3-N-Methylspiperone (BioDeep_00000173967)

   

human metabolite blood metabolite


代谢物信息卡片


8-[4-(4-fluorophenyl)-4-oxobutyl]-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

化学式: C24H28FN3O2 (409.2165)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CN1CN(C2(C1=O)CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4
InChI: InChI=1S/C24H28FN3O2/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19/h2-4,6-7,9-12H,5,8,13-18H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists

同义名列表

4 个代谢物同义名

8-[4-(4-fluorophenyl)-4-oxobutyl]-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; N-Methylspiroperidol; 3-N-Methylspiperone; N-methylspiperone



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • K Ishizu, D F Smith, D Bender, E Danielsen, S B Hansen, D F Wong, P Cumming, A Gjedde. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse (New York, N.Y.). 2000 Oct; 38(1):87-101. doi: 10.1002/1098-2396(200010)38:1<87::aid-syn10>3.0.co;2-c. [PMID: 10941144]
  • M Scarselli, M Armogida, S Chiacchio, M G DeMontis, A Colzi, G U Corsini, R Maggio. Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments. European journal of pharmacology. 2000 Jun; 397(2-3):291-6. doi: 10.1016/s0014-2999(00)00272-7. [PMID: 10844126]
  • O Inoue, K Kobayashi, R Hosoi, A Gee. Opposing effects of clomipramine on [125I]RTI-55 and [3H]N-methylspiperone binding in mouse striatum: important role of other factors than endogenous dopamine?. Synapse (New York, N.Y.). 1998 Nov; 30(3):338-40. doi: 10.1002/(sici)1098-2396(199811)30:3<338::aid-syn12>3.0.co;2-w. [PMID: 9776138]
  • D F Wong, G D Pearlson, L E Tune, L T Young, C C Meltzer, R F Dannals, H T Ravert, J Reith, M J Kuhar, A Gjedde. Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1997 Mar; 17(3):331-42. doi: 10.1097/00004647-199703000-00010. [PMID: 9119906]
  • P Hartvig, R Torstenson, J Tedroff, Y Watanabe, K J Fasth, P Bjurling, B Långström. Amphetamine effects on dopamine release and synthesis rate studied in the Rhesus monkey brain by positron emission tomography. Journal of neural transmission (Vienna, Austria : 1996). 1997; 104(4-5):329-39. doi: 10.1007/bf01277655. [PMID: 9295169]
  • A L Nordström, L Farde, S Nyberg, P Karlsson, C Halldin, G Sedvall. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients. The American journal of psychiatry. 1995 Oct; 152(10):1444-9. doi: 10.1176/ajp.152.10.1444. [PMID: 7573582]
  • S J Gatley. Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1993 Dec; 34(12):2208-15. doi: NULL. [PMID: 8254413]
  • R L Ehrenkaufer, S Klam, K Makoroff, S Giandinoto, T Morton, D Moroney, P Nowak. Internal-surface reversed-phase chromatography for plasma metabolite analysis of radiopharmaceuticals. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1992 Aug; 19(6):651-7. doi: 10.1016/0883-2897(92)90099-k. [PMID: 1522019]
  • D J Schlyer, N D Volkow, J S Fowler, A P Wolf, C Y Shiue, S L Dewey, B Bendriem, J Logan, R Raulli, R Hitzemann. Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol. Synapse (New York, N.Y.). 1992 May; 11(1):10-9. doi: 10.1002/syn.890110103. [PMID: 1604422]
  • J Logan, S L Dewey, A P Wolf, J S Fowler, J D Brodie, B Angrist, N D Volkow, S J Gatley. Effects of endogenous dopamine on measures of [18F]N-methylspiroperidol binding in the basal ganglia: comparison of simulations and experimental results from PET studies in baboons. Synapse (New York, N.Y.). 1991 Nov; 9(3):195-207. doi: 10.1002/syn.890090306. [PMID: 1685599]
  • H J Coppens, C J Slooff, A M Paans, T Wiegman, W Vaalburg, J Korf. High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients. Biological psychiatry. 1991 Apr; 29(7):629-34. doi: 10.1016/0006-3223(91)90132-6. [PMID: 1675892]
  • H Karbe, K Wienhard, K Hamacher, M Huber, K Herholz, H H Coenen, G Stöcklin, A Lövenich, W D Heiss. Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol. Journal of neural transmission. General section. 1991; 86(3):163-73. doi: 10.1007/bf01250702. [PMID: 1837996]
  • F J Monsma, A C Barton, D R Sibley. Expression of functional D2 dopamine receptors following differentiation of Y-79 human retinoblastoma cells. Journal of neurochemistry. 1990 Apr; 54(4):1200-7. doi: 10.1111/j.1471-4159.1990.tb01949.x. [PMID: 1968958]
  • S L Dewey, J D Brodie, J S Fowler, R R MacGregor, D J Schlyer, P T King, D L Alexoff, N D Volkow, C Y Shiue, A P Wolf. Positron emission tomography (PET) studies of dopaminergic/cholinergic interactions in the baboon brain. Synapse (New York, N.Y.). 1990; 6(4):321-7. doi: 10.1002/syn.890060403. [PMID: 1981112]
  • M Smith, A P Wolf, J D Brodie, C D Arnett, F Barouche, C Y Shiue, J S Fowler, J A Russell, R R MacGregor, A Wolkin. Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients. Biological psychiatry. 1988 Apr; 23(7):653-63. doi: 10.1016/0006-3223(88)90048-0. [PMID: 2967093]
  • C D Arnett, A P Wolf, C Y Shiue, J S Fowler, R R MacGregor, D R Christman, M R Smith. Improved delineation of human dopamine receptors using [18F]-N-methylspiroperidol and PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1986 Dec; 27(12):1878-82. doi: NULL. [PMID: 3491193]
  • D F Wong, A Gjedde, H N Wagner. Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1986 Apr; 6(2):137-46. doi: 10.1038/jcbfm.1986.27. [PMID: 2937794]
  • J S Fowler, C D Arnett, A P Wolf, C Y Shiue, R R MacGregor, C Halldin, B Långström, H N Wagner. A direct comparison of the brain uptake and plasma clearance of N-[11C]methylspiroperidol and [18F]N-methylspiroperidol in baboon using PET. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1986; 13(3):281-4. doi: 10.1016/0883-2897(86)90109-1. [PMID: 3771261]
  • C D Arnett, J S Fowler, A P Wolf, C Y Shiue, D W McPherson. [18F]-N-Methylspiroperidol: the radioligand of choice for PETT studies of the dopamine receptor in human brain. Life sciences. 1985 Apr; 36(14):1359-66. doi: 10.1016/0024-3205(85)90041-4. [PMID: 3872397]