4-Amino-3-phenylbutanoic acid (BioDeep_00000174321)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H13NO2 (179.09462380000002)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 33.33%
分子结构信息
SMILES: C1=CC=C(C=C1)C(CC(=O)O)CN
InChI: InChI=1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
16 个代谢物同义名
4-Amino-3-phenylbutyric acid, (DL)-(+-)-mixture; 4-Amino-3-phenylbutyric acid, (L)-(-)-isomer; 4-Amino-3-phenylbutyric acid hydrochloride; beta-(Aminomethyl)benzenepropanoic acid; beta-(Aminomethyl)hydrocinnamic acid; beta-Phenyl-gamma-aminobutyric acid; 4-Amino-3-phenylbutanoic acid; 4-Amino-3-phenylbutyric acid; 4-Amino-3-phenylbutanoate; Fenibut citrate; Phenyl-gaba; Citrocard; Phenibut; Phenybut; Noophen; Fenibut
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:136039
- PubChem: 14113
- HMDB: HMDB0246346
- DrugBank: DB13455
- ChEMBL: CHEMBL315818
- Wikipedia: Phenibut
- chemspider: 13491
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Sahagian, Alicia Mastrocco, Jennifer Prittie. Phenibut toxicosis in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2023 Jul; 33(4):472-476. doi:
10.1111/vec.13313. [PMID: 37436877] - Bryan VanDreese, Ashley Holland, Andrew Murray. Chronic Phenibut Use: Symptoms, Severe Withdrawal, and Recovery.
WMJ : official publication of the State Medical Society of Wisconsin.
2022 Apr; 121(1):E1-E4. doi:
. [PMID: 35442585] - Einars Kupats, Gundega Stelfa, Baiba Zvejniece, Solveiga Grinberga, Edijs Vavers, Marina Makrecka-Kuka, Baiba Svalbe, Liga Zvejniece, Maija Dambrova. Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury.
Oxidative medicine and cellular longevity.
2020; 2020(?):9364598. doi:
10.1155/2020/9364598. [PMID: 33274011] - Ivan Sergeevich Mokrousov, Valentina Nikolaevna Perfilova, Igor Igorevich Prokofiev, Tamara Alexandrovna Popova, Ekaterina Gennadievna Vodopyanova, Olga Sergeevna Vasil'eva, Ivan Nikolaevich Tyurenkov. Effect of a new cyclic derivative of GABA, RGPU-207, on the functions of cardiac and cerebral mitochondria of stressed animals.
The Journal of pharmacy and pharmacology.
2019 Jul; 71(7):1055-1064. doi:
10.1111/jphp.13086. [PMID: 30864160] - I N Tyurenkov, T A Popova, V N Perfilova, I I Prokofiev, A V Borisov, M V Kustova, G I Zaypullaev, О V Ostrovskij. [Protective effects of a new glutamic acid derivative against stress after nNOS blockade].
Biomeditsinskaia khimiia.
2017 Jan; 63(1):47-55. doi:
10.18097/pbmc2017630147. [PMID: 28251951] - E V Volotova, I S Filina, D A Bakulin, D V Kurkin, I N Tyurenkov. NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY.
Eksperimental'naia i klinicheskaia farmakologiia.
2016 Aug; 79(4):18-25. doi:
NULL. [PMID: 29949699] - Michael A Downes, Ingrid L Berling, Ahmed Mostafa, Jeffrey Grice, Michael S Roberts, Geoffrey K Isbister. Acute behavioural disturbance associated with phenibut purchased via an internet supplier.
Clinical toxicology (Philadelphia, Pa.).
2015; 53(7):636-8. doi:
10.3109/15563650.2015.1059945. [PMID: 26114346] - I N Tyurenkov, V N Perfilova, V I Karamysheva, L B Reznikova, I S Mokrousov, L I Mikhailova, V M Berestovitskaya, O S Vasil'eva. Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.
Bulletin of experimental biology and medicine.
2014 Dec; 158(2):219-21. doi:
10.1007/s10517-014-2726-3. [PMID: 25432276] - I N Tyurenkov, V N Perfi Lova, L B Reznikova, L A Smirnova, A F Ryabukha, E A Suchkov, K A Kuznetsov. GABA derivatives citrocard and salifen reduce the intensity of experimental gestosis.
Bulletin of experimental biology and medicine.
2014 May; 157(1):42-4. doi:
10.1007/s10517-014-2487-z. [PMID: 24913573] - I N Tiurenkov, V N Perfilova, V I Karamysheva, T A Popova, S A Lebedeva, L I Mikhaĭlova, G A Zhakupova. [Gravidaprotective action of phenibut in experimental pre-eclampsia].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(11):6-10. doi:
". [PMID: 25668940] - L A Smirnova, V N Perfilova, I N Tyurenkov, A F Ryabukha, E A Suchkov, S A Lebedeva. Study of the absolute bioavailability of citrocard, a new GABA derivative.
Bulletin of experimental biology and medicine.
2013 Aug; 155(4):458-60. doi:
10.1007/s10517-013-2177-2. [PMID: 24143367] - I N Tyurenkov, V N Perfilova, T A Popova, L B Ivanova, I I Prokofiev, O V Gulyaeva, L I Stepa. Changes in oxidant and antioxidant status of females with experimental gestosis under the effect of GABA derivatives.
Bulletin of experimental biology and medicine.
2013 Jul; 155(3):363-5. doi:
10.1007/s10517-013-2154-9. [PMID: 24137604] - I N Tiurenkov, V N Perfilova, L A Smirnova, A F Riabukha, E A Suchkov, S A Lebedeva. [Hepatoduodenal circulation and excretion of the new GABA derivative citrocard].
Eksperimental'naia i klinicheskaia farmakologiia.
2013; 76(3):38-40. doi:
NULL. [PMID: 23767103] - A V Zhezlova, V G Belolipetskaia, S V Blagodatskikh, E V Merkulova. [Bioequivalence of anvifen and phenibut].
Eksperimental'naia i klinicheskaia farmakologiia.
2011; 74(5):43-4. doi:
NULL. [PMID: 21809698] - M A Samotrueva, M M Magomedov, E B Khlebtsova, I N Tiurenkov. [Influence of GABA derivatives on some indices of lipid peroxidation in immunocompetent organs under experimental immunopathology conditions].
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2011; 74(8):32-6. doi:
". [PMID: 22232912] - Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
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Eksperimental'naia i klinicheskaia farmakologiia.
2003 Jul; 66(4):21-4. doi:
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Eksperimental'naia i klinicheskaia farmakologiia.
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". [PMID: 12025796] - V V Bul'on, I S Zavodskaia, L K Khnychenko. [The effect of neurotropic agents on lipid peroxidation in the heart and stomach with neurogenic lesions].
Eksperimental'naia i klinicheskaia farmakologiia.
1994 May; 57(3):18-20. doi:
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Eksperimental'naia i klinicheskaia farmakologiia.
1992 May; 55(3):70-2. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1990 Nov; 110(11):504-6. doi:
". [PMID: 1964607] - L K Rägo, R A Kiivet, J E Harro, L H Allikmets. Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists.
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1986 Jan; 24(1):1-3. doi:
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