4-(4-Guanidinobenzoyloxy)phenylacetate (BioDeep_00000174269)

   

human metabolite blood metabolite


代谢物信息卡片


2-(4-{4-[(diaminomethylidene)amino]benzoyloxy}phenyl)acetic acid

化学式: C16H15N3O4 (313.106251)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 75%

分子结构信息

SMILES: C1=CC(=CC=C1CC(=O)O)OC(=O)C2=CC=C(C=C2)N=C(N)N
InChI: InChI=1S/C16H15N3O4/c17-16(18)19-12-5-3-11(4-6-12)15(22)23-13-7-1-10(2-8-13)9-14(20)21/h1-8H,9H2,(H,20,21)(H4,17,18,19)

描述信息

同义名列表

4 个代谢物同义名

2-(4-{4-[(diaminomethylidene)amino]benzoyloxy}phenyl)acetic acid; (4-{4-[(diaminomethylidene)amino]benzoyloxy}phenyl)acetic acid; 4-(4-Guanidinobenzoyloxy)phenylacetic acid; 4-(4-Guanidinobenzoyloxy)phenylacetate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Johanna Weiss, Gzona Bajraktari-Sylejmani, Walter Emil Haefeli. Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions. Chemico-biological interactions. 2021 Apr; 338(?):109428. doi: 10.1016/j.cbi.2021.109428. [PMID: 33647240]
  • Kamal Albarazanji, Matthew Jennis, Cassandre R Cavanaugh, Wensheng Lang, Bhanu Singh, James C Lanter, James M Lenhard, Pamela J Hornby. Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. American journal of physiology. Gastrointestinal and liver physiology. 2019 05; 316(5):G653-G667. doi: 10.1152/ajpgi.00404.2018. [PMID: 30920846]
  • Ai Maekawa, Yutaka Kakizoe, Taku Miyoshi, Naoki Wakida, Takehiro Ko, Naoki Shiraishi, Masataka Adachi, Kimio Tomita, Kenichiro Kitamura. Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. Journal of hypertension. 2009 Jan; 27(1):181-9. doi: 10.1097/hjh.0b013e328317a762. [PMID: 19145783]
  • I Midgley, A J Hood, P Proctor, L F Chasseaud, S R Irons, K N Cheng, C J Brindley, R Bonn. Metabolic fate of 14C-camostat mesylate in man, rat and dog after intravenous administration. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Jan; 24(1):79-92. doi: 10.3109/00498259409043223. [PMID: 8165824]
  • K Beckh, H Weidenbach, F Weidenbach, R Müller, G Adler. Hepatic and pancreatic metabolism and biliary excretion of the protease inhibitor camostat mesilate. International journal of pancreatology : official journal of the International Association of Pancreatology. 1991 Nov; 10(3-4):197-205. doi: 10.1007/bf02924157. [PMID: 1787334]
  • M Otsuki, S Tani, Y Okabayashi, M Fuji, T Nakamura, T Fujisawa, H Itoh. Beneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats. Digestive diseases and sciences. 1990 Feb; 35(2):242-50. doi: 10.1007/bf01536770. [PMID: 1689237]