4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid (BioDeep_00000174293)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H19NO5 (233.1263164)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 25%
分子结构信息
SMILES: CC(C)(CO)C(C(=O)NCCCC(=O)O)O
InChI: InChI=1S/C10H19NO5/c1-10(2,6-12)8(15)9(16)11-5-3-4-7(13)14/h8,12,15H,3-6H2,1-2H3,(H,11,16)(H,13,14)
描述信息
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
同义名列表
18 个代谢物同义名
4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid; 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoate; 4-(2,4-dihydroxy-3,3-dimethylbutanamido)butanoic acid; Pantogab, calcium (2:1) salt, (R)-isomer; Pantogab, sodium salt, (R)-isomer; Pantogab, calcium (2:1) salt; Calcium homopantothenate; Pantogab, (+-)-isomer; Homopantothenic acid; Pantogab, (R)-isomer; Pantogab, (S)-isomer; Calcium hopantenate; Hopantenic acid; GABA pantoate; GABA-pantoyl; Pantoyl-gaba; Pantogam; Pantogab
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M V Karlina, O N Pozharitskaia, V M Kosman, A N Shikov, M A Lazukina, G I D'iachuk. [Pharmacokinetics of hopantenic acid upon peroral administration].
Eksperimental'naia i klinicheskaia farmakologiia.
2010 Aug; 73(8):46-8. doi:
NULL. [PMID: 20919560] - E Küsters, C Spöndlin, C Eder. Analytical studies on the chiral separation and simultaneous determination of pantothenic acid and hopantenic acid enantiomers in rat plasma by gas chromatography-mass fragmentography: a reply.
Journal of chromatography.
1992 Apr; 576(1):179-80; author reply 181. doi:
10.1016/0378-4347(92)80192-s. [PMID: 1500455] - S Noda, J Haratake, A Sasaki, N Ishii, H Umezaki, A Horie. Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs.
Liver.
1991 Jun; 11(3):134-42. doi:
10.1111/j.1600-0676.1991.tb00506.x. [PMID: 1886458] - K Banno, S Horimoto, M Matsuoka. Analytical studies on the chiral separation and simultaneous determination of pantothenic acid and hopantenic acid enantiomers in rat plasma by gas chromatography-mass fragmentography.
Journal of chromatography.
1991 Mar; 564(1):1-10. doi:
10.1016/0378-4347(91)80065-k. [PMID: 1860905] - M Matsumoto, T Kuhara, Y Inoue, T Shinka, I Matsumoto. Abnormal fatty acid metabolism in patients in hopantenate therapy during clinical episodes.
Journal of chromatography.
1991 Jan; 562(1-2):139-45. doi:
10.1016/0378-4347(91)80572-t. [PMID: 2026687] - T Sasaki, M Minagawa, T Yamamoto, H Ichihashi. A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.
Brain & development.
1991; 13(1):52-5. doi:
10.1016/s0387-7604(12)80298-1. [PMID: 2063999] - M Kajita, K Iwase, M Matsumoto, T Kuhara, T Sinka, I Matsumoto. [Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration].
No to hattatsu = Brain and development.
1990 May; 22(3):267-73. doi:
NULL. [PMID: 2194543] - M Otsuka, T Akiba, Y Okita, K Tomita, N Yoshiyama, T Sasaoka, M Kanayama, F Marumo. Lactic acidosis with hypoglycemia and hyperammonemia observed in two uremic patients during calcium hopantenate treatment.
Japanese journal of medicine.
1990 May; 29(3):324-8. doi:
10.2169/internalmedicine1962.29.324. [PMID: 2273615] - T Nakanishi, S Funahashi, A Shimizu, A Hayashi. Urinary organic acids in elderly Japanese patients with ketosis and encephalopathy who have taken panto-yl-gamma-aminobutyrate, calcium salt (calcium hopantenate, HOPA).
Clinica chimica acta; international journal of clinical chemistry.
1990 Apr; 188(1):85-90. doi:
10.1016/0009-8981(90)90149-m. [PMID: 2347085] - M Matsumoto, T Kuhara, Y Inoue, T Shinka, I Matsumoto, M Kajita. Mass spectrometric identification of 2-hydroxydodecanedioic acid and its homologues in urine from patients with hopantenate therapy during clinical episode.
Biomedical & environmental mass spectrometry.
1990 Mar; 19(3):171-5. doi:
10.1002/bms.1200190313. [PMID: 2331533] - K Banno, M Matsuoka, S Horimoto, J Kato. Simultaneous determination of pantothenic acid and hopantenic acid in biological samples and natural products by gas chromatography-mass fragmentography.
Journal of chromatography.
1990 Feb; 525(2):255-64. doi:
10.1016/s0378-4347(00)83402-7. [PMID: 2109760] - S Ohsuga, H Ohsuga, T Takeoka, A Ikeda, Y Shinohara. [Metabolic acidosis and hypoglycemia during calcium hopantenate administration--report on 5 patients].
Rinsho shinkeigaku = Clinical neurology.
1989 Jun; 29(6):741-6. doi:
NULL. [PMID: 2582687] - M Suno, A Nagaoka. [Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1988 May; 91(5):295-9. doi:
10.1254/fpj.91.295. [PMID: 3410376] - S Noda, H Umezaki, K Yamamoto, T Araki, T Murakami, N Ishii. Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
Journal of neurology, neurosurgery, and psychiatry.
1988 Apr; 51(4):582-5. doi:
10.1136/jnnp.51.4.582. [PMID: 3379435] - T Mitsuma, D H Sun, T Nogimori, M Chaya, K Ohtake, Y Hirooka. Calcium hopantenate, a GABA agonist, induces elevation of plasma beta-endorphin-like immunoreactivity levels in rats.
Experimental and clinical endocrinology.
1987 Apr; 89(2):181-7. doi:
. [PMID: 2956119] - K Nakano, H Ando, Y Sugawara, M Ohashi, S Harigaya. Hopantenic acid beta-glucoside as a new urinary metabolite of calcium hopantenate in dogs.
Drug metabolism and disposition: the biological fate of chemicals.
1986 Nov; 14(6):740-5. doi:
. [PMID: 2877836] - A Kimura, I Yoshida, E Ono, T Matsuishi, M Yoshino, F Yamashita, M Yamamoto, T Hashimoto, T Shinka, T Kuhara. Acute encephalopathy with hyperammonemia and dicarboxylic aciduria during calcium hopantenate therapy: a patient report.
Brain & development.
1986; 8(6):601-5. doi:
10.1016/s0387-7604(86)80006-7. [PMID: 3826551] - Y Sugiyama, T Fujita, M Matsumoto, K Okamoto, I Imada. Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs.
Journal of pharmacobio-dynamics.
1985 Dec; 8(12):1006-17. doi:
10.1248/bpb1978.8.1006. [PMID: 2871147] - M Suno, A Nagaoka. Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.
Biochemical and biophysical research communications.
1984 Dec; 125(3):1046-52. doi:
10.1016/0006-291x(84)91389-5. [PMID: 6517932] - Y Nishizawa. Studies on homopantothenic acid.
Medical journal of Osaka University.
1984 Sep; 35(1-2):41-50. doi:
NULL. [PMID: 6396501] - G Benzi, R F Villa, M Dossena, L Vercesi, A Gorini, O Pastoris. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia.
Journal of neuroscience research.
1984; 11(4):437-50. doi:
10.1002/jnr.490110410. [PMID: 6748113] - T Mitsuma, T Nogimori. Effects of calcium hopantenate on the hypothalamic-pituitary-thyroid axis in rats.
Hormone research.
1983; 18(4):210-4. doi:
10.1159/000179797. [PMID: 6416983] - Y Umeno, K Nakai, E Matsushima, T Marunaka. Gas chromatographic--mass fragmentographic determination of homopantothenic acid in plasma.
Journal of chromatography.
1981 Dec; 226(2):333-9. doi:
10.1016/s0378-4347(00)86067-3. [PMID: 7320164]