4-Anilinoquinazoline (BioDeep_00000174344)
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H11N3 (221.0953)
中文名称: 4-苯氨基喹唑啉, 4-苯胺基喹唑啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)NC2=NC=NC3=CC=CC=C32
InChI: InChI=1S/C14H11N3/c1-2-6-11(7-3-1)17-14-12-8-4-5-9-13(12)15-10-16-14/h1-10H,(H,15,16,17)
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 324081
- HMDB: HMDB0246372
- ChEMBL: CHEMBL289959
- chemspider: 287031
- CAS: 34923-95-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Dong Cao, Xiaoyan Wang, Lei Lei, Liang Ma, Zhuang Yang, Fang Wang, Lijuan Chen. Synthesis and Biological Evaluation of Novel Substituted 4-Anilinoquinazolines as Antitumor Agents.
Chemical biology & drug design.
2020 10; 96(4):1084-1094. doi:
10.1111/cbdd.12706. [PMID: 26691926] - Yujia Xu, Kun Zeng, Xiaoge Wang, Jieyu Zhang, Biyin Cao, Zubin Zhang, Chunhua Qiao, Xiaofeng Xu, Qi Wang, Yuanying Zeng, Xinliang Mao. Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway.
Bioscience trends.
2020 May; 14(2):96-103. doi:
10.5582/bst.2019.01302. [PMID: 32173687] - Huiqiang Wei, Yuqing Duan, Wenfeng Gou, Jie Cui, Hongxin Ning, Deguan Li, Yong Qin, Qiang Liu, Yiliang Li. Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.
European journal of medicinal chemistry.
2019 Nov; 181(?):111552. doi:
10.1016/j.ejmech.2019.07.055. [PMID: 31387063] - Annalisa Bianco, Veronica Reghellin, Lorena Donnici, Simone Fenu, Reinaldo Alvarez, Chiara Baruffa, Francesco Peri, Massimiliano Pagani, Sergio Abrignani, Petra Neddermann, Raffaele De Francesco. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
PLoS pathogens.
2012; 8(3):e1002576. doi:
10.1371/journal.ppat.1002576. [PMID: 22412376] - Shun-Chieh Yang, Su-Sen Chang, Hsin-Yi Chen, Calvin Yu-Chian Chen. Identification of potent EGFR inhibitors from TCM Database@Taiwan.
PLoS computational biology.
2011 Oct; 7(10):e1002189. doi:
10.1371/journal.pcbi.1002189. [PMID: 22022246] - Christopher Dardick, Pamela Ronald. Plant and animal pathogen recognition receptors signal through non-RD kinases.
PLoS pathogens.
2006 Jan; 2(1):e2. doi:
10.1371/journal.ppat.0020002. [PMID: 16424920] - Silvana Aparecida Rocco, Jesus Antonio Velho, Rodrigo Miguel Marin, Luís de Arruda Rolim Filho, Anibal Eugênio Vercesi, Roberto Rittner, Kleber Gomes Franchini. High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Mar; 817(2):297-302. doi:
10.1016/j.jchromb.2004.12.021. [PMID: 15686998] - Emiliano Calvo, Anthony W Tolcher, Lisa A Hammond, Amita Patnaik, Johan S de Bono, Irene A Eiseman, Stephen C Olson, Peter F Lenehan, Heather McCreery, Patricia Lorusso, Eric K Rowinsky. Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Nov; 10(21):7112-20. doi:
10.1158/1078-0432.ccr-04-1187. [PMID: 15534081] - Stephanie L Matheson, James P McNamee, Bertrand J Jean-Claude. Differential responses of EGFR-/AGT-expressing cells to the 'combi-triazene' SMA41.
Cancer chemotherapy and pharmacology.
2003 Jan; 51(1):11-20. doi:
10.1007/s00280-002-0525-4. [PMID: 12497201]
