2,2',3,4,4',5'-Hexachlorobiphenyl (BioDeep_00000174182)
human metabolite blood metabolite Industrial Pollutants
代谢物信息卡片
1,2,3-trichloro-4-(2,4,5-trichlorophenyl)benzene
化学式: C12H4Cl6 (357.8444164)
中文名称: 异辛烷中PCB138溶液
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1C2=CC(=C(C=C2Cl)Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H4Cl6/c13-7-2-1-5(11(17)12(7)18)6-3-9(15)10(16)4-8(6)14/h1-4H
描述信息
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiong Wu, Hindrik Bouwman, Ryan C Uren, Carl D van der Lingen, Walter Vetter. Halogenated natural products and anthropogenic persistent organic pollutants in chokka squid (Loligo reynaudii) from three sites along the South Atlantic and Indian Ocean coasts of South Africa.
Environmental pollution (Barking, Essex : 1987).
2019 Dec; 255(Pt 2):113282. doi:
10.1016/j.envpol.2019.113282. [PMID: 31563788] - Ling-Chuan Guo, Shengbing Yu, De Wu, Jinxu Huang, Tao Liu, Jianpeng Xiao, Weixiong Huang, Yanhong Gao, Xing Li, Weilin Zeng, Shannon Rutherford, Wenjun Ma, Yonghui Zhang, Lifeng Lin. Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt B):112925. doi:
10.1016/j.envpol.2019.07.093. [PMID: 31454572] - Juan Pedro Arrebola, Juan José Ramos, Mónica Bartolomé, Marta Esteban, Olga Huetos, Ana I Cañas, Ana López-Herranz, Eva Calvo, Beatriz Pérez-Gómez, Argelia Castaño. Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study.
Environment international.
2019 02; 123(?):512-521. doi:
10.1016/j.envint.2018.12.030. [PMID: 30622076] - Juan Pedro Arrebola, Argelia Castaño, Marta Esteban, Mónica Bartolomé, Beatriz Pérez-Gómez, Juan José Ramos. Differential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults. Data from BIOAMBIENT.ES project.
The Science of the total environment.
2018 Sep; 634(?):235-242. doi:
10.1016/j.scitotenv.2018.03.283. [PMID: 29627546] - Yeon A Kim, Hye Young Kim, Yoo Jin Oh, Woo Young Kwon, Mi Hwa Lee, Ju Yong Bae, Min Seok Woo, Jong-Min Kim, Young Hyun Yoo. Polychlorinated biphenyl 138 exposure-mediated lipid droplet enlargement endows adipocytes with resistance to TNF-α-induced cell death.
Toxicology letters.
2018 Aug; 292(?):55-62. doi:
10.1016/j.toxlet.2018.04.029. [PMID: 29704545] - B González-Alzaga, M Lacasaña, A F Hernández, J P Arrebola, I López-Flores, F Artacho-Cordón, J P Bonde, N Olea, C Aguilar-Garduño. Serum concentrations of organochlorine compounds and predictors of exposure in children living in agricultural communities from South-Eastern Spain.
Environmental pollution (Barking, Essex : 1987).
2018 Jun; 237(?):685-694. doi:
10.1016/j.envpol.2017.10.109. [PMID: 29129429] - Aina Jansen, Anuschka Polder, Mette H B Müller, Eystein Skjerve, Jan Aaseth, Jan L Lyche. Increased levels of persistent organic pollutants in serum one year after a great weight loss in humans: Are the levels exceeding health based guideline values?.
The Science of the total environment.
2018 May; 622-623(?):1317-1326. doi:
10.1016/j.scitotenv.2017.11.241. [PMID: 29890598] - Maria Wielsøe, Peder Kern, Eva Cecilie Bonefeld-Jørgensen. Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study.
Environmental health : a global access science source.
2017 06; 16(1):56. doi:
10.1186/s12940-017-0269-6. [PMID: 28610584] - Hye Young Kim, Woo Young Kwon, Yeon A Kim, Yoo Jin Oh, Seung Hee Yoo, Mi Hwa Lee, Ju Yong Bae, Jong-Min Kim, Young Hyun Yoo. Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27.
Archives of toxicology.
2017 Jun; 91(6):2353-2363. doi:
10.1007/s00204-016-1889-2. [PMID: 27837308] - Yoshihisa Kato, Aki Fujii, Koichi Haraguchi, Yukiko Fujii, Kazutaka Atobe, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga, Chiho Ohta, Shizuo Yamada, Masakuni Degawa. Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.
The Journal of toxicological sciences.
2017; 42(6):663-669. doi:
10.2131/jts.42.663. [PMID: 29142165] - M Elizabeth Marder, Parinya Panuwet, Ronald E Hunter, P Barry Ryan, Michele Marcus, Dana Boyd Barr. Quantification of Polybrominated and Polychlorinated Biphenyls in Human Matrices by Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry.
Journal of analytical toxicology.
2016 Sep; 40(7):511-8. doi:
10.1093/jat/bkw041. [PMID: 27445313] - Şafak Ulusoy, Özkan Özden, Olaf Päpke. Distribution of OCPs and PCBs in Mussels (Mytilus galloprovincialis) from the Marmara Sea Coastal Sites.
Bulletin of environmental contamination and toxicology.
2016 Aug; 97(2):191-7. doi:
10.1007/s00128-016-1848-x. [PMID: 27329111] - Rachel G Felton, Cynthia C Steiner, Barbara S Durrant, Duane H Keisler, Matthew R Milnes, Christopher W Tubbs. Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals.
Endocrinology.
2015 Dec; 156(12):4448-57. doi:
10.1210/en.2015-1448. [PMID: 26372180] - Keren Agay-Shay, David Martinez, Damaskini Valvi, Raquel Garcia-Esteban, Xavier Basagaña, Oliver Robinson, Maribel Casas, Jordi Sunyer, Martine Vrijheid. Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach.
Environmental health perspectives.
2015 Oct; 123(10):1030-7. doi:
10.1289/ehp.1409049. [PMID: 25956007] - Juan P Arrebola, Ricardo Ocaña-Riola, Antonio L Arrebola-Moreno, María Fernández-Rodríguez, Piedad Martin-Olmedo, Mariana F Fernández, Nicolás Olea. Associations of accumulated exposure to persistent organic pollutants with serum lipids and obesity in an adult cohort from Southern Spain.
Environmental pollution (Barking, Essex : 1987).
2014 Dec; 195(?):9-15. doi:
10.1016/j.envpol.2014.08.003. [PMID: 25173983] - M J Cascaes, R T Oliveira, M M Ubarana, R M Sato, P Baldassin, F I Colabuono, J Leonel, S Taniguchi, R R Weber. Persistent organic pollutants in liver of Brazilian sharpnose shark (Rhizoprionodon lalandii) from southeastern coast of Brazil.
Marine pollution bulletin.
2014 Sep; 86(1-2):591-593. doi:
10.1016/j.marpolbul.2014.05.032. [PMID: 25127497] - L L Aylward, J J Collins, K M Bodner, M Wilken, C M Bodnar. 'Intrinsic' elimination rate and dietary intake estimates for selected indicator PCBs: toxicokinetic modeling using serial sampling data in US subjects, 2005-2010.
Chemosphere.
2014 Sep; 110(?):48-52. doi:
10.1016/j.chemosphere.2014.03.070. [PMID: 24880598] - J A Jenkins, H M Olivier, R O Draugelis-Dale, B E Eilts, L Torres, R Patiño, E Nilsen, S L Goodbred. Assessing reproductive and endocrine parameters in male largescale suckers (Catostomus macrocheilus) along a contaminant gradient in the lower Columbia River, USA.
The Science of the total environment.
2014 Jun; 484(?):365-78. doi:
10.1016/j.scitotenv.2013.09.097. [PMID: 24182618] - Sihem Ben Hassine, Bechir Hammami, Walid Ben Ameur, Yassine El Megdiche, Badriddine Barhoumi, Rached El Abidi, Mohamed Ridha Driss. Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and their relation with age, gender, and BMI for the general population of Bizerte, Tunisia.
Environmental science and pollution research international.
2014 May; 21(10):6303-13. doi:
10.1007/s11356-013-1480-9. [PMID: 23338993] - Patrick De Boever, Britt Wens, Jordi Boix, Vicente Felipo, Greet Schoeters. Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months.
Chemical research in toxicology.
2013 Aug; 26(8):1159-67. doi:
10.1021/tx300510v. [PMID: 23829299] - Helena Bjermo, Per Ola Darnerud, Sanna Lignell, Monika Pearson, Panu Rantakokko, Cecilia Nälsén, Heléne Enghardt Barbieri, Hannu Kiviranta, Anna Karin Lindroos, Anders Glynn. Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population.
Environment international.
2013 Jan; 51(?):88-96. doi:
10.1016/j.envint.2012.10.010. [PMID: 23201820] - Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner.
Toxicology and applied pharmacology.
2012 Aug; 263(1):7-13. doi:
10.1016/j.taap.2012.05.016. [PMID: 22664347] - Thomas Schettgen, A Alt, D Preim, D Keller, T Kraus. Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building.
Toxicology letters.
2012 Aug; 213(1):116-21. doi:
10.1016/j.toxlet.2011.06.005. [PMID: 21699966] - Kusheng Wu, Xijin Xu, Junxiao Liu, Yongyong Guo, Xia Huo. In utero exposure to polychlorinated biphenyls and reduced neonatal physiological development from Guiyu, China.
Ecotoxicology and environmental safety.
2011 Nov; 74(8):2141-7. doi:
10.1016/j.ecoenv.2011.07.038. [PMID: 21851983] - B Wens, P De Boever, M Maes, K Hollanders, G Schoeters. Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells.
Toxicology.
2011 Sep; 287(1-3):113-23. doi:
10.1016/j.tox.2011.06.004. [PMID: 21703328] - Laura Marabini, Rossella Calò, Serena Fucile. Genotoxic effects of polychlorinated biphenyls (PCB 153, 138, 101, 118) in a fish cell line (RTG-2).
Toxicology in vitro : an international journal published in association with BIBRA.
2011 Aug; 25(5):1045-52. doi:
10.1016/j.tiv.2011.04.004. [PMID: 21504788] - Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Nobuyuki Koga. [In vivo metabolism of 2,2',3,4,4',5'-hexachlorobiphenyl (CB138) in guinea pigs].
Fukuoka igaku zasshi = Hukuoka acta medica.
2011 Apr; 102(4):167-74. doi:
NULL. [PMID: 21706897] - Jordi Sunyer, Raquel Garcia-Esteban, Mar Alvarez, Mònica Guxens, Fernando Goñi, Mikel Basterrechea, Martine Vrijheid, Stefano Guerra, Josep M Antó. DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants.
Epidemiology (Cambridge, Mass.).
2010 Sep; 21(5):729-35. doi:
10.1097/ede.0b013e3181e5ea96. [PMID: 20616741] - Renée Dallaire, Eric Dewailly, Daria Pereg, Serge Dery, Pierre Ayotte. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults.
Environmental health perspectives.
2009 Sep; 117(9):1380-6. doi:
10.1289/ehp.0900633. [PMID: 19750101] - Daniela Cocchi, Giovanni Tulipano, Alessandra Colciago, Valeria Sibilia, Francesca Pagani, Daniela Viganò, Tiziana Rubino, Daniela Parolaro, Patrizia Bonfanti, Anita Colombo, Fabio Celotti. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring.
Toxicology and applied pharmacology.
2009 Jun; 237(2):127-36. doi:
10.1016/j.taap.2009.03.008. [PMID: 19327374] - Milena Cerná, Marek Malý, Roman Grabic, Andrea Batáriová, Jirí Smíd, Bohuslav Benes. Serum concentrations of indicator PCB congeners in the Czech adult population.
Chemosphere.
2008 Jul; 72(8):1124-31. doi:
10.1016/j.chemosphere.2008.04.019. [PMID: 18547604] - Xuemei Li, Qinghua Zhang, Jiayin Dai, Yiping Gan, Jun Zhou, Xiangping Yang, Hong Cao, Guibin Jiang, Muqi Xu. Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian wastewater treatment plant.
Chemosphere.
2008 Jul; 72(8):1145-51. doi:
10.1016/j.chemosphere.2008.03.049. [PMID: 18472141] - K Haraguchi, Y Kato, N Koga, M Degawa. Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2',5'-penta- and 2,3,4,2',3',6'-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs.
Xenobiotica; the fate of foreign compounds in biological systems.
2005 Jan; 35(1):85-96. doi:
10.1080/00498250400026456. [PMID: 15788370] - Thomas Høj Rasmussen, Flemming Nielsen, Helle Raun Andersen, Jesper Bo Nielsen, Pal Weihe, Philippe Grandjean. Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts.
Environmental health : a global access science source.
2003 Oct; 2(1):12. doi:
10.1186/1476-069x-2-12. [PMID: 14613489] - Russ Hauser, Zuying Chen, Lucille Pothier, Louise Ryan, Larisa Altshul. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE.
Environmental health perspectives.
2003 Sep; 111(12):1505-11. doi:
10.1289/ehp.6175. [PMID: 12948891] - V Daniel, W Huber, K Bauer, C Suesal, C Conradt, G Opelz. Associations of blood levels of PCB, HCHS, and HCB with numbers of lymphocyte subpopulations, in vitro lymphocyte response, plasma cytokine levels, and immunoglobulin autoantibodies.
Environmental health perspectives.
2001 Feb; 109(2):173-8. doi:
10.1289/ehp.01109173. [PMID: 11266329] - G M Lackmann, J Angerer, U Töllner. Parental smoking and neonatal serum levels of polychlorinated biphenyls and hexachlorobenzene.
Pediatric research.
2000 May; 47(5):598-601. doi:
10.1203/00006450-200005000-00007. [PMID: 10813583] - L Gribaldo, M G Sacco, S Casati, I Zucchi, M K Dosanjh, P Catalani, E Marafante. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line.
Journal of toxicology and environmental health. Part A.
1998 Sep; 55(2):121-31. doi:
10.1080/009841098158557. [PMID: 9761132]