Endurobol (BioDeep_00000174144)
human metabolite blood metabolite
代谢物信息卡片
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
化学式: C21H18F3NO3S2 (453.0680154)
中文名称: GW-501516
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O
InChI: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
描述信息
同义名列表
14 个代谢物同义名
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid; 2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxyacetic acid; UNII-7I2ha1nu22; GW 501,516; GW-501,516; Endurobol; GW-501516; GW501,516; GW501516; GW 1516; GW-1516; GSK-516; GW-516; GW1516
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:73726
- PubChem: 9803963
- HMDB: HMDB0246147
- DrugBank: DB05416
- ChEMBL: CHEMBL38943
- Wikipedia: GW_501516
- chemspider: 7979723
- CAS: 317318-70-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mi Liang, Zhong-Shi Lyu, Yuan-Yuan Zhang, Shu-Qian Tang, Tong Xing, Yu-Hong Chen, Yu Wang, Qian Jiang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong. Activation of PPARδ in bone marrow endothelial progenitor cells improves their hematopoiesis-supporting ability after myelosuppressive injury.
Cancer letters.
2024 Jun; 592(?):216937. doi:
10.1016/j.canlet.2024.216937. [PMID: 38704134] - Jung Seok Hwang, Eunsu Kim, Hyuk Gyoon Lee, Won Jin Lee, Jun Pil Won, Jinwoo Hur, Junichi Fujii, Han Geuk Seo. Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112223. doi:
10.1016/j.biopha.2021.112223. [PMID: 34649350] - Olivia Venezia, Sadia Islam, Christine Cho, Alicia R Timme-Laragy, Karilyn E Sant. Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio.
Toxicology and applied pharmacology.
2021 09; 426(?):115653. doi:
10.1016/j.taap.2021.115653. [PMID: 34302850] - Kai Liu, Xing Zhao, Xue Qi, Dong-Liang Hou, Hao-Bin Li, Yu-Hao Gu, Qing-Long Xu. Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
European journal of medicinal chemistry.
2021 Jun; 218(?):113388. doi:
10.1016/j.ejmech.2021.113388. [PMID: 33784603] - Stéphane Trevisiol, Yves Moulard, Vivian Delcourt, Murielle Jaubert, Sophie Boyer, Sophie Tendon, Hayate Haryouli, Wafek Taleb, Mylène Caroff, Benjamin Chabot, Laura Drif, François André, Patrice Garcia, Benoit Loup, Marie-Agnès Popot, Ludovic Bailly-Chouriberry. Comprehensive characterization of the peroxisome proliferator activated receptor-δ agonist GW501516 for horse doping control analysis.
Drug testing and analysis.
2021 Jun; 13(6):1191-1202. doi:
10.1002/dta.3013. [PMID: 33547737] - Jacob Amersfoort, Frank H Schaftenaar, Hidde Douna, Peter J van Santbrink, Gijs H M van Puijvelde, Bram Slütter, Amanda C Foks, Amy Harms, Estefania Moreno-Gordaliza, Yanyan Wang, Thomas Hankemeier, Ilze Bot, Hongbo Chi, Johan Kuiper. Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.
Cardiovascular research.
2021 04; 117(5):1309-1324. doi:
10.1093/cvr/cvaa208. [PMID: 32653923] - Hideaki Ishii, Mariko Shibuya, Gary Ngai-Wa Leung, Shozo Yamashita, Masayuki Yamada, Asuka Kushiro, Yoshinori Kasashima, Jun Okada, Kazumi Kawasaki, Isao Kijima-Suda. Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometry for doping control.
Rapid communications in mass spectrometry : RCM.
2021 Mar; 35(5):e9028. doi:
10.1002/rcm.9028. [PMID: 33319421] - Tim Sobolevsky, Brian Ahrens. High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction.
Drug testing and analysis.
2021 Feb; 13(2):283-298. doi:
10.1002/dta.2917. [PMID: 32852861] - Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong. Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
Journal of medicinal chemistry.
2020 12; 63(24):16012-16027. doi:
10.1021/acs.jmedchem.0c01874. [PMID: 33325691] - Hideaki Ishii, Gary Ngai-Wa Leung, Shozo Yamashita, Masayuki Yamada, Asuka Kushiro, Yoshinori Kasashima, Jun Okada, Kazumi Kawasaki, Isao Kijima-Suda. Doping control analysis of GW1516 in equine plasma using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2020 Dec; 34(23):e8920. doi:
10.1002/rcm.8920. [PMID: 32776613] - Vanessa E Jahnke, Jennifer M Peterson, Jack H Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K Jaiswal, Kanneboyina Nagaraju. Mitochondrial dysfunction and consequences in calpain-3-deficient muscle.
Skeletal muscle.
2020 12; 10(1):37. doi:
10.1186/s13395-020-00254-1. [PMID: 33308300] - Sander Lefere, Tobias Puengel, Jana Hundertmark, Christian Penners, Anna Katharina Frank, Adrien Guillot, Kevin de Muynck, Felix Heymann, Vanessa Adarbes, Evelyne Defrêne, Céline Estivalet, Anja Geerts, Lindsey Devisscher, Guillaume Wettstein, Frank Tacke. Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆.
Journal of hepatology.
2020 10; 73(4):757-770. doi:
10.1016/j.jhep.2020.04.025. [PMID: 32360434] - Jeayoung C Shin, Eunyoung Lee, Seungchan An, Sun Hee Jin, Jaehyoun Ha, Won Jun Choi, Minsoo Noh. Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Sep; 67(?):104886. doi:
10.1016/j.tiv.2020.104886. [PMID: 32407875] - Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda. Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
The Journal of toxicological sciences.
2020; 45(4):227-236. doi:
10.2131/jts.45.227. [PMID: 32238697] - Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Tabinda Sidrat, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong. The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.
International journal of molecular sciences.
2019 Dec; 20(23):. doi:
10.3390/ijms20236066. [PMID: 31810173] - Almudena Bermejo, Aida Collado, Isabel Barrachina, Patrice Marqués, Noureddine El Aouad, Xavier Franck, Francisco Garibotto, Catherine Dacquet, Daniel H Caignard, Fernando D Suvire, Ricardo D Enriz, Laura Piqueras, Bruno Figadère, María-Jesús Sanz, Nuria Cabedo, Diego Cortes. Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect.
Journal of natural products.
2019 07; 82(7):1802-1812. doi:
10.1021/acs.jnatprod.9b00003. [PMID: 31268307] - Sungjin Ahn, Jungmin Kim, Seungchan An, Jeong Joo Pyo, Daram Jung, Joochang Lee, Seok Young Hwang, Junpyo Gong, Iljin Shin, Hong Pyo Kim, Hyoungsu Kim, Minsoo Noh. 2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.
Bioorganic & medicinal chemistry.
2019 07; 27(13):2948-2958. doi:
10.1016/j.bmc.2019.05.028. [PMID: 31128991] - Yuri L Boteon, Joseph Attard, Amanda P C S Boteon, Lorraine Wallace, Gary Reynolds, Stefan Hubscher, Darius F Mirza, Hynek Mergental, Ricky H Bhogal, Simon C Afford. Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2019 07; 25(7):1007-1022. doi:
10.1002/lt.25439. [PMID: 30821045] - Mohammad Zarei, Emma Barroso, Xavier Palomer, Joan Carles Escolà-Gil, Lidia Cedó, Walter Wahli, Manuel Vázquez-Carrera. Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes.
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis.
2019 May; 31(3):111-118. doi:
10.1016/j.arteri.2019.01.004. [PMID: 30987865] - Zheng Li, Yueming Chen, Zongtao Zhou, Liming Deng, Yawen Xu, Lijun Hu, Bing Liu, Luyong Zhang. Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents.
European journal of medicinal chemistry.
2019 Feb; 164(?):352-365. doi:
10.1016/j.ejmech.2018.12.069. [PMID: 30605833] - Samuel D Saibil, Michael St Paul, Robert C Laister, Carlos R Garcia-Batres, Kavita Israni-Winger, Alisha R Elford, Natasha Grimshaw, Céline Robert-Tissot, Dominic G Roy, Russell G Jones, Linh T Nguyen, Pamela S Ohashi. Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy.
Cancer research.
2019 02; 79(3):445-451. doi:
10.1158/0008-5472.can-17-3053. [PMID: 30573521] - Jinha Yu, Seyeon Ahn, Hee Jin Kim, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Sun Hee Jin, Eunyoung Lee, Gyudong Kim, Jae Hoon Cheong, Kenneth A Jacobson, Lak Shin Jeong, Minsoo Noh. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Journal of medicinal chemistry.
2017 09; 60(17):7459-7475. doi:
10.1021/acs.jmedchem.7b00805. [PMID: 28799755] - Dragana Nikolic, Giuseppa Castellino, Maciej Banach, Peter P Toth, Ekaterina Ivanova, Alexander N Orekhov, Giuseppe Montalto, Manfredi Rizzo. PPAR Agonists, Atherogenic Dyslipidemia and Cardiovascular Risk.
Current pharmaceutical design.
2017 03; 23(6):894-902. doi:
10.2174/1381612822666161006151134. [PMID: 27719644] - Jing Guo, Wen-Fa Lu, Shuang Liang, Jeong-Woo Choi, Nam-Hyung Kim, Xiang-Shun Cui. Peroxisome proliferator-activated receptor δ improves porcine blastocyst hatching via the regulation of fatty acid oxidation.
Theriogenology.
2017 Mar; 90(?):266-275. doi:
10.1016/j.theriogenology.2016.11.018. [PMID: 28166979] - Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5258-5269. doi:
10.1016/j.bmc.2016.08.045. [PMID: 27591006] - Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5455-5461. doi:
10.1016/j.bmc.2016.08.067. [PMID: 27622746] - Dongsheng Mou, Hua Yang, Changhua Qu, Juan Chen, Chaogui Zhang. Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell.
Inflammation.
2016 Aug; 39(4):1538-46. doi:
10.1007/s10753-016-0389-0. [PMID: 27278004] - Ajmer S Grewal, Meenu Beniwal, Deepti Pandita, Bhupinder S Sekhon, Viney Lather. Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2016; 12(1):3-21. doi:
10.2174/1573406411666150525105826. [PMID: 26004782] - Rico Schwarz, Dirk Tänzler, Christian H Ihling, Andrea Sinz. Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding.
PloS one.
2016; 11(3):e0151412. doi:
10.1371/journal.pone.0151412. [PMID: 26992147] - D'Angelo C Magliano, Aline Penna-de-Carvalho, Manuel Vazquez-Carrera, Carlos A Mandarim-de-Lacerda, Marcia B Aguila. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system.
Endocrine.
2015 Nov; 50(2):355-67. doi:
10.1007/s12020-015-0590-1. [PMID: 25854303] - Jana Tumova, Lucia Malisova, Michal Andel, Jan Trnka. Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.
Lipids.
2015 Oct; 50(10):955-64. doi:
10.1007/s11745-015-4058-0. [PMID: 26255030] - Xiuli Li, Jin Li, Xiaolan Lu, Huihui Ma, Haitao Shi, Hong Li, Danhong Xie, Lei Dong, Chunlian Liang. Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model.
International journal of molecular medicine.
2015 Sep; 36(3):767-75. doi:
10.3892/ijmm.2015.2270. [PMID: 26133486] - Xi Fang, Li Fang, Ao Liu, Xiaohong Wang, Beilei Zhao, Nanping Wang. Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.
British journal of pharmacology.
2015 Aug; 172(15):3728-36. doi:
10.1111/bph.13160. [PMID: 25857370] - Wei Chen, Rong Gao, Xinni Xie, Zhibing Zheng, Haijing Li, Song Li, Fangting Dong, Lili Wang. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice.
Scientific reports.
2015 May; 5(?):9884. doi:
10.1038/srep09884. [PMID: 25943561] - Taha Haffar, Félix-Antoine Bérubé-Simard, Nicolas Bousette. Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.
Biochemical and biophysical research communications.
2015 Mar; 459(1):54-9. doi:
10.1016/j.bbrc.2015.02.062. [PMID: 25712520] - Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
PloS one.
2015; 10(2):e0112655. doi:
10.1371/journal.pone.0112655. [PMID: 25689681] - Marina Kemmerer, Florian Finkernagel, Marcela Frota Cavalcante, Dulcineia Saes Parra Abdalla, Rolf Müller, Bernhard Brüne, Dmitry Namgaladze. AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
PloS one.
2015; 10(6):e0130893. doi:
10.1371/journal.pone.0130893. [PMID: 26098914] - Hongjuan Ding, Yiyu Zhang, Lun Liu, Hongyan Yuan, Jian Qu, Rong Shen. Activation of peroxisome proliferator activator receptor delta in mouse impacts lipid composition and placental development at early stage of gestation.
Biology of reproduction.
2014 Sep; 91(3):57. doi:
10.1095/biolreprod.113.116772. [PMID: 24920036] - M P Mosti, A K Stunes, M Ericsson, H Pullisaar, J E Reseland, M Shabestari, E F Eriksen, U Syversen. Effects of the peroxisome proliferator-activated receptor (PPAR)-δ agonist GW501516 on bone and muscle in ovariectomized rats.
Endocrinology.
2014 Jun; 155(6):2178-89. doi:
10.1210/en.2013-1166. [PMID: 24708238] - Xavier Palomer, Eva Capdevila-Busquets, Gaia Botteri, Laia Salvadó, Emma Barroso, Mercy M Davidson, Liliane Michalik, Walter Wahli, Manuel Vázquez-Carrera. PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.
International journal of cardiology.
2014 Jun; 174(1):110-8. doi:
10.1016/j.ijcard.2014.03.176. [PMID: 24767130] - Amirhossein Sahebkar, Gerard T Chew, Gerald F Watts. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease.
Expert opinion on pharmacotherapy.
2014 Mar; 15(4):493-503. doi:
10.1517/14656566.2014.876992. [PMID: 24428677] - Yuan Z Feng, Nataša Nikolić, Siril S Bakke, Mark V Boekschoten, Sander Kersten, Eili T Kase, Arild C Rustan, G Hege Thoresen. PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference.
Archives of physiology and biochemistry.
2014 Feb; 120(1):12-21. doi:
10.3109/13813455.2013.829105. [PMID: 23991827] - Cairui Wang, Guopeng Zhou, Zeng Zeng. Effects of peroxisome proliferator-activated receptor-β/δ on sepsis induced acute lung injury.
Chinese medical journal.
2014; 127(11):2129-37. doi:
NULL. [PMID: 24890166] - Lazar A Bojic, Amy C Burke, Sanjiv S Chhoker, Dawn E Telford, Brian G Sutherland, Jane Y Edwards, Cynthia G Sawyez, Rommel G Tirona, Hao Yin, J Geoffrey Pickering, Murray W Huff. Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology.
2014 Jan; 34(1):52-60. doi:
10.1161/atvbaha.113.301830. [PMID: 24158519] - Rithwick Rajagopal, Clay F Semenkovich. Peroxisome proliferator activated receptor-δ: the middle child vies for attention.
Arteriosclerosis, thrombosis, and vascular biology.
2014 Jan; 34(1):5-7. doi:
10.1161/atvbaha.113.302777. [PMID: 24335675] - Louise S Mackenzie, Lisa Lione. Harnessing the benefits of PPARβ/δ agonists.
Life sciences.
2013 Dec; 93(25-26):963-7. doi:
10.1016/j.lfs.2013.10.022. [PMID: 24184294] - Shashi Shrivastav, Liyan Zhang, Koji Okamoto, Hewang Lee, Claudia Lagranha, Yoshifusa Abe, Ashok Balasubramanyam, Gary D Lopaschuk, Tomoshige Kino, Jeffrey B Kopp. HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.
Molecular endocrinology (Baltimore, Md.).
2013 Sep; 27(9):1564-76. doi:
10.1210/me.2012-1370. [PMID: 23842279] - Hongyan Yuan, Jin Lu, Junfeng Xiao, Geeta Upadhyay, Rachel Umans, Bhaskar Kallakury, Yuhzi Yin, Michael E Fant, Levy Kopelovich, Robert I Glazer. PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.
Cancer research.
2013 Jul; 73(14):4349-61. doi:
10.1158/0008-5472.can-13-0322. [PMID: 23811944] - Jung-Kyu Han, Hack-Lyoung Kim, Ki-Hyun Jeon, Young-Eun Choi, Hyun-Sook Lee, Yoo-Wook Kwon, Ja-June Jang, Hyun-Jai Cho, Hyun-Jae Kang, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim. Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks.
European heart journal.
2013 Jun; 34(23):1755-65. doi:
10.1093/eurheartj/ehr365. [PMID: 21920965] - Lazar A Bojic, Murray W Huff. Peroxisome proliferator-activated receptor δ: a multifaceted metabolic player.
Current opinion in lipidology.
2013 Apr; 24(2):171-7. doi:
10.1097/mol.0b013e32835cc949. [PMID: 23481229] - Mario Thevis, Ines Möller, Simon Beuck, Wilhelm Schänzer. Synthesis, mass spectrometric characterization, and analysis of the PPARδ agonist GW1516 and its major human metabolites: targets in sports drug testing.
Methods in molecular biology (Clifton, N.J.).
2013; 952(?):301-12. doi:
10.1007/978-1-62703-155-4_22. [PMID: 23100242] - Guangjie Liu, Xuan Li, Yan Li, Xin Tang, Jie Xu, Ran Li, Peng Hao, Yongchang Sun. PPARδ agonist GW501516 inhibits PDGF-stimulated pulmonary arterial smooth muscle cell function related to pathological vascular remodeling.
BioMed research international.
2013; 2013(?):903947. doi:
10.1155/2013/903947. [PMID: 23607100] - Tim Sobolevsky, Marina Dikunets, Irina Sukhanova, Edward Virus, Grigory Rodchenkov. Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine.
Drug testing and analysis.
2012 Oct; 4(10):754-60. doi:
10.1002/dta.1413. [PMID: 22977012] - Eric J Olson, Gregory L Pearce, Nigel P Jones, Dennis L Sprecher. Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Sep; 32(9):2289-94. doi:
10.1161/atvbaha.112.247890. [PMID: 22814748] - Elena Makoveichuk, Valentina Sukonina, Olessia Kroupa, Petra Thulin, Ewa Ehrenborg, Thomas Olivecrona, Gunilla Olivecrona. Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed.
Biochemical and biophysical research communications.
2012 Aug; 425(2):138-43. doi:
10.1016/j.bbrc.2012.07.048. [PMID: 22820186] - Taejung Kim, Woojung Lee, Kyu Hyuk Jeong, Jung Ho Song, Soon-Hye Park, Pilju Choi, Su-Nam Kim, Seokjoon Lee, Jungyeob Ham. Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Bioorganic & medicinal chemistry letters.
2012 Jun; 22(12):4122-6. doi:
10.1016/j.bmcl.2012.04.062. [PMID: 22579420] - Jin-Hee Park, Kuy-Sook Lee, Hyun-Joung Lim, Hanna Kim, Hyun-Jeong Kwak, Hyun-Young Park. The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.
Journal of cellular biochemistry.
2012 Jun; 113(6):1947-54. doi:
10.1002/jcb.24063. [PMID: 22234939] - Sun Ah Ham, Jung Seok Hwang, Taesik Yoo, Hanna Lee, Eun Sil Kang, Chankyu Park, Jae-Wook Oh, Hoon Taek Lee, Gyesik Min, Jin-Hoi Kim, Han Geuk Seo. Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.
The Biochemical journal.
2012 May; 444(1):27-38. doi:
10.1042/bj20111832. [PMID: 22335598] - Anne Tailleux, Kristiaan Wouters, Bart Staels. Roles of PPARs in NAFLD: potential therapeutic targets.
Biochimica et biophysica acta.
2012 May; 1821(5):809-18. doi:
10.1016/j.bbalip.2011.10.016. [PMID: 22056763] - Anna-Maria Ordelheide, Martin Heni, Claus Thamer, Fausto Machicao, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger. In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo.
European journal of clinical investigation.
2011 Dec; 41(12):1323-9. doi:
10.1111/j.1365-2362.2011.02547.x. [PMID: 21615395] - Esther M M Ooi, Gerald F Watts, Dennis L Sprecher, Dick C Chan, P Hugh R Barrett. Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity.
The Journal of clinical endocrinology and metabolism.
2011 Oct; 96(10):E1568-76. doi:
10.1210/jc.2011-1131. [PMID: 21816786] - Ji-Ming Ye, Jennifer Tid-Ang, Nigel Turner, Xiao-Yi Zeng, Hai-Yan Li, Gregory J Cooney, Erik Max Wulff, Per Sauerberg, Edward W Kraegen. PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.
British journal of pharmacology.
2011 Jun; 163(3):556-66. doi:
10.1111/j.1476-5381.2011.01240.x. [PMID: 21265823] - Emma Barroso, Ricardo Rodríguez-Calvo, Lucía Serrano-Marco, Alma M Astudillo, Jesús Balsinde, Xavier Palomer, Manuel Vázquez-Carrera. The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.
Endocrinology.
2011 May; 152(5):1848-59. doi:
10.1210/en.2010-1468. [PMID: 21363937] - Markus Meissner, Barbara Berlinski, Monika Doll, Igor Hrgovic, Vesselina Laubach, Gabi Reichenbach, Stefan Kippenberger, Jens Gille, Roland Kaufmann. AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.
Experimental dermatology.
2011 May; 20(5):425-9. doi:
10.1111/j.1600-0625.2011.01253.x. [PMID: 21496113] - David Alvarez-Guardia, Xavier Palomer, Teresa Coll, Lucía Serrano, Ricardo Rodríguez-Calvo, Mercy M Davidson, Manuel Merlos, Ilhem El Kochairi, Liliane Michalik, Walter Wahli, Manuel Vázquez-Carrera. PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.
Biochimica et biophysica acta.
2011 Feb; 1811(2):59-67. doi:
10.1016/j.bbalip.2010.11.002. [PMID: 21070867] - Qihuang Jin, Li-Rong Yu, Lifeng Wang, Zhijing Zhang, Lawryn H Kasper, Ji-Eun Lee, Chaochen Wang, Paul K Brindle, Sharon Y R Dent, Kai Ge. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
The EMBO journal.
2011 Jan; 30(2):249-62. doi:
10.1038/emboj.2010.318. [PMID: 21131905] - Monique Heald, Michael A Cawthorne. Dual acting and pan-PPAR activators as potential anti-diabetic therapies.
Handbook of experimental pharmacology.
2011; ?(203):35-51. doi:
10.1007/978-3-642-17214-4_2. [PMID: 21484566] - Xu Yang, Shinji Kume, Yuki Tanaka, Keiji Isshiki, Shin-ichi Araki, Masami Chin-Kanasaki, Toshiro Sugimoto, Daisuke Koya, Masakazu Haneda, Takeshi Sugaya, Detian Li, Ping Han, Yoshihiko Nishio, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uzu. GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.
PloS one.
2011; 6(9):e25271. doi:
10.1371/journal.pone.0025271. [PMID: 21966476] - Justin Cresser, Arend Bonen, Adrian Chabowski, Leslie E Stefanyk, Roberto Gulli, Ian Ritchie, David J Dyck. Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Aug; 299(2):R470-9. doi:
10.1152/ajpregu.00431.2009. [PMID: 20538899] - Teresa Coll, David Alvarez-Guardia, Emma Barroso, Anna Maria Gómez-Foix, Xavier Palomer, Juan C Laguna, Manuel Vázquez-Carrera. Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
Endocrinology.
2010 Apr; 151(4):1560-9. doi:
10.1210/en.2009-1211. [PMID: 20185762] - Mario Thevis, Ines Möller, Andreas Thomas, Simon Beuck, Grigory Rodchenkov, Wolfgang Bornatsch, Hans Geyer, Wilhelm Schänzer. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls.
Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2479-91. doi:
10.1007/s00216-009-3283-x. [PMID: 19946680] - Yael Riahi, Yoav Sin-Malia, Guy Cohen, Evgenia Alpert, Arie Gruzman, Juergen Eckel, Bart Staels, Michel Guichardant, Shlomo Sasson. The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta.
Diabetes.
2010 Apr; 59(4):808-18. doi:
10.2337/db09-1207. [PMID: 20107107] - M Perreault, S Will, D Panza, T Gareski, K Harding, D Kubasiak, M Jalenak, K Gartrell, S Wang, G Bollag, D R Artis, P N Ibrahim, P Womack, J J Lin, E Saiah, T S Mansour, G P Vlasuk, D V Erbe, J F Tobin. Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice.
Diabetes, obesity & metabolism.
2010 Mar; 12(3):234-45. doi:
10.1111/j.1463-1326.2009.01157.x. [PMID: 20152000] - Yihong Wan, Ronald M Evans. Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.
Journal of molecular endocrinology.
2010 Feb; 44(2):135-42. doi:
10.1677/jme-09-0090. [PMID: 19850645] - Jun Wan, Li Jiang, Qingguo Lü, Linqiu Ke, Xiaoyu Li, Nanwei Tong. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.
Biochemical and biophysical research communications.
2010 Jan; 391(3):1567-72. doi:
10.1016/j.bbrc.2009.12.127. [PMID: 20040361] - Mario Thevis, Andreas Thomas, Maxie Kohler, Simon Beuck, Ines Möller, Mathias Schäfer, Grigory Rodchenkov, Sheng Yin, Joseph A Loo, Hans Geyer, Wilhelm Schänzer. Mass spectrometry-based characterization of new drugs and methods of performance manipulation in doping control analysis.
European journal of mass spectrometry (Chichester, England).
2010; 16(3):301-12. doi:
10.1255/ejms.1047. [PMID: 20530837] - Masaki Ogata, Maki Tsujita, Mohammad Anwar Hossain, Nobukatsu Akita, Frank J Gonzalez, Bart Staels, Shogo Suzuki, Tatsuya Fukutomi, Genjiro Kimura, Shinji Yokoyama. On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Atherosclerosis.
2009 Aug; 205(2):413-9. doi:
10.1016/j.atherosclerosis.2009.01.008. [PMID: 19201410] - Gemma Fuster, Sílvia Busquets, Maite Figueras, Elisabet Ametller, Cibely Cristine Fontes de Oliveira, Mireia Oliván, Paul A Grimaldi, Josep M Argilés, Francisco J López-Soriano. PPARdelta mediates IL15 metabolic actions in myotubes: effects of hyperthermia.
International journal of molecular medicine.
2009 Jul; 24(1):63-8. doi:
10.3892/ijmm_00000207. [PMID: 19513536] - Mario Thevis, Simon Beuck, Andreas Thomas, Birthe Kortner, Maxie Kohler, Grigory Rodchenkov, Wilhelm Schänzer. Doping control analysis of emerging drugs in human plasma - identification of GW501516, S-107, JTV-519, and S-40503.
Rapid communications in mass spectrometry : RCM.
2009 Apr; 23(8):1139-46. doi:
10.1002/rcm.3987. [PMID: 19280612] - Lakshmi Gopinathan, Daniel B Hannon, Jeffrey M Peters, John P Vanden Heuvel. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Mar; 108(1):48-58. doi:
10.1093/toxsci/kfn260. [PMID: 19103650] - Harikishore Pingali, Mukul Jain, Shailesh Shah, Sujay Basu, Pankaj Makadia, Amitgiri Goswami, Pandurang Zaware, Pravin Patil, Atul Godha, Suresh Giri, Ashish Goel, Megha Patel, Harilal Patel, Pankaj Patel. Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Bioorganic & medicinal chemistry letters.
2008 Oct; 18(20):5586-90. doi:
10.1016/j.bmcl.2008.08.112. [PMID: 18805005] - Wei Chen, Li-Li Wang, Hong-Ying Liu, Long Long, Song Li. Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice.
Basic & clinical pharmacology & toxicology.
2008 Sep; 103(3):240-6. doi:
10.1111/j.1742-7843.2008.00268.x. [PMID: 18684227] - Lingchun Zeng, Yan Geng, Maria Tretiakova, Xuemei Yu, Peter Sicinski, Todd G Kroll. Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors.
Cancer research.
2008 Aug; 68(16):6578-86. doi:
10.1158/0008-5472.can-08-0855. [PMID: 18701481] - Petra Thulin, Björn Glinghammar, Josefin Skogsberg, Kerstin Lundell, Ewa Ehrenborg. PPARdelta increases expression of the human apolipoprotein A-II gene in human liver cells.
International journal of molecular medicine.
2008 Jun; 21(6):819-24. doi:
10.3892/ijmm.21.6.819. [PMID: 18506377] - Ulf Risérus, Dennis Sprecher, Tony Johnson, Eric Olson, Sandra Hirschberg, Aixue Liu, Zeke Fang, Priti Hegde, Duncan Richards, Leli Sarov-Blat, Jay C Strum, Samar Basu, Jane Cheeseman, Barbara A Fielding, Sandy M Humphreys, Theodore Danoff, Niall R Moore, Peter Murgatroyd, Stephen O'Rahilly, Pauline Sutton, Tim Willson, David Hassall, Keith N Frayn, Fredrik Karpe. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Diabetes.
2008 Feb; 57(2):332-9. doi:
10.2337/db07-1318. [PMID: 18024853] - Elizabeth E Girroir, Holly E Hollingshead, Andrew N Billin, Timothy M Willson, Gavin P Robertson, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Jeffrey M Peters. Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
Toxicology.
2008 Jan; 243(1-2):236-43. doi:
10.1016/j.tox.2007.10.023. [PMID: 18054822] - Dennis L Sprecher. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
The American journal of cardiology.
2007 Dec; 100(11 A):n20-4. doi:
10.1016/j.amjcard.2007.08.009. [PMID: 18047848] - Holly E Hollingshead, Renee L Killins, Michael G Borland, Elizabeth E Girroir, Andrew N Billin, Timothy M Willson, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Jeffrey M Peters. Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Carcinogenesis.
2007 Dec; 28(12):2641-9. doi:
10.1093/carcin/bgm183. [PMID: 17693664] - Jun-Ichi Kasuga, Izumi Nakagome, Atsushi Aoyama, Kumiko Sako, Michiyasu Ishizawa, Michitaka Ogura, Makoto Makishima, Shuichi Hirono, Yuichi Hashimoto, Hiroyuki Miyachi. Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Bioorganic & medicinal chemistry.
2007 Aug; 15(15):5177-90. doi:
10.1016/j.bmc.2007.05.023. [PMID: 17532641] - David Kitz Krämer, Lubna Al-Khalili, Bruno Guigas, Ying Leng, Pablo M Garcia-Roves, Anna Krook. Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
The Journal of biological chemistry.
2007 Jul; 282(27):19313-20. doi:
10.1074/jbc.m702329200. [PMID: 17500064] - Yen-Chuan Ou, Chi-Rei Yang, Chen-Li Cheng, Shue-Ling Raung, Yu-Yeh Hung, Chun-Jung Chen. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
European journal of pharmacology.
2007 Jun; 563(1-3):49-60. doi:
10.1016/j.ejphar.2007.01.071. [PMID: 17341418] - Per Sauerberg, Grith S Olsen, Lone Jeppesen, John P Mogensen, Ingrid Pettersson, Claus B Jeppesen, Jens R Daugaard, Elisabeth D Galsgaard, Lars Ynddal, Jan Fleckner, Vladimira Panajotova, Zdenek Polivka, Pavel Pihera, Miroslav Havranek, Erik M Wulff. Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Journal of medicinal chemistry.
2007 Apr; 50(7):1495-503. doi:
10.1021/jm061202u. [PMID: 17343371] - Joachim Rudolph, Libing Chen, Dyuti Majumdar, William H Bullock, Michael Burns, Thomas Claus, Fernando E Dela Cruz, Michelle Daly, Frederick J Ehrgott, Jeffrey S Johnson, James N Livingston, Robert W Schoenleber, Jeffrey Shapiro, Ling Yang, Manami Tsutsumi, Xin Ma. Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.
Journal of medicinal chemistry.
2007 Mar; 50(5):984-1000. doi:
10.1021/jm061299k. [PMID: 17274610] - Michael L Sierra, Véronique Beneton, Anne-Bénédict Boullay, Thierry Boyer, Andrew G Brewster, Frédéric Donche, Marie-Claire Forest, Marie-Hélène Fouchet, Françoise J Gellibert, Didier A Grillot, Millard H Lambert, Alain Laroze, Christelle Le Grumelec, Jean Michel Linget, Valerie G Montana, Van-Loc Nguyen, Edwige Nicodème, Vipul Patel, Annie Penfornis, Olivier Pineau, Danig Pohin, Florent Potvain, Géraldine Poulain, Cécile Bertho Ruault, Michael Saunders, Jérôme Toum, H Eric Xu, Robert X Xu, Pascal M Pianetti. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
Journal of medicinal chemistry.
2007 Feb; 50(4):685-95. doi:
10.1021/jm058056x. [PMID: 17243659] - Dennis L Sprecher, Christine Massien, Greg Pearce, Andrew N Billin, Itay Perlstein, Timothy M Willson, David G Hassall, Nicolas Ancellin, Scott D Patterson, David C Lobe, Tony G Johnson. Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
Arteriosclerosis, thrombosis, and vascular biology.
2007 Feb; 27(2):359-65. doi:
10.1161/01.atv.0000252790.70572.0c. [PMID: 17110604] - Lihong Xu, Chang Han, Tong Wu. A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.
The Journal of biological chemistry.
2006 Nov; 281(45):33982-96. doi:
10.1074/jbc.m600135200. [PMID: 16966336] - B Brunmair, K Staniek, J Dörig, Z Szöcs, K Stadlbauer, V Marian, F Gras, C Anderwald, H Nohl, W Waldhäusl, C Fürnsinn. Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids.
Diabetologia.
2006 Nov; 49(11):2713-22. doi:
10.1007/s00125-006-0357-6. [PMID: 16960684] - I Kharroubi, C-H Lee, P Hekerman, M I Darville, R M Evans, D L Eizirik, M Cnop. BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Diabetologia.
2006 Oct; 49(10):2350-8. doi:
10.1007/s00125-006-0366-5. [PMID: 16896941] - Tatsuya Nagasawa, Yoichi Inada, Shigeru Nakano, Toru Tamura, Tetsuaki Takahashi, Kazuyasu Maruyama, Yoshinobu Yamazaki, Junji Kuroda, Nobuo Shibata. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.
European journal of pharmacology.
2006 Apr; 536(1-2):182-91. doi:
10.1016/j.ejphar.2006.02.028. [PMID: 16574099]