1-[(2R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-2-pyrimidinone (BioDeep_00000174366)
human metabolite blood metabolite
代谢物信息卡片
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
化学式: C9H12N2O5 (228.07461819999997)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 57.14%
分子结构信息
SMILES: C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rajat Pant, Shaheen Wasil Kabeer, Shivam Sharma, Vinod Kumar, Debarun Patra, Durba Pal, Kulbhushan Tikoo. Pharmacological inhibition of DNMT1 restores macrophage autophagy and M2 polarization in western diet-induced Nonalcoholic fatty liver disease.
The Journal of biological chemistry.
2023 May; ?(?):104779. doi:
10.1016/j.jbc.2023.104779. [PMID: 37142224] - Junhua Kong, Virginie Garcia, Enric Zehraoui, Linda Stammitti, Ghislaine Hilbert, Christel Renaud, Stéphane Maury, Alain Delaunay, Stéphanie Cluzet, Fatma Lecourieux, David Lecourieux, Emeline Teyssier, Philippe Gallusci. Zebularine, a DNA Methylation Inhibitor, Activates Anthocyanin Accumulation in Grapevine Cells.
Genes.
2022 07; 13(7):. doi:
10.3390/genes13071256. [PMID: 35886036] - Klara Prochazkova, Andreas Finke, Eva Dvořák Tomaštíková, Jaroslav Filo, Heinrich Bente, Petr Dvořák, Miroslav Ovečka, Jozef Šamaj, Ales Pecinka. Zebularine induces enzymatic DNA-protein crosslinks in 45S rDNA heterochromatin of Arabidopsis nuclei.
Nucleic acids research.
2022 01; 50(1):244-258. doi:
10.1093/nar/gkab1218. [PMID: 34904670] - David Roquis, Marta Robertson, Liang Yu, Michael Thieme, Magdalena Julkowska, Etienne Bucher. Genomic impact of stress-induced transposable element mobility in Arabidopsis.
Nucleic acids research.
2021 10; 49(18):10431-10447. doi:
10.1093/nar/gkab828. [PMID: 34551439] - Klára Konečná, Pavla Polanská Sováková, Karin Anteková, Jiří Fajkus, Miloslava Fojtová. Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure.
International journal of molecular sciences.
2021 Jan; 22(1):. doi:
10.3390/ijms22010468. [PMID: 33466545] - Patwira Boonjing, Yukari Masuta, Kosuke Nozawa, Atsushi Kato, Hidetaka Ito. The effect of zebularine on the heat-activated retrotransposon ONSEN in Arabidopsis thaliana and Vigna angularis.
Genes & genetic systems.
2020 Oct; 95(4):165-172. doi:
10.1266/ggs.19-00046. [PMID: 32741853] - Anna Nowicka, Barbara Tokarz, Jana Zwyrtková, Eva Dvořák Tomaštíková, Klára Procházková, Ugur Ercan, Andreas Finke, Wilfried Rozhon, Brigitte Poppenberger, Miroslav Otmar, Igor Niezgodzki, Marcela Krečmerová, Ingo Schubert, Ales Pecinka. Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
The Plant journal : for cell and molecular biology.
2020 04; 102(1):68-84. doi:
10.1111/tpj.14612. [PMID: 31733119] - Michael L Hayes, Paola I Santibanez. A plant pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editing in vitro.
The Journal of biological chemistry.
2020 03; 295(11):3497-3505. doi:
10.1074/jbc.ra119.011790. [PMID: 31996373] - Pavla Polanská Sováková, Alžbeta Magdolenová, Klára Konečná, Veronika Rájecká, Jiří Fajkus, Miloslava Fojtová. Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis.
Plant molecular biology.
2018 Sep; 98(1-2):81-99. doi:
10.1007/s11103-018-0765-2. [PMID: 30128721] - E Jean Finnegan, Brett Ford, Xiaomei Wallace, Filomena Pettolino, Patrick T Griffin, Robert J Schmitz, Peng Zhang, Jose M Barrero, Matthew J Hayden, Scott A Boden, Colin A Cavanagh, Steve M Swain, Ben Trevaskis. Zebularine treatment is associated with deletion of FT-B1 leading to an increase in spikelet number in bread wheat.
Plant, cell & environment.
2018 06; 41(6):1346-1360. doi:
10.1111/pce.13164. [PMID: 29430678] - Patrick T Griffin, Chad E Niederhuth, Robert J Schmitz. A Comparative Analysis of 5-Azacytidine- and Zebularine-Induced DNA Demethylation.
G3 (Bethesda, Md.).
2016 09; 6(9):2773-80. doi:
10.1534/g3.116.030262. [PMID: 27402357] - Xuhui Ma, Qing Wang, Yanzhi Wang, Jieyun Ma, Nan Wu, Shuang Ni, Tengxiao Luo, Lifang Zhuang, Chenggen Chu, Seong-Woo Cho, Hisashi Tsujimoto, Zengjun Qi. Chromosome aberrations induced by zebularine in triticale.
Genome.
2016 Jul; 59(7):485-92. doi:
10.1139/gen-2016-0047. [PMID: 27334255] - Xiaoyan Jia, Bidisha Chanda, Mingzhe Zhao, Amy M Brunner, Eric P Beers. Instability of the Arabidopsis mutant csn5a-2 caused by epigenetic modification of intronic T-DNA.
Plant science : an international journal of experimental plant biology.
2015 Sep; 238(?):53-63. doi:
10.1016/j.plantsci.2015.05.015. [PMID: 26259174] - Chun-Hsin Liu, Andreas Finke, Mariana Díaz, Wilfried Rozhon, Brigitte Poppenberger, Tuncay Baubec, Ales Pecinka. Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
The Plant cell.
2015 Jun; 27(6):1788-800. doi:
10.1105/tpc.114.135467. [PMID: 26023162] - Sukhwinder S Aulakh, Richard E Veilleux, Guozhu Tang, Barry S Flinn. Characterization of a potato activation-tagged mutant, nikku, and its partial revertant.
Planta.
2015 Jun; 241(6):1481-95. doi:
10.1007/s00425-015-2272-x. [PMID: 25772042] - Mahmoud W Yaish, Mingsheng Peng, Steven J Rothstein. Global DNA methylation analysis using methyl-sensitive amplification polymorphism (MSAP).
Methods in molecular biology (Clifton, N.J.).
2014; 1062(?):285-98. doi:
10.1007/978-1-62703-580-4_16. [PMID: 24057373] - Eva Majerová, Miloslava Fojtová, Iva Mozgová, Miroslava Bittová, Jiří Fajkus. Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells.
Plant molecular biology.
2011 Nov; 77(4-5):371-80. doi:
10.1007/s11103-011-9816-7. [PMID: 21866390] - Esther M E van Straten, Vincent W Bloks, Nicolette C A Huijkman, Julius F W Baller, Hester van Meer, Dieter Lütjohann, Folkert Kuipers, Torsten Plösch. The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Feb; 298(2):R275-82. doi:
10.1152/ajpregu.00413.2009. [PMID: 19889862] - Tuncay Baubec, Ales Pecinka, Wilfried Rozhon, Ortrun Mittelsten Scheid. Effective, homogeneous and transient interference with cytosine methylation in plant genomic DNA by zebularine.
The Plant journal : for cell and molecular biology.
2009 Feb; 57(3):542-54. doi:
10.1111/j.1365-313x.2008.03699.x. [PMID: 18826433]