2',3-Dimethyl-4-aminobiphenyl (BioDeep_00000174322)

   

human metabolite blood metabolite


代谢物信息卡片


2,3-Dimethyl-4-aminobiphenyl hydrochloride

化学式: C14H15N (197.120443)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 85.9%

分子结构信息

SMILES: CC1=CC=CC=C1C1=CC(C)=C(N)C=C1
InChI: InChI=1S/C14H15N/c1-10-5-3-4-6-13(10)12-7-8-14(15)11(2)9-12/h3-9H,15H2,1-2H3

描述信息

D009676 - Noxae > D002273 - Carcinogens

同义名列表

4 个代谢物同义名

2,3-Dimethyl-4-aminobiphenyl hydrochloride; 2,3-dimethyl-[1,1-biphenyl]-4-amine; 3,2-Dimethyl-4-aminobiphenyl; 2,3-Dimethyl-4-aminobiphenyl



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wei Guo, Xia Wu, Yi Li, Jixue Gao, Feng Wang, Yongsheng Jin, Tie Chong, Anshoo Malhotra. Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer. Journal of drug targeting. 2020 01; 28(1):41-45. doi: 10.1080/1061186x.2019.1601199. [PMID: 30943812]
  • Laiyuan Zhao, Mitsuru Futakuchi, Shugo Suzuki, Yoshiaki Ohhara, Takashi Hashimoto, Tatsuya Suzuki, Tadao Manabe, Tomoyuki Shirai. Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Clinical & experimental metastasis. 2005; 22(4):309-18. doi: 10.1007/s10585-005-0054-8. [PMID: 16170667]
  • T Mori, K Imaida, S Tamano, M Sano, S Takahashi, M Asamoto, M Takeshita, H Ueda, T Shirai. Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl. Japanese journal of cancer research : Gann. 2001 Oct; 92(10):1026-33. doi: 10.1111/j.1349-7006.2001.tb01056.x. [PMID: 11676852]
  • Y Feng, J W Finley, C D Davis, W K Becker, A J Fretland, D W Hein. Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl. Toxicology and applied pharmacology. 1999 May; 157(1):36-42. doi: 10.1006/taap.1999.8623. [PMID: 10329505]
  • C D Davis, Y Feng. Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl. The Journal of nutrition. 1999 May; 129(5):1060-7. doi: 10.1093/jn/129.5.1060. [PMID: 10222400]
  • C D Davis, Y Feng, D W Hein, J W Finley. The chemical form of selenium influences 3,2'-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon. The Journal of nutrition. 1999 Jan; 129(1):63-9. doi: 10.1093/jn/129.1.63. [PMID: 9915877]
  • S Imaoka, Y Yoneda, T Matsuda, M Degawa, S Fukushima, Y Funae. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Biochemical pharmacology. 1997 Sep; 54(6):677-83. doi: 10.1016/s0006-2952(97)00216-5. [PMID: 9310344]
  • T Shirai, S Tamano, M Sano, K Imaida, A Hagiwara, M Futakuchi, S Takahashi, M Hirose. Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2'-dimethyl-4-aminobiphenyl: dose-dependent induction of invasive carcinomas. Japanese journal of cancer research : Gann. 1995 Jul; 86(7):645-8. doi: 10.1111/j.1349-7006.1995.tb02447.x. [PMID: 7559081]
  • T Shirai, S Iwasaki, T Masui, T Mori, T Kato, N Ito. Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl. Japanese journal of cancer research : Gann. 1993 Oct; 84(10):1023-30. doi: 10.1111/j.1349-7006.1993.tb02796.x. [PMID: 7693634]
  • T Suzuki, Y Tamura, Y Takezawa, T Mashimo, K Imai, H Yuasa, H Yamanaka, T Shirai. Ultrasonic diagnosis of 3,2'-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats. The Prostate. 1993; 22(3):235-41. doi: 10.1002/pros.2990220306. [PMID: 8488156]
  • Y Tagawa, K Ozaki, S Takahashi, K Ogawa, T Shirai. Lack of effects of post-initiation cholesterol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis. The Prostate. 1992; 20(3):179-85. doi: 10.1002/pros.2990200303. [PMID: 1574465]
  • M Hirose, K Ozaki, K Takaba, S Fukushima, T Shirai, N Ito. Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis. 1991 Oct; 12(10):1917-21. doi: 10.1093/carcin/12.10.1917. [PMID: 1657429]
  • A Nakamura, T Shirai, K Ogawa, S Wada, N A Fujimoto, A Ito, N Ito. Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis. Cancer letters. 1990 Sep; 53(2-3):151-7. doi: 10.1016/0304-3835(90)90208-f. [PMID: 2208075]
  • M C Bosland, M K Prinsen, T J Dirksen, B J Spit. Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate. Cancer research. 1990 Feb; 50(3):700-9. doi: NULL. [PMID: 2105161]
  • N Ito, M Hirose, M Shibata, H Tanaka, T Shirai. Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea. Carcinogenesis. 1989 Dec; 10(12):2255-9. doi: 10.1093/carcin/10.12.2255. [PMID: 2591015]
  • M Fouarge, M Mercier, F Poncelet. Liver, kidney and small-intestine microsomal-mediated mutagenicity of carcinogenic aromatic amines. Mutation research. 1984 Jan; 125(1):23-31. doi: 10.1016/0027-5107(84)90028-9. [PMID: 6361544]
  • B S Reddy, Y Maeura, M Wayman. Effect of dietary corn bran and autohydrolyzed lignin on 3,2'-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in male F344 rats. Journal of the National Cancer Institute. 1983 Aug; 71(2):419-23. doi: NULL. [PMID: 6308324]
  • M Nussbaum, E S Fiala, B Kulkarni, K El-Bayoumy, J H Weisburger. In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat. Environmental health perspectives. 1983 Mar; 49(?):223-31. doi: 10.1289/ehp.8349223. [PMID: 6682032]
  • M Fouarge, M Mercier, F Poncelet. Mutagenicity of three aromatic amines in the presence of fractions from various tissues. Toxicology letters. 1982 May; 11(3-4):313-20. doi: 10.1016/0378-4274(82)90166-7. [PMID: 7048632]