PMID: 33176880]
  • Nahit Rizaner, Sercan Uzun, Scott P Fraser, Mustafa B A Djamgoz, Seyhan Altun. Riluzole: Anti-invasive effects on rat prostate cancer cells under normoxic and hypoxic conditions. Basic & clinical pharmacology & toxicology. 2020 Oct; 127(4):254-264. doi: 10.1111/bcpt.13417. [PMID: 32304618]
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  • Naomi Ak Hanemaaijer, Marko A Popovic, Xante Wilders, Sara Grasman, Oriol Pavón Arocas, Maarten Hp Kole. Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling. eLife. 2020 06; 9(?):. doi: 10.7554/elife.54566. [PMID: 32553116]
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  • Masafumi Amano, Noriko Amiya, Minami Takaoka, Haruka Sato, Tomohiro Takatani, Osamu Arakawa, Yoshitaka Sakakura. Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes. Toxicon : official journal of the International Society on Toxinology. 2019 Dec; 171(?):54-61. doi: 10.1016/j.toxicon.2019.09.024. [PMID: 31580836]
  • Edina Varga, Erzsébet Farkas, Györgyi Zséli, Andrea Kádár, Alexandra Venczel, Dóra Kővári, Dorottya Németh, Zoltán Máté, Ferenc Erdélyi, András Horváth, Ottó Szenci, Masahiko Watanabe, Ronald M Lechan, Balázs Gereben, Csaba Fekete. Thyrotropin-Releasing-Hormone-Synthesizing Neurons of the Hypothalamic Paraventricular Nucleus Are Inhibited by Glycinergic Inputs. Thyroid : official journal of the American Thyroid Association. 2019 12; 29(12):1858-1868. doi: 10.1089/thy.2019.0357. [PMID: 31659941]
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  • Elisabetta Coppi, Federica Cherchi, Irene Fusco, Paola Failli, Alessia Vona, Ilaria Dettori, Lisa Gaviano, Elena Lucarini, Kenneth A Jacobson, Dilip K Tosh, Daniela Salvemini, Carla Ghelardini, Felicita Pedata, Lorenzo Di Cesare Mannelli, Anna Maria Pugliese. Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. Pain. 2019 05; 160(5):1103-1118. doi: 10.1097/j.pain.0000000000001488. [PMID: 31008816]
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  • Andrea Boente-Juncal, Carmen Vale, Manuel Cifuentes, Paz Otero, Mercedes Camiña, Mercedes Rodriguez-Vieytes, Luis Miguel Botana. Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity. Toxins. 2019 02; 11(2):. doi: 10.3390/toxins11020096. [PMID: 30736354]
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  • Su Chen, Ying Wan, Xiangming Liu, Xinxin Pan. Inhibitive effect of loureirin B plus capsaicin on tetrodotoxin-resistant sodium channel. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2018 12; 38(6):842-852. doi: . [PMID: 32186131]
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  • Sweyta Lohani, Adria K Martig, Suzanne M Underhill, Alicia DeFrancesco, Melanie J Roberts, Linda Rinaman, Susan Amara, Bita Moghaddam. Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 09; 43(10):2083-2092. doi: 10.1038/s41386-018-0088-7. [PMID: 29795245]
  • Mari Yotsu-Yamashita, Yuuma Nagaoka, Koji Muramoto, Yuko Cho, Keiichi Konoki. Pufferfish Saxitoxin and Tetrodotoxin Binding Protein (PSTBP) Analogues in the Blood Plasma of the Pufferfish Arothron nigropunctatus, A. hispidus, A. manilensis, and Chelonodon patoca. Marine drugs. 2018 Jun; 16(7):. doi: 10.3390/md16070224. [PMID: 29966285]
  • Bihong Hong, Jipeng Sun, Hongzhi Zheng, Qingqing Le, Changsen Wang, Kaikai Bai, Jianlin He, Huanghuang He, Yanming Dong. Effect of Tetrodotoxin Pellets in a Rat Model of Postherpetic Neuralgia. Marine drugs. 2018 Jun; 16(6):. doi: 10.3390/md16060195. [PMID: 29874779]
  • Dominic A Gioia, Minfu Xu, Wesley N Wayman, John J Woodward. Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology. 2018 06; 135(?):316-327. doi: 10.1016/j.neuropharm.2018.03.031. [PMID: 29580953]
  • Tânia C Gonçalves, Rachid Boukaiba, Jordi Molgó, Muriel Amar, Michel Partiseti, Denis Servent, Evelyne Benoit. Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches. Neuropharmacology. 2018 05; 133(?):404-414. doi: 10.1016/j.neuropharm.2018.02.016. [PMID: 29474819]
  • Maria Rambla-Alegre, Sandra Leonardo, Yann Barguil, Cintia Flores, Josep Caixach, Katrina Campbell, Christopher T Elliott, Claude Maillaud, Michael J Boundy, D Tim Harwood, Mònica Campàs, Jorge Diogène. Rapid screening and multi-toxin profile confirmation of tetrodotoxins and analogues in human body fluids derived from a puffer fish poisoning incident in New Caledonia. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Feb; 112(?):188-193. doi: 10.1016/j.fct.2017.12.039. [PMID: 29292021]
  • Chong Chen, Songhua Wang, Qingjuan Hu, Lvming Zeng, Hailong Peng, Chao Liu, Li-Ping Huang, Hao Song, Yuping Li, Li-Hua Yao, Wei Meng. Voltage-Gated Na+ Channels are Modulated by Glucose and Involved in Regulating Cellular Insulin Content of INS-1 Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(2):446-457. doi: 10.1159/000486921. [PMID: 29402835]
  • Hui Jin, Rijun Gui, Jie Sun, Yanfeng Wang. RETRACTED: Facilely self-assembled magnetic nanoparticles/aptamer/carbon dots nanocomposites for highly sensitive up-conversion fluorescence turn-on detection of tetrodotoxin. Talanta. 2018 01; 176(?):277-283. doi: 10.1016/j.talanta.2017.08.043. [PMID: 28917752]
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  • Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima. Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK₁. Marine drugs. 2017 Jul; 15(7):. doi: 10.3390/md15070225. [PMID: 28714912]
  • Rafael González-Cano, Miguel Ángel Tejada, Antonia Artacho-Cordón, Francisco Rafael Nieto, José Manuel Entrena, John N Wood, Cruz Miguel Cendán. Effects of Tetrodotoxin in Mouse Models of Visceral Pain. Marine drugs. 2017 Jun; 15(6):. doi: 10.3390/md15060188. [PMID: 28635651]
  • Bihong Hong, Hui Chen, Jiacai Han, Quanling Xie, Jianlin He, Kaikai Bai, Yanming Dong, Ruizao Yi. A Study of 11-[³H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats. Marine drugs. 2017 Jun; 15(6):. doi: 10.3390/md15060159. [PMID: 28574462]
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