3h-Pteridine (BioDeep_00000174250)
human metabolite blood metabolite
代谢物信息卡片
1,2-dihydropteridine
化学式: C6H6N4 (134.0592)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1NC2=NC=CN=C2C=N1
InChI: InChI=1S/C6H6N4/c1-2-9-6-5(8-1)3-7-4-10-6/h1-3H,4H2,(H,9,10)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Francesco Porta, Alessandro Mussa, Daniela Concolino, Marco Spada, Alberto Ponzone. Dopamine agonists in dihydropteridine reductase deficiency.
Molecular genetics and metabolism.
2012 Apr; 105(4):582-4. doi:
10.1016/j.ymgme.2012.01.013. [PMID: 22325981] - Thomas Opladen, Bettina Abu Seda, Anahita Rassi, Beat Thöny, Georg F Hoffmann, Nenad Blau. Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Journal of inherited metabolic disease.
2011 Jun; 34(3):819-26. doi:
10.1007/s10545-011-9300-1. [PMID: 21416196] - Han-Zhi Wu, Lin Guo, Yuen-Fun Mak, Ning Liu, Wing-Tat Poon, Yan-Wo Chan, Zongwei Cai. Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues.
Analytical and bioanalytical chemistry.
2011 Apr; 399(10):3431-9. doi:
10.1007/s00216-010-4463-4. [PMID: 21152904] - Manju A Kurian, Yan Li, Juan Zhen, Esther Meyer, Nebula Hai, Hans-Jürgen Christen, Georg F Hoffmann, Philip Jardine, Arpad von Moers, Santosh R Mordekar, Finbar O'Callaghan, Evangeline Wassmer, Elizabeth Wraige, Christa Dietrich, Timothy Lewis, Keith Hyland, Simon Heales, Terence Sanger, Paul Gissen, Birgit E Assmann, Maarten E A Reith, Eamonn R Maher. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.
The Lancet. Neurology.
2011 Jan; 10(1):54-62. doi:
10.1016/s1474-4422(10)70269-6. [PMID: 21112253] - B K Binukumar, Amanjit Bal, Ramesh J L Kandimalla, Kiran Dip Gill. Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes.
Molecular brain.
2010 Nov; 3(?):35. doi:
10.1186/1756-6606-3-35. [PMID: 21073741] - Jean-Louis Dhondt. Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Journal of inherited metabolic disease.
2010 Oct; 33(Suppl 2):S219-23. doi:
10.1007/s10545-010-9091-9. [PMID: 20458544] - Janet Best, H Frederik Nijhout, Michael Reed. Serotonin synthesis, release and reuptake in terminals: a mathematical model.
Theoretical biology & medical modelling.
2010 Aug; 7(?):34. doi:
10.1186/1742-4682-7-34. [PMID: 20723248] - Olaf Jahn, Stefan Tenzer, Hauke B Werner. Myelin proteomics: molecular anatomy of an insulating sheath.
Molecular neurobiology.
2009 Aug; 40(1):55-72. doi:
10.1007/s12035-009-8071-2. [PMID: 19452287] - Akrem Jalel, Mrabet Yassine, Mohamed Hédi Hamdaoui. Oxidative stress in experimental vitiligo C57BL/6 mice.
Indian journal of dermatology.
2009 Jul; 54(3):221-4. doi:
10.4103/0019-5154.55628. [PMID: 20161850] - Nicola Longo. Disorders of biopterin metabolism.
Journal of inherited metabolic disease.
2009 Jun; 32(3):333-42. doi:
10.1007/s10545-009-1067-2. [PMID: 19234759] - Marcello Tonelli, Natasha Wiebe, Brenda Hemmelgarn, Scott Klarenbach, Catherine Field, Braden Manns, Ravi Thadhani, John Gill. Trace elements in hemodialysis patients: a systematic review and meta-analysis.
BMC medicine.
2009 May; 7(?):25. doi:
10.1186/1741-7015-7-25. [PMID: 19454005] - K L Kavanagh, H Jörnvall, B Persson, U Oppermann. Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Cellular and molecular life sciences : CMLS.
2008 Dec; 65(24):3895-906. doi:
10.1007/s00018-008-8588-y. [PMID: 19011750] - Shubhangi K Pingle, Rajani G Tumane, Aruna A Jawade. Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases.
Indian journal of occupational and environmental medicine.
2008 Dec; 12(3):107-11. doi:
10.4103/0019-5278.44690. [PMID: 20040967] - D Concolino, G Muzzi, M Rapsomaniki, M T Moricca, M G Pascale, P Strisciuglio. Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients.
Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S193-7. doi:
10.1007/s10545-007-0788-3. [PMID: 18425437] - Jennifer M Anderson, Daniel E Sonenshine, Jesus G Valenzuela. Exploring the mialome of ticks: an annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae).
BMC genomics.
2008 Nov; 9(?):552. doi:
10.1186/1471-2164-9-552. [PMID: 19021911] - Antonio Di Giulio, Alessandra Bonamore. Globin interactions with lipids and membranes.
Methods in enzymology.
2008; 436(?):239-53. doi:
10.1016/s0076-6879(08)36013-3. [PMID: 18237636] - Ling Yang, Zhi-xin Zhang, Jun Ye, Zhong-shu Zhou, Ming Shen, Lian-shu Han, Wenjuan Qiu, Wei-min Yu, Xue-fan Gu. [Clinical study of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency in southern and northern Chinese patients].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2007 Jun; 24(3):310-3. doi:
NULL. [PMID: 17557244] - Dinara G Gilyazova, Andrey A Rosenkranz, Pavel V Gulak, Vladimir G Lunin, Olga V Sergienko, Yuri V Khramtsov, Kirill N Timofeyev, Mikhail A Grin, Andrey F Mironov, Andrey B Rubin, Georgii P Georgiev, Alexander S Sobolev. Targeting cancer cells by novel engineered modular transporters.
Cancer research.
2006 Nov; 66(21):10534-40. doi:
10.1158/0008-5472.can-06-2393. [PMID: 17079476] - A B Engin, D Tuzun, G Sahin. Evaluation of pteridine metabolism in battery workers chronically exposed to lead.
Human & experimental toxicology.
2006 Jul; 25(7):353-9. doi:
10.1191/0960327106ht634oa. [PMID: 16898163] - Lin Wang, Wei-min Yu, Xiao-wen Li, Chun He, Ming Chang, Ming Shen, Shi-ping Zhao, Gui-xiang Fu, Shu Shen, Tze-tze Liu, Kuang-jen Hsiao. [Study on tetrahydrobiopterin deficiency in Northern Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2006 Jun; 23(3):275-9. doi:
. [PMID: 16767663] - Andrea C Rinaldi, Alessandra Bonamore, Alberto Macone, Alberto Boffi, Argante Bozzi, Antonio Di Giulio. Interaction of Vitreoscilla hemoglobin with membrane lipids.
Biochemistry.
2006 Apr; 45(13):4069-76. doi:
10.1021/bi052277n. [PMID: 16566580] - Marcel R Zurflüh, Marcello Giovannini, Laura Fiori, Betina Fiege, Yasemin Gokdemir, Tolunay Baykal, Lucja Kierat, Konrad H Gärtner, Beat Thöny, Nenad Blau. Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Molecular genetics and metabolism.
2005 Dec; 86 Suppl 1(?):S96-103. doi:
10.1016/j.ymgme.2005.09.011. [PMID: 16275037] - T Baydar, A B Engin, A Aydin, G Sahin. Effect of aluminum exposure on pteridine metabolism.
Biological trace element research.
2005 Aug; 106(2):153-64. doi:
10.1385/bter:106:2:153. [PMID: 16116247] - Zhi-xin Zhang, Jun Ye, Wen-juan Qiu, Lian-shu Han, Xue-fan Gu. [Tetrahydrobiopterin loading test in differential diagnosis among hyperphenylalaninemia patients].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2005 Aug; 22(4):438-40. doi:
NULL. [PMID: 16086286] - Zhi-xin Zhang, Jun Ye, Wen-juan Qiu, Lian-shu Han, Xue-fan Gu. [Screening and diagnosis of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency with tetrahydrobiopterin loading test].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2005 May; 43(5):335-9. doi:
NULL. [PMID: 15924746] - Paola D'Angelo, Debora Lucarelli, Stefano della Longa, Maurizio Benfatto, Jean Louis Hazemann, Alessandro Feis, Giulietta Smulevich, Andrea Ilari, Alessandra Bonamore, Alberto Boffi. Unusual heme iron-lipid acyl chain coordination in Escherichia coli flavohemoglobin.
Biophysical journal.
2004 Jun; 86(6):3882-92. doi:
10.1529/biophysj.103.034876. [PMID: 15189885] - Alessandra Bonamore, Anna Farina, Maurizio Gattoni, M Eugenia Schininà, Andrea Bellelli, Alberto Boffi. Interaction with membrane lipids and heme ligand binding properties of Escherichia coli flavohemoglobin.
Biochemistry.
2003 May; 42(19):5792-801. doi:
10.1021/bi0206311. [PMID: 12741837] - Thomas Lücke, Sabine Illsinger, Christa Aulehla-Scholz, Johannes Sander, Anibh M Das. BH4-sensitive hyperphenylalaninemia: new case and review of literature.
Pediatric neurology.
2003 Mar; 28(3):228-30. doi:
10.1016/s0887-8994(02)00516-7. [PMID: 12770680] - Andrea Ilari, Alessandra Bonamore, Anna Farina, Kenneth A Johnson, Alberto Boffi. The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unexpected geometry of the distal heme pocket.
The Journal of biological chemistry.
2002 Jun; 277(26):23725-32. doi:
10.1074/jbc.m202228200. [PMID: 11964402] - H Shintaku. Disorders of tetrahydrobiopterin metabolism and their treatment.
Current drug metabolism.
2002 Apr; 3(2):123-31. doi:
10.2174/1389200024605145. [PMID: 12003346] - J L Dhondt, J M Hayte. [Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients].
Annales de biologie clinique.
2002 Mar; 60(2):165-71. doi:
. [PMID: 11937441] - K Shinozaki, A Hirayama, Y Nishio, Y Yoshida, T Ohtani, T Okamura, M Masada, R Kikkawa, K Kodama, A Kashiwagi. Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.
Journal of the American College of Cardiology.
2001 Dec; 38(7):1821-8. doi:
10.1016/s0735-1097(01)01659-x. [PMID: 11738280] - H S Kalkanoglu, A Romstad, T Coşkun, F Güttler. Evaluation of a fetus at risk for dihydropteridine reductase deficiency by direct mutation analysis using denaturing gradient gel electrophoresis.
Prenatal diagnosis.
2001 Oct; 21(10):868-70. doi:
10.1002/pd.161. [PMID: 11746132] - P J Waters, C R Scriver, M A Parniak. Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia.
Molecular genetics and metabolism.
2001 Jul; 73(3):230-8. doi:
10.1006/mgme.2001.3198. [PMID: 11461190] - L J Spaapen, J A Bakker, C Velter, W Loots, M E Rubio-Gozalbo, P P Forget, L Dorland, T J De Koning, B T Poll-The, H K Ploos van Amstel, J Bekhof, N Blau, M Duran, M E Rubio-Gonzalbo. Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates.
Journal of inherited metabolic disease.
2001 Jun; 24(3):352-8. doi:
10.1023/a:1010596317296. [PMID: 11486900]
