4-Amino-1H-imidazole-2-carboxamide (BioDeep_00000174316)
human metabolite blood metabolite
代谢物信息卡片
4-amino-3H-imidazole-2-carboxamide
化学式: C4H6N4O (126.05415860000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 4.55%
分子结构信息
SMILES: C1=C(NC(=N1)C(=O)N)N
InChI: InChI=1S/C4H6N4O/c5-2-1-7-4(8-2)3(6)9/h1H,5H2,(H2,6,9)(H,7,8)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eun Jeong Lee, Minseok Kang, Yeong Shik Kim. Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice.
Planta medica.
2012 Sep; 78(14):1536-42. doi:
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The Journal of biological chemistry.
2012 Jul; 287(28):23451-63. doi:
10.1074/jbc.m111.331926. [PMID: 22610379] - J Lempiäinen, P Finckenberg, J Levijoki, E Mervaala. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney.
British journal of pharmacology.
2012 Jul; 166(6):1905-15. doi:
10.1111/j.1476-5381.2012.01895.x. [PMID: 22324445] - Bella Kalderon, Narmen Azazmeh, Nili Azulay, Noam Vissler, Michael Valitsky, Jacob Bar-Tana. Suppression of adipose lipolysis by long-chain fatty acid analogs.
Journal of lipid research.
2012 May; 53(5):868-878. doi:
10.1194/jlr.m022673. [PMID: 22338010] - Nanthakumar Subramaniam, Mara H Sherman, Renuka Rao, Caroline Wilson, Sally Coulter, Annette R Atkins, Ronald M Evans, Christopher Liddle, Michael Downes. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.
Cancer prevention research (Philadelphia, Pa.).
2012 Apr; 5(4):553-61. doi:
10.1158/1940-6207.capr-12-0053. [PMID: 22406377] - Mini P Sajan, Sonali Nimal, Stephen Mastorides, Mildred Acevedo-Duncan, C Ronald Kahn, Alan P Fields, Ursula Braun, Michael Leitges, Robert V Farese. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
Metabolism: clinical and experimental.
2012 Apr; 61(4):459-69. doi:
10.1016/j.metabol.2011.12.008. [PMID: 22225955] - Eun-Jeong Jung, Kang-Yo Lee, Byung-Hoon Lee. Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.
The Journal of toxicological sciences.
2012; 37(4):813-21. doi:
10.2131/jts.37.813. [PMID: 22863860] - Seog Hyeon Youn, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Je Ryong Kim, Eil Sung Chang. Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
Biological & pharmaceutical bulletin.
2012; 35(1):105-10. doi:
10.1248/bpb.35.105. [PMID: 22223345] - Juan-Pablo Idrovo, Weng-Lang Yang, Akihisa Matsuda, Jeffrey Nicastro, Gene F Coppa, Ping Wang. Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury.
Shock (Augusta, Ga.).
2012 Jan; 37(1):39-46. doi:
10.1097/shk.0b013e31823185d7. [PMID: 21841537] - John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production.
PloS one.
2012; 7(1):e30712. doi:
10.1371/journal.pone.0030712. [PMID: 22303451] - Andrew J Mulherin, Amy H Oh, Helena Kim, Anthony Grieco, Lina M Lauffer, Patricia L Brubaker. Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell.
Endocrinology.
2011 Dec; 152(12):4610-9. doi:
10.1210/en.2011-1485. [PMID: 21971158] - Mohamed Kodiha, Dennis Ho-Wo-Cheong, Ursula Stochaj. Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology.
American journal of physiology. Cell physiology.
2011 Dec; 301(6):C1307-15. doi:
10.1152/ajpcell.00309.2011. [PMID: 21918180] - Karen S Galea, Laura MacCalman, Kate Jones, John Cocker, Paul Teedon, Anne J Sleeuwenhoek, John W Cherrie, Martie van Tongeren. Biological monitoring of pesticide exposures in residents living near agricultural land.
BMC public health.
2011 Nov; 11(?):856. doi:
10.1186/1471-2458-11-856. [PMID: 22074397] - Mamoru Tanida, Naoki Yamamoto. Central AMP-activated protein kinase affects sympathetic nerve activity in rats.
Neuroscience letters.
2011 Oct; 503(3):167-70. doi:
10.1016/j.neulet.2011.08.013. [PMID: 21893163] - A Michael Tabony, Tadashi Yoshida, Sarah Galvez, Yusuke Higashi, Sergiy Sukhanov, Bysani Chandrasekar, William E Mitch, Patrice Delafontaine. Angiotensin II upregulates protein phosphatase 2Cα and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting.
Hypertension (Dallas, Tex. : 1979).
2011 Oct; 58(4):643-9. doi:
10.1161/hypertensionaha.111.174839. [PMID: 21844485] - Marlies Bosselaar, Paul Smits, Luc J C van Loon, Cees J Tack. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect.
Journal of clinical pharmacology.
2011 Oct; 51(10):1449-58. doi:
10.1177/0091270010382912. [PMID: 21148051] - Eun-Jeong Jung, Sung-Won Kwon, Byung-Hwa Jung, Seon-Hee Oh, Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.
Journal of lipid research.
2011 Sep; 52(9):1617-25. doi:
10.1194/jlr.m015263. [PMID: 21757781] - Mandeep P Gaidhu, Andrea Frontini, Steven Hung, Kathryn Pistor, Saverio Cinti, Rolando B Ceddia. Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity.
Journal of lipid research.
2011 Sep; 52(9):1702-11. doi:
10.1194/jlr.m015354. [PMID: 21737753] - Yanzhuo Ma, Yi Liu, Shaowei Liu, Yan Qu, Rutao Wang, Chenhai Xia, Haifeng Pei, Kun Lian, Tao Yin, Xiaoyan Lu, Lu Sun, Lu Yang, Yanjie Cao, Wayne Bond Lau, Erhe Gao, Haichang Wang, Ling Tao. Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice.
American journal of physiology. Endocrinology and metabolism.
2011 Sep; 301(3):E447-55. doi:
10.1152/ajpendo.00687.2010. [PMID: 21586697] - Su Liu, Yi-Fen Lee, Samuel Chou, Hideo Uno, Gonghui Li, Paul Brookes, Michael P Massett, Qiao Wu, Lu-Min Chen, Chawnshang Chang. Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.
Molecular endocrinology (Baltimore, Md.).
2011 Aug; 25(8):1301-10. doi:
10.1210/me.2010-0455. [PMID: 21622535] - Jean-Baptiste Menassol, Claire Tautou, Armelle Collet, Didier Chesneau, Didier Lomet, Joëlle Dupont, Benoît Malpaux, Rex J Scaramuzzi. The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?.
BMC neuroscience.
2011 Jul; 12(?):76. doi:
10.1186/1471-2202-12-76. [PMID: 21801416] - Russell A Miller, Qingwei Chu, John Le Lay, Philipp E Scherer, Rexford S Ahima, Klaus H Kaestner, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.
The Journal of clinical investigation.
2011 Jun; 121(6):2518-28. doi:
10.1172/jci45942. [PMID: 21606593] - Whitney Sealls, Brent A Penque, Jeffrey S Elmendorf. Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.
Arteriosclerosis, thrombosis, and vascular biology.
2011 May; 31(5):1139-40. doi:
10.1161/atvbaha.110.222158. [PMID: 21311039] - Magali Kitzmann, Louise Lantier, Sophie Hébrard, Jacques Mercier, Marc Foretz, Celine Aguer. Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.
Biochimica et biophysica acta.
2011 Apr; 1812(4):423-30. doi:
10.1016/j.bbadis.2010.12.007. [PMID: 21172433] - Yun Wang, Zeyu Wu, Dan Li, Duan Wang, Xiaoming Wang, Xiang Feng, Min Xia. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.
The Journal of biological chemistry.
2011 Apr; 286(13):11119-31. doi:
10.1074/jbc.m110.203323. [PMID: 21296878] - J Jeppesen, P H Albers, A J Rose, J B Birk, P Schjerling, N Dzamko, G R Steinberg, B Kiens. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.
Journal of lipid research.
2011 Apr; 52(4):699-711. doi:
10.1194/jlr.m007138. [PMID: 21297178] - Jiyoung Yeo, Young-Mi Kang, Su-In Cho, Myeong-Ho Jung. Effects of a multi-herbal extract on type 2 diabetes.
Chinese medicine.
2011 Mar; 6(?):10. doi:
10.1186/1749-8546-6-10. [PMID: 21375727] - Ryota Narishima, Masahiro Yamasaki, Shinya Hasegawa, Saki Yoshida, Shinya Tanaka, Tetsuya Fukui. Leptin controls ketone body utilization in hypothalamic neuron.
Neuroscience letters.
2011 Mar; 490(3):185-90. doi:
10.1016/j.neulet.2010.11.081. [PMID: 21194556] - Rhianna C Laker, Belinda A Henry, Glenn D Wadley, Iain J Clarke, Benedict J Canny, Glenn K McConell. Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Feb; 300(2):R511-8. doi:
10.1152/ajpregu.00079.2010. [PMID: 21148475] - Ioana Alesutan, Michael Föller, Mentor Sopjani, Miribane Dërmaku-Sopjani, Christine Zelenak, Henning Fröhlich, Ana Velic, Scott Fraser, Bruce E Kemp, Guiscard Seebohm, Harald Völkl, Florian Lang. Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase.
Molecular membrane biology.
2011 Feb; 28(2):79-89. doi:
10.3109/09687688.2010.520037. [PMID: 21231794] - George S Karaoglanidis, Anastasios N Markoglou, George A Bardas, Eleftherios G Doukas, Sotiris Konstantinou, John F Kalampokis. Sensitivity of Penicillium expansum field isolates to tebuconazole, iprodione, fludioxonil and cyprodinil and characterization of fitness parameters and patulin production.
International journal of food microbiology.
2011 Jan; 145(1):195-204. doi:
10.1016/j.ijfoodmicro.2010.12.017. [PMID: 21251724] - Celine Aguer, Marc Foretz, Louise Lantier, Sophie Hebrard, Benoit Viollet, Jacques Mercier, Magali Kitzmann. Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients.
PloS one.
2011; 6(12):e28981. doi:
10.1371/journal.pone.0028981. [PMID: 22194967] - N Zhang, Q Z Li, X J Gao, H B Yan. Potential role of adenosine monophosphate-activated protein kinase in regulation of energy metabolism in dairy goat mammary epithelial cells.
Journal of dairy science.
2011 Jan; 94(1):218-22. doi:
10.3168/jds.2010-3386. [PMID: 21183032] - David Hauton. Does long-term metformin treatment increase cardiac lipoprotein lipase?.
Metabolism: clinical and experimental.
2011 Jan; 60(1):32-42. doi:
10.1016/j.metabol.2009.12.015. [PMID: 20153488] - Eugenia Villa-Cuesta, Joan M Boylan, Marc Tatar, Philip A Gruppuso. Resveratrol inhibits protein translation in hepatic cells.
PloS one.
2011; 6(12):e29513. doi:
10.1371/journal.pone.0029513. [PMID: 22242130] - Scott B Rothbart, Alexandra C Racanelli, Richard G Moran. Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.
Cancer research.
2010 Dec; 70(24):10299-309. doi:
10.1158/0008-5472.can-10-1873. [PMID: 21159649] - John C Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V Relling, William E Evans. Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.
PLoS computational biology.
2010 Dec; 6(12):e1001019. doi:
10.1371/journal.pcbi.1001019. [PMID: 21152005] - Joshua C Drake, Stephen E Alway, John M Hollander, David L Williamson. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Dec; 299(6):R1546-54. doi:
10.1152/ajpregu.00337.2010. [PMID: 20844264] - Rodrigo Alzamora, Fan Gong, Christine Rondanino, Jeffrey K Lee, Christy Smolak, Núria M Pastor-Soler, Kenneth R Hallows. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.
American journal of physiology. Renal physiology.
2010 Dec; 299(6):F1308-19. doi:
10.1152/ajprenal.00423.2010. [PMID: 20861072] - Lindsey D Bogachus, Lorraine P Turcotte. Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.
American journal of physiology. Cell physiology.
2010 Dec; 299(6):C1549-61. doi:
10.1152/ajpcell.00279.2010. [PMID: 20844250] - Jennifer Woodard, Sonali Joshi, Benoit Viollet, Nissim Hay, Leonidas C Platanias. AMPK as a therapeutic target in renal cell carcinoma.
Cancer biology & therapy.
2010 Dec; 10(11):1168-77. doi:
10.4161/cbt.10.11.13629. [PMID: 20948309] - Abraham Schneider, Ronald B Gartenhaus. AMPK signaling: a targetable tumor suppressor pathway?.
Cancer biology & therapy.
2010 Dec; 10(11):1178-81. doi:
10.4161/cbt.10.11.13921. [PMID: 21057216] - Sakhr Ajouz, Véronique Decognet, Philippe C Nicot, Marc Bardin. Microsatellite stability in the plant pathogen Botrytis cinerea after exposure to different selective pressures.
Fungal biology.
2010 Nov; 114(11-12):949-54. doi:
10.1016/j.funbio.2010.09.004. [PMID: 21036339] - A Nerstedt, A Johansson, C X Andersson, E Cansby, U Smith, M Mahlapuu. AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).
Diabetologia.
2010 Nov; 53(11):2406-16. doi:
10.1007/s00125-010-1856-z. [PMID: 20652679] - Dan Li, Duan Wang, Yun Wang, Wenhua Ling, Xiang Feng, Min Xia. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
The Journal of biological chemistry.
2010 Oct; 285(43):33499-33509. doi:
10.1074/jbc.m110.159772. [PMID: 20713354] - Jae-Hoon Choi, Nobuo Abe, Hidekazu Tanaka, Keiji Fushimi, Yoshifumi Nishina, Akio Morita, Yoshikazu Kiriiwa, Reiko Motohashi, Daisuke Hashizume, Hiroyuki Koshino, Hirokazu Kawagishi. Plant-growth regulator, imidazole-4-carboxamide, produced by the fairy ring forming fungus Lepista sordida.
Journal of agricultural and food chemistry.
2010 Sep; 58(18):9956-9. doi:
10.1021/jf101619a. [PMID: 20734987] - Leiyan Yan, Qianqian Yang, George W Sundin, Hongye Li, Zhonghua Ma. The mitogen-activated protein kinase kinase BOS5 is involved in regulating vegetative differentiation and virulence in Botrytis cinerea.
Fungal genetics and biology : FG & B.
2010 Sep; 47(9):753-60. doi:
10.1016/j.fgb.2010.06.002. [PMID: 20595070] - Jaw-Shiun Tsai, Ching-Yu Chen, Yuh-Lien Chen, Lee-Ming Chuang. Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes.
Journal of cellular biochemistry.
2010 Aug; 110(6):1410-9. doi:
10.1002/jcb.22657. [PMID: 20506517] - Mandeep P Gaidhu, Robert L S Perry, Fawad Noor, Rolando B Ceddia. Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes.
Molecular endocrinology (Baltimore, Md.).
2010 Jul; 24(7):1434-40. doi:
10.1210/me.2009-0502. [PMID: 20501641] - Hui Li, Ramon F Thali, Christy Smolak, Fan Gong, Rodrigo Alzamora, Theo Wallimann, Roland Scholz, Núria M Pastor-Soler, Dietbert Neumann, Kenneth R Hallows. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.
American journal of physiology. Renal physiology.
2010 Jul; 299(1):F167-77. doi:
10.1152/ajprenal.00162.2010. [PMID: 20462973] - Melinda Andrasi, Rose Bustos, Attila Gaspar, Frank A Gomez, Almos Klekner. Analysis and stability study of temozolomide using capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jul; 878(21):1801-8. doi:
10.1016/j.jchromb.2010.05.008. [PMID: 20627825] - Lisa Miranda, Sarah Carpentier, Anna Platek, Nusrat Hussain, Marie-Agnès Gueuning, Didier Vertommen, Yurda Ozkan, Brice Sid, Louis Hue, Pierre J Courtoy, Mark H Rider, Sandrine Horman. AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.
Biochemical and biophysical research communications.
2010 Jun; 396(3):656-61. doi:
10.1016/j.bbrc.2010.04.151. [PMID: 20438708] - M Henneke, S Dreha-Kulaczewski, K Brockmann, M van der Graaf, M A A P Willemsen, U Engelke, P Dechent, A Heerschap, G Helms, R A Wevers, J Gärtner. In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency.
NMR in biomedicine.
2010 Jun; 23(5):441-5. doi:
10.1002/nbm.1480. [PMID: 20175147] - Dan Yang Huang, Huanhuan Gao, Krishna M Boini, Hartmut Osswald, Bernd Nürnberg, Florian Lang. In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake.
Pflugers Archiv : European journal of physiology.
2010 Jun; 460(1):187-96. doi:
10.1007/s00424-010-0803-7. [PMID: 20349193] - Benjamin T Bikman, Donghai Zheng, Melissa A Reed, Robert C Hickner, Joseph A Houmard, G Lynis Dohm. Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Jun; 298(6):R1692-9. doi:
10.1152/ajpregu.00190.2009. [PMID: 20393162] - Stephen A Stricker, Lee Swiderek, Thanh Nguyen. Stimulators of AMP-activated kinase (AMPK) inhibit seawater- but not cAMP-induced oocyte maturation in a marine worm: Implications for interactions between cAMP and AMPK signaling.
Molecular reproduction and development.
2010 Jun; 77(6):497-510. doi:
10.1002/mrd.21177. [PMID: 20336704] - Hyun Jin Kwon, Ji Heon Rhim, Ik-Soon Jang, Go-Eun Kim, Sang Chul Park, Eui-Ju Yeo. Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts.
Experimental & molecular medicine.
2010 Apr; 42(4):254-69. doi:
10.3858/emm.2010.42.4.025. [PMID: 20177150] - O Bourron, M Daval, I Hainault, E Hajduch, J M Servant, J F Gautier, P Ferré, F Foufelle. Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase.
Diabetologia.
2010 Apr; 53(4):768-78. doi:
10.1007/s00125-009-1639-6. [PMID: 20043143] - Andreas Thomas, Simon Beuck, Jens Christian Eickhoff, Sven Guddat, Oliver Krug, Matthias Kamber, Wilhelm Schänzer, Mario Thevis. Quantification of urinary AICAR concentrations as a matter of doping controls.
Analytical and bioanalytical chemistry.
2010 Apr; 396(8):2899-908. doi:
10.1007/s00216-010-3560-8. [PMID: 20225061] - LiYong Chen, FuRong Wang, XiangLan Sun, Jing Zhou, Ling Gao, YuLian Jiao, XiaoLei Hou, Cheng Yong Qin, JiaJun Zhao. Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium.
Experimental & molecular medicine.
2010 Mar; 42(3):205-15. doi:
10.3858/emm.2010.42.3.021. [PMID: 20164678] - Joseph W McFadden, Benjamin A Corl. Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells.
Biochemical and biophysical research communications.
2009 Dec; 390(3):388-93. doi:
10.1016/j.bbrc.2009.09.017. [PMID: 19747896] - Marcia J Abbott, Arthur M Edelman, Lorraine P Turcotte. CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Dec; 297(6):R1724-32. doi:
10.1152/ajpregu.00179.2009. [PMID: 19812359] - Hakam Alkhateeb, Adrian Chabowski, Jan F C Glatz, Brendon Gurd, Joost J F P Luiken, Arend Bonen. Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids.
American journal of physiology. Endocrinology and metabolism.
2009 Nov; 297(5):E1056-66. doi:
10.1152/ajpendo.90908.2008. [PMID: 19724017] - S Beck Jørgensen, H M O'Neill, K Hewitt, B E Kemp, G R Steinberg. Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity.
Diabetologia.
2009 Nov; 52(11):2395-404. doi:
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The Journal of endocrinology.
2009 Sep; 202(3):441-51. doi:
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American journal of physiology. Endocrinology and metabolism.
2009 Sep; 297(3):E759-66. doi:
10.1152/ajpendo.00141.2009. [PMID: 19602584] - Chad R Blystone, Christy S Lambright, Mary C Cardon, Johnathan Furr, Cynthia V Rider, Phillip C Hartig, Vickie S Wilson, Leon E Gray. Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Sep; 111(1):179-88. doi:
10.1093/toxsci/kfp137. [PMID: 19564212] - Sachiko Chikahisa, Nobuhiro Fujiki, Kazuyoshi Kitaoka, Noriyuki Shimizu, Hiroyoshi Séi. Central AMPK contributes to sleep homeostasis in mice.
Neuropharmacology.
2009 Sep; 57(4):369-74. doi:
10.1016/j.neuropharm.2009.07.015. [PMID: 19615388] - D Sporrer, M Weber, J Wanninger, J Weigert, M Neumeier, F Stögbauer, E Lieberer, M Bala, A Kopp, A Schäffler, C Buechler. Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.
European journal of clinical investigation.
2009 Aug; 39(8):671-9. doi:
10.1111/j.1365-2362.2009.02170.x. [PMID: 19490068] - Sebastian Beck Jørgensen, Jane Honeyman, Jonathan S Oakhill, Daniel Fazakerley, Jacqueline Stöckli, Bruce E Kemp, Gregory R Steinberg. Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.
American journal of physiology. Endocrinology and metabolism.
2009 Jul; 297(1):E57-66. doi:
10.1152/ajpendo.90744.2008. [PMID: 19435854] - Masja M van Oort, Jan M van Doorn, Mohammed El Hasnaoui, Jan F C Glatz, Arend Bonen, Dick J van der Horst, Kees W Rodenburg, Joost J F P Luiken. Effects of AMPK activators on the sub-cellular distribution of fatty acid transporters CD36 and FABPpm.
Archives of physiology and biochemistry.
2009 Jul; 115(3):137-46. doi:
10.1080/13813450902975090. [PMID: 19480562] - Jacob Jeppesen, Peter Albers, Joost J Luiken, Jan F C Glatz, Bente Kiens. Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma.
Molecular and cellular biochemistry.
2009 Jun; 326(1-2):45-53. doi:
10.1007/s11010-008-0006-0. [PMID: 19142713] - A Peairs, A Radjavi, S Davis, L Li, A Ahmed, S Giri, C M Reilly. Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells.
Clinical and experimental immunology.
2009 Jun; 156(3):542-51. doi:
10.1111/j.1365-2249.2009.03924.x. [PMID: 19438609] - Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masakatsu Wakeno, Shin Ito, Akiko Ogai, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Masaru Sugimachi, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Circulation.
2009 May; 119(19):2568-77. doi:
10.1161/circulationaha.108.798561. [PMID: 19414638] - B Viollet, B Guigas, J Leclerc, S Hébrard, L Lantier, R Mounier, F Andreelli, M Foretz. AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.
Acta physiologica (Oxford, England).
2009 May; 196(1):81-98. doi:
10.1111/j.1748-1716.2009.01970.x. [PMID: 19245656] - Mandeep P Gaidhu, Sergiu Fediuc, Nicole M Anthony, Mandy So, Mani Mirpourian, Robert L S Perry, Rolando B Ceddia. Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL.
Journal of lipid research.
2009 Apr; 50(4):704-15. doi:
10.1194/jlr.m800480-jlr200. [PMID: 19050316] - Steven J Greco, Sraboni Sarkar, Jane M Johnston, Nikolaos Tezapsidis. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Biochemical and biophysical research communications.
2009 Feb; 380(1):98-104. doi:
10.1016/j.bbrc.2009.01.041. [PMID: 19166821] - Wei Wang, Alla Fridman, William Blackledge, Stephen Connelly, Ian A Wilson, Renate B Pilz, Gerry R Boss. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.
The Journal of biological chemistry.
2009 Feb; 284(6):3521-8. doi:
10.1074/jbc.m806707200. [PMID: 19068483] - Hélène Klein, Line Garneau, Nguyen Thu Ngan Trinh, Anik Privé, François Dionne, Eugénie Goupil, Dominique Thuringer, Lucie Parent, Emmanuelle Brochiero, Rémy Sauvé. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.
American journal of physiology. Cell physiology.
2009 Feb; 296(2):C285-95. doi:
10.1152/ajpcell.00418.2008. [PMID: 19052260] - Cyril Gitiaux, Irène Ceballos-Picot, Sandrine Marie, Vassili Valayannopoulos, Marlène Rio, Séverine Verrieres, Jean François Benoist, Marie Françoise Vincent, Isabelle Desguerre, Nadia Bahi-Buisson. Misleading behavioural phenotype with adenylosuccinate lyase deficiency.
European journal of human genetics : EJHG.
2009 Jan; 17(1):133-6. doi:
10.1038/ejhg.2008.174. [PMID: 18830228] - Philippe G Cammisotto, Moïse Bendayan. Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli.
Journal of molecular histology.
2008 Dec; 39(6):579-84. doi:
10.1007/s10735-008-9198-6. [PMID: 18941912] - A Jurecka, A Tylki-Szymanska, M Zikanova, J Krijt, S Kmoch. D-ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: absence of positive effect.
Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S329-32. doi:
10.1007/s10545-008-0904-z. [PMID: 18649008] - Yanhong Liu, Weihua Zhang, Yuhui Yang. Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma.
Talanta.
2008 Oct; 77(1):412-21. doi:
10.1016/j.talanta.2008.07.004. [PMID: 18804654] - H Boon, M Bosselaar, S F E Praet, E E Blaak, W H M Saris, A J M Wagenmakers, S L McGee, C J Tack, P Smits, M Hargreaves, L J C van Loon. Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.
Diabetologia.
2008 Oct; 51(10):1893-900. doi:
10.1007/s00125-008-1108-7. [PMID: 18709353] - Hanna K Nyblom, Ernest Sargsyan, Peter Bergsten. AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels.
Journal of molecular endocrinology.
2008 Sep; 41(3):187-94. doi:
10.1677/jme-08-0006. [PMID: 18579684] - Michael Kristensen, Martin Krøyer Rasmussen, Carsten Juel. Na(+)-K (+) pump location and translocation during muscle contraction in rat skeletal muscle.
Pflugers Archiv : European journal of physiology.
2008 Aug; 456(5):979-89. doi:
10.1007/s00424-008-0449-x. [PMID: 18214523] - Vladimir Kus, Tomas Prazak, Petr Brauner, Michal Hensler, Ondrej Kuda, Pavel Flachs, Petra Janovska, Dasa Medrikova, Martin Rossmeisl, Zuzana Jilkova, Bohumir Stefl, Eva Pastalkova, Zdenek Drahota, Josef Houstek, Jan Kopecky. Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E356-67. doi:
10.1152/ajpendo.90256.2008. [PMID: 18492779] - Kazuo Kajita, Tomoatsu Mune, Takahide Ikeda, Masami Matsumoto, Yoshihiro Uno, Chiyo Sugiyama, Kenji Matsubara, Hiroyuki Morita, Masao Takemura, Mitsuru Seishima, Jun Takeda, Tatsuo Ishizuka. Effect of fasting on PPARgamma and AMPK activity in adipocytes.
Diabetes research and clinical practice.
2008 Aug; 81(2):144-9. doi:
10.1016/j.diabres.2008.05.003. [PMID: 18562038] - Osamu Maeda, Chie Oikawa, Nobuo Shiomi, Akira Toriba, Kazuichi Hayakawa. A clean-up method by photocatalysis for HPLC analysis of iprodione in dry basil.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2008 Aug; 24(8):1053-5. doi:
10.2116/analsci.24.1053. [PMID: 18689949] - Livia Puljak, Vinay Parameswara, Svjetlana Dolovcak, Shar L Waldrop, Daniel Emmett, Victoria Esser, J Gregory Fitz, Gordan Kilic. Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.
Experimental cell research.
2008 Jun; 314(10):2100-9. doi:
10.1016/j.yexcr.2008.03.002. [PMID: 18405894] - Polina Gadeva, Boyan Dimitrov. Genotoxic effects of the pesticides Rubigan, Omite and Rovral in root-meristem cells of Crepis capillaris L.
Mutation research.
2008 Apr; 652(2):191-7. doi:
10.1016/j.mrgentox.2008.02.007. [PMID: 18420449] - Philippe G Cammisotto, Irene Londono, Diane Gingras, Moïse Bendayan. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats.
American journal of physiology. Renal physiology.
2008 Apr; 294(4):F881-9. doi:
10.1152/ajprenal.00373.2007. [PMID: 18256313] - Jing Du, Qiu Chen, Hiroshi Takemori, Haiyan Xu. SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes.
Obesity (Silver Spring, Md.).
2008 Mar; 16(3):531-8. doi:
10.1038/oby.2007.98. [PMID: 18239551] - Min Lu, Qingbo Tang, Jerrold M Olefsky, Pamela L Mellon, Nicholas J G Webster. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.
Molecular endocrinology (Baltimore, Md.).
2008 Mar; 22(3):760-71. doi:
10.1210/me.2007-0330. [PMID: 18006641] - Masayuki Adachi, David A Brenner. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.
Hepatology (Baltimore, Md.).
2008 Feb; 47(2):677-85. doi:
10.1002/hep.21991. [PMID: 18220291] - C Rantzau, M Christopher, F P Alford. Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism.
Journal of applied physiology (Bethesda, Md. : 1985).
2008 Feb; 104(2):363-70. doi:
10.1152/japplphysiol.00500.2007. [PMID: 18032581] - Hsiang-Ming Wang, Sonya Mehta, Rishipal Bansode, Wei Huang, Kamal D Mehta. AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade.
Biochemical pharmacology.
2008 Jan; 75(2):457-67. doi:
10.1016/j.bcp.2007.08.028. [PMID: 17945190] - Charity Nofziger, Kameljit Kalsi, T Aaron West, Deborah Baines, Bonnie L Blazer-Yost. Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2008; 22(5-6):487-96. doi:
10.1159/000185505. [PMID: 19088430] - Dan Zheng, Anjana Perianayagam, Donna H Lee, M Douglas Brannan, Li E Yang, David Tellalian, Pei Chen, Kathleen Lemieux, André Marette, Jang H Youn, Alicia A McDonough. AMPK activation with AICAR provokes an acute fall in plasma [K+].
American journal of physiology. Cell physiology.
2008 Jan; 294(1):C126-35. doi:
10.1152/ajpcell.00464.2007. [PMID: 18003746]