3-Deazaneplanocin (BioDeep_00000173889)
human metabolite blood metabolite
代谢物信息卡片
5-{4-amino-1H-imidazo[4,5-c]pyridin-1-yl}-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
化学式: C12H14N4O3 (262.1065854)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
InChI: InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shanshan Zou, Jianing Chen, Peihui Zhou, Mengzhu Xue, Ming Wu, Li Wang. Multi-Omics Integrated Analysis of the Protective Effect of EZH2 Inhibition in Mice with Renal Ischemia-Reperfusion Injury.
Kidney & blood pressure research.
2024; 49(1):196-207. doi:
10.1159/000537866. [PMID: 38368866] - Anna Nowicka, Barbara Tokarz, Jana Zwyrtková, Eva Dvořák Tomaštíková, Klára Procházková, Ugur Ercan, Andreas Finke, Wilfried Rozhon, Brigitte Poppenberger, Miroslav Otmar, Igor Niezgodzki, Marcela Krečmerová, Ingo Schubert, Ales Pecinka. Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
The Plant journal : for cell and molecular biology.
2020 04; 102(1):68-84. doi:
10.1111/tpj.14612. [PMID: 31733119] - Marita Liebisch, Gunter Wolf. AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
American journal of nephrology.
2020; 51(9):676-692. doi:
10.1159/000510140. [PMID: 32854097] - Yingfeng Shi, Min Tao, Yi Wang, Xiujuan Zang, Xiaoyan Ma, Andong Qiu, Shougang Zhuang, Na Liu. Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis.
The Journal of pathology.
2020 01; 250(1):79-94. doi:
10.1002/path.5352. [PMID: 31579944] - Dallas M Rohraff, Ye He, Evan A Farkash, Mark Schonfeld, Pei-Suen Tsou, Amr H Sawalha. Inhibition of EZH2 Ameliorates Lupus-Like Disease in MRL/lpr Mice.
Arthritis & rheumatology (Hoboken, N.J.).
2019 10; 71(10):1681-1690. doi:
10.1002/art.40931. [PMID: 31106974] - Jun Ni, Xiying Hou, Xueqiao Wang, Yinfeng Shi, Liuqing Xu, Xiaoqing Zheng, Na Liu, Andong Qiu, Shougang Zhuang. 3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression.
Cell death & disease.
2019 05; 10(5):355. doi:
10.1038/s41419-019-1589-y. [PMID: 31043583] - Hotake Takizawa, Yuko Hara, Yoshitaka Mizobe, Taisuke Ohno, Sadafumi Suzuki, Ken Inoue, Eri Takeshita, Yuko Shimizu-Motohashi, Akihiko Ishiyama, Mikio Hoshino, Hirofumi Komaki, Shin'ichi Takeda, Yoshitsugu Aoki. Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride.
Scientific reports.
2019 03; 9(1):3807. doi:
10.1038/s41598-019-40421-z. [PMID: 30846748] - X Zhou, X Zang, Y Guan, T Tolbert, T C Zhao, G Bayliss, S Zhuang. Targeting enhancer of zeste homolog 2 protects against acute kidney injury.
Cell death & disease.
2018 10; 9(11):1067. doi:
10.1038/s41419-018-1012-0. [PMID: 30341286] - Imari Mimura, Yosuke Hirakawa, Yasuharu Kanki, Ryo Nakaki, Yutaka Suzuki, Tetsuhiro Tanaka, Hiroyuki Aburatani, Masaomi Nangaku. Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.
Scientific reports.
2018 02; 8(1):3779. doi:
10.1038/s41598-018-22180-5. [PMID: 29491489] - Feng Sun, Lawrence Lee, Zhiwei Zhang, Xiaochong Wang, Qiang Yu, XiaoQun Duan, Eli Chan. Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus™.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Sep; 77(?):290-302. doi:
10.1016/j.ejps.2015.06.021. [PMID: 26116990] - Lucyna Dymińska. Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials.
Bioorganic & medicinal chemistry.
2015 Sep; 23(18):6087-99. doi:
10.1016/j.bmc.2015.07.045. [PMID: 26314922] - Jérémie Gaudichon, Francesco Milano, Julie Cahu, Lætitia DaCosta, Anton C Martens, Jack-Michel Renoir, Brigitte Sola. Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche.
PloS one.
2014; 9(9):e107009. doi:
10.1371/journal.pone.0107009. [PMID: 25255316] - Serena Vella, Daniela Gnani, Annalisa Crudele, Sara Ceccarelli, Cristiano De Stefanis, Stefania Gaspari, Valerio Nobili, Franco Locatelli, Victor E Marquez, Rossella Rota, Anna Alisi. EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
International journal of molecular sciences.
2013 Dec; 14(12):24154-68. doi:
10.3390/ijms141224154. [PMID: 24351808] - Cody J Peer, Mahadev Rao, Shawn D Spencer, Shandiz Shahbazi, Patricia S Steeg, David S Schrump, William D Figg. A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 May; 927(?):142-6. doi:
10.1016/j.jchromb.2013.01.003. [PMID: 23352636] - Feng Sun, Jian Li, Qiang Yu, Eli Chan. Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Feb; 80(2):323-31. doi:
10.1016/j.ejpb.2011.10.014. [PMID: 22061261] - Annette Hayden, Peter W M Johnson, Graham Packham, Simon J Crabb. S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.
Breast cancer research and treatment.
2011 May; 127(1):109-19. doi:
10.1007/s10549-010-0982-0. [PMID: 20556507] - Feng Sun, Jasmine Chiat-Ling Ong, Qiang Yu, Eli Chan. Quantification of 3-deazaneplanocin A, a novel epigenetic anticancer agent, in rat biosamples by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Feb; 879(3-4):285-90. doi:
10.1016/j.jchromb.2010.12.009. [PMID: 21195038] - Zhigang Xie, Chonglei Bi, Lip Lee Cheong, Shaw Cheng Liu, Gaofeng Huang, Jianbiao Zhou, Qiang Yu, Chien-Shing Chen, Wee Joo Chng. Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells.
PloS one.
2011; 6(6):e21583. doi:
10.1371/journal.pone.0021583. [PMID: 21720561] - Antonia Kalushkova, Mårten Fryknäs, Miguel Lemaire, Charlotte Fristedt, Prasoon Agarwal, Maria Eriksson, Sarah Deleu, Peter Atadja, Anders Osterborg, Kenneth Nilsson, Karin Vanderkerken, Fredrik Oberg, Helena Jernberg-Wiklund. Polycomb target genes are silenced in multiple myeloma.
PloS one.
2010 Jul; 5(7):e11483. doi:
10.1371/journal.pone.0011483. [PMID: 20634887]