2,2',3,4,4',5,5'-Heptachlorobiphenyl (BioDeep_00000174183)
human metabolite blood metabolite Industrial Pollutants
代谢物信息卡片
1,2,3,4-tetrachloro-5-(2,4,5-trichlorophenyl)benzene
化学式: C12H3Cl7 (391.80544480000003)
中文名称: 2,2,3,4,4,5,5-七氯联苯标准溶液
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C(=CC(=C1Cl)Cl)Cl)C2=CC(=C(C(=C2Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H3Cl7/c13-6-3-8(15)7(14)1-4(6)5-2-9(16)11(18)12(19)10(5)17/h1-3H
描述信息
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:165220
- PubChem: 37036
- HMDB: HMDB0246192
- ChEMBL: CHEMBL375479
- chemspider: 33985
- CAS: 35065-29-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sonia Alarcón, Javier Esteban, Robert Roos, Päivi Heikkinen, Ismael Sánchez-Pérez, Annika Adamsson, Jorma Toppari, Antti Koskela, Mikko A J Finnilä, Juha Tuukkanen, Maria Herlin, Gerd Hamscher, Heather A Leslie, Merja Korkalainen, Krister Halldin, Dieter Schrenk, Helen Håkansson, Matti Viluksela. Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats.
Reproductive toxicology (Elmsford, N.Y.).
2021 06; 102(?):109-127. doi:
10.1016/j.reprotox.2021.04.004. [PMID: 33992733] - Ling-Chuan Guo, Shengbing Yu, De Wu, Jinxu Huang, Tao Liu, Jianpeng Xiao, Weixiong Huang, Yanhong Gao, Xing Li, Weilin Zeng, Shannon Rutherford, Wenjun Ma, Yonghui Zhang, Lifeng Lin. Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt B):112925. doi:
10.1016/j.envpol.2019.07.093. [PMID: 31454572] - Antti Pikkarainen, Marko Lehtonen, Helen Håkansson, Seppo Auriola, Matti Viluksela. Gender- and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180.
Toxicology and applied pharmacology.
2019 05; 370(?):56-64. doi:
10.1016/j.taap.2019.03.013. [PMID: 30880216] - Panagiotis Filis, Natasha Walker, Linda Robertson, Emily Eaton-Turner, Lauma Ramona, Michelle Bellingham, Maria R Amezaga, Zulin Zhang, Beatrice Mandon-Pepin, Neil P Evans, Richard M Sharpe, Corinne Cotinot, William D Rees, Peter O'Shaughnessy, Paul A Fowler. Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males.
Environment international.
2019 03; 124(?):98-108. doi:
10.1016/j.envint.2019.01.003. [PMID: 30641261] - B González-Alzaga, M Lacasaña, A F Hernández, J P Arrebola, I López-Flores, F Artacho-Cordón, J P Bonde, N Olea, C Aguilar-Garduño. Serum concentrations of organochlorine compounds and predictors of exposure in children living in agricultural communities from South-Eastern Spain.
Environmental pollution (Barking, Essex : 1987).
2018 Jun; 237(?):685-694. doi:
10.1016/j.envpol.2017.10.109. [PMID: 29129429] - N Ramanujam, M Sivaselvakumar, S Ramalingam. Fast and parallel determination of PCB 77 and PCB 180 in plasma using ultra performance liquid chromatography with diode array detection: A pharmacokinetic study in Swiss albino mouse.
Biomedical chromatography : BMC.
2017 Nov; 31(11):. doi:
10.1002/bmc.4000. [PMID: 28485018] - Ho Jung Moon, Jung-Eun Lim, Sun Ha Jee. Association between serum concentrations of persistent organic pollutants and smoking in Koreans: A cross-sectional study.
Journal of epidemiology.
2017 Feb; 27(2):63-68. doi:
10.1016/j.je.2016.09.006. [PMID: 28142013] - M Elizabeth Marder, Parinya Panuwet, Ronald E Hunter, P Barry Ryan, Michele Marcus, Dana Boyd Barr. Quantification of Polybrominated and Polychlorinated Biphenyls in Human Matrices by Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry.
Journal of analytical toxicology.
2016 Sep; 40(7):511-8. doi:
10.1093/jat/bkw041. [PMID: 27445313] - Şafak Ulusoy, Özkan Özden, Olaf Päpke. Distribution of OCPs and PCBs in Mussels (Mytilus galloprovincialis) from the Marmara Sea Coastal Sites.
Bulletin of environmental contamination and toxicology.
2016 Aug; 97(2):191-7. doi:
10.1007/s00128-016-1848-x. [PMID: 27329111] - Keren Agay-Shay, David Martinez, Damaskini Valvi, Raquel Garcia-Esteban, Xavier Basagaña, Oliver Robinson, Maribel Casas, Jordi Sunyer, Martine Vrijheid. Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach.
Environmental health perspectives.
2015 Oct; 123(10):1030-7. doi:
10.1289/ehp.1409049. [PMID: 25956007] - Maria C Ferrante, Paola Amero, Anna Santoro, Anna Monnolo, Raffaele Simeoli, Francesca Di Guida, Giuseppina Mattace Raso, Rosaria Meli. Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes.
Toxicology and applied pharmacology.
2014 Sep; 279(3):401-408. doi:
10.1016/j.taap.2014.06.016. [PMID: 24978599] - M J Cascaes, R T Oliveira, M M Ubarana, R M Sato, P Baldassin, F I Colabuono, J Leonel, S Taniguchi, R R Weber. Persistent organic pollutants in liver of Brazilian sharpnose shark (Rhizoprionodon lalandii) from southeastern coast of Brazil.
Marine pollution bulletin.
2014 Sep; 86(1-2):591-593. doi:
10.1016/j.marpolbul.2014.05.032. [PMID: 25127497] - Helena E Christiansen, Alvine C Mehinto, Fahong Yu, Russell W Perry, Nancy D Denslow, Alec G Maule, Matthew G Mesa. Correlation of gene expression and contaminant concentrations in wild largescale suckers: a field-based study.
The Science of the total environment.
2014 Jun; 484(?):379-89. doi:
10.1016/j.scitotenv.2013.08.034. [PMID: 24050789] - Sihem Ben Hassine, Bechir Hammami, Walid Ben Ameur, Yassine El Megdiche, Badriddine Barhoumi, Rached El Abidi, Mohamed Ridha Driss. Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and their relation with age, gender, and BMI for the general population of Bizerte, Tunisia.
Environmental science and pollution research international.
2014 May; 21(10):6303-13. doi:
10.1007/s11356-013-1480-9. [PMID: 23338993] - Jin-Young Min, Rokho Kim, Kyoung-Bok Min. Serum polychlorinated biphenyls concentrations and hearing impairment in adults.
Chemosphere.
2014 May; 102(?):6-11. doi:
10.1016/j.chemosphere.2013.11.046. [PMID: 24360845] - Matti Viluksela, Päivi Heikkinen, Leo T M van der Ven, Filip Rendel, Robert Roos, Javier Esteban, Merja Korkalainen, Sanna Lensu, Hanna M Miettinen, Kari Savolainen, Satu Sankari, Hellmuth Lilienthal, Annika Adamsson, Jorma Toppari, Maria Herlin, Mikko Finnilä, Juha Tuukkanen, Heather A Leslie, Timo Hamers, Gerd Hamscher, Lauy Al-Anati, Ulla Stenius, Kine-Susann Dervola, Inger-Lise Bogen, Frode Fonnum, Patrik L Andersson, Dieter Schrenk, Krister Halldin, Helen Håkansson. Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.
PloS one.
2014; 9(8):e104639. doi:
10.1371/journal.pone.0104639. [PMID: 25137063] - Patrick De Boever, Britt Wens, Jordi Boix, Vicente Felipo, Greet Schoeters. Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months.
Chemical research in toxicology.
2013 Aug; 26(8):1159-67. doi:
10.1021/tx300510v. [PMID: 23829299] - Eva Morales, Mireia Gascon, David Martinez, Maribel Casas, Ferran Ballester, Clara L Rodríguez-Bernal, Jesus Ibarluzea, Loreto Santa Marina, Mercedes Espada, Fernando Goñi, Esther Vizcaino, Joan O Grimalt, Jordi Sunyer. Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy.
Environment international.
2013 Jul; 57-58(?):34-41. doi:
10.1016/j.envint.2013.03.011. [PMID: 23651836] - Jennifer M Daley, Todd A Leadley, Trevor E Pitcher, Ken G Drouillard. The effect of food provisioning on persistent organic pollutant bioamplification in Chinook salmon larvae.
Chemosphere.
2013 Jun; 92(1):10-5. doi:
10.1016/j.chemosphere.2013.03.036. [PMID: 23597729] - U Uslu, S Sandal, A Cumbul, S Yildiz, M Aydin, B Yilmaz. Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay.
Human & experimental toxicology.
2013 May; 32(5):476-82. doi:
10.1177/0960327112472999. [PMID: 23515497] - Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner.
Toxicology and applied pharmacology.
2012 Aug; 263(1):7-13. doi:
10.1016/j.taap.2012.05.016. [PMID: 22664347] - Thomas Schettgen, A Alt, D Preim, D Keller, T Kraus. Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building.
Toxicology letters.
2012 Aug; 213(1):116-21. doi:
10.1016/j.toxlet.2011.06.005. [PMID: 21699966] - Mayumi Tsuji, Christoph F A Vogel, Chihaya Koriyama, Suminori Akiba, Takahiko Katoh, Toshihiro Kawamoto, Fumio Matsumura. Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children.
Chemosphere.
2012 Jun; 87(11):1228-34. doi:
10.1016/j.chemosphere.2012.01.022. [PMID: 22326254] - Kusheng Wu, Xijin Xu, Junxiao Liu, Yongyong Guo, Xia Huo. In utero exposure to polychlorinated biphenyls and reduced neonatal physiological development from Guiyu, China.
Ecotoxicology and environmental safety.
2011 Nov; 74(8):2141-7. doi:
10.1016/j.ecoenv.2011.07.038. [PMID: 21851983] - B Wens, P De Boever, M Maes, K Hollanders, G Schoeters. Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells.
Toxicology.
2011 Sep; 287(1-3):113-23. doi:
10.1016/j.tox.2011.06.004. [PMID: 21703328] - Robert Roos, Patrik L Andersson, Krister Halldin, Helen Håkansson, Emma Westerholm, Timo Hamers, Gerd Hamscher, Päivi Heikkinen, Merja Korkalainen, Heather A Leslie, Marjo Niittynen, Satu Sankari, Hans-Joachim Schmitz, Leo T M van der Ven, Matti Viluksela, Dieter Schrenk. Hepatic effects of a highly purified 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in male and female rats.
Toxicology.
2011 Jun; 284(1-3):42-53. doi:
10.1016/j.tox.2011.03.013. [PMID: 21458519] - Jordi Sunyer, Raquel Garcia-Esteban, Mar Alvarez, Mònica Guxens, Fernando Goñi, Mikel Basterrechea, Martine Vrijheid, Stefano Guerra, Josep M Antó. DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants.
Epidemiology (Cambridge, Mass.).
2010 Sep; 21(5):729-35. doi:
10.1097/ede.0b013e3181e5ea96. [PMID: 20616741] - Ana Passuello, Montse Mari, Martí Nadal, Marta Schuhmacher, José L Domingo. POP accumulation in the food chain: Integrated risk model for sewage sludge application in agricultural soils.
Environment international.
2010 Aug; 36(6):577-83. doi:
10.1016/j.envint.2010.04.015. [PMID: 20471680] - Renée Dallaire, Eric Dewailly, Daria Pereg, Serge Dery, Pierre Ayotte. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults.
Environmental health perspectives.
2009 Sep; 117(9):1380-6. doi:
10.1289/ehp.0900633. [PMID: 19750101] - Daniela Cocchi, Giovanni Tulipano, Alessandra Colciago, Valeria Sibilia, Francesca Pagani, Daniela Viganò, Tiziana Rubino, Daniela Parolaro, Patrizia Bonfanti, Anita Colombo, Fabio Celotti. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring.
Toxicology and applied pharmacology.
2009 Jun; 237(2):127-36. doi:
10.1016/j.taap.2009.03.008. [PMID: 19327374] - Joanne S Colt, Nathaniel Rothman, Richard K Severson, Patricia Hartge, James R Cerhan, Nilanjan Chatterjee, Wendy Cozen, Lindsay M Morton, Anneclaire J De Roos, Scott Davis, Stephen Chanock, Sophia S Wang. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
Blood.
2009 Feb; 113(9):1899-905. doi:
10.1182/blood-2008-04-153858. [PMID: 19066394] - Milena Cerná, Marek Malý, Roman Grabic, Andrea Batáriová, Jirí Smíd, Bohuslav Benes. Serum concentrations of indicator PCB congeners in the Czech adult population.
Chemosphere.
2008 Jul; 72(8):1124-31. doi:
10.1016/j.chemosphere.2008.04.019. [PMID: 18547604] - Edward F Fitzgerald, Erin E Belanger, Marta I Gomez, Michael Cayo, Robert J McCaffrey, Richard F Seegal, Robert L Jansing, Syni-an Hwang, Heraline E Hicks. Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities.
Environmental health perspectives.
2008 Feb; 116(2):209-15. doi:
10.1289/ehp.10432. [PMID: 18288320] - Johan Maervoet, Veerle Beck, Simon A Roelens, Adrian Covaci, Stefan Voorspoels, Jan M C Geuns, Veerle M Darras, Paul Schepens. Uptake and tissue-specific distribution of selected polychlorinated biphenyls in developing chicken embryos.
Environmental toxicology and chemistry.
2005 Mar; 24(3):597-602. doi:
10.1897/04-266r.1. [PMID: 15779759] - Edward F Fitzgerald, Syni-An Hwang, George Lambert, Marta Gomez, Alice Tarbell. PCB exposure and in vivo CYP1A2 activity among Native Americans.
Environmental health perspectives.
2005 Mar; 113(3):272-7. doi:
10.1289/ehp.7370. [PMID: 15743714] - Thomas Høj Rasmussen, Flemming Nielsen, Helle Raun Andersen, Jesper Bo Nielsen, Pal Weihe, Philippe Grandjean. Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts.
Environmental health : a global access science source.
2003 Oct; 2(1):12. doi:
10.1186/1476-069x-2-12. [PMID: 14613489] - G M Lackmann, J Angerer, U Töllner. Parental smoking and neonatal serum levels of polychlorinated biphenyls and hexachlorobenzene.
Pediatric research.
2000 May; 47(5):598-601. doi:
10.1203/00006450-200005000-00007. [PMID: 10813583]