5-(m-Hydroxyphenyl)-5-phenylhydantoin (BioDeep_00000173911)

   

human metabolite blood metabolite


代谢物信息卡片


5-(3-hydroxyphenyl)-5-phenylimidazolidine-2,4-dione

化学式: C15H12N2O3 (268.0847882)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC(=CC=C3)O
InChI: InChI=1S/C15H12N2O3/c18-12-8-4-7-11(9-12)15(10-5-2-1-3-6-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)

描述信息

同义名列表

7 个代谢物同义名

5-(3-hydroxyphenyl)-5-phenylimidazolidine-2,4-dione; 5-(3-Hydroxyphenyl)-5-phenylhydantoin, (+-)-isomer; 5-(3-Hydroxyphenyl)-5-phenylhydantoin, (R)-isomer; 5-(3-Hydroxyphenyl)-5-phenylhydantoin, (S)-isomer; 5-(m-Hydroxyphenyl)-5-phenylhydantoin; 5-(3-Hydroxyphenyl)-5-phenylhydantoin; 5-HPPH



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zenghan Tong, David S Hage. Characterization of interaction kinetics between chiral solutes and human serum albumin by using high-performance affinity chromatography and peak profiling. Journal of chromatography. A. 2011 Sep; 1218(39):6892-7. doi: 10.1016/j.chroma.2011.08.026. [PMID: 21872871]
  • Corey M Ohnmacht, Shirley Chen, Zenghan Tong, David S Hage. Studies by biointeraction chromatography of binding by phenytoin metabolites to human serum albumin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 May; 836(1-2):83-91. doi: 10.1016/j.jchromb.2006.03.043. [PMID: 16621742]
  • L R Soma, C E Uboh, F Guan, E K Birks, D C Teleis, J A Rudy, D S Tsang, A O Watson. Disposition, elimination, and bioavailability of phenytoin and its major metabolite in horses. American journal of veterinary research. 2001 Apr; 62(4):483-9. doi: 10.2460/ajvr.2001.62.483. [PMID: 11327452]
  • E Tanaka, N Sakamoto, M Inubushi, S Misawa. Simultaneous determination of plasma phenytoin and its primary hydroxylated metabolites in carbon tetrachloride-intoxicated rats by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Nov; 673(1):147-51. doi: 10.1016/0378-4347(95)00250-m. [PMID: 8925069]
  • E A Peeters, B R Bloem, M A Kuiper, P Vermeij, F A de Wolff, E C Wolters, R A Roos, M D Ferrari. Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease. Clinical neurology and neurosurgery. 1994 Nov; 96(4):296-9. doi: 10.1016/0303-8467(94)90117-1. [PMID: 7889690]
  • S Eto, H Noda, A Noda. Chiral separation of barbiturates and hydantoins by reversed-phase high-performance liquid chromatography using a 25 or 50 mm short ODS cartridge column via beta-cyclodextrin inclusion complexes. Journal of chromatography. 1992 Sep; 579(2):253-8. doi: 10.1016/0378-4347(92)80389-8. [PMID: 1429972]
  • R P Remmel, S A Miller, N M Graves. Simultaneous assay of felbamate plus carbamazepine, phenytoin, and their metabolites by liquid chromatography with mobile phase optimization. Therapeutic drug monitoring. 1990 Jan; 12(1):90-6. doi: 10.1097/00007691-199001000-00017. [PMID: 2305427]
  • P E Nolan, F I Marcus, G L Hoyer, M Bliss, K Gear. Pharmacokinetic interaction between intravenous phenytoin and amiodarone in healthy volunteers. Clinical pharmacology and therapeutics. 1989 Jul; 46(1):43-50. doi: 10.1038/clpt.1989.104. [PMID: 2743707]
  • E M Rimmer, A Richens. Interaction between vigabatrin and phenytoin. British journal of clinical pharmacology. 1989; 27 Suppl 1(?):27S-33S. doi: 10.1111/j.1365-2125.1989.tb03458.x. [PMID: 2757906]
  • S Fritz, W Lindner, I Roots, B M Frey, A Küpfer. Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans. The Journal of pharmacology and experimental therapeutics. 1987 May; 241(2):615-22. doi: NULL. [PMID: 3572817]
  • W A Geary, G F Wooten, J B Perlin, E W Lothman. In vitro and in vivo distribution and binding of phenytoin to rat brain. The Journal of pharmacology and experimental therapeutics. 1987 May; 241(2):704-13. doi: ". [PMID: 3572819]
  • S A Mira, Y M el-Sayed, S I Islam. Simultaneous measurement of phenobarbital, carbamazepine, phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in serum by high-performance liquid chromatography. The Analyst. 1987 Jan; 112(1):57-60. doi: 10.1039/an9871200057. [PMID: 3565781]
  • J S McClanahan, J H Maguire. High-performance liquid chromatographic determination of the enantiomeric composition of urinary phenolic metabolites of phenytoin. Journal of chromatography. 1986 Sep; 381(2):438-46. doi: 10.1016/s0378-4347(00)83612-9. [PMID: 3760100]
  • D P Geaney, J G Carver, C L Davies, J K Aronson. Pharmacokinetic investigation of the interaction of azapropazone with phenytoin. British journal of clinical pharmacology. 1983 Jun; 15(6):727-34. doi: 10.1111/j.1365-2125.1983.tb01557.x. [PMID: 6871071]
  • A J Glazko, F E Peterson, T Chang, W A Dill, T C Smith, R A Buchanan. Phenytoin metabolism in subjects with long and short plasma half-lives. Therapeutic drug monitoring. 1982; 4(3):281-92. doi: 10.1097/00007691-198208000-00006. [PMID: 7135458]
  • J Hermansson, T Iversen, U Lindquist. Isolation and determination of the diastereomers of the glucuronidated 5-(4-hydroxyphenyl)-5-phenylhydantoin in human urine using HPLC. Acta pharmaceutica Suecica. 1982; 19(3):199-210. doi: NULL. [PMID: 7113727]
  • J H Maguire, T C Butler, K H Dudley. Absolute configurations of the dihydrodiol metabolites of 5,5-diphenylhydantoin (phenytoin) from rat, dog, and human urine. Drug metabolism and disposition: the biological fate of chemicals. 1980 Sep; 8(5):325-31. doi: NULL. [PMID: 6107230]
  • J H Maguire, B L Kraus, T C Butler, K H Dudley. Determination of 5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (Dihydrodiol) and quantitative studies of phenytoin metabolism in man. Therapeutic drug monitoring. 1979; 1(3):359-70. doi: 10.1097/00007691-197901030-00009. [PMID: 555579]