3-Propyl-1H-pyrazole (BioDeep_00000173997)
human metabolite blood metabolite
代谢物信息卡片
3-propyl-1H-Pyrazole
化学式: C6H10N2 (110.084394)
中文名称: 3-正丙基-吡唑
谱图信息:
最多检出来源 Homo sapiens(blood) 95.45%
分子结构信息
SMILES: CCCC1=CC=NN1
InChI: InChI=1S/C6H10N2/c1-2-3-6-4-5-7-8-6/h4-5H,2-3H2,1H3,(H,7,8)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Liu, P H Bisschop, L Eggels, E Foppen, E Fliers, J N Zhou, A Kalsbeek. Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats.
Endocrinology.
2012 Jul; 153(7):3337-44. doi:
10.1210/en.2011-2176. [PMID: 22562172] - Silvina Gutiérrez, Liliana d V Sosa, Juan P Petiti, Jorge H Mukdsi, Iván D Mascanfroni, Claudia G Pellizas, Ana L De Paul, María J Cambiasso, Alicia I Torres. 17β-Estradiol stimulates the translocation of endogenous estrogen receptor α at the plasma membrane of normal anterior pituitary cells.
Molecular and cellular endocrinology.
2012 May; 355(1):169-79. doi:
10.1016/j.mce.2012.02.008. [PMID: 22366173] - José E Sánchez-Criado, Kourtney Trudgen, Yolanda Millán, Alfonso Blanco, José Monterde, José C Garrido-Gracia, Ana Gordon, Rafaela Aguilar, Juana Martín de Las Mulas, CheMyong Ko. Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice.
Reproduction (Cambridge, England).
2012 Apr; 143(4):549-58. doi:
10.1530/rep-11-0214. [PMID: 22367588] - Janne Lebeck, Patrizia Gena, Heidi O'Neill, Mariusz T Skowronski, Sten Lund, Giuseppe Calamita, Jeppe Praetorius. Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Feb; 302(3):G365-74. doi:
10.1152/ajpgi.00437.2011. [PMID: 22114114] - A Tashiro, K Okamoto, D A Bereiter. Rapid estrogenic effects on TMJ-responsive brainstem neurons.
Journal of dental research.
2012 Feb; 91(2):210-4. doi:
10.1177/0022034511428156. [PMID: 22058119] - R W Irwin, J Yao, J To, R T Hamilton, E Cadenas, R D Brinton. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function.
Journal of neuroendocrinology.
2012 Jan; 24(1):236-48. doi:
10.1111/j.1365-2826.2011.02251.x. [PMID: 22070562] - Elise F Saunier, Omar I Vivar, Andrea Rubenstein, Xiaoyue Zhao, Moshe Olshansky, Scott Baggett, Richard E Staub, Mary Tagliaferri, Isaac Cohen, Terence P Speed, John D Baxter, Dale C Leitman. Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation.
PloS one.
2011; 6(12):e28333. doi:
10.1371/journal.pone.0028333. [PMID: 22163294] - L K Davis, Y Katsu, T Iguchi, D T Lerner, T Hirano, E G Grau. Transcriptional activity and biological effects of mammalian estrogen receptor ligands on three hepatic estrogen receptors in Mozambique tilapia.
The Journal of steroid biochemistry and molecular biology.
2010 Oct; 122(4):272-8. doi:
10.1016/j.jsbmb.2010.05.009. [PMID: 20553864] - Hsien-Yu Peng, Gin-Den Chen, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsao-Hsun Hsu, Hsi-Chin Wu, Tzer-Bin Lin. PI3K modulates estrogen-dependent facilitation of colon-to-urethra cross-organ reflex sensitization in ovariectomized female rats.
Journal of neurochemistry.
2010 Apr; 113(1):54-66. doi:
10.1111/j.1471-4159.2010.06577.x. [PMID: 20067569] - Danielle Doucet, Chirag Badami, David Palange, R Paul Bonitz, Qi Lu, Da-Zhong Xu, Kolenkode B Kannan, Iriana Colorado, Rena Feinman, Edwin A Deitch. Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats.
PloS one.
2010 Feb; 5(2):e9421. doi:
10.1371/journal.pone.0009421. [PMID: 20195535] - Heather B Patisaul, Katherine T Burke, Ruth E Hinkle, Heather B Adewale, Damian Shea. Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats.
Hormones and behavior.
2009 Feb; 55(2):319-28. doi:
10.1016/j.yhbeh.2008.11.004. [PMID: 19071129] - Shyam N Sundar, Crystal N Marconett, Victor B Doan, Jamin A Willoughby, Gary L Firestone. Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells.
Carcinogenesis.
2008 Dec; 29(12):2252-8. doi:
10.1093/carcin/bgn214. [PMID: 18784357] - Zheng F Ba, Jun-Te Hsu, Jianguo Chen, Wen-Hong Kan, Martin G Schwacha, Irshad H Chaudry. Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhage.
Shock (Augusta, Ga.).
2008 Nov; 30(5):585-9. doi:
10.1097/shk.0b013e31816f1a45. [PMID: 18391854] - Zheng F Ba, Irshad H Chaudry. Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage.
American journal of physiology. Heart and circulatory physiology.
2008 Nov; 295(5):H2061-7. doi:
10.1152/ajpheart.00707.2008. [PMID: 18805896] - L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright, A Khan. The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.
The Journal of endocrinology.
2008 11; 199(2):X1. doi:
10.1530/joe-08-0192e. [PMID: 18757549] - Tomoharu Shimizu, Takao Suzuki, Huang-Ping Yu, Yukihiro Yokoyama, Mashkoor A Choudhry, Kirby I Bland, Irshad H Chaudry. The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: direct modulation of CINC-1 production by Kupffer cells.
Cytokine.
2008 Jul; 43(1):88-92. doi:
10.1016/j.cyto.2008.04.001. [PMID: 18468914] - Araceli Morales, Miriam Gonzalez, Raquel Marin, Mario Diaz, Rafael Alonso. Estrogen inhibition of norepinephrine responsiveness is initiated at the plasma membrane of GnRH-producing GT1-7 cells.
The Journal of endocrinology.
2007 Jul; 194(1):193-200. doi:
10.1677/joe-06-0001. [PMID: 17592033] - Jing Li, Robert W McMurray. Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model.
Clinical immunology (Orlando, Fla.).
2007 May; 123(2):219-26. doi:
10.1016/j.clim.2007.01.008. [PMID: 17336162] - José C Garrido-Gracia, Ana Gordon, Carmina Bellido, Rafaela Aguilar, Inmaculada Barranco, Yolanda Millán, Juana Martín de Las Mulas, José E Sánchez-Criado. The integrated action of oestrogen receptor isoforms and sites with progesterone receptor in the gonadotrope modulates LH secretion: evidence from tamoxifen-treated ovariectomized rats.
The Journal of endocrinology.
2007 Apr; 193(1):107-19. doi:
10.1677/joe-06-0214. [PMID: 17400808] - Takao Suzuki, Tomoharu Shimizu, Huang-Ping Yu, Ya-Ching Hsieh, Mashkoor A Choudhry, Martin G Schwacha, Irshad H Chaudry. Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage.
Journal of applied physiology (Bethesda, Md. : 1985).
2007 Jan; 102(1):163-8. doi:
10.1152/japplphysiol.00964.2006. [PMID: 17023568] - Takao Suzuki, Tomoharu Shimizu, Huang-Ping Yu, Ya-Ching Hsieh, Mashkoor A Choudhry, Kirby I Bland, Irshad H Chaudry. 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha.
Surgery.
2006 Aug; 140(2):141-8. doi:
10.1016/j.surg.2006.02.014. [PMID: 16904963] - Alicia A Walf, Madeline E Rhodes, Cheryl A Frye. Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats.
Neurobiology of learning and memory.
2006 Jul; 86(1):35-46. doi:
10.1016/j.nlm.2006.01.004. [PMID: 16529958] - Laurie Beth J Morales, Kyi Kyi Loo, Hong-Biao Liu, Cory Peterson, Seema Tiwari-Woodruff, Rhonda R Voskuhl. Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Jun; 26(25):6823-33. doi:
10.1523/jneurosci.0453-06.2006. [PMID: 16793889] - Frank Hildebrand, William J Hubbard, Mashkoor A Choudhry, Bjoern M Thobe, Hans-Christoph Pape, Irshad H Chaudry. Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?.
Journal of leukocyte biology.
2006 Jun; 79(6):1173-80. doi:
10.1189/jlb.0106029. [PMID: 16531562] - Kyu Lee Han, Myeong Ho Jung, Jong Hee Sohn, Jae-Kwan Hwang. Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes.
Biological & pharmaceutical bulletin.
2006 Jan; 29(1):110-3. doi:
10.1248/bpb.29.110. [PMID: 16394521] - J Alejandro Arreguin-Arevalo, Terry M Nett. A nongenomic action of 17beta-estradiol as the mechanism underlying the acute suppression of secretion of luteinizing hormone.
Biology of reproduction.
2005 Jul; 73(1):115-22. doi:
10.1095/biolreprod.105.040329. [PMID: 15772257] - Carolyn M Klinge, Kristy A Blankenship, Kelly E Risinger, Shephali Bhatnagar, Edouard L Noisin, Wasana K Sumanasekera, Lei Zhao, Darren M Brey, Robert S Keynton. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.
The Journal of biological chemistry.
2005 Mar; 280(9):7460-8. doi:
10.1074/jbc.m411565200. [PMID: 15615701] - Helen H Wang, Nezam H Afdhal, David Q-H Wang. Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones.
Gastroenterology.
2004 Jul; 127(1):239-49. doi:
10.1053/j.gastro.2004.03.059. [PMID: 15236189] - José E Sánchez-Criado, Juana Martín De Las Mulas, Carmina Bellido, Manuel Tena-Sempere, Rafaela Aguilar, Alfonso Blanco. Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat.
Neuroendocrinology.
2004; 79(5):247-58. doi:
10.1159/000079100. [PMID: 15205556] - Scott A Jelinsky, Heather A Harris, Eugene L Brown, Kathryn Flanagan, Xiaochun Zhang, Christopher Tunkey, KehDih Lai, Malcolm V Lane, Donna K Simcoe, Mark J Evans. Global transcription profiling of estrogen activity: estrogen receptor alpha regulates gene expression in the kidney.
Endocrinology.
2003 Feb; 144(2):701-10. doi:
10.1210/en.2002-220728. [PMID: 12538633] - Heather A Harris, John A Katzenellenbogen, Benita S Katzenellenbogen. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand.
Endocrinology.
2002 Nov; 143(11):4172-7. doi:
10.1210/en.2002-220403. [PMID: 12399409] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435] - T Uemura, G Sakaguchi, T Ito, K Okazawa, S Sakai. Experimental diarrhea in cynomolgus monkeys by oral administration with Clostridium perfringens type A viable cells or enterotoxin.
Japanese journal of medical science & biology.
1975 Jun; 28(3):165-77. doi:
10.7883/yoken1952.28.165. [PMID: 525]