3-Hydroxypropyl methacrylate (BioDeep_00000173934)
human metabolite blood metabolite
代谢物信息卡片
3-hydroxypropyl 2-methylprop-2-enoate
化学式: C7H12O3 (144.0786402)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(=C)C(=O)OCCCO
InChI: InChI=1S/C7H12O3/c1-6(2)7(9)10-5-3-4-8/h8H,1,3-5H2,2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Liu, Xiaojie Li, Yinfeng Qian, Xianglong Hu, Shiyong Liu. Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties.
Biomaterials.
2012 Mar; 33(8):2521-31. doi:
10.1016/j.biomaterials.2011.12.013. [PMID: 22204981] - Mareli Allmeroth, Dorothea Moderegger, Barbara Biesalski, Kaloian Koynov, Frank Rösch, Oliver Thews, Rudolf Zentel. Modifying the body distribution of HPMA-based copolymers by molecular weight and aggregate formation.
Biomacromolecules.
2011 Jul; 12(7):2841-9. doi:
10.1021/bm2005774. [PMID: 21692523] - Zhenqiang Zhao, Zhibin Chen, Xiubo Zhao, Fang Pan, Meihua Cai, Tan Wang, Henggui Zhang, Jian R Lu, Ming Lei. Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions.
Journal of biomedical science.
2011 Jun; 18(?):37. doi:
10.1186/1423-0127-18-37. [PMID: 21645412] - Chao Zhao, Lingyan Li, Qiuming Wang, Qiuming Yu, Jie Zheng. Effect of film thickness on the antifouling performance of poly(hydroxy-functional methacrylates) grafted surfaces.
Langmuir : the ACS journal of surfaces and colloids.
2011 Apr; 27(8):4906-13. doi:
10.1021/la200061h. [PMID: 21405141] - S Sadekar, A Ray, M Janàt-Amsbury, C M Peterson, H Ghandehari. Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice.
Biomacromolecules.
2011 Jan; 12(1):88-96. doi:
10.1021/bm101046d. [PMID: 21128624] - Chao Zhao, Lingyan Li, Jie Zheng. Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization.
Langmuir : the ACS journal of surfaces and colloids.
2010 Nov; 26(22):17375-82. doi:
10.1021/la103382j. [PMID: 20942427] - Irvin L Pan, Ryan McQuinn, James J Giovannoni, Vivian F Irish. Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development.
Journal of experimental botany.
2010 Jun; 61(6):1795-806. doi:
10.1093/jxb/erq046. [PMID: 20335407] - Song-Qi Gao, Yongen Sun, Pavla Kopecková, C Matthew Peterson, Jindrich Kopecek. Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.
Pharmaceutical research.
2008 Jan; 25(1):218-26. doi:
10.1007/s11095-007-9465-3. [PMID: 17929146] - Huaizhong Pan, Pavla Kopecková, Jihua Liu, Dong Wang, Scott C Miller, Jindrich Kopecek. Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.
Pharmaceutical research.
2007 Dec; 24(12):2270-80. doi:
10.1007/s11095-007-9449-3. [PMID: 17899324] - Dezeng Fan, Zhiyuan Jia, Xinhao Yan, Xiaolei Liu, Wei Dong, Fuyu Sun, Jian Ji, Jianping Xu, Kefeng Ren, Weidong Chen, Jiacong Shen, Hong Qiu, Runlin Gao. [Pilot study of a cell membrane like biomimetic drug-eluting coronary stent].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2007 Jun; 24(3):599-602. doi:
NULL. [PMID: 17713270] - Song-Qi Gao, Zheng-Rong Lu, Pavla Kopecková, Jindrich Kopecek. Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
Journal of controlled release : official journal of the Controlled Release Society.
2007 Feb; 117(2):179-85. doi:
10.1016/j.jconrel.2006.10.024. [PMID: 17150276] - Handan Yavuz, Sinan Akgöl, Ridvan Say, Adil Denizli. Affinity separation of immunoglobulin G subclasses on dye attached poly(hydroxypropyl methacrylate) beads.
International journal of biological macromolecules.
2006 Nov; 39(4-5):303-9. doi:
10.1016/j.ijbiomac.2006.04.009. [PMID: 16764922] - Bahar Zarabi, Anjan Nan, Jiachen Zhuo, Rao Gullapalli, Hamidreza Ghandehari. Macrophage targeted N-(2-hydroxypropyl)methacrylamide conjugates for magnetic resonance imaging.
Molecular pharmaceutics.
2006 Sep; 3(5):550-7. doi:
10.1021/mp060072i. [PMID: 17009854] - Twan Lammers, Rainer Kühnlein, Maria Kissel, Vladimir Subr, Tomas Etrych, Robert Pola, Michal Pechar, Karel Ulbrich, Gert Storm, Peter Huber, Peter Peschke. Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
Journal of controlled release : official journal of the Controlled Release Society.
2005 Dec; 110(1):103-18. doi:
10.1016/j.jconrel.2005.09.010. [PMID: 16274831] - Qing-Hui Zhou, Douglas L Miller, Robert C Carlisle, Leonard W Seymour, David Oupicky. Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.
Journal of controlled release : official journal of the Controlled Release Society.
2005 Sep; 106(3):416-27. doi:
10.1016/j.jconrel.2005.05.002. [PMID: 15967534] - . Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products.
International journal of toxicology.
2005; 24 Suppl 5(?):53-100. doi:
10.1080/10915810500434209. [PMID: 16596769] - Dong Wang, Scott C Miller, Monika Sima, Dennis Parker, Henry Buswell, K Craig Goodrich, Pavla Kopecková, Jindrich Kopecek. The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study.
Pharmaceutical research.
2004 Oct; 21(10):1741-9. doi:
10.1023/b:pham.0000045232.18134.e9. [PMID: 15553217] - Giuseppe Chirico, Maddalena Collini, Francesca Olivini, Moreno Zamai, Enrico Frigerio, Valeria R Caiolfa. Aggregation properties of a HPMA-camptothecin copolymer in isotonic solutions.
Biophysical chemistry.
2004 Aug; 110(3):281-95. doi:
10.1016/j.bpc.2004.03.004. [PMID: 15228964] - Jian-Ping Xu, Jian Ji, Wei-Dong Chen, Hui-Fang Zhao, Jia-Cong Shen, De-Zeng Fan, Yu-Fu Sun. A novel crosslinkable polymer as drug-loaded coating for biomedical device.
Journal of materials science. Materials in medicine.
2004 Feb; 15(2):137-43. doi:
10.1023/b:jmsm.0000011814.05438.12. [PMID: 15330047] - Aparna Nori, Keith D Jensen, Monica Tijerina, Pavla Kopecková, Jindrich Kopecek. Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.
Journal of controlled release : official journal of the Controlled Release Society.
2003 Aug; 91(1-2):53-9. doi:
10.1016/s0168-3659(03)00213-x. [PMID: 12932637] - Blanka Ríhová, Jirí Strohalm, Jana Prausová, Katerina Kubácková, Markéta Jelínková, Lad'ka Rozprimová, Milada Sírová, Dana Plocová, Tomás Etrych, Vladimír Subr, Tomás Mrkvan, Marek Kovár, Karel Ulbrich. Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data.
Journal of controlled release : official journal of the Controlled Release Society.
2003 Aug; 91(1-2):1-16. doi:
10.1016/s0168-3659(03)00235-9. [PMID: 12932633] - Ronit Satchi-Fainaro, Hanna Hailu, John W Davies, Clive Summerford, Ruth Duncan. PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination.
Bioconjugate chemistry.
2003 Jul; 14(4):797-804. doi:
10.1021/bc020091k. [PMID: 12862433] - C Matthew Peterson, Jane-Guo Shiah, Yongen Sun, Pavla Kopecková, Tamara Minko, Richard C Straight, Jindrich Kopecek. HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.
Advances in experimental medicine and biology.
2003; 519(?):101-23. doi:
10.1007/0-306-47932-x_7. [PMID: 12675211] - M Tijerina, P Kopecková, J Kopecek. The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.
Journal of controlled release : official journal of the Controlled Release Society.
2001 Jul; 74(1-3):269-73. doi:
10.1016/s0168-3659(01)00334-0. [PMID: 11489506] - M Kissel, P Peschke, V Subr, K Ulbrich, J Schuhmacher, J Debus, E Friedrich. Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
PDA journal of pharmaceutical science and technology.
2001 May; 55(3):191-201. doi:
NULL. [PMID: 11417110] - M P Patel, M B Johnstone, F J Hughes, M Braden. The effect of two hydrophilic monomers on the water uptake of a heterocyclic methacrylate system.
Biomaterials.
2001 Jan; 22(1):81-6. doi:
10.1016/s0142-9612(00)00171-x. [PMID: 11085387]