4-Tert-butyl-N-methyl-N-phenylbenzamide (BioDeep_00000174513)
human metabolite blood metabolite
代谢物信息卡片
Antigens, leukemia, common acute lymphoblastic
化学式: C18H21NO (267.1623)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 15.22%
分子结构信息
SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)N(C)C2=CC=CC=C2
InChI: InChI=1S/C18H21NO/c1-18(2,3)15-12-10-14(11-13-15)17(20)19(4)16-8-6-5-7-9-16/h5-13H,1-4H3
描述信息
同义名列表
34 个代谢物同义名
Antigens, leukemia, common acute lymphoblastic; Common acute lymphoblastic leukemia antigens; Carboxypeptidase, enkephalin dipeptidyl; 4-Tert-butyl-N-methyl-N-phenylbenzamide; Dipeptidyl carboxypeptidase, enkephalin; Neutral proteinase, kidney-brush-border; Kidney-brush-border neutral proteinase; Metalloendopeptidase, thermolysin-like; Enkephalin dipeptidyl carboxypeptidase; Kidney brush border neutral proteinase; Thermolysin-like metalloendopeptidase; Thermolysin like metalloendopeptidase; Metallo-endopeptidase, membrane; Membrane metallo endopeptidase; Membrane metallo-endopeptidase; Endopeptidase 24.11, neutral; Neutral endopeptidase 24.11; Endopeptidase, neutral; Neutral endopeptidase; Enkephalinase-24.11; Endopeptidase-24.11; Enzyme, ygg-forming; Endopeptidase 24.11; Enkephalinase 24.11; YGG-forming enzyme; YGG forming enzyme; Atriopeptidase; Antigens, CD10; CD10 Antigens; Antigen, CD10; Enkephalinase; CALLA antigen; CD10 Antigen; Neprilysin
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zhenguo G Wang, Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Hongyun Huang, Lin Chen, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharma. Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury.
International review of neurobiology.
2023; 172(?):145-185. doi:
10.1016/bs.irn.2023.06.006. [PMID: 37833011] - Georges Ephrem, Jonathan C McCollum, Deborah Green-Hess, Maya E Guglin, Stephen G Sawada, Roopa A Rao. Subjective and Objective Impact of Angiotensin Receptor-Neprilysin Inhibitors on Systemic Right Ventricle Patients.
Heart, lung & circulation.
2022 Jul; 31(7):964-973. doi:
10.1016/j.hlc.2022.02.005. [PMID: 35279372] - Yan Wang, Peng Zhao, Lili Wang, Jigang Wang, Xiaobin Ji, Yunxia Li, Hailei Shi, Yujun Li, Wei Zhang, Yanxia Jiang. Analysis of clinicopathological and molecular features of ELOC(TCEB1)-mutant renal cell carcinoma.
Pathology, research and practice.
2022 Jul; 235(?):153960. doi:
10.1016/j.prp.2022.153960. [PMID: 35653922] - Oi Wah Liew, Timothy C R Prickett, Elena Revuelta-López, Samantha S M Ling, Adriana Cserkóová, Josep Lupón, Jessica Y X Ng, Jenny P C Chong, Shera Lilyanna, Siew-Pang Chan, Qifeng Lin, Teck K Lim, Qingsong Lin, Jaume Barallat, Antoni Bayés-Genís, A Mark Richards. Finding a reliable assay for soluble neprilysin.
Clinical biochemistry.
2022 Jun; 104(?):51-58. doi:
10.1016/j.clinbiochem.2022.03.004. [PMID: 35331754] - Thibault Michel, Hélène Nougué, Jérôme Cartailler, Guillaume Lefèvre, Malha Sadoune, François Picard, Alain Cohen-Solal, Damien Logeart, Jean-Marie Launay, Nicolas Vodovar. proANP Metabolism Provides New Insights Into Sacubitril/Valsartan Mode of Action.
Circulation research.
2022 05; 130(11):e44-e57. doi:
10.1161/circresaha.122.320882. [PMID: 35485239] - Simon Thonsgaard, Timothy C R Prickett, Lasse H Hansen, Nicolai J Wewer Albrechtsen, Ulrik Ø Andersen, Dijana Terzic, Peter Plomgaard, Finn Gustafsson, Jens P Goetze, Peter D Mark. Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men.
Clinical chemistry.
2022 05; 68(5):713-720. doi:
10.1093/clinchem/hvac005. [PMID: 35175317] - Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan. Angiotensin Receptor and Neprilysin Inhibitors for COVID-19 Treatment and Personalized Medicine?.
Omics : a journal of integrative biology.
2022 05; 26(5):318-319. doi:
10.1089/omi.2022.0030. [PMID: 35483040] - Kristian Hellenkamp, Kathleen Nolte, Stephan von Haehling. Pharmacological treatment options for heart failure with reduced ejection fraction: A 2022 update.
Expert opinion on pharmacotherapy.
2022 Apr; 23(6):673-680. doi:
10.1080/14656566.2022.2047647. [PMID: 35260016] - Xi-Wu Yan, Huai-Jun Liu, Yu-Xing Hong, Ting Meng, Jun Du, Cheng Chang. lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease.
Journal of neurogenetics.
2022 03; 36(1):11-20. doi:
10.1080/01677063.2022.2028784. [PMID: 35098860] - Nathalie Esser, Stephen M Mongovin, Jacqueline Parilla, Breanne M Barrow, Thomas O Mundinger, Brendy S Fountaine, Megan J Larmore, Joseph J Castillo, Rehana Akter, Rebecca L Hull, Sakeneh Zraika. Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction.
American journal of physiology. Endocrinology and metabolism.
2022 03; 322(3):E307-E318. doi:
10.1152/ajpendo.00234.2021. [PMID: 35128957] - Xingjian Zhang, Yan Zhou, Ruixia Ma. Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease.
Journal of diabetes and its complications.
2022 01; 36(1):108056. doi:
10.1016/j.jdiacomp.2021.108056. [PMID: 34893426] - Justin Miron, Cynthia Picard, Anne Labonté, Daniel Auld, Judes Poirier. MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
Journal of Alzheimer's disease : JAD.
2022; 86(1):283-296. doi:
10.3233/jad-215410. [PMID: 35034907] - Yan Tan, Jiani Zhang, Ke Yang, Zihui Xu, Huawei Zhang, Weihang Chen, Tiantian Peng, Xu Wang, Zhaoheng Liu, Peng Wei, Na Li, Zhenqiang Zhang, Tonghua Liu, Qian Hua. Anti-Stroke Chinese Herbal Medicines Inhibit Abnormal Amyloid-β Protein Precursor Processing in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2022; 85(1):261-272. doi:
10.3233/jad-210652. [PMID: 34776438] - Ratna Priya, Vaishali Jain, Javed Akhtar, Geeta Chauhan, Puja Sakhuja, Surbhi Goyal, Anil Kumar Agarwal, Amit Javed, Ankit P Jain, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar, Poonam Gautam. Plasma-derived candidate biomarkers for detection of gallbladder carcinoma.
Scientific reports.
2021 12; 11(1):23554. doi:
10.1038/s41598-021-02923-7. [PMID: 34876625] - Iuliia Polina, Morgan J Spicer, Mark Domondon, Ryan S Schibalski, Elizaveta Sarsenova, Regina F Sultanova, Daria V Ilatovskaya. Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats.
Renal failure.
2021 Dec; 43(1):315-324. doi:
10.1080/0886022x.2021.1879856. [PMID: 33541194] - Xuefei Liu, Kaushik P Patel, Hong Zheng. Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.
Journal of the American Heart Association.
2021 11; 10(21):e022542. doi:
10.1161/jaha.121.022542. [PMID: 34713714] - Marta Jiménez-Blanco Bravo, Alfonso Valle, Jara Gayán Ordás, Susana Del Prado Díaz, David Cordero Pereda, Herminio Morillas Climent, Ramón Bascompte Claret, Julia Seller Moya, José Luis Zamorano Gómez, Gonzalo Luis Alonso Salinas. Safety and Efficacy of the Combination of Sacubitril/Valsartan and SGLT2i in HFrEF Patients (SECSI Registry).
Journal of cardiovascular pharmacology.
2021 11; 78(5):e662-e668. doi:
10.1097/fjc.0000000000001111. [PMID: 34321396] - Suriya Prausmüller, Georg Spinka, Henrike Arfsten, Stefanie Stasek, Rene Rettl, Philipp Emanuel Bartko, Georg Goliasch, Guido Strunk, Julia Riebandt, Julia Mascherbauer, Diana Bonderman, Christian Hengstenberg, Martin Hülsmann, Noemi Pavo. Relevance of Neutrophil Neprilysin in Heart Failure.
Cells.
2021 10; 10(11):. doi:
10.3390/cells10112922. [PMID: 34831146] - Shubin Yu, Yiwen Lu, An Su, Jianing Chen, Jiang Li, Boxuan Zhou, Xinwei Liu, Qidong Xia, Yihong Li, Jiaqian Li, Min Huang, Yingying Ye, Qiyi Zhao, Sushi Jiang, Xiaoqing Yan, Xiaojuan Wang, Can Di, Jiayao Pan, Shicheng Su. A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2021 10; 8(19):e2101848. doi:
10.1002/advs.202101848. [PMID: 34363355] - Jessica Saunders, Allison Marie Callejas Salgado, Joseph Y Ting, Cherry Mammen, Jefferson Terry, Jonathan W Bush. Quantifying Proximal Collecting Tubule Deficiency in Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Fetopathy.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.
2021 Sep; 24(5):438-444. doi:
10.1177/10935266211018922. [PMID: 34082612] - Nevin Tüten, Eduard Malik, Koray Gök, Kübra Hamzaoglu, Melike Makul, Yahya Özgün Öner, Huri Bulut, Abdullah Tüten, Onur Güralp. Serum neprilysin levels are elevated in preeclampsia.
Taiwanese journal of obstetrics & gynecology.
2021 Sep; 60(5):869-873. doi:
10.1016/j.tjog.2021.07.015. [PMID: 34507663] - Karina Oliveira Garcia, Thiago Cerqueira Silva, Maria C Pereira Nunes, Iuri Ferreira Felix, Murilo Araujo Oliveira, Maria E Lisboa Marques, Leila S Brito Santos, Paulo R S Peixoto Sousa, Pedro J Ramiro Muiños, Renata Martins Maia, Marília Bazzo Catto, Pedro A Pereira Jesus, Lucas C Barbosa eSilva, Antonio L Pinho Ribeiro, Roque Aras, Giovanna Ladeia Rocha, Karen L Furie, Jamary Oliveira-Filho. Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy.
The American journal of tropical medicine and hygiene.
2021 07; 105(3):638-642. doi:
10.4269/ajtmh.20-0401. [PMID: 34280134] - Wang Lihua, Lin Cheng, Haiyan Chen, Fang Wei, Aili Jiang. Use of Angiotensin Receptor Neprilysin Inhibitor in Patients on Maintenance Hemodialysis with Reduced Cardiac Ejection Fraction, Real-World Experience From a Single Center.
Iranian journal of kidney diseases.
2021 Jul; 15(4):288-299. doi:
NULL. [PMID: 34279000] - Debasish Banerjee, Giuseppe Rosano, Charles A Herzog. Management of Heart Failure Patient with CKD.
Clinical journal of the American Society of Nephrology : CJASN.
2021 07; 16(7):1131-1139. doi:
10.2215/cjn.14180920. [PMID: 33495289] - Justin T Kelley, Noah A Brown, Alexandra C Hristov, Scott C Bresler. Primary cutaneous follicle center lymphoma with extensive plasmacytic differentiation and t(14;18) in both the lymphoid and plasma cell components.
Journal of cutaneous pathology.
2021 Jul; 48(7):969-974. doi:
10.1111/cup.14020. [PMID: 33786907] - Devasahayam Arokia Balaya Rex, Sumaithangi Thattai Arun Kumar, Prashant Kumar Modi, Thottethodi Subrahmanya Keshava Prasad. Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe, or Promising Molecular Target?.
Omics : a journal of integrative biology.
2021 07; 25(7):408-416. doi:
10.1089/omi.2021.0080. [PMID: 34191617] - Henrike Arfsten, Georg Goliasch, Philipp E Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Hülsmann, Noemi Pavo. Neprilysin inhibition does not alter dynamic of proenkephalin-A 119-159 and pro-substance P in heart failure.
ESC heart failure.
2021 06; 8(3):2016-2024. doi:
10.1002/ehf2.13278. [PMID: 33742565] - Eva Babusikova, Dusan Dobrota, Anthony J Turner, Natalia N Nalivaeva. Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
Biochemistry. Biokhimiia.
2021 Jun; 86(6):680-692. doi:
10.1134/s0006297921060067. [PMID: 34225591] - Teng Jiang, Xiaoli Diao, Meili Ding, Xiao Niu, Chao Wang, Yan Qi, Wei Jia, Lijuan Pang, Wenhao Hu, Hong Zou, Feng Li. SR-B1 and CD10 combined immunoprofile for differential diagnosis of metastatic clear cell renal cell carcinoma and clear cell carcinoma of the ovary.
Journal of molecular histology.
2021 Jun; 52(3):539-544. doi:
10.1007/s10735-021-09963-3. [PMID: 33608777] - Yasir AlSiraj, Sean E Thatcher, Ching Ling Liang, Heba Ali, Mark Ensor, Lisa A Cassis. Therapeutic Assessment of Combination Therapy with a Neprilysin Inhibitor and Angiotensin Type 1 Receptor Antagonist on Angiotensin II-Induced Atherosclerosis, Abdominal Aortic Aneurysms, and Hypertension.
The Journal of pharmacology and experimental therapeutics.
2021 06; 377(3):326-335. doi:
10.1124/jpet.121.000525. [PMID: 33707301] - Marie-Camille Chaumais, Mohamed Reda Amar Djessas, Raphaël Thuillet, Amélie Cumont, Ly Tu, Guillaume Hebert, Pauline Gaignard, Alice Huertas, Laurent Savale, Marc Humbert, Christophe Guignabert. Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension.
Cardiovascular research.
2021 04; 117(5):1391-1401. doi:
10.1093/cvr/cvaa200. [PMID: 32653925] - Juan Brignone, Kasper Bostlund Assersen, Mia Jensen, Boye L Jensen, Brian Kloster, Morten Jønler, Lars Lund. Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors.
Pflugers Archiv : European journal of physiology.
2021 04; 473(4):595-610. doi:
10.1007/s00424-021-02555-w. [PMID: 33844072] - Christine Henke, Sven Haufe, Doreen Ziehl, Stefan R Bornstein, Jeanette Schulz-Menger, Martin Heni, Stefan Engeli, Jens Jordan, Andreas L Birkenfeld. Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects.
ESC heart failure.
2021 04; 8(2):938-942. doi:
10.1002/ehf2.13220. [PMID: 33638612] - Hui Jiang, Fengnan Niu, Yan Zheng, Yun Xu. CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes.
Molecular medicine reports.
2021 04; 23(4):. doi:
10.3892/mmr.2021.11919. [PMID: 33604684] - Shigeki Hirabayashi, Kotaro Shirakawa, Yoshihito Horisawa, Tadahiko Matsumoto, Hiroyuki Matsui, Hiroyuki Yamazaki, Anamaria Daniela Sarca, Yasuhiro Kazuma, Ryosuke Nomura, Yoshinobu Konishi, Suguru Takeuchi, Emani Stanford, Hideya Kawaji, Yasuhiro Murakawa, Akifumi Takaori-Kondo. APOBEC3B is preferentially expressed at the G2/M phase of cell cycle.
Biochemical and biophysical research communications.
2021 03; 546(?):178-184. doi:
10.1016/j.bbrc.2021.02.008. [PMID: 33592502] - Diana Herman, Peter Mantle. Rat Tumour Histopathology Associated with Experimental Chronic Dietary Exposure to Ochratoxin A in Prediction of the Mycotoxin's Risk for Human Cancers.
Toxins.
2021 03; 13(3):. doi:
10.3390/toxins13030205. [PMID: 33808971] - Vardan T Karamyan. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19?.
Physiological reports.
2021 03; 9(5):e14796. doi:
10.14814/phy2.14796. [PMID: 33687143] - Rajendra Kumar Gokhroo, Kaul Anushri, M T Tarik, C Kailash, N Rajesh, K Ashish, G Manish, C Subhash. 1 year follow Up results of 'ARTIM HF TRIAL' (angiotensin receptor neprilysin inhibitor effect on TEI index & left ventricular mass in heart failure).
Indian heart journal.
2021 Mar; 73(2):205-210. doi:
10.1016/j.ihj.2021.01.010. [PMID: 33865519] - Donna S-H Lin, Tzung-Dau Wang, Peera Buranakitjaroen, Chen-Huan Chen, Hao-Min Cheng, Yook Chin Chia, Apichard Sukonthasarn, Jam Chin Tay, Boon Wee Teo, Yuda Turana, Ji-Guang Wang, Kazuomi Kario. Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: Evidence from Asia and around the globe.
Journal of clinical hypertension (Greenwich, Conn.).
2021 03; 23(3):556-567. doi:
10.1111/jch.14120. [PMID: 33305531] - Henrike Arfsten, Georg Goliasch, Philipp E Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Helmuth Haslacher, Guido Strunk, Joachim Struck, Martin Hülsmann, Noemi Pavo. Increased concentrations of bioactive adrenomedullin subsequently to angiotensin-receptor/neprilysin-inhibitor treatment in chronic systolic heart failure.
British journal of clinical pharmacology.
2021 03; 87(3):916-924. doi:
10.1111/bcp.14442. [PMID: 32598074] - Fayez T Hammad, Suhail Al-Salam, Sarah S AlZaabi, Maryam M Alfalasi, Awwab F Hammad, Javed Yasin, Loay Lubbad. The effect of neprilysin and renin inhibition on the renal dysfunction following ischemia-reperfusion injury in the rat.
Physiological reports.
2021 03; 9(6):e14723. doi:
10.14814/phy2.14723. [PMID: 33719192] - Antonio Vitiello, Raffaele La Porta, Francesco Ferrara. Scientific hypothesis and rational pharmacological for the use of sacubitril/valsartan in cardiac damage caused by COVID-19.
Medical hypotheses.
2021 Feb; 147(?):110486. doi:
10.1016/j.mehy.2021.110486. [PMID: 33460992] - Surya Banerjee, Christine Woods, Micheal Burnett, Scarlet J Park, William W Ja, Jennifer Curtiss. The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage.
Scientific reports.
2021 01; 11(1):2099. doi:
10.1038/s41598-021-81165-z. [PMID: 33483521] - Runali Sankhe, Sreedhara Ranganath K Pai, Anoop Kishore. Tumour suppression through modulation of neprilysin signaling: A comprehensive review.
European journal of pharmacology.
2021 Jan; 891(?):173727. doi:
10.1016/j.ejphar.2020.173727. [PMID: 33160935] - V Nemcekova, E Malikova, E Goncalvesova, P Krenek, J Klimas. Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction.
Bratislavske lekarske listy.
2021; 122(1):28-33. doi:
10.4149/bll_2021_002. [PMID: 33393317] - Youbin Liu, Ying Fan, Jinglong Li, Meng Chen, Anyong Chen, Dahao Yang, Xue Guan, Yong Cao. Combination of LCZ696 and ACEI further improves heart failure and myocardial fibrosis after acute myocardial infarction in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110824. doi:
10.1016/j.biopha.2020.110824. [PMID: 33378988] - Parminder K Judge, Richard Haynes. TaleNeprilysin and Neprilysin inhibition in chronic kidney disease.
Current opinion in nephrology and hypertension.
2021 01; 30(1):123-130. doi:
10.1097/mnh.0000000000000659. [PMID: 33148948] - Yasunori Suematsu, Kohei Tashiro, Hidetaka Morita, Akihito Ideishi, Takashi Kuwano, Shin-Ichiro Miura. Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):9916789. doi:
10.1155/2021/9916789. [PMID: 34394711] - Teruhiko Imamura, Masakazu Hori, Koichiro Kinugawa. Optimal Therapeutic Strategy Using Sacubitril/Valsartan in a Patient with Systolic Heart Failure and Chronic Kidney Disease - An Initial Case Report in Japan.
Internal medicine (Tokyo, Japan).
2021; 60(17):2807-2809. doi:
10.2169/internalmedicine.6713-20. [PMID: 34470986] - Martin H Bernardi, Ludwig Wagner, Sylvia Ryz, Juergen Puchinger, Larissa Nixdorf, Maximilian Edlinger-Stanger, Johannes Geilen, Matthias Kainz, Michael J Hiesmayr, Andrea Lassnigg. Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study.
European journal of anaesthesiology.
2021 01; 38(1):13-21. doi:
10.1097/eja.0000000000001321. [PMID: 32941200] - Manar Mohammed El Tabaa, Maram Mohammed El Tabaa. New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19.
European journal of pharmacology.
2020 Dec; 889(?):173615. doi:
10.1016/j.ejphar.2020.173615. [PMID: 33011243] - Małgorzata Sobocińska, Maciej Salaga, Jakub Fichna, Elżbieta Kamysz. Anti-Inflammatory Effect of Homo- and Heterodimers of Natural Enkephalinase Inhibitors in Experimental Colitis in Mice.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245820. [PMID: 33321720] - N N Nalivaeva, I A Zhuravin, A J Turner. Neprilysin expression and functions in development, ageing and disease.
Mechanisms of ageing and development.
2020 12; 192(?):111363. doi:
10.1016/j.mad.2020.111363. [PMID: 32987038] - Yu Feng, Yongmei Yin, Rong Deng, Haonan Li. Renal safety and efficacy of angiotensin receptor-neprilysin inhibitor: A meta-analysis of randomized controlled trials.
Journal of clinical pharmacy and therapeutics.
2020 Dec; 45(6):1235-1243. doi:
10.1111/jcpt.13243. [PMID: 32776562] - Alessandro Bellis, Ciro Mauro, Emanuele Barbato, Bruno Trimarco, Carmine Morisco. The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19.
International journal of molecular sciences.
2020 Nov; 21(22):. doi:
10.3390/ijms21228612. [PMID: 33203141] - Massimo Mapelli, Elisabetta Salvioni, Fabiana de Martino, Irene Mattavelli, Alice Bonomi, Valentina Sassi, Paola Gugliandolo, Carlo Vignati, Alessandra Magini, Sara Rovai, Stefania Paolillo, Piergiuseppe Agostoni. Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction.
Journal of cardiovascular medicine (Hagerstown, Md.).
2020 Nov; 21(11):882-888. doi:
10.2459/jcm.0000000000001018. [PMID: 32740412] - Jitendra Kanodia, Arthur Lo, R Michael Baldwin, Ken Colley, Kefei Zhou, David L Bourdet. Safety, Pharmacokinetics, and Pharmacodynamics of TD-0714, a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects.
Clinical and translational science.
2020 11; 13(6):1307-1315. doi:
10.1111/cts.12831. [PMID: 32506827] - Baoxin Li, Na Li, Shuqin Guo, Mali Zhang, Jie Li, Na Zhai, He Wang, Yunliang Zhang. The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients.
Journal of diabetes and its complications.
2020 11; 34(11):107686. doi:
10.1016/j.jdiacomp.2020.107686. [PMID: 32768333] - Gerardo Casucci, Domenico Acanfora, Raffaele Antonelli Incalzi. The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets.
Drugs & aging.
2020 11; 37(11):779-785. doi:
10.1007/s40266-020-00808-4. [PMID: 33084001] - Hani N Sabbah, Kefei Zhang, Ramesh C Gupta, Jiang Xu, Vinita Singh-Gupta. Effects of Angiotensin-Neprilysin Inhibition in Canines with Experimentally Induced Cardiorenal Syndrome.
Journal of cardiac failure.
2020 Nov; 26(11):987-997. doi:
10.1016/j.cardfail.2020.08.009. [PMID: 32841710] - Thomas A Zelniker, Sebastian Spaich, Jan Stiepak, Florian Steger, Hugo A Katus, Michael R Preusch. Serum neprilysin and the risk of death in patients with out-of-hospital cardiac arrest of non-traumatic origin.
European heart journal. Acute cardiovascular care.
2020 Nov; 9(4_suppl):S169-S174. doi:
10.1177/2048872618815062. [PMID: 30449136] - Huaning Kang, Jinhua Zhang, Xiaoting Zhang, Guicheng Qin, Ke Wang, Zhenyu Deng, Yi Fang, Guihong Chen. Effects of sacubitril/valsartan in patients with heart failure and chronic kidney disease: A meta-analysis.
European journal of pharmacology.
2020 Oct; 884(?):173444. doi:
10.1016/j.ejphar.2020.173444. [PMID: 32739172] - Xueling Li, Qin Zhu, Qingcheng Wang, Qinggang Zhang, Yaru Zheng, Lihong Wang, Qinyang Jin. Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice.
Cardiovascular drugs and therapy.
2020 10; 34(5):629-640. doi:
10.1007/s10557-020-06995-x. [PMID: 32444995] - Sashiananthan Ganesananthan, Nisar Shah, Parin Shah, Hossam Elsayed, Julie Phillips, Ann Parkes, Angharad Morgan, Zaheer Yousef. Real-world treatment switching to sacubitril/valsartan in patients with heart failure with reduced ejection fraction: A cohort study.
Open heart.
2020 10; 7(2):. doi:
10.1136/openhrt-2020-001305. [PMID: 33020255] - Basim A S Messiha, Mohammed R A Ali, Mahmoud M Khattab, Amira M Abo-Youssef. Perindopril ameliorates experimental Alzheimer's disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling.
Inflammopharmacology.
2020 Oct; 28(5):1343-1364. doi:
10.1007/s10787-020-00724-4. [PMID: 32488543] - Finnian R Mc Causland, Martin P Lefkowitz, Brian Claggett, Nagesh S Anavekar, Michele Senni, Mauro Gori, Pardeep S Jhund, Martina M McGrath, Milton Packer, Victor Shi, Dirk J Van Veldhuisen, Faiez Zannad, Josep Comin-Colet, Marc A Pfeffer, John J V McMurray, Scott D Solomon. Angiotensin-Neprilysin Inhibition and Renal Outcomes in Heart Failure With Preserved Ejection Fraction.
Circulation.
2020 09; 142(13):1236-1245. doi:
10.1161/circulationaha.120.047643. [PMID: 32845715] - Weigang Jia, Wei Wang, Rui Li, Quanyu Zhou, Ying Qu, Yumei Jia, Zhiheng Zhang, Chengwei Wan, Wanwan Zhang. Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough.
BMC complementary medicine and therapies.
2020 Sep; 20(1):289. doi:
10.1186/s12906-020-03081-5. [PMID: 32962697] - Ian S Zagon, Joseph W Sassani, Indira Purushothaman, Patricia J McLaughlin. Dysregulation of the OGF-OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat.
Experimental biology and medicine (Maywood, N.J.).
2020 09; 245(15):1414-1421. doi:
10.1177/1535370220940273. [PMID: 32640891] - Shreya Bendre, Zhengxing Zhang, Hsiou-Ting Kuo, Julie Rousseau, Chengcheng Zhang, Helen Merkens, Áron Roxin, François Bénard, Kuo-Shyan Lin. Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics.
Molecules (Basel, Switzerland).
2020 Aug; 25(17):. doi:
10.3390/molecules25173854. [PMID: 32854201] - Cheryl L Laffer, Fernando Elijovich, Melis Sahinoz, Ashley Pitzer, Annet Kirabo. New Insights Into the Renin-Angiotensin System in Chronic Kidney Disease.
Circulation research.
2020 08; 127(5):607-609. doi:
10.1161/circresaha.120.317624. [PMID: 32790525] - Christopher C Kaltenecker, Oliver Domenig, Chantal Kopecky, Marlies Antlanger, Marko Poglitsch, Gabriela Berlakovich, Renate Kain, Johannes Stegbauer, Masudur Rahman, Roland Hellinger, Christian Gruber, Nadja Grobe, Harun Fajkovic, Farsad Eskandary, Georg A Böhmig, Marcus D Säemann, Johannes J Kovarik. Critical Role of Neprilysin in Kidney Angiotensin Metabolism.
Circulation research.
2020 08; 127(5):593-606. doi:
10.1161/circresaha.119.316151. [PMID: 32418507] - Ik Jun Choi, Sungmin Lim, Youngdeok Hwang, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon. Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study.
BMC cardiovascular disorders.
2020 08; 20(1):360. doi:
10.1186/s12872-020-01636-5. [PMID: 32762650] - Robert Claus, Dominik Berliner, Udo Bavendiek, Nicolas Vodovar, Ralf Lichtinghagen, Sascha David, Margret Patecki, Jean-Marie Launay, Johann Bauersachs, Hermann Haller, Marcus Hiss, Michael S Balzer. Soluble neprilysin, NT-proBNP, and growth differentiation factor-15 as biomarkers for heart failure in dialysis patients (SONGBIRD).
Clinical research in cardiology : official journal of the German Cardiac Society.
2020 Aug; 109(8):1035-1047. doi:
10.1007/s00392-020-01597-x. [PMID: 32002632] - Manar Mohammed El Tabaa, Maram Mohammed El Tabaa. Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost.
Biochemical pharmacology.
2020 08; 178(?):114057. doi:
10.1016/j.bcp.2020.114057. [PMID: 32470547] - Evgeniya Vaskova, Gentaro Ikeda, Yuko Tada, Christine Wahlquist, Marc Mercola, Phillip C Yang. Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR-181a in a Rodent Chronic Myocardial Infarction Model.
Journal of the American Heart Association.
2020 07; 9(13):e015640. doi:
10.1161/jaha.119.015640. [PMID: 32538237] - Damien Legallois, Clémence Macquaire, Amir Hodzic, Stéphane Allouche, Ismaïl El Khouakhi, Alain Manrique, Paul Milliez, Eric Saloux, Farzin Beygui. Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction.
BMC cardiovascular disorders.
2020 07; 20(1):316. doi:
10.1186/s12872-020-01578-y. [PMID: 32615924] - Dimitrios Kouroupis, Annie C Bowles, Thomas M Best, Lee D Kaplan, Diego Correa. CD10/Neprilysin Enrichment in Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells Under Regulatory-Compliant Conditions: Implications for Efficient Synovitis and Fat Pad Fibrosis Reversal.
The American journal of sports medicine.
2020 07; 48(8):2013-2027. doi:
10.1177/0363546520917699. [PMID: 32427493] - Domenico Acanfora, Marco Matteo Ciccone, Pietro Scicchitano, Chiara Acanfora, Gerardo Casucci. Neprilysin inhibitor-angiotensin II receptor blocker combination (sacubitril/valsartan): rationale for adoption in SARS-CoV-2 patients.
European heart journal. Cardiovascular pharmacotherapy.
2020 07; 6(3):135-136. doi:
10.1093/ehjcvp/pvaa028. [PMID: 32282032] - Domenico Acanfora, Marco Matteo Ciccone, Pietro Scicchitano, Chiara Acanfora, Gerardo Casucci. Sacubitril/valsartan in COVID-19 patients: the need for trials.
European heart journal. Cardiovascular pharmacotherapy.
2020 07; 6(4):253-254. doi:
10.1093/ehjcvp/pvaa044. [PMID: 32369103] - Beril Kadıoğlu Yaman, Özge Çevik, Kübra Yalman, Büşra Ertaş, Ali Şen, Göksel Şener. Myrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats.
Gene.
2020 Jun; 744(?):144616. doi:
10.1016/j.gene.2020.144616. [PMID: 32222531] - Mai Kanuka, Fuka Ouchi, Nagisa Kato, Riko Katsuki, Saori Ito, Kohta Miura, Masaki Hikida, Taku Tamura. Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant.
International journal of molecular sciences.
2020 Jun; 21(12):. doi:
10.3390/ijms21124237. [PMID: 32545905] - Suriya Prausmüller, Henrike Arfsten, Georg Spinka, Claudia Freitag, Philipp E Bartko, Georg Goliasch, Guido Strunk, Noemi Pavo, Martin Hülsmann. Plasma Neprilysin Displays No Relevant Association With Neurohumoral Activation in Chronic HFrEF.
Journal of the American Heart Association.
2020 06; 9(11):e015071. doi:
10.1161/jaha.119.015071. [PMID: 32427034] - Rolf Wachter, Sanjiv J Shah, Martin R Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske. Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial.
ESC heart failure.
2020 06; 7(3):856-864. doi:
10.1002/ehf2.12694. [PMID: 32297449] - Muhammad Imran Khan, Jin Hyuk Shin, Min Yong Kim, Tai Sun Shin, Jong Deog Kim. Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Aβ Peptide Levels in SweAPP N2a Cells.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102334. [PMID: 32429462] - Marcin Książczyk, Małgorzata Lelonek. Angiotensin receptor/neprilysin inhibitor-a breakthrough in chronic heart failure therapy: summary of subanalysis on PARADIGM-HF trial findings.
Heart failure reviews.
2020 05; 25(3):393-402. doi:
10.1007/s10741-019-09879-x. [PMID: 31713710] - Yuan Zhao, Hong Chen, Yan Xie, Chuanhong Zhang, Yirui Hou, Mulan Jin. Clinicopathologic features and prognostic factors in patients with renal cell carcinoma with sarcomatoid differentiation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2020 May; 128(5):378-386. doi:
10.1111/apm.13035. [PMID: 32048364] - Brandon R Goblirsch, Edward E Pryor, Michael C Wiener. The tripartite architecture of the eukaryotic integral membrane protein zinc metalloprotease Ste24.
Proteins.
2020 04; 88(4):604-615. doi:
10.1002/prot.25841. [PMID: 31644822] - Elena Revuelta-López, Julio Núñez, Paloma Gastelurrutia, Germán Cediel, James L Januzzi, Nasrien E Ibrahim, Michele Emdin, Roland VanKimmenade, Domingo Pascual-Figal, Eduardo Núñez, Frank Gommans, Josep Lupón, Antoni Bayés-Genís. Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study.
ESC heart failure.
2020 04; 7(2):559-566. doi:
10.1002/ehf2.12607. [PMID: 32045114] - Richard Haynes, Doreen Zhu, Parminder K Judge, William G Herrington, Philip A Kalra, Colin Baigent. Chronic kidney disease, heart failure and neprilysin inhibition.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 04; 35(4):558-564. doi:
10.1093/ndt/gfz058. [PMID: 31028383] - Abd AlRahman Mohammad Foda, Samia Rafi, Nadeem Ikram, Mariya Syed Alam, Sana Ayesha. Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis.
Pathology oncology research : POR.
2020 Apr; 26(2):1313-1318. doi:
10.1007/s12253-019-00704-2. [PMID: 31372897] - Estrellita Uijl, Daan C 't Hart, Lodi C W Roksnoer, Marian C Clahsen-van Groningen, Richard van Veghel, Ingrid M Garrelds, René de Vries, Johan van der Vlag, Robert Zietse, Tom Nijenhuis, Jaap A Joles, Ewout J Hoorn, A H Jan Danser. Angiotensin-neprilysin inhibition confers renoprotection in rats with diabetes and hypertension by limiting podocyte injury.
Journal of hypertension.
2020 04; 38(4):755-764. doi:
10.1097/hjh.0000000000002326. [PMID: 31790054] - Xiaogen Chen, Chunna Jin, Lan Xie, Meixiang Xiang. LCZ696 and preservation of renal function in heart failure: A meta-analysis of 6 randomized trials.
Reviews in cardiovascular medicine.
2020 Mar; 21(1):113-118. doi:
10.31083/j.rcm.2020.01.2. [PMID: 32259909] - Fu-Chih Hsiao, Chun-Li Wang, Po-Cheng Chang, Yu-Ying Lu, Chien-Ying Huang, Pao-Hsien Chu. Angiotensin Receptor Neprilysin Inhibitor for Patients With Heart Failure and Reduced Ejection Fraction: Real-World Experience From Taiwan.
Journal of cardiovascular pharmacology and therapeutics.
2020 03; 25(2):152-157. doi:
10.1177/1074248419872958. [PMID: 31514513] - Laale F Alawi, Sana E Emberesh, Brenda A Owuor, Harshita Chodavarapu, Rucha Fadnavis, Salim S El-Amouri, Khalid M Elased. Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice.
Physiological reports.
2020 02; 8(3):e14364. doi:
10.14814/phy2.14364. [PMID: 32026607] - Runali Sankhe, Manas Kinra, Jayesh Mudgal, Devinder Arora, Madhavan Nampoothiri. Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury.
Toxicology mechanisms and methods.
2020 Feb; 30(2):88-99. doi:
10.1080/15376516.2019.1669246. [PMID: 31532266] - Pierre Ronco, Hanna Debiec. Molecular Pathogenesis of Membranous Nephropathy.
Annual review of pathology.
2020 01; 15(?):287-313. doi:
10.1146/annurev-pathol-020117-043811. [PMID: 31622560] - Mysuru Natarajan Savitha, Kanve Nagaraj Suvilesh, Jalahalli Mariswamy Siddesha, M D Milan Gowda, Manisha Choudhury, Devadasan Velmurugan, Muddegowda Umashankar, Bannikuppe Sannanaik Vishwanath. Combinatorial inhibition of Angiotensin converting enzyme, Neutral endopeptidase and Aminopeptidase N by N-methylated peptides alleviates blood pressure and fibrosis in rat model of dexamethasone-induced hypertension.
Peptides.
2020 01; 123(?):170180. doi:
10.1016/j.peptides.2019.170180. [PMID: 31715212] - Faleh Alqahtani, Mohamed Mohany, Abdullah F Alasmari, Ahmed Z Alanazi, Osamah M Belali, Mohammed M Ahmed, Salim S Al-Rejaie. Angiotensin II receptor Neprilysin inhibitor (LCZ696) compared to Valsartan attenuates Hepatotoxicity in STZ-induced hyperglycemic rats.
International journal of medical sciences.
2020; 17(18):3098-3106. doi:
10.7150/ijms.49373. [PMID: 33173431] - Kumaresan Ramanathan, Giri Padmanabhan. Soluble neprilysin: A versatile biomarker for heart failure, cardiovascular diseases and diabetic complications-A systematic review.
Indian heart journal.
2020 Jan; 72(1):14-19. doi:
10.1016/j.ihj.2020.01.006. [PMID: 32423555]
