Dilacor XR (BioDeep_00000174180)
human metabolite blood metabolite
代谢物信息卡片
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
化学式: C22H26N2O4S (414.16131960000007)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
InChI: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3
描述信息
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
15 个代谢物同义名
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; 3-Acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; diltiazem hydrochloride; Diltiazem malate; Dilacor XR; Diltiazem; Cardizem; CRD-401; Dilacor; CRD 401; Aldizem; Tiazac; Dilren; Dilzem; Cardil
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:82814
- PubChem: 3076
- HMDB: HMDB0246186
- ChEMBL: CHEMBL603584
- Wikipedia: Diltiazem
- MeSH: Diltiazem
- chemspider: 2967
- CAS: 1242184-41-3
- CAS: 112259-41-3
- CAS: 56209-45-1
- CAS: 34933-06-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li. Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.
Hypertension in pregnancy.
2024 Dec; 43(1):2329068. doi:
10.1080/10641955.2024.2329068. [PMID: 38488570] - Sudipta Mukherjee, Jasmina Khanam. Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis.
Chemical & pharmaceutical bulletin.
2024 May; 72(5):454-470. doi:
10.1248/cpb.c23-00652. [PMID: 38644216] - Jie Liu, Xuyang Shang, Bingyi Yao, Yuanjin Zhang, Shengbo Huang, Yuanqing Guo, Xin Wang. Design and construction of Carboxylesterase 2c Gene knockout Rats by CRISPR/Cas9.
Current drug metabolism.
2023 Jan; ?(?):. doi:
10.2174/1389200224666230123140919. [PMID: 36694315] - Yue Yang, Ke Feng, Yuting Lei, Li Qiu, Chengjiang Liu, Guofeng Li. Comparing the efficacy and safety of different analgesic strategies after open hemorrhoidectomy: a systematic review and network meta-analysis.
International journal of colorectal disease.
2023 Jan; 38(1):4. doi:
10.1007/s00384-022-04294-5. [PMID: 36609578] - Ya-Hui Yuan, Rong Yuan, Yu Miao, Ya Wang, Peng-Qi Li, Jia-Qi Hui, Yu-Fan Pan, Zi-Han Li, Qi-Qi Xin, Wei-Hong Cong. [Effect and mechanism of Huangqi Shengmai Decoction in treatment of joint rat model of fatigue and myocardial injury].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(19):5292-5298. doi:
10.19540/j.cnki.cjcmm.20220325.702. [PMID: 36472036] - Min-Hui Tan, Seow-Yeing Yee, Rosnawati Yahya. Lessons of the month 2: A case of inappropriate drug-drug interaction in kidney transplant.
Clinical medicine (London, England).
2022 03; 22(2):169-171. doi:
10.7861/clinmed.2021-0789. [PMID: 35304379] - Ebrahim Lari, S Rebekah Burket, Dylan Steinkey, Bryan W Brooks, Greg G Pyle. Interaction of the Olfactory System of Rainbow Trout (Oncorhynchus mykiss) with Diltiazem.
Environmental toxicology and chemistry.
2022 03; 41(3):544-550. doi:
10.1002/etc.4854. [PMID: 33463738] - S R Vaibavi, Manoj Sivasubramaniapandian, Rahul Vaippully, Privita Edwina, Basudev Roy, Saumendra Kumar Bajpai. Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells.
Cell biochemistry and biophysics.
2022 Mar; 80(1):171-190. doi:
10.1007/s12013-021-01035-3. [PMID: 34643835] - Xinxin Wang, Jie Luo, Zhiyuan Wen, Lei Shuai, Chong Wang, Gongxun Zhong, Xijun He, Huizhen Cao, Renqiang Liu, Jinying Ge, Ronghong Hua, Ziruo Sun, Xijun Wang, Jinliang Wang, Zhigao Bu. Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung.
PLoS pathogens.
2022 02; 18(2):e1010343. doi:
10.1371/journal.ppat.1010343. [PMID: 35176124] - Jie Liu, Xuyang Shang, Shengbo Huang, Yuan Xu, Jian Lu, Yuanjin Zhang, Zongjun Liu, Xin Wang. Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene.
Molecular pharmacology.
2021 11; 100(5):480-490. doi:
10.1124/molpharm.121.000357. [PMID: 34503976] - X Peng, D-F Peng, S-Y Tang. Effect of diltiazem on exercise tolerance in patients with stable coronary artery disease and hypertension.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2021 Aug; 72(4):. doi:
10.26402/jpp.2021.4.07. [PMID: 34987129] - Malik Nadeem Azam, Khalid Mehmood Raja, Abdur Rehman Arshad, Faryal Riaz Khan, Abdul Wahab Mir, Taleah Tahir, Batool Butt, Anum Khan. The Comparison Of Efficacy Between Losartan And Diltiazem As Antiproteinuric Agent In Non-Diabetic Renal Diseases.
Journal of Ayub Medical College, Abbottabad : JAMC.
2021 Jul; 33(3):492-495. doi:
NULL. [PMID: 34487664] - Qi Huang, Wen Ting Wang, Shi Sheng Wang, De An Pei, Xiang Qian Sui. Cardiovascular magnetic resonance image analysis and mechanism study for the changes after treatments for primary microvascular angina pectoris.
Medicine.
2021 May; 100(21):e26038. doi:
10.1097/md.0000000000026038. [PMID: 34032727] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ning Li, Shujuan He, Chunlan Li, Fatang Yang, Yuming Dong. Sensitive Analysis of Metoprolol Tartrate and Diltiazem Hydrochloride in Human Serum by Capillary Zone Electrophoresis Combining on Column Field-Amplified Sample Injection.
Journal of chromatographic science.
2021 Apr; 59(5):465-472. doi:
10.1093/chromsci/bmab025. [PMID: 33675354] - Abhijit R Lodha, Ashwin Pillai, Kaushik Sheth, Jagdish Hiremath. A retrospective cohort study exploring diltiazem as a pharmaco-enhancer for tacrolimus, in a post-heart transplant setting.
Clinical transplantation.
2020 12; 34(12):e14100. doi:
10.1111/ctr.14100. [PMID: 32981136] - Yuzhou Gui, Youli Lu, Shuijun Li, Mengqi Zhang, Xiaokun Duan, Charles C Liu, Jingying Jia, Gangyi Liu. Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring.
Scientific reports.
2020 09; 10(1):15550. doi:
10.1038/s41598-020-72490-w. [PMID: 32968164] - Andrés Pizzorno, Blandine Padey, Thomas Julien, Sophie Trouillet-Assant, Aurélien Traversier, Elisabeth Errazuriz-Cerda, Julien Fouret, Julia Dubois, Alexandre Gaymard, François-Xavier Lescure, Victoria Dulière, Pauline Brun, Samuel Constant, Julien Poissy, Bruno Lina, Yazdan Yazdanpanah, Olivier Terrier, Manuel Rosa-Calatrava. Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia.
Cell reports. Medicine.
2020 07; 1(4):100059. doi:
10.1016/j.xcrm.2020.100059. [PMID: 32835306] - Abdul Wahab Arif, Muhammad Shahzeb Khan, Abdallah Masri, Benjamin Mba, Muhammad Talha Ayub, Rami Doukky. BRASH Syndrome with Hyperkalemia: An Under-Recognized Clinical Condition.
Methodist DeBakey cardiovascular journal.
2020 Jul; 16(3):241-244. doi:
10.14797/mdcj-16-3-241. [PMID: 33133361] - Maria M Posada, Bridget L Morse, P Kellie Turner, Palaniappan Kulanthaivel, Stephen D Hall, Gemma L Dickinson. Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Journal of clinical pharmacology.
2020 07; 60(7):915-930. doi:
10.1002/jcph.1584. [PMID: 32080863] - Mona Elfiky, Nehal Salahuddin, Atsunori Matsuda. Green fabrication of 3D hierarchical blossom-like hybrid of peeled montmorillonite-ZnO for in-vitro electrochemical sensing of diltiazem hydrochloride drug.
Materials science & engineering. C, Materials for biological applications.
2020 Jun; 111(?):110773. doi:
10.1016/j.msec.2020.110773. [PMID: 32279745] - Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122125. doi:
10.1016/j.jchromb.2020.122125. [PMID: 32371329] - Gavin N Saari, Samuel P Haddad, Rachel M Mole, Bridgett N Hill, W Baylor Steele, Lea M Lovin, C Kevin Chambliss, Bryan W Brooks. Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2020 May; 231(?):108719. doi:
10.1016/j.cbpc.2020.108719. [PMID: 31987992] - Andreas Nordholm-Carstensen, Helene Perregaard, Kirsten Lykke Wahlstrøm, Kikke Bartholin Hagen, Helene Tarri Hougaard, Peter-Martin Krarup. Treatment of chronic anal fissure: a feasibility study on Levorag® Emulgel versus Diltiazem gel 2.
International journal of colorectal disease.
2020 Apr; 35(4):615-621. doi:
10.1007/s00384-020-03515-z. [PMID: 31980871] - Phuong Pham, Stephan Schmidt, Lawrence Lesko, Gregory Y H Lip, Joshua D Brown. Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.
JAMA network open.
2020 04; 3(4):e203593. doi:
10.1001/jamanetworkopen.2020.3593. [PMID: 32329770] - Afrasim Moin, Hosahalli V Gangadharappa, Mohd Adnan, Syed M Rizvi, Syed A Ashraf, Mitesh Patel, Amr S Abu Lila, Ahmed N Allam. Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
Drug design, development and therapy.
2020; 14(?):5325-5336. doi:
10.2147/dddt.s279955. [PMID: 33293794] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - Hsien-Tsung Yao, Jia-Hsuan Lin, Yun-Ta Liu, Mei-Ling Li, Wenchang Chiang. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats.
Nutrients.
2019 Oct; 11(10):. doi:
10.3390/nu11102473. [PMID: 31618937] - Dylan Steinkey, Ebrahim Lari, Samuel G Woodman, Rylan Steinkey, Kim H Luong, Charles S Wong, Greg G Pyle. The effects of diltiazem on growth, reproduction, energy reserves, and calcium-dependent physiology in Daphnia magna.
Chemosphere.
2019 Oct; 232(?):424-429. doi:
10.1016/j.chemosphere.2019.05.176. [PMID: 31158637] - Wai-Ping Yau, Charlene Wei-Ting Loh, Anantharaman Vathsala. Conversion from Twice-Daily Prograf® to Once-Daily Advagraf® in Multi-ethnic Asian Adult Renal Transplant Recipients With or Without Concomitant Use of Diltiazem: Impact of CYP3A5 and MDR1 Genetic Polymorphisms on Tacrolimus Exposure.
European journal of drug metabolism and pharmacokinetics.
2019 Aug; 44(4):481-492. doi:
10.1007/s13318-018-0531-5. [PMID: 30471066] - W Casan Scott, Samuel P Haddad, Gavin N Saari, C Kevin Chambliss, Jeremy L Conkle, Cole W Matson, Bryan W Brooks. Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis.
Chemosphere.
2019 Aug; 229(?):434-442. doi:
10.1016/j.chemosphere.2019.04.188. [PMID: 31082711] - Abdullah Hamadi, Andrew P Grigg, Gasim Dobie, Kate L Burbury, Anthony P Schwarer, Faith A Kwa, Denise E Jackson. Ponatinib Tyrosine Kinase Inhibitor Induces a Thromboinflammatory Response.
Thrombosis and haemostasis.
2019 Jul; 119(7):1112-1123. doi:
10.1055/s-0039-1688787. [PMID: 31079415] - Yun Lin, Jinxiang Zhang, Wei Lei, Miaoyuan Li, Zhi Zhang, Yanmeng Lu, Linqiang Chen, Jin Yang, Jianjian Liang, Yehui Chen. Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats.
Andrologia.
2019 Jun; 51(5):e13251. doi:
10.1111/and.13251. [PMID: 30821033] - Ken Takahashi, Shogo Hayashi, Mari Miyajima, Marei Omori, Jing Wang, Keiko Kaihara, Masatoshi Morimatsu, Chen Wang, Jian Chen, Gentaro Iribe, Keiji Naruse, Masahiro Sokabe. L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2.
Cell calcium.
2019 05; 79(?):68-74. doi:
10.1016/j.ceca.2019.02.008. [PMID: 30836292] - Rebecca E Wrishko, Jacqueline B McCrea, Ka Lai Yee, Wen Liu, Deborah Panebianco, Eric Mangin, Manu Chakravarthy, Maria P Martinez-Cantarin, Walter K Kraft. Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects.
Clinical drug investigation.
2019 May; 39(5):441-451. doi:
10.1007/s40261-019-00764-x. [PMID: 30810914] - Laila H Emara, Ahmed A El-Ashmawy, Nesrin F Taha. Stability and bioavailability of diltiazem/polyethylene oxide matrix tablets.
Pharmaceutical development and technology.
2018 Dec; 23(10):1057-1066. doi:
10.1080/10837450.2017.1341523. [PMID: 28604151] - Ahmed Subahi, Walid Ibrahim, Ashraf Abugroun. Diltiazem-Associated Cardiogenic Shock in Thyrotoxic Crisis.
American journal of therapeutics.
2018 Nov; 25(6):e666-e669. doi:
10.1097/mjt.0000000000000739. [PMID: 29521654] - Gavin N Saari, Jone Corrales, Samuel P Haddad, C Kevin Chambliss, Bryan W Brooks. Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients.
Environmental toxicology and chemistry.
2018 11; 37(11):2835-2850. doi:
10.1002/etc.4242. [PMID: 30055012] - C L Choong, H S Wong, F Y Lee, C K Lee, J V Kho, Y X Lai, T Vikneswaran. Dose-Response Relationship Between Diltiazem and Tacrolimus and Its Safety in Renal Transplant Recipients.
Transplantation proceedings.
2018 Oct; 50(8):2515-2520. doi:
10.1016/j.transproceed.2018.04.024. [PMID: 30316389] - S-H Ok, I-W Shin, S H Lee, J Park, M S Woo, J-M Hong, J Kim, J-T Sohn. Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Human & experimental toxicology.
2018 Jun; 37(6):636-646. doi:
10.1177/0960327117721963. [PMID: 28741374] - Mohamad Badr Jandali. Safety of Intravenous Diltiazem in Reduced Ejection Fraction Heart Failure with Rapid Atrial Fibrillation.
Clinical drug investigation.
2018 Jun; 38(6):503-508. doi:
10.1007/s40261-018-0631-7. [PMID: 29478238] - James Naples, Robert Cox, Gregory Bonaiuto, Kourosh Parham. Prestin as an Otologic Biomarker of Cisplatin Ototoxicity in a Guinea Pig Model.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.
2018 03; 158(3):541-546. doi:
10.1177/0194599817742093. [PMID: 29160156] - Jonathan H Sin, Andrew Tom, Alexander Toyoda, Nathalie Roy, Bryan D Hayes. High-dose intravenous lipid emulsion affecting successful initiation of continuous venovenous hemofiltration and extracorporeal membrane oxygenation.
Clinical toxicology (Philadelphia, Pa.).
2018 02; 56(2):149-150. doi:
10.1080/15563650.2017.1341633. [PMID: 28681624] - Xiao-Feng Guan, Dai-Yang Li, Wen-Jun Yin, Jun-Jie Ding, Ling-Yun Zhou, Jiang-Lin Wang, Rong-Rong Ma, Xiao-Cong Zuo. Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients.
European journal of drug metabolism and pharmacokinetics.
2018 Feb; 43(1):55-62. doi:
10.1007/s13318-017-0425-y. [PMID: 28646274] - Abidemi J Akindele, Gabriel O Oludadepo, Kennedy I Amagon, Dhirendra Singh, Daniel D Osiagwu. Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
Pharmacology research & perspectives.
2018 02; 6(1):. doi:
10.1002/prp2.381. [PMID: 29417758] - Emmy Luu, Kevin B Ita, Matthew J Morra, Inna E Popova. The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine.
Current drug delivery.
2018; 15(10):1449-1458. doi:
10.2174/1567201815666180730125941. [PMID: 30058488] - Luca Morini, Matteo Moretti, Francesca Brandolini, Antonio Marco Maria Osculati, Angelo Groppi, Claudia Vignali. Two Fatal Cases Involving Cardiovascular Drugs Diltiazem and Amlodipine.
Journal of analytical toxicology.
2018 Jan; 42(1):e15-e19. doi:
10.1093/jat/bkx087. [PMID: 29140511] - James A Chenoweth, Daniel K Colby, Mark E Sutter, Joshua B Radke, Jonathan B Ford, J Nilas Young, John R Richards. Massive diltiazem and metoprolol overdose rescued with extracorporeal life support.
The American journal of emergency medicine.
2017 Oct; 35(10):1581.e3-1581.e5. doi:
10.1016/j.ajem.2017.07.023. [PMID: 28705745] - Bhargavi Latha Athukuri, Prasad Neerati. Enhanced Oral Bioavailability of Diltiazem by the Influence of Gallic Acid and Ellagic Acid in Male Wistar Rats: Involvement of CYP3A and P-gp Inhibition.
Phytotherapy research : PTR.
2017 Sep; 31(9):1441-1448. doi:
10.1002/ptr.5873. [PMID: 28766866] - Bekir Inan, Selma Sönmez Ergün, Asiye Nurten, Canan Küçükgergin, Aslı Zengin Türkmen, Şule Seçkin, Kerem Erkalp, Sedat Ziyade. Effects of Cilostazol and Diltiazem Hydrochloride on Ischemia-Reperfusion Injury in a Rat Hindlimb Model.
The heart surgery forum.
2017 Apr; 20(2):E058-E065. doi:
10.1532/hsf.1663. [PMID: 28481745] - Udom Krairittichai, Veerasak Sarinnapakorn, Rungrawee Mahannopkul, Ploypassorn Ainwan. Renal Protective Effects of Combination of Diltiazem and ACEI/ARB on the Progression of Diabetic Nephropathy: Randomized Controlled Trial.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2017 Feb; 100 Suppl 1(?):S40-7. doi:
. [PMID: 29927180] - Basma Ismail, Rob A deKemp, Etienne Croteau, Tayebeh Hadizad, Kevin D Burns, Rob S Beanlands, Jean N DaSilva. Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.
PloS one.
2017; 12(5):e0177451. doi:
10.1371/journal.pone.0177451. [PMID: 28542215] - G Ozmerdiven, B A Vuruskan, O Kaygisiz, H Vuruskan. Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats.
Bratislavske lekarske listy.
2017; 118(4):228-232. doi:
10.4149/bll_2017_045. [PMID: 28471234] - Alaa E El-Sisi, Samia S Sokar, Sally E Abu-Risha, Hanaa A Ibrahim. Combination of tadalafil and diltiazem attenuates renal ischemia reperfusion-induced acute renal failure in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):861-869. doi:
10.1016/j.biopha.2016.10.009. [PMID: 27736652] - Nageshwar R Budha, Tao Ji, Luna Musib, Steve Eppler, Mark Dresser, Yuan Chen, Jin Y Jin. Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.
Clinical pharmacokinetics.
2016 11; 55(11):1435-1445. doi:
10.1007/s40262-016-0412-5. [PMID: 27225997] - Charalampos I Liakos, Gregory P Vyssoulis, Maria I Markou, Nikolaos V Kafkas, Konstantinos P Toutouzas, Dimitrios Tousoulis. Twenty-Four-Hour Urine α1 -Microglobulin as a Marker of Hypertension-Induced Renal Impairment and Its Response on Different Blood Pressure-Lowering Drugs.
Journal of clinical hypertension (Greenwich, Conn.).
2016 10; 18(10):1000-1006. doi:
10.1111/jch.12811. [PMID: 26992096] - Atsuko Shihyakugari, Satoko Hori, Akiko Miki, Yasufumi Sawada. Induced next-day somnolence in an elderly patient taking suvorexant concomitantly with diltiazem.
International journal of clinical pharmacology and therapeutics.
2016 Aug; 54(8):645-8. doi:
10.5414/cp202624. [PMID: 27191770] - Christoph Steinbach, Viktoriia Burkina, Heike Schmidt-Posthaus, Alzbeta Stara, Jitka Kolarova, Josef Velisek, Tomas Randak, Hana Kocour Kroupova. Effect of the human therapeutic drug diltiazem on the haematological parameters, histology and selected enzymatic activities of rainbow trout Oncorhynchus mykiss.
Chemosphere.
2016 Aug; 157(?):57-64. doi:
10.1016/j.chemosphere.2016.04.137. [PMID: 27208646] - Ying Zhang, Xin Zhao, Yanzhong Chang, Yuanyuan Zhang, Xi Chu, Xuan Zhang, Zhenyi Liu, Hui Guo, Na Wang, Yonggang Gao, Jianping Zhang, Li Chu. Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.
Toxicology and applied pharmacology.
2016 06; 301(?):50-60. doi:
10.1016/j.taap.2016.04.008. [PMID: 27095094] - L-Y Zhou, X-C Zuo, K Chen, J-L Wang, Q-J Chen, Y-N Zhou, H Yuan, Y Ma, L-J Zhu, Y-X Peng, Y-Z Ming. Significant impacts of CYP3A4*1G and CYP3A5*3 genetic polymorphisms on the pharmacokinetics of diltiazem and its main metabolites in Chinese adult kidney transplant patients.
Journal of clinical pharmacy and therapeutics.
2016 Jun; 41(3):341-7. doi:
10.1111/jcpt.12394. [PMID: 27149910] - Rabinarayan Parhi, Podilam Suresh, Subasini Pattnaik. Pluronic lecithin organogel (PLO) of diltiazem hydrochloride: effect of solvents/penetration enhancers on ex vivo permeation.
Drug delivery and translational research.
2016 06; 6(3):243-53. doi:
10.1007/s13346-015-0276-5. [PMID: 26754742] - Olga Koba, Christoph Steinbach, Hana Kocour Kroupová, Kateřina Grabicová, Tomáš Randák, Roman Grabic. Investigation of diltiazem metabolism in fish using a hybrid quadrupole/orbital trap mass spectrometer.
Rapid communications in mass spectrometry : RCM.
2016 May; 30(9):1153-62. doi:
10.1002/rcm.7543. [PMID: 27060844] - Sam H Muller, James H Diaz, Alan David Kaye. Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice.
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society.
2016 May; 168(3):101-3. doi:
". [PMID: 27389379] - Christoph Steinbach, Roman Grabic, Ganna Fedorova, Olga Koba, Oksana Golovko, Katerina Grabicova, Hana Kocour Kroupova. Bioconcentration, metabolism and half-life time of the human therapeutic drug diltiazem in rainbow trout Oncorhynchus mykiss.
Chemosphere.
2016 Feb; 144(?):154-9. doi:
10.1016/j.chemosphere.2015.08.038. [PMID: 26356646] - Akihiro Ryuge, Hideaki Shimizu, Yukako Ohyama, Makoto Yamaguchi, Atsushi Nomura, Shoichi Maruyama, Hiroshi Kitamura, Yoshiro Fujita. Ischemic Acute Tubular Necrosis due to Diltiazem Overdose.
Internal medicine (Tokyo, Japan).
2016; 55(9):1149-51. doi:
10.2169/internalmedicine.55.5232. [PMID: 27150870] - Nursah Basol, Oytun Erbas. The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication.
Human & experimental toxicology.
2016 Jan; 35(1):29-34. doi:
10.1177/0960327115574920. [PMID: 25724422] - Bing Zhu, Bozo Zonja, Oscar Gonzalez, Carme Sans, Sandra Pérez, Damia Barceló, Santiago Esplugas, Ke Xu, Zhimin Qiang. Degradation kinetics and pathways of three calcium channel blockers under UV irradiation.
Water research.
2015 Dec; 86(?):9-16. doi:
10.1016/j.watres.2015.05.028. [PMID: 26003333] - Qingen Ke, Mohammed A Samad, Soochan Bae, David J Chaplin, Peter M Kang. Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem.
Vascular pharmacology.
2015 Nov; 74(?):73-79. doi:
10.1016/j.vph.2015.05.004. [PMID: 25989107] - Asuka Baba, Masahiro Tachi, Yoshio Maruyama, Itsuro Kazama. Suppressive effects of diltiazem and verapamil on delayed rectifier K(+)-channel currents in murine thymocytes.
Pharmacological reports : PR.
2015 Oct; 67(5):959-64. doi:
10.1016/j.pharep.2015.01.009. [PMID: 26398391] - Changwoo Kang, Dong Hoon Kim, Seong Chun Kim, Soo Hoon Lee, Jin Hee Jeong, Tae-Sin Kang, Il-Woo Shin, Rock Bum Kim, Dong Hoon Lee. The effects of intravenous lipid emulsion on prolongation of survival in a rat model of calcium channel blocker toxicity.
Clinical toxicology (Philadelphia, Pa.).
2015 Jul; 53(6):540-4. doi:
10.3109/15563650.2015.1045979. [PMID: 25984591] - Yi-xi Wang, Jia-li Li, Xue-ding Wang, Yu Zhang, Chang-xi Wang, Min Huang. Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation.
Acta pharmacologica Sinica.
2015 Jul; 36(7):855-62. doi:
10.1038/aps.2015.6. [PMID: 25891084] - Natalia Dionisio, Tarik Smani, Geoffrey E Woodard, Antonio Castellano, Gines M Salido, Juan A Rosado. Homer proteins mediate the interaction between STIM1 and Cav1.2 channels.
Biochimica et biophysica acta.
2015 May; 1853(5):1145-53. doi:
10.1016/j.bbamcr.2015.02.014. [PMID: 25712868] - Charles E Frost, Wonkyung Byon, Yan Song, Jessie Wang, Alan E Schuster, Rebecca A Boyd, Donglu Zhang, Zhigang Yu, Clapton Dias, Andrew Shenker, Frank LaCreta. Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor.
British journal of clinical pharmacology.
2015 May; 79(5):838-46. doi:
10.1111/bcp.12541. [PMID: 25377242] - Evelyn Pawlik, Hellmut Mahler, Benno Hartung, Gerd Plässer, Thomas Daldrup. Drug-related death: adulterants from cocaine preparations in lung tissue and blood.
Forensic science international.
2015 Apr; 249(?):294-303. doi:
10.1016/j.forsciint.2015.02.006. [PMID: 25747329] - Carolyn Y Ho, Neal K Lakdawala, Allison L Cirino, Steven E Lipshultz, Elizabeth Sparks, Siddique A Abbasi, Raymond Y Kwong, Elliott M Antman, Christopher Semsarian, Arantxa González, Begoña López, Javier Diez, E John Orav, Steven D Colan, Christine E Seidman. Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression.
JACC. Heart failure.
2015 Feb; 3(2):180-8. doi:
10.1016/j.jchf.2014.08.003. [PMID: 25543971] - Kosuke Takeya, Xuemei Wang, Iris Kathol, Kathy Loutzenhiser, Rodger Loutzenhiser, Michael P Walsh. Endothelin-1, but not angiotensin II, induces afferent arteriolar myosin diphosphorylation as a potential contributor to prolonged vasoconstriction.
Kidney international.
2015 Feb; 87(2):370-81. doi:
10.1038/ki.2014.284. [PMID: 25140913] - Erica Daina, Paolo Cravedi, Mirella Alpa, Dario Roccatello, Sara Gamba, Annalisa Perna, Flavio Gaspari, Giuseppe Remuzzi, Piero Ruggenenti. A multidrug, antiproteinuric approach to alport syndrome: a ten-year cohort study.
Nephron.
2015; 130(1):13-20. doi:
10.1159/000381480. [PMID: 25895746] - Takeshi Ogura, Ririko Takeda, Hidetoshi Ooigawa, Hiroyuki Nakajima, Hiroki Kurita. Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.
Acta neurochirurgica. Supplement.
2015; 120(?):47-50. doi:
10.1007/978-3-319-04981-6_8. [PMID: 25366598] - Dieter Becker, Jin Zhang, Tycho Heimbach, Robert C Penland, Christoph Wanke, Jeff Shimizu, Kenneth Kulmatycki. Novel orally swallowable IntelliCap(®) device to quantify regional drug absorption in human GI tract using diltiazem as model drug.
AAPS PharmSciTech.
2014 Dec; 15(6):1490-7. doi:
10.1208/s12249-014-0172-1. [PMID: 25023947] - Ning Li, Chun-lan Li, Ning-wei Lu, Yu-ming Dong. A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):90-7. doi:
10.1016/j.jchromb.2014.07.019. [PMID: 25086418] - Mustafa Naziroglu, Suleyman Kutluhan, Ishak Suat Ovey, Mehmet Aykur, Vedat Ali Yurekli. Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatum.
Nutritional neuroscience.
2014 Sep; 17(5):214-21. doi:
10.1179/1476830513y.0000000083. [PMID: 24075078] - A J Akindele, A A Adeneye, F Olatoye, A S Benebo. Protective effect of selected calcium channel blockers and prednisolone, a phospholipase-A2 inhibitor, against gentamicin and carbon tetrachloride-induced nephrotoxicity.
Human & experimental toxicology.
2014 Aug; 33(8):831-46. doi:
10.1177/0960327113509660. [PMID: 24220874] - Daniel D Rhoads, Richard A Sivak, Octavia M Peck Palmer. Plasma abnormalities following overdose.
Clinical chemistry.
2014 Jul; 60(7):1020-1. doi:
10.1373/clinchem.2013.219212. [PMID: 24973432] - Khosro Adibkia, Saeed Ghanbarzadeh, Mohammad Hosein Shokri, Zahra Arami, Zeinab Arash, Javad Shokri. Micro-porous surfaces in controlled drug delivery systems: design and evaluation of diltiazem hydrochloride controlled porosity osmotic pump using non-ionic surfactants as pore-former.
Pharmaceutical development and technology.
2014 Jun; 19(4):507-12. doi:
10.3109/10837450.2013.805774. [PMID: 23763379] - Gunjan Sarkar, Nayan Ranjan Saha, Indranil Roy, Amartya Bhattacharyya, Madhura Bose, Roshnara Mishra, Dipak Rana, Debashis Bhattacharjee, Dipankar Chattopadhyay. Taro corms mucilage/HPMC based transdermal patch: an efficient device for delivery of diltiazem hydrochloride.
International journal of biological macromolecules.
2014 May; 66(?):158-65. doi:
10.1016/j.ijbiomac.2014.02.024. [PMID: 24556117] - M Muz, S Ak, O T Komesli, C F Gokcay. Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.
Environmental technology.
2014 May; 35(9-12):1055-63. doi:
10.1080/09593330.2013.861020. [PMID: 24701901] - Hatice Beyazal, Zuhal Caliskan, Cengiz Utaç. Comparison of effects of isotonic sodium chloride with diltiazem in prevention of contrast-induced nephropathy.
Renal failure.
2014 Apr; 36(3):351-5. doi:
10.3109/0886022x.2013.866016. [PMID: 24341598] - N D Filipets, A I Gozhenko. [Comparative assessment of nephroprotective properties of potassium and calcium channel modulators in experimental renal injury].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(1):10-2. doi:
. [PMID: 24649595] - Yu-Yuan Chiu, Larry Ereshefsky, Sheldon H Preskorn, Nagaraju Poola, Antony Loebel. Lurasidone drug-drug interaction studies: a comprehensive review.
Drug metabolism and drug interactions.
2014; 29(3):191-202. doi:
10.1515/dmdi-2014-0005. [PMID: 24825095] - Wen Li, Qi Shi, Weibing Wang, Jianrong Liu, Qi Li, Fenggang Hou. Calcium channel blockers and risk of breast cancer: a meta-analysis of 17 observational studies.
PloS one.
2014; 9(9):e105801. doi:
10.1371/journal.pone.0105801. [PMID: 25184210] - Muhammad Sarwar Zia, Khadija Qamar, Ruhila Hanif, Moazzam Khalil. Effect of monosodium glutamate on the serum estrogen and progesterone levels in female rat and prevention of this effect with diltiazem.
Journal of Ayub Medical College, Abbottabad : JAMC.
2014 Jan; 26(1):18-20. doi:
NULL. [PMID: 25358208] - Önder Kaplan, Mustafa Nazıroğlu, Mehmet Güney, Mehmet Aykur. Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea.
Journal of reproductive immunology.
2013 Dec; 100(2):87-92. doi:
10.1016/j.jri.2013.10.004. [PMID: 24295715] - Muhammad Shoaib Akhtar, Sajid Bashir, Muhammad Nasir-Hayat Malik, Rashida Manzoor. Cardiotonic activity of methanolic extract of Saussurea lappa Linn roots.
Pakistan journal of pharmaceutical sciences.
2013 Nov; 26(6):1197-201. doi:
". [PMID: 24191326] - Wu Deng, Laurie Farricielli. Hypoxic hepatitis and acute liver failure in a patient with newly onset atrial fibrillation and diltiazem infusion.
BMJ case reports.
2013 Sep; 2013(?):. doi:
10.1136/bcr-2013-200573. [PMID: 24042208] - Michael Levine, Steven C Curry, Angela Padilla-Jones, Anne-Michelle Ruha. Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.
Annals of emergency medicine.
2013 Sep; 62(3):252-8. doi:
10.1016/j.annemergmed.2013.03.018. [PMID: 23642908] - Minghui Gao, Sze Yui Wong, Pui Man Lau, Siu Kai Kong. Ferutinin induces in vitro eryptosis/erythroptosis in human erythrocytes through membrane permeabilization and calcium influx.
Chemical research in toxicology.
2013 Aug; 26(8):1218-28. doi:
10.1021/tx400127w. [PMID: 23848973] - Lucas F Sobrado, Bruno B Varone, Ananda D Machado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli, Richard L Verrier. Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
Journal of cardiovascular electrophysiology.
2013 Aug; 24(8):914-8. doi:
10.1111/jce.12155. [PMID: 23647933] - Maggie K M Ma, Lorraine P Y Kwan, Maggie M Y Mok, Desmond Y H Yap, Colin S O Tang, Tak Mao Chan. Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant recipients with or without concomitant diltiazem treatment.
Renal failure.
2013 Aug; 35(7):942-5. doi:
10.3109/0886022x.2013.808134. [PMID: 23815459]