Penicillamine disulfide (BioDeep_00000174019)

   

human metabolite blood metabolite


代谢物信息卡片


2-amino-3-[(1-amino-1-carboxy-2-methylpropan-2-yl)disulfanyl]-3-methylbutanoic acid

化学式: C10H20N2O4S2 (296.0864)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CC(C)(C(C(=O)O)N)SSC(C)(C)C(C(=O)O)N
InChI: InChI=1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)

描述信息

同义名列表

22 个代谢物同义名

2-amino-3-[(1-amino-1-carboxy-2-methylpropan-2-yl)disulfanyl]-3-methylbutanoic acid; Penicillamine disulfide, (D)-isomer; D-Penicillamine disulphide; Penicillamine disulphide; Penicillamine disulfide; (+/-)-penicillamine disulfide; 2-Amino-3-(2-amino-2-carboxy-1,1-dimethyl-ethyldisulfanyl)-3-methyl-butyric acid; 2-amino-3-[(1-amino-1-carboxy-2-methylpropan-2-yl)disulanyl]-3-methylbutanoic acid; 2-amino-3-[(2-amino-3-hydroxy-1,1-dimethyl-3-oxo-propyl)disulfanyl]-3-methyl-butanoic acid; 3,3'-Disulfanediylbis(2-amino-3-methylbutanoic acid); 3,3'-Dithiobis(2-amino-3-methylbutanoic acid); 3,3'-Dithiobis(2-amino-3-methylbutyric acid); CYSTINE, 3,3,3',3'-TETRAMETHYL-; D-Valine, 3,3'-dithiobis-; L-PENICILLAMINE DISULFIDE (disulfide bond); NCIOpen2_005362; PENICILLAMINE DISULFIDE DL-FORM; PENICILLAMINE DISULFIDE DL-FORM [MI]; PENICILLAMINE DISULFIDE, (+/-)-; POYPKGFSZHXASD-UHFFFAOYSA-N; Valine, 3,3'-dithiobis-; VALINE, 3,3'-DITHIODI-



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • G T Yamashita, D L Rabenstein. Determination of penicillamine, penicillamine disulfide and penicillamine-glutathione mixed disulfide by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1989 Jul; 491(2):341-54. doi: 10.1016/s0378-4347(00)82852-2. [PMID: 2808620]
  • J K Nicholson, J A Walshe, I D Wilson. Application of high resolution 1H-NMR spectroscopy to the detection of penicillamine and its metabolites in human urine. Drug metabolism and drug interactions. 1988; 6(3-4):439-46. doi: 10.1515/dmdi.1988.6.3-4.439. [PMID: 3271649]
  • J Wong, D A Applegarth. Quantification of pipecolic acid in plasma, and of urinary cystine in the presence of penicillamine-cystine disulfide, with the Beckman 6300 amino acid analyzer. Clinical chemistry. 1987 Jul; 33(7):1302-3. doi: NULL. [PMID: 3594900]
  • F Matthey, D Perrett, R N Greenwood, L R Baker. The use of D-penicillamine in patients with rheumatoid arthritis undergoing hemodialysis. Clinical nephrology. 1986 May; 25(5):268-71. doi: NULL. [PMID: 3720037]
  • T F Yu, J Roboz, S Johnson, C Kaung. Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. The Journal of rheumatology. 1984 Aug; 11(4):467-70. doi: NULL. [PMID: 6481720]
  • J C Crawhall. Methods for assaying D-penicillamine in a clinical setting. Clinical and investigative medicine. Medecine clinique et experimentale. 1984; 7(1):31-4. doi: NULL. [PMID: 6723121]
  • G Carruthers, M Harth, D Freeman, D Weir, R Rothwell, M Butler. Pharmacokinetics of the major metabolites of D-penicillamine in patients with rheumatoid arthritis. Clinical and investigative medicine. Medecine clinique et experimentale. 1984; 7(1):35-40. doi: NULL. [PMID: 6723122]
  • K Kyogoku, K Inoue, T Otake, K Noda, M Ohzeki. [Determination of D-penicillamine and its metabolites in blood and urine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1982 Apr; 102(4):322-7. doi: 10.1248/yakushi1947.102.4_322. [PMID: 7131247]
  • J C CRAWHALL, C J THOMPSON. CYSTINURIA: EFFECT OF D-PENICILLAMINE ON PLASMA AND URINARY CYSTINE CONCENTRATIONS. Science (New York, N.Y.). 1965 Mar; 147(3664):1459-60. doi: 10.1126/science.147.3664.1459. [PMID: 14263760]