4-Nitro-3-(trifluoromethyl)aniline (BioDeep_00000174227)
human metabolite blood metabolite
代谢物信息卡片
化学式: C7H5F3N2O2 (206.0303106)
中文名称: 4-硝基-3-三氟甲基苯胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1N)C(F)(F)F)[N+](=O)[O-]
InChI: InChI=1S/C7H5F3N2O2/c8-7(9,10)5-3-4(11)1-2-6(5)12(13)14/h1-3H,11H2
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jessica Amadio, Cormac D Murphy. Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.
Biotechnology letters.
2011 Feb; 33(2):321-6. doi:
10.1007/s10529-010-0425-3. [PMID: 20931353] - Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari, Yasushi Yamazoe. Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Jan; 37(1):97-105. doi:
10.1124/dmd.108.021964. [PMID: 18832480] - Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese, James A Nieman. Bioactivation of flutamide metabolites by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1425-37. doi:
10.1124/dmd.108.020370. [PMID: 18411402] - Annica Tevell, Hans Lennernäs, Mats Jönsson, Maria Norlin, Bo Lennernäs, Ulf Bondesson, Mikael Hedeland. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jun; 34(6):984-92. doi:
10.1124/dmd.105.008516. [PMID: 16540588] - Rika Goda, Daichi Nagai, Yuji Akiyama, Kiyohiro Nishikawa, Isao Ikemoto, Yoshio Aizawa, Kiyoshi Nagata, Yasushi Yamazoe. Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients.
Drug metabolism and disposition: the biological fate of chemicals.
2006 May; 34(5):828-35. doi:
10.1124/dmd.105.008623. [PMID: 16507648] - Di Wu, Zengru Wu, Jun Yang, Vipin A Nair, Duane D Miller, James T Dalton. Pharmacokinetics and metabolism of a selective androgen receptor modulator in rats: implication of molecular properties and intensive metabolic profile to investigate ideal pharmacokinetic characteristics of a propanamide in preclinical study.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Mar; 34(3):483-94. doi:
10.1124/dmd.105.006643. [PMID: 16381665] - Yoshio Aizawa, Isao Ikemoto, Koichi Kishimoto, Tetsuro Wada, Haruki Yamazaki, Yukihiko Ohishi, Hiroshi Kiyota, Nozomu Furuta, Hidenori Suzuki, Masataka Ueda. Flutamide-induced hepatic dysfunction in relation to steady-state plasma concentrations of flutamide and its metabolites.
Molecular and cellular biochemistry.
2003 Oct; 252(1-2):149-56. doi:
10.1023/a:1025560513308. [PMID: 14577588] - M Schulz, A Schmoldt, F Donn, H Becker. The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment.
European journal of clinical pharmacology.
1988; 34(6):633-6. doi:
10.1007/bf00615229. [PMID: 3169114]