4-Aminobenzamidine (BioDeep_00000174328)
human metabolite blood metabolite
代谢物信息卡片
化学式: C7H9N3 (135.0796434)
中文名称: 4-氨基苯甲脒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C(=N)N)N
InChI: InChI=1S/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 1725
- HMDB: HMDB0246353
- ChEMBL: CHEMBL124632
- chemspider: 1662
- CAS: 1185995-47-4
- CAS: 1329499-33-3
- CAS: 3858-83-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - N Pozzi, L Acquasaliente, R Frasson, A Cristiani, S Moro, A Banzato, V Pengo, G L Scaglione, A Arcovito, R De Cristofaro, V De Filippis. β2 -Glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions.
Journal of thrombosis and haemostasis : JTH.
2013 Jun; 11(6):1093-102. doi:
10.1111/jth.12238
. [PMID: 23578283] - Gulay Bayramoglu, M Yakup Arica. Development of a sensitive method for selection of affinity ligand for trypsin using quartz crystal microbalance sensor.
Bioprocess and biosystems engineering.
2012 Mar; 35(3):423-31. doi:
10.1007/s00449-011-0581-4
. [PMID: 21853329] - Ian P Lewkowich, Scottie B Day, John R Ledford, Ping Zhou, Krista Dienger, Marsha Wills-Karp, Kristen Page. Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation.
Respiratory research.
2011 Sep; 12(?):122. doi:
10.1186/1465-9921-12-122
. [PMID: 21936897] - Ya-Chi Su, Tara N Miller, Duraiswamy Navaneetham, Robert T Schoonmaker, Dipali Sinha, Peter N Walsh. The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2.
The Journal of biological chemistry.
2011 Sep; 286(36):31904-14. doi:
10.1074/jbc.m111.257527
. [PMID: 21778227] - Chung-Yang Kao, Chia-Ni Lin, Yung-Li Yang, Nobuko Hamaguchi, Shu-Jhu Yang, Ming-Ching Shen, Jau-Tsuen Kao, Shu-Wha Lin. Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B.
Thrombosis and haemostasis.
2011 Apr; 105(4):616-26. doi:
10.1160/th10-11-0762
. [PMID: 21301787] - Xue-Qing Wang, Lan Chen, Rong Pan, Jing Zhao, Ying Liu, Rong-Qiao He. An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells.
BMC biochemistry.
2008 Nov; 9(?):30. doi:
10.1186/1471-2091-9-30
. [PMID: 19025649] - D Gailani, A Schmidt, M-F Sun, P H Bolton-Maggs, S P Bajaj. A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect.
Journal of thrombosis and haemostasis : JTH.
2007 Apr; 5(4):781-7. doi:
10.1111/j.1538-7836.2007.02390.x
. [PMID: 17229051] - Ruijun Tian, Xinning Jiang, Xin Li, Xiaogang Jiang, Shun Feng, Songyun Xu, Guanghui Han, Mingliang Ye, Hanfa Zou. Biological fingerprinting analysis of the interactome of a kinase inhibitor in human plasma by a chemiproteomic approach.
Journal of chromatography. A.
2006 Nov; 1134(1-2):134-42. doi:
10.1016/j.chroma.2006.08.097
. [PMID: 16982065] - Vibha Bansal, Pradip K Roychoudhury, Bo Mattiasson, Ashok Kumar. Recovery of urokinase from integrated mammalian cell culture cryogel bioreactor and purification of the enzyme using p-aminobenzamidine affinity chromatography.
Journal of molecular recognition : JMR.
2006 Jul; 19(4):332-9. doi:
10.1002/jmr.785
. [PMID: 16761300] - R Federico, L Leone, M Botta, C Binda, R Angelini, G Venturini, P Ascenzi. Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
Journal of enzyme inhibition.
2001; 16(2):147-55. doi:
10.1080/14756360109162364
. [PMID: 11342283] - M O Sousa, T L Miranda, E B Costa, E R Bittar, M M Santoro, A F Figueiredo. Linear competitive inhibition of human tissue kallikrein by 4-aminobenzamidine and benzamidine and linear mixed inhibition by 4-nitroaniline and aniline.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2001 Jan; 34(1):35-44. doi:
10.1590/s0100-879x2001000100004
. [PMID: 11151026] - D Wang, T J Girard, T P Kasten, R M LaChance, M A Miller-Wideman, R C Durley. Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
Journal of natural products.
1998 Nov; 61(11):1352-5. doi:
10.1021/np980117p
. [PMID: 9834151] - L Ercolini, R Angelini, R Federico, G Rea, G Venturini, P Ascenzi. Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.
Journal of enzyme inhibition.
1998 Sep; 13(6):465-71. doi:
10.3109/14756369809020550
. [PMID: 9825309] - C Festuccia, F Guerra, S D'Ascenzo, D Giunciuglio, A Albini, M Bologna. In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin.
International journal of cancer.
1998 Jan; 75(3):418-31. doi:
10.1002/(sici)1097-0215(19980130)75:3<418::aid-ijc16>3.0.co;2-4
. [PMID: 9455804] - A Mathur, D Zhong, A K Sabharwal, K J Smith, S P Bajaj. Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X.
The Journal of biological chemistry.
1997 Sep; 272(37):23418-26. doi:
10.1074/jbc.272.37.23418
. [PMID: 9287357] - S W Lin, C N Lin, N Hamaguchi, K J Smith, M C Shen. Characterization of a factor IX variant with a glycine207 to glutamic acid mutation.
Blood.
1994 Sep; 84(6):1866-73. doi:
NULL
. [PMID: 7915915] - H Nishimura, H Takeya, T Miyata, K Suehiro, T Okamura, Y Niho, S Iwanaga. Factor IX Fukuoka. Substitution of ASN92 by His in the second epidermal growth factor-like domain results in defective interaction with factors VIIa/X.
The Journal of biological chemistry.
1993 Nov; 268(32):24041-6. doi:
10.1016/s0021-9258(20)80489-x
. [PMID: 8226948] - M Veijola, H Rajaniemi. Luteinising hormones activate a factor(s) in testicular interstitial fluid which increases testicular vascular permeability.
Molecular and cellular endocrinology.
1986 May; 45(2-3):113-8. doi:
10.1016/0303-7207(86)90138-3
. [PMID: 3709960] - D B Muchmore, B U Raess, R W Bergstrom, C de Haën. On the mechanisms of inhibition of insulin action by small-molecular-weight trypsin inhibitors.
Diabetes.
1982 Nov; 31(11):976-84. doi:
10.2337/diacare.31.11.976
. [PMID: 6757016]