All-trans 4-Keto Retinoic Acid (BioDeep_00000174425)

   

human metabolite blood metabolite


代谢物信息卡片


3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

化学式: C20H26O3 (314.1881846)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C=CC1=C(C)C(=O)CCC1(C)C)=CC=CC(C)=CC(O)=O
InChI: InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)

描述信息

同义名列表

4 个代谢物同义名

3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate; all-trans 4-Keto Retinoic Acid; all-trans 4-Keto retinoate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • F Grønhøj Larsen, P Jakobsen, C Grønhøj Larsen, M Heidenheim, E Held, F Nielsen-Kudsk. The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. The British journal of dermatology. 2009 Sep; 161(3):664-70. doi: 10.1111/j.1365-2133.2009.09241.x. [PMID: 19563582]
  • Olivier Sorg, Christian Tran, Pierre Carraux, Denise Grand, Christelle Barraclough, Jean-François Arrighi, Patrick Descombes, Vincent Piguet, Jean-Hilaire Saurat. Metabolism and biological activities of topical 4-oxoretinoids in mouse skin. The Journal of investigative dermatology. 2008 Apr; 128(4):999-1008. doi: 10.1038/sj.jid.5701106. [PMID: 17943179]
  • Thomas E Gundersen, Nasser E Bastani, Rune Blomhoff. Quantitative high-throughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2007; 21(7):1176-86. doi: 10.1002/rcm.2946. [PMID: 17330217]
  • Sherry A Ferguson, Paul H Siitonen, F Javier Cisneros, Bobby Gough, John F Young. Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats. Basic & clinical pharmacology & toxicology. 2006 Jun; 98(6):582-7. doi: 10.1111/j.1742-7843.2006.pto_359.x. [PMID: 16700821]
  • Ralph Rühl. Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(16):2497-504. doi: 10.1002/rcm.2621. [PMID: 16862622]
  • Virginie E Bérubé, Monique H Boily, Chistian DeBlois, Nathalie Dassylva, Philip A Spear. Plasma retinoid profile in bullfrogs, Rana catesbeiana, in relation to agricultural intensity of sub-watersheds in the Yamaska River drainage basin, Québec, Canada. Aquatic toxicology (Amsterdam, Netherlands). 2005 Jan; 71(2):109-20. doi: 10.1016/j.aquatox.2004.10.018. [PMID: 15642636]
  • Ralph Rühl, Florian J Schweigert. Automated solid-phase extraction and liquid chromatographic method for retinoid determination in biological samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Dec; 798(2):309-16. doi: 10.1016/j.jchromb.2003.10.001. [PMID: 14643511]
  • M Berggren Söderlund, G Fex, P Nilsson-Ehle. Decreasing serum concentrations of all-trans, 13-cis retinoic acids and retinol during fasting and caloric restriction. Journal of internal medicine. 2003 Mar; 253(3):375-80. doi: 10.1046/j.1365-2796.2003.01114.x. [PMID: 12603506]
  • Carsten K Schmidt, Jutta Volland, Gerd Hamscher, Heinz Nau. Characterization of a new endogenous vitamin A metabolite. Biochimica et biophysica acta. 2002 Jul; 1583(2):237-51. doi: 10.1016/s1388-1981(02)00212-3. [PMID: 12117568]
  • James V Chithalen, Luong Luu, Martin Petkovich, Glenville Jones. HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A. Journal of lipid research. 2002 Jul; 43(7):1133-42. doi: 10.1194/jlr.m100343-jlr200. [PMID: 12091498]
  • Xiaojia Guo, Beatrice S Knudsen, Donna M Peehl, Alberto Ruiz, Dean Bok, Robert R Rando, Johng S Rhim, David M Nanus, Lorraine J Gudas. Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer research. 2002 Mar; 62(6):1654-61. doi: . [PMID: 11912136]
  • X Guo, D M Nanus, A Ruiz, R R Rando, D Bok, L J Gudas. Reduced levels of retinyl esters and vitamin A in human renal cancers. Cancer research. 2001 Mar; 61(6):2774-81. doi: NULL. [PMID: 11289161]
  • C Liu, R M Russell, H K Seitz, X D Wang. Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1. Gastroenterology. 2001 Jan; 120(1):179-89. doi: 10.1053/gast.2001.20877. [PMID: 11208727]
  • C Eckhoff, H Nau. Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma. Journal of lipid research. 1990 Aug; 31(8):1445-54. doi: NULL. [PMID: 2280185]
  • W L Davis, L A Crawford, O J Cooper, G R Farmer, D Thomas, B L Freeman. Generation of radical oxygen species by neural crest cells treated in vitro with isotretinoin and 4-oxo-isotretinoin. Journal of craniofacial genetics and developmental biology. 1990; 10(3):295-310. doi: NULL. [PMID: 2175753]