3,3'-Dichlorobiphenyl (BioDeep_00000174016)
human metabolite blood metabolite Industrial Pollutants Volatile Flavor Compounds
代谢物信息卡片
化学式: C12H8Cl2 (222.0003028)
中文名称: 3,3-二氯联苯, 3,3'-二氯联苯
谱图信息:
最多检出来源 Homo sapiens(blood) 40%
分子结构信息
SMILES: C1=CC(=CC(=C1)Cl)C2=CC(=CC=C2)Cl
InChI: InChI=1S/C12H8Cl2/c13-11-5-1-3-9(7-11)10-4-2-6-12(14)8-10/h1-8H
描述信息
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
同义名列表
数据库引用编号
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Monika A Roy, Charlotte K Gridley, Sida Li, Yeonhwa Park, Alicia R Timme-Laragy. Nrf2a dependent and independent effects of early life exposure to 3,3'-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio).
Aquatic toxicology (Amsterdam, Netherlands).
2022 Aug; 249(?):106219. doi:
10.1016/j.aquatox.2022.106219. [PMID: 35700651] - Jana Slováčková, Josef Slavík, Pavel Kulich, Josef Večeřa, Ondrej Kováč, Hana Paculová, Nicol Straková, Radek Fedr, João Pedro Silva, Félix Carvalho, Miroslav Machala, Jiřina Procházková. Polychlorinated environmental toxicants affect sphingolipid metabolism during neurogenesis in vitro.
Toxicology.
2021 11; 463(?):152986. doi:
10.1016/j.tox.2021.152986. [PMID: 34627992] - Monika A Roy, Perseverance R Duche, Alicia R Timme-Laragy. The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio).
Chemosphere.
2020 Dec; 260(?):127609. doi:
10.1016/j.chemosphere.2020.127609. [PMID: 32693259] - Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Ram Dhakal, Xin Hu, Lynn M Teesch, Gabriele Ludewig, Hans-Joachim Lehmler. 3,3'-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells.
Environmental science & technology.
2020 10; 54(19):12345-12357. doi:
10.1021/acs.est.0c03476. [PMID: 32910851] - Monika A Roy, Karilyn E Sant, Olivia L Venezia, Alix B Shipman, Stephen D McCormick, Panithi Saktrakulkla, Keri C Hornbuckle, Alicia R Timme-Laragy. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio).
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt A):113027. doi:
10.1016/j.envpol.2019.113027. [PMID: 31421573] - Sunjay Sethi, Kimberly P Keil, Hao Chen, Keri Hayakawa, Xueshu Li, Yanping Lin, Hans-Joachim Lehmler, Birgit Puschner, Pamela J Lein. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 08; 158(2):401-411. doi:
10.1093/toxsci/kfx100. [PMID: 28510766] - Fabian A Grimm, Hans-Joachim Lehmler, Wen Xin Koh, Jeanne DeWall, Lynn M Teesch, Keri C Hornbuckle, Peter S Thorne, Larry W Robertson, Michael W Duffel. Identification of a sulfate metabolite of PCB 11 in human serum.
Environment international.
2017 Jan; 98(?):120-128. doi:
10.1016/j.envint.2016.10.023. [PMID: 27816204] - Hongtao Shang, Yingming Li, Thanh Wang, Pu Wang, Haidong Zhang, Qinghua Zhang, Guibin Jiang. The presence of polychlorinated biphenyls in yellow pigment products in China with emphasis on 3,3'-dichlorobiphenyl (PCB 11).
Chemosphere.
2014 Mar; 98(?):44-50. doi:
10.1016/j.chemosphere.2013.09.075. [PMID: 24231041] - Yueming Zhu, Kranti A Mapuskar, Rachel F Marek, Wenjin Xu, Hans-Joachim Lehmler, Larry W Robertson, Keri C Hornbuckle, Douglas R Spitz, Nukhet Aykin-Burns. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11).
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Nov; 136(1):39-50. doi:
10.1093/toxsci/kft186. [PMID: 23997111] - Junchao Yu, Thanh Wang, Shanlong Han, Pu Wang, Qinghua Zhang, Guibin Jiang. Distribution of polychlorinated biphenyls in an urban riparian zone affected by wastewater treatment plant effluent and the transfer to terrestrial compartment by invertebrates.
The Science of the total environment.
2013 Oct; 463-464(?):252-7. doi:
10.1016/j.scitotenv.2013.06.006. [PMID: 23811358] - Xin Hu, Hans-Joachim Lehmler, Andrea Adamcakova-Dodd, Peter S Thorne. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite.
Environmental science & technology.
2013 May; 47(9):4743-51. doi:
10.1021/es3049114. [PMID: 23582014] - Carissa M Rocheleau, Stephen J Bertke, James A Deddens, Avima M Ruder, Christina C Lawson, Martha A Waters, Nancy B Hopf, Margaret A Riggs, Elizabeth A Whelan. Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study.
Environmental health : a global access science source.
2011 Mar; 10(?):20. doi:
10.1186/1476-069x-10-20. [PMID: 21418576]