3,4-Dihydropyridine (BioDeep_00000174040)
human metabolite blood metabolite
代谢物信息卡片
3,4-Dihydropyridine
化学式: C5H7N (81.0578462)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC=NC=C1
InChI: InChI=1S/C5H7N/c1-2-4-6-5-3-1/h2,4-5H,1,3H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zanna Hyvönen, Vesa Hämäläinen, Marika Ruponen, Bart Lucas, Joanna Rejman, Dries Vercauteren, Jo Demeester, Stefaan De Smedt, Kevin Braeckmans. Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Aug; 162(1):167-75. doi:
10.1016/j.jconrel.2012.06.013. [PMID: 22709591] - Yoshihiro Uesawa, Takahiro Takeuchi, Kiminori Mohri. Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions.
Current pharmaceutical biotechnology.
2012 Jul; 13(9):1705-17. doi:
10.2174/138920112800958878. [PMID: 22039822] - Corey B Toal, Peter A Meredith, Henry L Elliott. Long-acting dihydropyridine calcium-channel blockers and sympathetic nervous system activity in hypertension: a literature review comparing amlodipine and nifedipine GITS.
Blood pressure.
2012 Jul; 21 Suppl 1(?):3-10. doi:
10.3109/08037051.2012.690615. [PMID: 22762301] - Kinji Kobayashi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate. Dysferlin and animal models for dysferlinopathy.
Journal of toxicologic pathology.
2012 Jun; 25(2):135-47. doi:
10.1293/tox.25.135. [PMID: 22907980] - Mitesh Patel, Thomas Meyer, Ajit Tharakan, Joseph D Tobias. Intraoperative administration of clevidipine to prevent vasospasm after radial and internal mammary artery grafts during coronary artery bypass grafting.
American journal of therapeutics.
2012 May; 19(3):e114-7. doi:
10.1097/mjt.0b013e3181e907b9. [PMID: 20634670] - Mahmoud Sheha. Pharmacokinetic and ulcerogenic studies of naproxen prodrugs designed for specific brain delivery.
Archives of pharmacal research.
2012 Mar; 35(3):523-30. doi:
10.1007/s12272-012-0316-3. [PMID: 22477200] - Gastone Leonetti, Colin G Egan. Use of carvedilol in hypertension: an update.
Vascular health and risk management.
2012; 8(?):307-22. doi:
10.2147/vhrm.s31578. [PMID: 22661898] - Jianjun Wang, Yanqing Li, Zhaojun Han, Youli Zhu, Zhijuan Xie, Jian Wang, Yaping Liu, Xianchun Li. Molecular characterization of a ryanodine receptor gene in the rice leaffolder, Cnaphalocrocis medinalis (Guenée).
PloS one.
2012; 7(5):e36623. doi:
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Frontiers in pharmacology.
2012; 3(?):19. doi:
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PloS one.
2012; 7(6):e39096. doi:
10.1371/journal.pone.0039096. [PMID: 22701748] - Ilona Kurnatowska, Jerzy Królikowski, Kinga Jesionowska, Anna Marczak, Joanna Krajewska, Zbigniew Zbróg, Michał Nowicki. Prevalence of arterial hypertension and the number and classes of antihypertensive drugs prescribed for patients late after kidney transplantation.
Annals of transplantation.
2012 Jan; 17(1):50-7. doi:
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Frontiers in molecular neuroscience.
2012; 5(?):3. doi:
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The Journal of biological chemistry.
2011 Dec; 286(51):43717-43725. doi:
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Diabetology & metabolic syndrome.
2011 Dec; 3(?):35. doi:
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The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2011 Nov; 59(11):964-75. doi:
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Neurobiology of disease.
2011 Aug; 43(2):364-71. doi:
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Archives of pharmacal research.
2011 Jul; 34(7):1171-5. doi:
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Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.
2011 Jul; 15(3):182-4. doi:
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American journal of physiology. Cell physiology.
2011 Jul; 301(1):C44-52. doi:
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The Journal of biological chemistry.
2011 Jun; 286(25):22589-99. doi:
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Middle East journal of anaesthesiology.
2011 Jun; 21(2):269-74. doi:
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Life sciences.
2011 May; 88(19-20):898-907. doi:
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Skeletal muscle.
2011 Apr; 1(1):16. doi:
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Blood pressure. Supplement.
2011 Apr; 1(?):20-5. doi:
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2011 Apr; 39(4):1186-200. doi:
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BMC gastroenterology.
2011 Mar; 11(?):32. doi:
10.1186/1471-230x-11-32. [PMID: 21453541] - Renzhi Han. Muscle membrane repair and inflammatory attack in dysferlinopathy.
Skeletal muscle.
2011 Mar; 1(1):10. doi:
10.1186/2044-5040-1-10. [PMID: 21798087] - Tomislava Lovaković, Marija Poljak-Blazi, Gunars Duburs, Ana Cipak, Marina Cindrić, Brigita Vigante, Egils Bisenieks, Morana Jaganjac, Lidija Mrakovcić, Azra Dedić, Neven Zarković. Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants.
Collegium antropologicum.
2011 Mar; 35(1):137-41. doi:
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The Journal of membrane biology.
2011 Mar; 240(1):13-20. doi:
10.1007/s00232-011-9338-x. [PMID: 21274523] - Andoria Tjondrokoesoemo, Ki Ho Park, Christopher Ferrante, Shinji Komazaki, Sebastian Lesniak, Marco Brotto, Jae-Kyun Ko, Jingsong Zhou, Noah Weisleder, Jianjie Ma. Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
PloS one.
2011; 6(9):e25740. doi:
10.1371/journal.pone.0025740. [PMID: 21984944] - Diogo M O Marçal, Elen Rizzi, Alisson Martins-Oliveira, Carla S Ceron, Danielle A Guimaraes, Raquel F Gerlach, Jose E Tanus-Santos. Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jan; 383(1):35-44. doi:
10.1007/s00210-010-0573-y. [PMID: 21058008] - E Melendez, M Bidet, J L Reyes, S Martial, O Barbier, M Tauc, E Sanchez, P Poujeol. New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.
Nephron. Physiology.
2011; 118(4):p73-81. doi:
10.1159/000325467. [PMID: 21502768] - Adriana Oliveira Dos Santos, Elizandra Aparecida Britta, Everson Miguel Bianco, Tania Ueda-Nakamura, Benedito Prado Dias Filho, Renato Crespo Pereira, Celso Vataru Nakamura. 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.
Marine drugs.
2011; 9(11):2369-2383. doi:
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Nature.
2010 Dec; 468(7324):696-700. doi:
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2010 Dec; 101(3):251-64. doi:
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Journal of cardiovascular pharmacology.
2010 Dec; 56(6):669-75. doi:
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Free radical biology & medicine.
2010 Nov; 49(10):1480-6. doi:
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Experimental & molecular medicine.
2010 Sep; 42(9):614-27. doi:
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Vascular health and risk management.
2010 Sep; 6(?):701-9. doi:
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Acta physiologica Hungarica.
2010 Sep; 97(3):281-9. doi:
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Blood pressure monitoring.
2010 Aug; 15(4):173-80. doi:
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Journal of biomedical nanotechnology.
2010 Aug; 6(4):318-24. doi:
10.1166/jbn.2010.1130. [PMID: 21323104] - P Tripathi, R Kumar, A K Sharma, A Mishra, R Gupta. Pistia stratiotes (Jalkumbhi).
Pharmacognosy reviews.
2010 Jul; 4(8):153-60. doi:
10.4103/0973-7847.70909. [PMID: 22228955] - Pika Miklavc, Manfred Frick, Oliver H Wittekindt, Thomas Haller, Paul Dietl. Fusion-activated Ca(2+) entry: an 'active zone' of elevated Ca(2+) during the postfusion stage of lamellar body exocytosis in rat type II pneumocytes.
PloS one.
2010 Jun; 5(6):e10982. doi:
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The Journal of general physiology.
2010 Jun; 135(6):629-40. doi:
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Current vascular pharmacology.
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Die Pharmazie.
2010 May; 65(5):375-8. doi:
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Experimental biology and medicine (Maywood, N.J.).
2010 Apr; 235(4):497-505. doi:
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2010 Apr; 48(4):735-45. doi:
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European journal of medicinal chemistry.
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International journal of molecular sciences.
2010 Jan; 11(1):254-267. doi:
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The Journal of biological chemistry.
2009 Dec; 284(50):34490-505. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
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PloS one.
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Journal of biomedical science.
2009 Jun; 16(?):57. doi:
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2009 Jun; 46(6):1016-26. doi:
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Therapeutics and clinical risk management.
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PLoS medicine.
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PloS one.
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
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Orvosi hetilap.
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PLoS genetics.
2009 Feb; 5(2):e1000372. doi:
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Yonsei medical journal.
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Circulation.
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Neuroscience.
2008 Nov; 157(2):376-84. doi:
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Pflugers Archiv : European journal of physiology.
2008 Nov; 457(2):361-75. doi:
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Bioorganic & medicinal chemistry.
2008 Oct; 16(20):9349-58. doi:
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International journal of sports medicine.
2008 Oct; 29(10):795-802. doi:
10.1055/s-2008-1038433. [PMID: 18401808] - Pirkko Sallinen, Satu Mänttäri, Hanna Leskinen, Olli Vakkuri, Heikki Ruskoaho, Seppo Saarela. Long-term postinfarction melatonin administration alters the expression of DHPR, RyR2, SERCA2, and MT2 and elevates the ANP level in the rat left ventricle.
Journal of pineal research.
2008 Aug; 45(1):61-9. doi:
10.1111/j.1600-079x.2008.00556.x. [PMID: 18284551] - Anna Buj-Bello, Françoise Fougerousse, Yannick Schwab, Nadia Messaddeq, Danièle Spehner, Christopher R Pierson, Muriel Durand, Christine Kretz, Olivier Danos, Anne-Marie Douar, Alan H Beggs, Patrick Schultz, Marie Montus, Patrice Denèfle, Jean-Louis Mandel. AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.
Human molecular genetics.
2008 Jul; 17(14):2132-43. doi:
10.1093/hmg/ddn112. [PMID: 18434328] - Maria A S Fernandes, Susana P S Pereira, Amália S Jurado, José B A Custódio, Maria S Santos, António J M Moreno, Gunars Duburs, Joaquim A F Vicente. Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance to the length of the alkoxyl chain in positions 3 and 5 of the DHP ring.
Chemico-biological interactions.
2008 Jun; 173(3):195-204. doi:
10.1016/j.cbi.2008.03.001. [PMID: 18452904] - Rose M Snopko, Josefina Ramos-Franco, Alessandro Di Maio, Kimberly L Karko, Christopher Manley, Erika Piedras-Rentería, Rafael Mejía-Alvarez. Ca2+ sparks and cellular distribution of ryanodine receptors in developing cardiomyocytes from rat.
Journal of molecular and cellular cardiology.
2008 Jun; 44(6):1032-44. doi:
10.1016/j.yjmcc.2008.03.015. [PMID: 18468619] - Elke Wühl, Franz Schaefer. Therapeutic strategies to slow chronic kidney disease progression.
Pediatric nephrology (Berlin, Germany).
2008 May; 23(5):705-16. doi:
10.1007/s00467-008-0789-y. [PMID: 18335252] - Liisa M Peltonen, Satu Mänttäri. Is there life in the horny layer? Dihydropyridine and ryanodine receptors in the skin of female and male chickens (Gallus domesticus).
The Journal of experimental biology.
2008 May; 211(Pt 9):1394-401. doi:
10.1242/jeb.014282. [PMID: 18424673] - Alicia M Ebert, Catherine A McAnelly, Ashok Srinivasan, Rachel Lockridge Mueller, David B Garrity, Deborah M Garrity. The calcium channel beta2 (CACNB2) subunit repertoire in teleosts.
BMC molecular biology.
2008 Apr; 9(?):38. doi:
10.1186/1471-2199-9-38. [PMID: 18419826] - R A Bannister, H M Colecraft, K G Beam. Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.
Biophysical journal.
2008 Apr; 94(7):2631-8. doi:
10.1529/biophysj.107.116467. [PMID: 18192376] - Khalid Tai, Marie-Christine Hamaide, Huguette Debaix, Philippe Gailly, Maurice Wibo, Nicole Morel. Agonist-evoked calcium entry in vascular smooth muscle cells requires IP3 receptor-mediated activation of TRPC1.
European journal of pharmacology.
2008 Mar; 583(1):135-47. doi:
10.1016/j.ejphar.2008.01.007. [PMID: 18289524] - Satomi Onoue, Naoko Igarashi, Yukinori Yamauchi, Noriaki Murase, Yu Zhou, Takashi Kojima, Shizuo Yamada, Yoshiko Tsuda. In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 Mar; 33(3):262-70. doi:
10.1016/j.ejps.2007.12.004. [PMID: 18207709] - Janina Briede, Mara Stivrina, Brigita Vigante, Dzintra Stoldere, Gunars Duburs. Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in the isolated, perfused normal rat heart.
Cell biochemistry and function.
2008 Mar; 26(2):238-45. doi:
10.1002/cbf.1442. [PMID: 17990288] - Charlotte Hadtstein, Franz Schaefer. Hypertension in children with chronic kidney disease: pathophysiology and management.
Pediatric nephrology (Berlin, Germany).
2008 Mar; 23(3):363-71. doi:
10.1007/s00467-007-0643-7. [PMID: 17990006] - Yoshihiro Uesawa, Kiminori Mohri. Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Jan; 128(1):117-22. doi:
10.1248/yakushi.128.117. [PMID: 18176062] - J Briede, M Stivrina, Dz Stoldere, B Vigante, G Duburs. Effect of cerebrocrast, a new long-acting compound on blood glucose and insulin levels in rats when administered before and after STZ-induced diabetes mellitus.
Cell biochemistry and function.
2007 Nov; 25(6):673-80. doi:
10.1002/cbf.1372. [PMID: 16986170] - Jawad Kiani, Sardar Z Imam. Medicinal importance of grapefruit juice and its interaction with various drugs.
Nutrition journal.
2007 Oct; 6(?):33. doi:
10.1186/1475-2891-6-33. [PMID: 17971226] - Brigitte Held, Volodymyr Tsvilovskyy, Marcel Meissner, Lars Kaestner, Andreas Ludwig, Sven Mossmang, Peter Lipp, Marc Freichel, Veit Flockerzi. Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse.
Cell calcium.
2007 Oct; 42(4-5):477-87. doi:
10.1016/j.ceca.2007.04.013. [PMID: 17580090] - Clive Rosendorff. Hypertension and coronary artery disease: a summary of the American Heart Association scientific statement.
Journal of clinical hypertension (Greenwich, Conn.).
2007 Oct; 9(10):790-5. doi:
10.1111/j.1751-7176.2007.tb00006.x. [PMID: 17917507] - Amy Cavalli, Mansoureh Eghbali, Tamara Y Minosyan, Enrico Stefani, Kenneth D Philipson. Localization of sarcolemmal proteins to lipid rafts in the myocardium.
Cell calcium.
2007 Sep; 42(3):313-22. doi:
10.1016/j.ceca.2007.01.003. [PMID: 17320949] - Julián Segura, José A García-Donaire, Luis M Ruilope. Are differences in calcium antagonists relevant across all stages of nephropathy or only proteinuric nephropathy?.
Current opinion in nephrology and hypertension.
2007 Sep; 16(5):422-6. doi:
10.1097/mnh.0b013e328285dfc4. [PMID: 17693756] - Zhong-Min Wang, Zhenlin Zheng, María L Messi, Osvaldo Delbono. Muscle fibers from senescent mice retain excitation-contraction coupling properties in culture.
In vitro cellular & developmental biology. Animal.
2007 Jul; 43(7):222-34. doi:
10.1007/s11626-007-9047-z. [PMID: 17712595] - Jerry E Johnson, Guy A Perkins, Anand Giddabasappa, Shawntay Chaney, Weimin Xiao, Andrew D White, Joshua M Brown, Jenna Waggoner, Mark H Ellisman, Donald A Fox. Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses.
Molecular vision.
2007 Jun; 13(?):887-919. doi:
. [PMID: 17653034] - Chui Fang, Mijun Peng, Guolin Li, Jinzhou Tian, Dazhong Yin. New functions of glucosamine as a scavenger of the lipid peroxidation product malondialdehyde.
Chemical research in toxicology.
2007 Jun; 20(6):947-53. doi:
10.1021/tx700059b. [PMID: 17480103] - Georg Wensing, Klaus Ochmann, Michael Boettcher, Anja Schäfer, Jochen Kuhlmann. Pharmacodynamic Effects of an Angiotensin II Receptor-Antagonist in Phase I-Comparison between Healthy Subjects and Patients with Hypertension.
Biomarker insights.
2007 Mar; 2(?):81-93. doi:
10.1177/117727190700200039. [PMID: 19662194] - Ramón C Hermida, Diana E Ayala, Carlos Calvo. Optimal timing for antihypertensive dosing: focus on valsartan.
Therapeutics and clinical risk management.
2007 Mar; 3(1):119-31. doi:
10.2147/tcrm.2007.3.1.119. [PMID: 18360620] - Hiromasa Suzuki, Ken Yokoyama, Yoshinori Akimoto, Hiroyuki Daida. Clinical efficacy of benidipine for vasospastic angina pectoris.
Arzneimittel-Forschung.
2007; 57(1):20-5. doi:
10.1055/s-0031-1296581. [PMID: 17341005]