3,5-Diiodothyropropionic acid (BioDeep_00000174066)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H12I2O4 (509.8825092)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 68%
分子结构信息
SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CCC(=O)O)I
InChI: InChI=1S/C15H12I2O4/c16-12-7-9(1-6-14(19)20)8-13(17)15(12)21-11-4-2-10(18)3-5-11/h2-5,7-8,18H,1,6H2,(H,19,20)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
12 个代谢物同义名
3-[4-(4-Hydroxyphenoxy)-3,5-diiodophenyl]propionic acid; 3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid; 3-[4-(4-Hydroxyphenoxy)-3,5-diiodophenyl]propionate; 3,5-Diiodo-4-(4-hydroxyphenoxy)hydrocinnamic acid; 3,5-Diiodo-4-(4-hydroxyphenoxy)hydrocinnamate; 3,5-Diiodothyropropionic acid; 3,5-Diiodothyropropanoic acid; 3,5-Diiodothyropropionate; 3,5-Diiodothyropropanoate; DITPA CPD; 3,5-Ditpa; DITPA
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134267
- PubChem: 160565
- HMDB: HMDB0246058
- DrugBank: DB12629
- ChEMBL: CHEMBL2348292
- chemspider: 141095
- CAS: 1158-10-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rosalba Senese, Federica Cioffi, Giuseppe Petito, Fernando Goglia, Antonia Lanni. Thyroid hormone metabolites and analogues.
Endocrine.
2019 10; 66(1):105-114. doi:
10.1007/s12020-019-02025-5. [PMID: 31359245] - Alfonso Massimiliano Ferrara, Xiao-Hui Liao, Honggang Ye, Roy E Weiss, Alexandra M Dumitrescu, Samuel Refetoff. The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency.
Endocrinology.
2015 Nov; 156(11):3889-94. doi:
10.1210/en.2015-1234. [PMID: 26322373] - Alfonso Massimiliano Ferrara, Xiao-Hui Liao, Pilar Gil-Ibáñez, Juan Bernal, Roy E Weiss, Alexandra M Dumitrescu, Samuel Refetoff. Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice.
Endocrinology.
2014 Oct; 155(10):4088-93. doi:
10.1210/en.2014-1085. [PMID: 25051435] - Charles F Verge, Daniel Konrad, Michal Cohen, Caterina Di Cosmo, Alexandra M Dumitrescu, Teresa Marcinkowski, Shihab Hameed, Jill Hamilton, Roy E Weiss, Samuel Refetoff. Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency.
The Journal of clinical endocrinology and metabolism.
2012 Dec; 97(12):4515-23. doi:
10.1210/jc.2012-2556. [PMID: 22993035] - Najah R Hadi, Fadhil G Al-amran, Ayad A Hussein. Effects of thyroid hormone analogue and a leukotrienes pathway-blocker on renal ischemia/reperfusion injury in mice.
BMC nephrology.
2011 Dec; 12(?):70. doi:
10.1186/1471-2369-12-70. [PMID: 22196041] - Iordanis Mourouzis, Francesca Forini, Constantinos Pantos, Giorgio Iervasi. Thyroid hormone and cardiac disease: from basic concepts to clinical application.
Journal of thyroid research.
2011; 2011(?):958626. doi:
10.4061/2011/958626. [PMID: 21765997] - Ran Meng, Heng-Yuan Tang, Jennifer Westfall, David London, James H Cao, Shaker A Mousa, Mary Luidens, Aleck Hercbergs, Faith B Davis, Paul J Davis, Hung-Yun Lin. Crosstalk between integrin αvβ3 and estrogen receptor-α is involved in thyroid hormone-induced proliferation in human lung carcinoma cells.
PloS one.
2011; 6(11):e27547. doi:
10.1371/journal.pone.0027547. [PMID: 22132110] - Anthony Martin Gerdes, Giorgio Iervasi. Thyroid replacement therapy and heart failure.
Circulation.
2010 Jul; 122(4):385-93. doi:
10.1161/circulationaha.109.917922. [PMID: 20660814] - P W Ladenson, M McCarren, E Morkin, R G Edson, Mei-Chiung Shih, S R Warren, J G Barnhill, L Churby, H Thai, T O'Brien, I Anand, A Warner, B Hattler, M Dunlap, J Erikson, S Goldman. Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study.
The Journal of clinical endocrinology and metabolism.
2010 Mar; 95(3):1349-54. doi:
10.1210/jc.2009-1209. [PMID: 20080837] - Caterina Di Cosmo, Xiao-Hui Liao, Alexandra M Dumitrescu, Roy E Weiss, Samuel Refetoff. A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.
Endocrinology.
2009 Sep; 150(9):4450-8. doi:
10.1210/en.2009-0209. [PMID: 19497976] - Maria Moreno, Pieter de Lange, Assunta Lombardi, Elena Silvestri, Antonia Lanni, Fernando Goglia. Metabolic effects of thyroid hormone derivatives.
Thyroid : official journal of the American Thyroid Association.
2008 Feb; 18(2):239-53. doi:
10.1089/thy.2007.0248. [PMID: 18279024] - Shaker A Mousa, Laura O'Connor, Faith B Davis, Paul J Davis. Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated.
Endocrinology.
2006 Apr; 147(4):1602-7. doi:
10.1210/en.2005-1390. [PMID: 16384862] - Eugene Morkin, Paul Ladenson, Steven Goldman, Cynthia Adamson. Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects.
Journal of molecular and cellular cardiology.
2004 Dec; 37(6):1137-46. doi:
10.1016/j.yjmcc.2004.09.013. [PMID: 15572044] - Eugene Morkin, Gregory D Pennock, Peter H Spooner, Joseph J Bahl, Steven Goldman. Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analogue, in heart failure.
Thyroid : official journal of the American Thyroid Association.
2002 Jun; 12(6):527-33. doi:
10.1089/105072502760143935. [PMID: 12165118] - Eugene Morkin, Gregory Pennock, Peter H Spooner, Joseph J Bahl, Katherine Underhill Fox, Steven Goldman. Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure.
Cardiology.
2002; 97(4):218-25. doi:
10.1159/000063110. [PMID: 12145478]