1H-1,2,3-Triazol-4-amine (BioDeep_00000174119)

   

human metabolite blood metabolite


代谢物信息卡片


1H-1,2,3-Triazol-4-amine

化学式: C2H4N4 (84.0435944)
中文名称: 1H-1,2,3-噻唑-5-胺
谱图信息: 最多检出来源 Mus musculus(blood) 66.67%

分子结构信息

SMILES: C1=NNN=C1N
InChI: InChI=1S/C2H4N4/c3-2-1-4-6-5-2/h1H,(H3,3,4,5,6)

描述信息

同义名列表

3 个代谢物同义名

1H-1,2,3-Triazol-4-amine; 2H-1,2,3-triazol-4-amine; 1H-1,2,3-TRIAZOL-5-AMINE



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Nikolay Mehterov, Salma Balazadeh, Jacques Hille, Valentina Toneva, Bernd Mueller-Roeber, Tsanko Gechev. Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes. Plant physiology and biochemistry : PPB. 2012 Oct; 59(?):20-9. doi: 10.1016/j.plaphy.2012.05.024. [PMID: 22710144]
  • Xinyu Deng, Kunwei Wu, Jingyuan Wan, Longjiang Li, Rong Jiang, Mengying Jia, Yuping Jing, Li Zhang. Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3073-8. doi: 10.1016/j.fct.2012.05.052. [PMID: 22687551]
  • Bianka Steffens, Alexander Kovalev, Stanislav N Gorb, Margret Sauter. Emerging roots alter epidermal cell fate through mechanical and reactive oxygen species signaling. The Plant cell. 2012 Aug; 24(8):3296-306. doi: 10.1105/tpc.112.101790. [PMID: 22904148]
  • Chi-Chi Peng, Wei Shi, Justin D Lutz, Kent L Kunze, Jun O Liu, Wendel L Nelson, Nina Isoherranen. Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):426-35. doi: 10.1124/dmd.111.042739. [PMID: 22106171]
  • Marta Moya, Marta Benet, Carla Guzmán, Laia Tolosa, Carmelo García-Monzón, Eugenia Pareja, José Vicente Castell, Ramiro Jover. Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver. PloS one. 2012; 7(1):e30014. doi: 10.1371/journal.pone.0030014. [PMID: 22238690]
  • Yao Xu, Qing Gao, Xian-Bing Gan, Lei Chen, Lei Zhang, Guo-Qing Zhu, Xing-Ya Gao. Endogenous hydrogen peroxide in paraventricular nucleus mediates sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Experimental physiology. 2011 Dec; 96(12):1282-92. doi: 10.1113/expphysiol.2011.059733. [PMID: 21890522]
  • Serge Kibinza, Jérémie Bazin, Christophe Bailly, Jill M Farrant, Françoise Corbineau, Hayat El-Maarouf-Bouteau. Catalase is a key enzyme in seed recovery from ageing during priming. Plant science : an international journal of experimental plant biology. 2011 Sep; 181(3):309-15. doi: 10.1016/j.plantsci.2011.06.003. [PMID: 21763542]
  • Candace E Elliott, Ellen M Fox, Renee S Jarvis, Barbara J Howlett. The cross-pathway control system regulates production of the secondary metabolite toxin, sirodesmin PL, in the ascomycete, Leptosphaeria maculans. BMC microbiology. 2011 Jul; 11(?):169. doi: 10.1186/1471-2180-11-169. [PMID: 21791055]
  • Guoyou Jin, Baofei Zhang, Youwen Tang, Xiongjun Zuo, Songcai Wang, Jingyi Tang. Imprinted functionalized silica sol-gel for solid-phase extraction of triazolamin. Talanta. 2011 May; 84(3):644-50. doi: 10.1016/j.talanta.2011.01.035. [PMID: 21482262]
  • Cimen Karasu. Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment. The open cardiovascular medicine journal. 2010 Nov; 4(?):240-56. doi: 10.2174/1874192401004010240. [PMID: 21270942]
  • Guillermo Suñé, Eduard Sarró, Marta Puigmulé, Joan López-Hellín, Madeleine Zufferey, Thomas Pertel, Jeremy Luban, Anna Meseguer. Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. PloS one. 2010 Nov; 5(11):e13930. doi: 10.1371/journal.pone.0013930. [PMID: 21085665]
  • Emiliano Panieri, Gabriele Toietta, Marina Mele, Valentina Labate, Sofia Chiatamone Ranieri, Salvatore Fusco, Valentina Tesori, Annalisa Antonini, Giuseppe Maulucci, Marco De Spirito, Tommaso Galeotti, Giovambattista Pani. Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging. 2010 Aug; 2(8):487-503. doi: 10.18632/aging.100183. [PMID: 20739737]
  • Guoxin Shen, Sundaram Kuppu, Sujatha Venkataramani, Jing Wang, Juqiang Yan, Xiaoyun Qiu, Hong Zhang. ANKYRIN REPEAT-CONTAINING PROTEIN 2A is an essential molecular chaperone for peroxisomal membrane-bound ASCORBATE PEROXIDASE3 in Arabidopsis. The Plant cell. 2010 Mar; 22(3):811-31. doi: 10.1105/tpc.109.065979. [PMID: 20215589]
  • Sami Banerjee, Jaroslaw W Zmijewski, Emmanuel Lorne, Gang Liu, Yonggang Sha, Edward Abraham. Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. The Journal of biological chemistry. 2010 Jan; 285(4):2665-75. doi: 10.1074/jbc.m109.060822. [PMID: 19933270]
  • Tsanko S Gechev, Margriet A Ferwerda, Nikolay Mehterov, Christophe Laloi, Muhammad K Qureshi, Jacques Hille. Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species. Biochemical and biophysical research communications. 2008 Oct; 375(4):639-44. doi: 10.1016/j.bbrc.2008.08.056. [PMID: 18725200]
  • Dae Goon Yoo, Yun Jeong Song, Eun Jung Cho, Sang Ki Lee, Jin Bong Park, Jae Hyeon Yu, Seung Pyung Lim, Jin Man Kim, Byeong Hwa Jeon. Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems. Lung cancer (Amsterdam, Netherlands). 2008 May; 60(2):277-84. doi: 10.1016/j.lungcan.2007.10.015. [PMID: 18061304]
  • Telma E Scarpeci, María I Zanor, Néstor Carrillo, Bernd Mueller-Roeber, Estela M Valle. Generation of superoxide anion in chloroplasts of Arabidopsis thaliana during active photosynthesis: a focus on rapidly induced genes. Plant molecular biology. 2008 Mar; 66(4):361-78. doi: 10.1007/s11103-007-9274-4. [PMID: 18158584]
  • Prosenjit Mondal, Mamata Ray, Sushmita Sahu, Surendra Chandra Sabat. Co-expression of GroEL/ES enhances the expression of plant catalase in bacterial cytosol. Protein and peptide letters. 2008; 15(10):1075-8. doi: 10.2174/092986608786071058. [PMID: 19075818]
  • Gustavo C Román. Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. Journal of the neurological sciences. 2007 Nov; 262(1-2):15-26. doi: 10.1016/j.jns.2007.06.023. [PMID: 17651757]
  • Lars Björkman, Birgitte F Lundekvam, Torgils Laegreid, Bjørn I Bertelsen, Inge Morild, Peer Lilleng, Birger Lind, Brita Palm, Marie Vahter. Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study. Environmental health : a global access science source. 2007 Oct; 6(?):30. doi: 10.1186/1476-069x-6-30. [PMID: 17931423]
  • Eun Sun Yang, Jeen-Woo Park. Antioxidant enzyme inhibitors enhance peroxynitrite-induced cell death in U937 cells. Molecular and cellular biochemistry. 2007 Jul; 301(1-2):61-8. doi: 10.1007/s11010-006-9397-y. [PMID: 17206381]
  • Yang Yu, Ming-Kui Zhong, Jing Li, Xiu-Lan Sun, Gui-Qing Xie, Wei Wang, Guo-Qing Zhu. Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Archiv : European journal of physiology. 2007 Jul; 454(4):551-7. doi: 10.1007/s00424-007-0256-9. [PMID: 17387509]
  • Sun Yee Kim, Su Min Lee, Jeen-Woo Park. Antioxidant enzyme inhibitors enhance singlet oxygen-induced cell death in HL-60 cells. Free radical research. 2006 Nov; 40(11):1190-7. doi: 10.1080/10715760600887768. [PMID: 17018401]
  • Hitomi Ohta, Iwao Okamoto, Toshiharu Hanaya, Shigeyuki Arai, Tsunetaka Ohta, Shigeharu Fukuda. Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2006 Aug; 143(4):484-91. doi: 10.1016/j.cbpc.2006.05.002. [PMID: 16807122]
  • E S Yang, J-W Park. Antioxidant enzyme inhibitors enhance nitric oxide-induced cell death in U937 cells. Biochimie. 2006 Jul; 88(7):869-78. doi: 10.1016/j.biochi.2006.02.001. [PMID: 16540229]
  • Kent L Kunze, Wendel L Nelson, Evan D Kharasch, Kenneth E Thummel, Nina Isoherranen. Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):583-90. doi: 10.1124/dmd.105.008508. [PMID: 16415110]
  • Oscar A Bizzozero, Jennifer L Ziegler, Gisela De Jesus, Federico Bolognani. Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins. Journal of neuroscience research. 2006 Mar; 83(4):656-67. doi: 10.1002/jnr.20771. [PMID: 16447283]
  • Matthias Schmidt, Jürgen Grief, Jürgen Feierabend. Mode of translational activation of the catalase (cat1) mRNA of rye leaves (Secale cereale L.) and its control through blue light and reactive oxygen. Planta. 2006 Mar; 223(4):835-46. doi: 10.1007/s00425-005-0125-8. [PMID: 16341707]
  • Tetyana V Bagnyukova, Kenneth B Storey, Volodymyr I Lushchak. Adaptive response of antioxidant enzymes to catalase inhibition by aminotriazole in goldfish liver and kidney. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2005 Nov; 142(3):335-41. doi: 10.1016/j.cbpb.2005.08.003. [PMID: 16168691]
  • Tatsiana Suvorava, Nadine Lauer, Stephanie Kumpf, Ralf Jacob, Wilfried Meyer, Georg Kojda. Endogenous vascular hydrogen peroxide regulates arteriolar tension in vivo. Circulation. 2005 Oct; 112(16):2487-95. doi: 10.1161/circulationaha.105.543157. [PMID: 16216962]
  • Yung-Chang Chen, Melissa A Cadnapaphornchai, Jianhui Yang, Sandra N Summer, Sandor Falk, Chunling Li, Weidong Wang, Robert W Schrier. Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism. American journal of physiology. Renal physiology. 2005 Oct; 289(4):F672-8. doi: 10.1152/ajprenal.00384.2004. [PMID: 15914774]
  • Tetyana V Bagnyukova, Olena Yu Vasylkiv, Kenneth B Storey, Volodymyr I Lushchak. Catalase inhibition by amino triazole induces oxidative stress in goldfish brain. Brain research. 2005 Aug; 1052(2):180-6. doi: 10.1016/j.brainres.2005.06.002. [PMID: 16023088]
  • Tsanko S Gechev, Ivan N Minkov, Jacques Hille. Hydrogen peroxide-induced cell death in Arabidopsis: transcriptional and mutant analysis reveals a role of an oxoglutarate-dependent dioxygenase gene in the cell death process. IUBMB life. 2005 Mar; 57(3):181-8. doi: 10.1080/15216540500090793. [PMID: 16036580]
  • Wojciech J Piotrowski, Jerzy Marczak, Zofia Kurmanowska, Paweł Górski. Concentration of TBA-reactive substances in type II pneumocytes exposed to oxidative stress. Archivum immunologiae et therapiae experimentalis. 2004 Nov; 52(6):435-40. doi: ". [PMID: 15577745]
  • J Dorval, A Hontela. Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss). Toxicology and applied pharmacology. 2003 Oct; 192(2):191-200. doi: 10.1016/s0041-008x(03)00281-3. [PMID: 14550752]
  • David Swarbreck, Pierre-Jean Ripoll, Donna A Brown, Keith J Edwards, Frederica Theodoulou. Isolation and characterisation of two multidrug resistance associated protein genes from maize. Gene. 2003 Oct; 315(?):153-64. doi: 10.1016/s0378-1119(03)00734-0. [PMID: 14557075]
  • Ioanna Andreadou, Anna Tsantili-Kakoulidou, Eleni Spyropoulou, Theodora Siatra. Reactions of indole derivatives with cardioprotective activity with reactive oxygen species. Comparison with melatonin. Chemical & pharmaceutical bulletin. 2003 Oct; 51(10):1128-31. doi: 10.1248/cpb.51.1128. [PMID: 14519915]
  • O V Lushchak, T V Bahniukova, V I Lushchak. [Effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase in tissues of two frog species--Rana ridibunda and Rana esculenta]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2003 Jul; 75(4):45-50. doi: . [PMID: 14681974]
  • Melissa A Cadnapaphornchai, Yang-Wook Kim, Andrey K Gurevich, Sandra N Summer, Sandor Falk, Joshua M Thurman, Robert W Schrier. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. Journal of the American Society of Nephrology : JASN. 2003 Mar; 14(3):566-74. doi: 10.1097/01.asn.0000053417.33945.63. [PMID: 12595491]
  • Andreas J Meyer, Mark D Fricker. Control of demand-driven biosynthesis of glutathione in green Arabidopsis suspension culture cells. Plant physiology. 2002 Dec; 130(4):1927-37. doi: 10.1104/pp.008243. [PMID: 12481075]
  • Virginia Garretón, Jorge Carpinelli, Xavier Jordana, Loreto Holuigue. The as-1 promoter element is an oxidative stress-responsive element and salicylic acid activates it via oxidative species. Plant physiology. 2002 Nov; 130(3):1516-26. doi: 10.1104/pp.009886. [PMID: 12428016]
  • J E Caminos, L M Seoane, S A Tovar, F F Casanueva, C Dieguez. Influence of thyroid status and growth hormone deficiency on ghrelin. European journal of endocrinology. 2002 Jul; 147(1):159-63. doi: 10.1530/eje.0.1470159. [PMID: 12088933]
  • T Gechev, I Gadjev, F Van Breusegem, D Inzé, S Dukiandjiev, V Toneva, I Minkov. Hydrogen peroxide protects tobacco from oxidative stress by inducing a set of antioxidant enzymes. Cellular and molecular life sciences : CMLS. 2002 Apr; 59(4):708-14. doi: 10.1007/s00018-002-8459-x. [PMID: 12022476]
  • M Y Moridani, S Khan, T Chan, S Teng, K Beard, P J O'Brien. Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity. Chemico-biological interactions. 2001 Jan; 130-132(1-3):931-42. doi: 10.1016/s0009-2797(00)00246-5. [PMID: 11306107]
  • G Xing, K Cui, L Ji, Y Wang, Z Li. Water stress and accumulation of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in grass pea (Lathyrus sativus). Journal of agricultural and food chemistry. 2001 Jan; 49(1):216-20. doi: 10.1021/jf000912k. [PMID: 11170580]
  • J Pedraza-Chaverrí, M D Granados-Silvestre, O N Medina-Campos, P D Maldonado, I M Olivares-Corichi, M E Ibarra-Rubio. Post-transcriptional control of catalase expression in garlic-treated rats. Molecular and cellular biochemistry. 2001 Jan; 216(1-2):9-19. doi: 10.1023/a:1011050619406. [PMID: 11216869]