3-Butene-1,2-diol (BioDeep_00000173871)

   

human metabolite blood metabolite


代谢物信息卡片


3,4-Dihydroxy-1-butene

化学式: C4H8O2 (88.0524)
中文名称: 丁烯二醇, 3-丁烯-1,2-二醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CC(CO)O
InChI: InChI=1S/C4H8O2/c1-2-4(6)3-5/h2,4-6H,1,3H2



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • John Mitchell. Small molecule immunosensing using surface plasmon resonance. Sensors (Basel, Switzerland). 2010; 10(8):7323-46. doi: 10.3390/s100807323. [PMID: 22163605]
  • Vernon E Walker, Dale M Walker, Quanxin Meng, Jacob D McDonald, Bobby R Scott, Steven K Seilkop, David J Claffey, Patricia B Upton, Mark W Powley, James A Swenberg, Rogene F Henderson. Genotoxicity of 1,3-butadiene and its epoxy intermediates. Research report (Health Effects Institute). 2009 Aug; ?(144):3-79. doi: . [PMID: 20017413]
  • Dale M Walker, Jacob D McDonald, Quanxin Meng, Dean A Kracko, Michael J Bauer, Steven K Seilkop, Elizabeth L Walker, Rogene F Henderson, Vernon E Walker. Measurement of plasma or urinary metabolites and Hprt mutant frequencies following inhalation exposure of mice and rats to 3-butene-1,2-diol. Chemico-biological interactions. 2007 Mar; 166(1-3):191-206. doi: 10.1016/j.cbi.2007.01.017. [PMID: 17316587]
  • Michael M Iba, Michael G Bird. Effect of n-hexane on the disposition and toxicity of the 1,3-butadiene metabolite 3-butene-1,2-diol. Chemico-biological interactions. 2007 Mar; 166(1-3):232-8. doi: 10.1016/j.cbi.2006.07.003. [PMID: 16935275]
  • Christopher L Sprague, Adnan A Elfarra. Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine. Toxicology and applied pharmacology. 2005 Sep; 207(3):266-74. doi: 10.1016/j.taap.2005.01.007. [PMID: 16129119]
  • Christopher L Sprague, Lynette A Phillips, Karen M Young, Adnan A Elfarra. Species and tissue differences in the toxicity of 3-butene-1,2-diol in male Sprague-Dawley rats and B6C3F1 mice. Toxicological sciences : an official journal of the Society of Toxicology. 2004 Jul; 80(1):3-13. doi: 10.1093/toxsci/kfh156. [PMID: 15129020]
  • Christopher L Sprague, Adnan A Elfarra. Mercapturic acid urinary metabolites of 3-butene-1,2-diol as in vivo evidence for the formation of hydroxymethylvinyl ketone in mice and rats. Chemical research in toxicology. 2004 Jun; 17(6):819-26. doi: 10.1021/tx049949f. [PMID: 15206903]
  • Christopher L Sprague, Adnan A Elfarra. Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene. Drug metabolism and disposition: the biological fate of chemicals. 2003 Aug; 31(8):986-92. doi: 10.1124/dmd.31.8.986. [PMID: 12867486]
  • Tiina Anttinen-Klemetti, Raija Vaaranrinta, Kimmo Peltonen. Dose-dependent excretion of unconjugated 3-butene-1,2-diol measured in urine with a gc/ms after 1,3-butadiene exposure. Toxicology mechanisms and methods. 2002; 12(3):211-20. doi: 10.1080/15376520208951157. [PMID: 20021174]
  • A A Elfarra, R J Krause, R A Kemper. Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism. Chemico-biological interactions. 2001 Jun; 135-136(?):239-48. doi: 10.1016/s0009-2797(01)00193-4. [PMID: 11397394]
  • T Anttinen-Klemetti, R Vaaranrinta, K Peltonen. Gas chromatographic determination of 3-butene-1,2-diol in urine samples after 1,3-butadiene exposure. Journal of chromatography. B, Biomedical sciences and applications. 1999 Jul; 730(2):257-64. doi: 10.1016/s0378-4347(99)00227-3. [PMID: 10448961]
  • R A Kemper, A A Elfarra, S R Myers. Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450. Drug metabolism and disposition: the biological fate of chemicals. 1998 Sep; 26(9):914-20. doi: . [PMID: 9733671]
  • R J Krause, J E Sharer, A A Elfarra. Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver. Drug metabolism and disposition: the biological fate of chemicals. 1997 Aug; 25(8):1013-5. doi: NULL. [PMID: 9280411]